The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Tetanic Stimulation Leads to Increased Accumulation of Ca2+/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons
Open accessAbstract
mRNA for the alpha-subunit of CaMKII is abundant in dendrites of neurons in the forebrain (Steward, 1997). Here we show that tetanic stimulation of the Schaffer collateral pathway causes an increase in the concentration of alpha-CaMKII in the dendrites of postsynaptic neurons. The increase is blocked by anisomycin and is detected by both quantitative immunoblot and semiquantitative immunocytochemistry. The increase in dendritic alpha-CaMKII can be measured 100-200 micrometer away from the neuronal cell bodies as early as 5 min after a tetanus. Transport mechanisms for macromolecules from neuronal cell bodies are not fast enough to account for this rapid increase in distal portions of the dendrites. Therefore, we conclude that dendritic protein synthesis must produce a portion of the newly accumulated CaMKII. The increase in concentration of dendritic CaMKII after tetanus, together with the previously demonstrated increase in autophosphorylated CaMKII (Ouyang et al., 1997), will produce a prolonged increase in steady-state kinase activity in the dendrites, potentially influencing mechanisms of synaptic plasticity that are controlled through phosphorylation by CaMKII.
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Cites
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · cited 6×
“Frey and Morris (1997) found evidence that late LTP requires both a synapse-specific “tag” induced by relatively weak tetanus and one or more proteins whose synthesis is stimulated more globally in the neuron during a strong tetanus.”
BackgroundInfluentialDeficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
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Autophosphorylation at Thr 286 of the α Calcium-Calmodulin Kinase II in LTP and Learning
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Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain
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Self-citationWu, L., Wells, D., Tay, J., Mendis, D., Abbott, M.-A., Barnitt, A., Quinlan, E., Heynen, A., Fallon, J. R., & Richter, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80630-3 · Cited by 488 · cited 2×
“Thus, one possible mechanism by which tetanic stimulation might increase a-CaMKII synthesis is via phosphorylation of the CPEB protein, which is indeed present in hippocampal dendrites (Wu et al., 1998).”
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Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus
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Self-citationThe absence of a major Ca 2+ signaling pathway in GABAergic neurons of the hippocampus
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Cited by
The molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193
Kanai, Y., Dohmae, N., & Hirokawa, N. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.022 · Cited by 1,108
Metaplasticity: tuning synapses and networks for plasticity
Abraham, W. C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2356 · Cited by 1,108
Metadata
- Authors
- Ouyang, Y., Rosenstein, A., Kreiman, G., Schuman, E. M., & Kennedy, M. B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-09-15
- Volume
- 19
- Issue
- 18
- Pages
- 7823-7833
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2137433892
- Cited by
- 292
- References
- 10
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Tetanic Stimulation Leads to Increased Accumulation of Ca2+/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons. https://app.cochat.ai/papers/10.1523/jneurosci.19-18-07823.1999
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- Ouyang, Y., Rosenstein, A., Kreiman, G., Schuman, E. M., & Kennedy, M. B. (1999). Tetanic Stimulation Leads to Increased Accumulation of Ca2+/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-18-07823.1999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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