Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S. W., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81369-0 · Cited by 3,073

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Shah, M. A., Datson, N. A., Srinidhi, L., Stanton, V. P., MacDonald, M. E., Allard, M. W., Youngman, S., Am, F., Mott, R., Draths, K., et al. (1993) · Cell · Cited by 3,055

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P., & Aronin, N. (1997) · Science · doi:10.1126/science.277.5334.1990 · Cited by 2,439

Neuropathological Classification of Huntingtonʼs Disease

VONSATTEL, J.-P., MYERS, R. H., STEVENS, T. J., FERRANTE, R. J., BIRD, E. D., & RICHARDSON, E. P. (1985) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-198511000-00003 · Cited by 2,227

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L., & Bates, G. P. (1997) · Cell · doi:10.1016/s0092-8674(00)80513-9 · Cited by 2,188

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the “phosphocreatine circuit” for cellular energy homeostasis

Wallimann, T., Wyss, M., Brdiczka, D., Nicolay, K., & Eppenberger, H. M. (1992) · Biochemical Journal · doi:10.1042/bj2810021 · Cited by 2,011

Spatial Localization in NMR Spectroscopy in Vivo

Bottomley, P. A. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb32915.x · Cited by 1,382

Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology

Gutekunst, C.-A., Li, S.-H., Yi, H., Mulroy, J. S., Kuemmerle, S., Jones, R., Rye, D., Ferrante, R. J., Hersch, S. M., & Li, X.-J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02522.1999 · Cited by 914

Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease

Saydoff, J. A., Garcia, R. A. G., Browne, S. E., Liu, L., Sheng, J. G., Brenneman, D., Hu, Z., Cardin, S., González, A., von Borstel, R. W., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.011 · Cited by 28

Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology

Lenz, H., Schmidt, M., Welge, V., Kueper, T., Schlattner, U., Wallimann, T., Elsässer, H., Wittern, K., Wenck, H., Stäb, F., et al. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9565-8 · Cited by 28

Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice

Mughal, M. R., Baharani, A., Chigurupati, S., Son, T. G., Chen, E., Yang, P. H., Okun, E., Arumugam, T. V., Chan, S. L., & Mattson, M. P. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq512 · Cited by 29

Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo

Denovan‐Wright, E. M., Rodríguez-Lebrón, E., Lewin, A. S., & Mandel, R. J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.11.003 · Cited by 27

Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes

Deschepper, M., Hoogendoorn, B., Brooks, S. P., Dunnett, S. B., & Jones, L. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.01.012 · Cited by 27

Targeting aggregation in the development of therapeutics for the treatment of Huntington?s disease and other polyglutamine repeat diseases

Steffan, J. S., & Thompson, L. M. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.2.201 · Cited by 26

Hippocampal N‐acetyl aspartate levels do not mirror neuronal cell densities in creatine‐supplemented epileptic rats

Vielhaber, S., Kudin, A. P., Kudina, T. A., Stiller, D., Scheich, H., Schoenfeld, M. A., Feistner, H., Heinze, H., Elger, C. E., & Kunz, W. S. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02954.x · Cited by 26

The "new" mitochondrial disorders

Schapira, A. H. V. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.2.144 · Cited by 26

Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases

Ebrahimi, A., Kamyab, A., Hosseini, S., Ebrahimi, S., & Ashkani‐Esfahani, S. (2023) · Biochemistry Research International · doi:10.1155/2023/5510874 · Cited by 29

Creatine Supplementation Augments Skeletal Muscle Carnosine Content in Senescence-Accelerated Mice (SAMP8)

Derave, W., Jones, G. A., Hespel, P., & Harris, R. C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0699 · Cited by 25

Neuroprotective effects of (±)-huprine Y on in vitro and in vivo models of excitoxicity damage

Canudas, A. M., Pubill, D., Sureda, F. X., Verdaguer, E., Camps, P., Muñoz‐Torrero, D., Jiménez, A., Camins, A., & Pallàs, M. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(02)00029-8 · Cited by 24

Gut Microbiota Modulation for Therapeutic Management of Various Diseases: A New Perspective Using Stem Cell Therapy

Ahmed, L. A., & Al‐Massri, K. F. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220222105004 · Cited by 23

Metabolic changes in visual cortex of neonatal monocular enucleated rat: a proton magnetic resonance spectroscopy study

Chow, A. M., Zhou, I. Y., Fan, S. J., Chan, K. W. Y., Chan, K. C., & Wu, E. X. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.10.002 · Cited by 23

Severe Hyperhomocysteinemia Decreases Respiratory Enzyme and Na+-K+ ATPase Activities, and Leads to Mitochondrial Alterations in Rat Amygdala

Kolling, J., Scherer, E. B. S., Siebert, C., Longoni, A., Loureiro, S. O., Weis, S. N., Pettenuzzo, L. F., & Wyse, Â. T. D. S. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9587-z · Cited by 23

Huntington's disease

Hersch, S. M. (2003) · Current Opinion in Neurology · doi:10.1097/01.wco.0000084229.82329.03 · Cited by 23

MR‐spectroscopic findings in juvenile‐onset Huntington's disease

Reynolds, N. C., Prost, R. W., Mark, L. P., & Joseph, S. A. (2008) · Movement Disorders · doi:10.1002/mds.22245 · Cited by 22

Effects of creatine monohydrate supplementation and exercise on depression-like behaviors and raphe 5-HT neurons in mice

Ahn, N.-R., Leem, Y. H., Kato, M., & Chang, H. (2016) · Physical Activity and Nutrition · doi:10.20463/jenb.2016.09.20.3.4 · Cited by 24

Increased expression of Bim contributes to the potentiation of serum deprivation-induced apoptotic cell death in Huntington's disease knock-in striatal cell line

Kong, P., Kil, M.-O., Lee, H. J., Kim, S., Johnson, G. V. W., & Chun, W. (2008) · Neurological Research · doi:10.1179/174313208x331572 · Cited by 22

A Hypothesis From Metabolomics Analysis of Diabetic Retinopathy: Arginine-Creatine Metabolic Pathway May Be a New Treatment Strategy for Diabetic Retinopathy

Sun, Y., Kong, L. D., Zhang, A., Han, Y., Sun, H. J., Yan, G., & Wang, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.858012 · Cited by 21

Effect of Leucine Administration to Female Rats During Pregnancy and Lactation on Oxidative Stress and Enzymes Activities of Phosphoryltransfer Network in Cerebral Cortex and Hippocampus of the Offspring

de Franceschi, I. D., Rieger, E., Vargas, A. P., Rojas, D. B., Campos, A. G., Rech, V. C., Feksa, L. R., & Wannmacher, C. M. D. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0961-4 · Cited by 21

The effects of aging, housing and ibuprofen treatment on brain neurochemistry in a triple transgene Alzheimer’s disease mouse model using magnetic resonance spectroscopy and imaging

Choi, J., Carreras, I., Aytan, N., Jenkins-Sahlin, E., Dedeoglu, A., & Jenkins, B. G. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.067 · Cited by 21

Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts

Esteves, S., Duarte‐Silva, S., & Maciel, P. (2016) · Medicinal Research Reviews · doi:10.1002/med.21425 · Cited by 22

Huntington's Disease and Related Disorders

Anderson, K. E. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.10.001 · Cited by 22

Synchrotron radiation Fourier-transform infrared and Raman microspectroscopy study showing an increased frequency of creatine inclusions in the rat hippocampal formation following pilocarpine-induced seizures

Dulinska, J., Setkowicz, Z., Janeczko, K. J., Sandt, C., Dumas, P., Uram, Ł. S., Gzieło, K., & Chwiej, J. G. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5488-z · Cited by 20

MRI of mouse models of neurological disorders

Anderson, S. A., & Frank, J. A. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1167 · Cited by 20

Long term creatine monohydrate supplementation, following neonatal hypoxic ischemic insult, improves neuromuscular coordination and spatial learning in male albino mouse

Iqbal, S., Ali, M. A., & Iqbal, F. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.006 · Cited by 20

Mouse Models of Triplet Repeat Diseases

Bates, G. P., & Gonitel, R. (2006) · Molecular Biotechnology · doi:10.1385/mb:32:2:147 · Cited by 20

Co-administration of creatine plus pyruvate prevents the effects of phenylalanine administration to female rats during pregnancy and lactation on enzymes activity of energy metabolism in cerebral cortex and hippocampus of the offspring

Bortoluzzi, V. T., de Franceschi, I. D., Rieger, E., & Wannmacher, C. M. D. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1353-8 · Cited by 19

Experimental Models of HD and Reflection on Therapeutic Strategies

Kim, J., Bordiuk, O. L., & Ferrante, R. J. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-381328-2.00016-x · Cited by 20

Mitochondrial and metabolic-based protective strategies in Huntington’s disease: the case of creatine and coenzyme Q

Naia, L., Ribeiro, M. J., & Rego, A. C. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.060 · Cited by 19

A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies

Askeland, G., Rodinová, M., Štufková, H., Dosoudilova, Z., Baxa, M., Šmatlíková, P., Bohuslavová, B., Klempíř, J., Nguyen, T. D., Kuśnierczyk, A., et al. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.035949 · Cited by 19

Creatinine downregulates TNF-α in macrophage and T cell lines

Riesberg, L. A., McDonald, T. L., Wang, Y., Chen, X., Holzmer, S. W., Tracy, S., & Drescher, K. M. (2018) · Cytokine · doi:10.1016/j.cyto.2018.04.021 · Cited by 19

A Creatine Transporter Is Operative at the Brush Border Level of the Rat Jejunal Enterocyte

Tosco, M., Faelli, A., Sironi, C., Gastaldi, G., & Orsenigo, M. (2004) · The Journal of Membrane Biology · doi:10.1007/s00232-004-0721-8 · Cited by 20

Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington's disease

Ouk, K., Aungier, J., & Morton, A. J. (2016) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.11.004 · Cited by 18

Pharmacological intervention in oxidative stress as a therapeutic target in neurological disorders

Sharma, S., Advani, D., Das, A., Malhotra, N., Khosla, A., Arora, V., Jha, A., Yadav, M., Ambasta, R. K., & Kumar, P. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab064 · Cited by 19

Toxin-induced mitochondrial dysfunction

Browne, S. E., & Beal, M. F. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)53010-5 · Cited by 17

Exercise-induced, but not creatine-induced, decrease in intramyocellular lipid content improves insulin sensitivity in rats

Vaisy, M., Szlufcik, K., Bock, K. D., Eijnde, B. O., Proeyen, K. V., Verbeke, K., Veldhoven, P. P. V., & Hespel, P. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.10.004 · Cited by 17

A suplementação de creatina prejudica a função renal?

Gualano, B., Ugrinowitsch, C., Seguro, A. C., & Lancha, A. H. (2008) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922008000100013 · Cited by 17

Creatine is Neuroprotective to Retinal Neurons In Vitro But Not In Vivo

Sia, P. I., Wood, J. P. M., Chidlow, G., & Casson, R. J. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-25858 · Cited by 16

Creatine Protects Against Cytosolic Calcium Dysregulation, Mitochondrial Depolarization and Increase of Reactive Oxygen Species Production in Rotenone-Induced Cell Death of Cerebellar Granule Neurons

Fortalezas, S., Marques‐da‐Silva, D., & Gutiérrez‐Merino, C. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9940-0 · Cited by 16

An Investigation of Neurochemical Changes in Chronic Cannabis Users

Newman, S. D., Cheng, H., Martin, A. M. S., Dydak, U., Dharmadhikari, S., Hetrick, W. P., & O’Donnell, B. F. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00318 · Cited by 15

Huntington's disease

Bonelli, R. M., & Beal, M. F. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00030-9 · Cited by 16

The Differential Profiling of Ubiquitin‐Proteasome and Autophagy Systems in Different Tissues before the Onset of H untington's Disease Models

Her, L., Lin, J., Fu, M., Chang, Y., Li, C., Tang, T., Jhang, Y.-L., Chang, C., Shih, M., Cheng, P., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12191 · Cited by 16

Endothelial Dysfunction in Huntington’s Disease: Pathophysiology and Therapeutic Implications

Hu, N., Chen, Z., Zhao, X., Peng, X., Wu, Y. S., Yang, K., & Sun, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041432 · Cited by 15

Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington’s Disease

Serranilla, M., & Woodin, M. A. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.817013 · Cited by 16

Large animal models for Huntington’s disease research

Han, B., 暨南大学粤港澳中枢神经系统再生研究院, 暨., Liang, W., Li, X., Li, S., Yan, S., Tu, Z., & 暨南大学医学院病理生理学系, 广. 广. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2023.199 · Cited by 14

Emerging pharmacological approaches for Huntington's disease

Singh, K., Jain, D., Sethi, P., Gupta, J. K., Tripathi, A. K., Kumar, S., Sarker, S. D., Nahar, L., & Guru, A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176873 · Cited by 15

Creatine supplementation improves neural progenitor cell survival in Huntington's disease

Widmer, H. R., Andres, R., & Wallimann, T. (2016) · Brain Circulation · doi:10.4103/2394-8108.192519 · Cited by 14

Effects of creatine in a rat intestinal model of ischemia/reperfusion injury

Orsenigo, M., Porta, C., Sironi, C., Laforenza, U., Meyer, G., & Tosco, M. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0222-3 · Cited by 14

Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington's disease

Kumar, A., Kneynsberg, A., Tucholski, J., Perry, G. M., van Groen, T., Detloff, P. J., & Lesort, M. J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.05.015 · Cited by 13

Neuroprotection in progressive brain disorders.

Djaldetti, R., Lev, N., & Melamed, E. (2003) · PubMed · Cited by 14

Molecular Biology of Huntington's Disease (HD) and HD-Like Disorders

Rubinsztein, D. C. (2003) · Elsevier eBooks · doi:10.1016/b978-012566652-7/50035-6 · Cited by 14

Creatine protects against 3-nitropropionic acid-induced cell death in murine corticostriatal slice cultures

Vis, J. C., Huizen, R. D. B.-V., Verbeek, M. M., de Waal, R. M. W., ten Donkelaar, H. J., & Kremer, B. H. P. H. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.087 · Cited by 14

Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults

Kaur, S., Birdsill, A. C., Steward, K. A., Pasha, E. P., Kružliak, P., Tanaka, H., & Haley, A. P. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-9961-z · Cited by 13

Creatine and neurotrophin-4/5 promote survival of nitric oxide synthase-expressing interneurons in striatal cultures

Ducray, A., Kipfer, S., Huber, A. W., Andres, R. H., Seiler, R. W., Schlattner, U., Wallimann, T., & Widmer, H. R. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.051 · Cited by 13

Metallothioneins protect cytosolic creatine kinases against stress induced by nitrogen-based oxidants

Chen, Z., Li, J., Zhao, T., Li, X., Meng, F.-G., Mu, H., Yan, Y., & Hai‐Meng, Z. H. O. U. (2011) · Biochemical Journal · doi:10.1042/bj20111565 · Cited by 13

The Biochemistry of Creatine

Turner, C. E., & Gant, N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-401688-0.00007-0 · Cited by 13

Oxidative Enhancement of Insulin Receptor Signaling: Experimental Findings and Clinical Implications

Dröge, W. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1071 · Cited by 13

The potential role of creatine supplementation in neurodegenerative diseases

Chang, H., & Leem, Y. (2023) · Physical Activity and Nutrition · doi:10.20463/pan.2023.0037 · Cited by 15

Effects of Creatine Supplementation on Histopathological and Biochemical Parameters in the Kidney and Pancreas of Streptozotocin-Induced Diabetic Rats

Gonçalves, M. G., Medeiros, M. A., de Lemos, L. I. C., Pedrosa, L. F. C., Santos, P. P. D. A., Abreu, B. J., & Lima, J. P. M. S. (2022) · Nutrients · doi:10.3390/nu14030431 · Cited by 12

The Complexity of Clinical Huntington’s Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers

Tippett, L. J., Waldvogel, H. J., Snell, R. G., Vonsattel, J., Young, A. B., & Faull, R. L. M. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-57193-5_5 · Cited by 12

Investigations Into Bioenergetic Neuroprotection of Cone Photoreceptors: Relevance to Retinitis Pigmentosa

Narayan, D. S., Chidlow, G., Wood, J. P. M., & Casson, R. J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01234 · Cited by 12

Huntington Disease

Wagner, L. A., Menalled, L., Goumeniouk, A. D., Brunner, D., & Leavitt, B. R. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00018-7 · Cited by 12

Neuroprotective therapy for Huntington’s disease: new prospects and challenges

Hersch, S. M., & Rosas, H. D. (2001) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.1.1.111 · Cited by 12

Neuroprotective possibilities for Huntington’s disease

Emerich, D. F. (2001) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.1.3.467 · Cited by 12

Creatine as a mitochondrial theranostic in predictive, preventive, and personalized medicine

Ostojić, S. M., & Rátgéber, L. (2025) · The EPMA Journal · doi:10.1007/s13167-025-00420-9 · Cited by 15

Current Therapeutic Advances in Patients and Experimental Models of Huntington's Disease

Brett, A., Rosenstock, T. R., & Rego, A. C. (2014) · Current Drug Targets · doi:10.2174/1389450114666131124140704 · Cited by 11

Cytotoxicity models of Huntington’s disease and relevance of hormetic mechanisms: A critical assessment of experimental approaches and strategies

Calabrese, E. J., Bhatia, T. N., Calabrese, V., Dhawan, G., Giordano, J., Hanekamp, Y. N., Kapoor, R., Kozumbo, W. J., & Leak, R. K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104371 · Cited by 12

Non-Cell Autonomous and Epigenetic Mechanisms of Huntington’s Disease

Kim, C., Yousefian-Jazi, A., Choi, S.-H., Chang, I., Lee, J.-H., & Ryu, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212499 · Cited by 13

Influência da suplementação aguda e crônica de creatina sobre as concentrações sanguíneas de glicose e lactato de ratos Wistar

de Souza, R. A., dos Santos, R. M., Osório, R. A. L., Cogo, J. C., Júnior, A. C. G. P., Lopes-Martins, R. Á. B., & Ribeiro, W. (2006) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922006000600012 · Cited by 11

Relationship Between Serum Level of Selenium and Metabolites Using 1HNMR-Based Metabonomics in Parkinson’s Disease

Fathi, F., Kyani, A., Darvizeh, F., Mehrpour, M., Tafazzoli, M., & Shahidi, G. A. (2013) · Applied Magnetic Resonance · doi:10.1007/s00723-013-0439-9 · Cited by 11

Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats

Mikati, M. A., Kurdi, R., Rahmeh, A. A., Farhat, F., Rialy, S. A., Lteif, L., Francis, E., Geha, G., & Maraashli, W. (2004) · Brain Injury · doi:10.1080/02699050410001719880 · Cited by 11

Experimental models of Huntington's disease

Raamsdonk, J. M. V., Hayden, M. R., & Leavitt, B. R. (2005) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2005.11.010 · Cited by 12

DNA Testing for Huntington Disease in the Turkish Population

Akbaş, F., & Erginel‐Ünaltuna, N. (2003) · European Neurology · doi:10.1159/000070854 · Cited by 11

Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?

Gualano, B., Ugrinowitsch, C., Artioli, G. G., Benatti, F. B., Scagliusi, F. B., Harris, R. C., & Lancha, A. H. (2008) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-5-16 · Cited by 12

Reduced transglutaminase-catalyzed protein aggregation is observed in the presence of creatine using sedimentation velocity

Burguera, E. F., & Love, B. J. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.12.015 · Cited by 11

Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions

Yılmaz, A., Akyol, S., Ashrafi, N., Saiyed, N., Türkoğlu, O., & Graham, S. F. (2025) · Metabolites · doi:10.3390/metabo15010010 · Cited by 10

Creatine Transporter Immunolocalization in Aged Human and Detached Retinas

de Souza, C. F., Kalloniatis, M., Christie, D. L., Polkinghorne, P. J., McGhee, C. N. J., & Acosta, M. L. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8462 · Cited by 10

Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3

Wang, Z. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.051 · Cited by 11

Mitochondria in neurodegeneration

Beal, M. F. (2002) · Springer eBooks · doi:10.1007/978-2-8178-0929-8_3 · Cited by 10

Efeitos da suplementação de creatina na captação de glicose em ratos submetidos ao exercício físico

Freire, T. O., Gualano, B., Leme, M., Polacow, V. O., & Lancha, A. H. (2008) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922008000500006 · Cited by 9

Effects of creatine supplementation on learning, memory retrieval, and apoptosis in an experimental animal model of Alzheimer disease.

Alimohammadi‐Kamalabadi, M., Eshraghian, M., Zarindast, M., Aliaghaei, A., & Pishva, H. (2015) · PubMed Central · Cited by 9

Creatine and creatine pyruvate reduce hypoxia-induced effects on phrenic nerve activity in the juvenile mouse respiratory system

Scheer, M., Bischoff, A.-M., Kružliak, P., Opatřilová, R., Bovell, D. L., & Büsselberg, D. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.07.006 · Cited by 8

Mitochondria and Parkinson's Disease

Simon, D. K., Chu, C. T., & Swerdlow, R. H. (2011) · Parkinson s Disease · doi:10.4061/2011/261791 · Cited by 8

Neuroprotective Effect of Creatine and Pyruvate on Enzyme Activities of Phosphoryl Transfer Network and Oxidative Stress Alterations Caused by Leucine Administration in Wistar Rats

Rieger, E., de Franceschi, I. D., Preissler, T., & Wannmacher, C. M. D. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9762-5 · Cited by 9

Trinucleotide Repeat Protocols

(2013) · Methods in molecular biology · doi:10.1007/978-1-62703-411-1 · Cited by 8

A Rapid Neurobehavioral Assessment Reveals that FK506 Delays Symptom Onset in R6/2 Huntington's Disease Mice

Ditzler, S. H., Stoeck, J., LeBlanc, M., Kooperberg, C. L., Hansen, S. J., & Olson, J. M. (2003) · Cited by 8

Huntington's disease: new hope for therapeutics

McMurray, C. T. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(01)00006-6 · Cited by 8

Effects of Creatine Treatment on Jejunal Phenotypes in a Rat Model of Acidosis

Sironi, C., Bodega, F., Zocchi, L., & Porta, C. (2019) · Antioxidants · doi:10.3390/antiox8070225 · Cited by 7

Preclinical studies: how much can we rely on?

Rothstein, J. D. (2004) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/17434470410020012 · Cited by 7

C. elegans comme modèle pour les maladies dégénératives héréditaires humaines

Néri, C., & Ségalat, L. (2003) · médecine/sciences · doi:10.1051/medsci/200319121218 · Cited by 7

Bioactive compounds in meat and their importance in human nutrition

Prasow, M., Domaradzki, P., Litwińczuk, A., & Kowalczyk, M. (2019) · Medycyna Ogólna i Nauki o Zdrowiu · doi:10.26444/monz/112261 · Cited by 8

Dianas farmacológicas en las enfermedades neurodegenerativas

Segura, T., Galindo, M. F., Rallo, B., Callejo, V. C., & Bueso, J. J. (2003) · Revista de Neurología · doi:10.33588/rn.3611.2003230 · Cited by 7

Effect of creatine supplementation on cardiac muscle of exercise-stressed rats

McClung, J. M., Hand, G. A., Davis, J., & Carson, J. A. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0746-6 · Cited by 7

Advantages and differences among various animal models of Huntington’s disease

Zhu, Y., Yang, W., & Yan, S. (2024) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2024.13 · Cited by 6

Neuroprotective Potential of Creatine. Hidden Resources of Its Therapeutic and Preventive Use

Нерсесова, Л. С., Petrosyan, M. S., & Arutjunyan, A. V. (2022) · Neurochemical Journal · doi:10.1134/s1819712422010093 · Cited by 7

New Targets for Therapy in Polyglutamine (polyQ) Expansion Diseases

Perrone, L., & Melone, M. A. B. (2008) · Current Drug Therapy · doi:10.2174/157488508785747835 · Cited by 6

Polyalanine and Polyglutamine Diseases: Possible Common Mechanisms?

Abu‐Baker, A., & Rouleau, G. A. (2006) · Elsevier eBooks · doi:10.1016/b978-012369462-1/50034-x · Cited by 6

Huntington's Disease: Can Mice Lead the Way to Treatment?

Crook, Z. R., & Housman, D. E. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.029 · Cited by 6

The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage

Andres, R. H., Ducray, A., Andereggen, L., Hohl, T., Schlattner, U., Wallimann, T., & Widmer, H. R. (2016) · Amino Acids · doi:10.1007/s00726-016-2238-8 · Cited by 6

Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice

Dedeoglu, A., Kubilus, J. K., Yang, L., Ferrante, K. L., Hersch, S. M., Beal, M. F., & Ferrante, A. R. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01706.x · Cited by 169

Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease

Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., Jenkins, B. G., Ferrante, K. L., Thomas, M., Friedlich, A., Browne, S. E., Schilling, G., Borchelt, D. R., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0406 · Cited by 293

Creatine: prescription for bad genes and a hostile environment?

Mattson, M. P. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01697-0 · Cited by 6

Neuroprotective effects of creatine

Beal, M. F. (2011) · Amino Acids · doi:10.1007/s00726-011-0851-0 · Cited by 196

Neuroprotective Effects of Creatine and Cyclocreatine in Animal Models of Huntington’s Disease

Matthews, R. T., Yang, L., Jenkins, B. G., Ferrante, R. J., Rosen, B. R., Kaddurah-Daouk, R. F., & Beal, M. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00156.1998 · Cited by 431