The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons
Open accessAbstract
The mechanisms underlying the subcellular localization of neurotrophins and their receptors are poorly understood. We show that in cultured hippocampal neurons, the mRNAs for BDNF and TrkB have a somatodendritic localization, and we quantify the extent of their dendritic mRNA localization. In the dendrites the labeling covers on average the proximal 30% of the total dendritic length. On high potassium depolarization, the labeling of BDNF and TrkB mRNA extends on average to 68% of the dendritic length. This increase does not depend on new RNA synthesis, is inhibited by the Na+channel blocker tetrodotoxin, and involves the activation of glutamate receptors. Extracellular Ca 2+, partly flowing through L-type Ca 2+channels, is absolutely required for this process to occur. At the protein level, a brief stimulation of hippocampal neurons with 10 m m KCl leads to a marked increase of BDNF and TrkB immunofluorescence density in the distal portion of dendrites, which also occurs, even if at lower levels, when transport is inhibited by nocodazole. The protein synthesis inhibitor cycloheximide abolishes this increase. The activity-dependent modulation of mRNA targeting and protein accumulation in the dendrites may provide a mechanism for achieving a selective local regulation of the activity of neurotrophins and their receptors, close to their sites of action.
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Cites
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
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Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02295.1997 · Cited by 1,097
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Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.
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“BDN F mRNA expression is upregulated by physiological stimuli (Castrén et al., 1992) and by stimuli leading to hippocampal long-term potentiation (Patterson et al., 1992; C astrén et al., 1993; Dragunow et al., 1993; Lindholm et al., 1994).”
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Cited by
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337
BDNF and synaptic plasticity, cognitive function, and dysfunction
Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945
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Metadata
- Authors
- Tongiorgi, E., Righi, M., & Cattaneo, A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-12-15
- Volume
- 17
- Issue
- 24
- Pages
- 9492-9505
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2143823065
- Cited by
- 328
- References
- 10
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tongiorgi, E., Righi, M., & Cattaneo, A. (1997). Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.17-24-09492.1997
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
