The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Chemical Stimulation of Synaptosomes Modulates α-Ca2+/Calmodulin-Dependent Protein Kinase II mRNA Association to Polysomes
Open accessAbstract
The presence of specific mRNAs in dendrites and at synapses is well established, but a direct and reliable demonstration that they are associated with polysomes is still missing. To address this point we analyzed the polysomal association of the mRNAs for the alpha-subunit of Ca(2+)/calmodulin-dependent protein kinase II (alpha-CaMKII), for type 1 inositol 1,4,5-trisphosphate receptor (InsP3R1) and for the activity-regulated cytoskeleton-associated protein (Arc) in a synaptosomal preparation devoid of contaminating material from neuronal and glial perikarya. We show that a fraction of alpha-CaMKII, InsP3R1, and Arc mRNAs present in synaptosomes is indeed associated with polysomes. Moreover, we show that polysomal association of alpha-CaMKII mRNA, but not InsP3R1 and Arc mRNAs, increases with depolarization of the synaptosomal membrane. Finally, we show that the synthesis of alpha-CaMKII protein increases with stimulation. Dendritic mRNA recruitment onto polysomes in response to synaptic stimulation might represent one of the mechanisms underlying the processes of learning and memory.
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Cited by
Dynamic predictions: Oscillations and synchrony in top–down processing
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Neurobiology of emotion perception I: the neural basis of normal emotion perception
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A taxonomy of external and internal attention.
Chun, M. M., Golomb, J. D., & Turk-Browne, N. B. (2011) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100427 · Cited by 1,472
Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Functional neuroanatomy of emotions: A meta-analysis
MURPHY, F. C., NIMMO-SMITH, I., & LAWRENCE, A. D. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.3.207 · Cited by 1,135
Metadata
- Authors
- Bagni, C., Mannucci, L., Dotti, C. G., & Amaldi, F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-05-15
- Volume
- 20
- Issue
- 10
- Pages
- RC76-RC76
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2142979031
- Cited by
- 357
- References
- 21
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bagni, C., Mannucci, L., Dotti, C. G., & Amaldi, F. (2000). Chemical Stimulation of Synaptosomes Modulates α-Ca2+/Calmodulin-Dependent Protein Kinase II mRNA Association to Polysomes. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-10-j0004.2000
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