Cited by 21Pain Mechanisms and TreatmentsPain Management and TreatmentPain Management and Placebo Effect

Subliminal (latent) processing of pain and its evolution to conscious awareness

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Borsook, David, Youssef, Andrew M., Barakat, Nadia, Sieberg, Christine B., Elman, Igor·2018·Neuroscience & Biobehavioral Reviews

Abstract

By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions.

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Crossref · 10.1016/j.neubiorev.2018.02.015

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  • The experience of pain eventually enters conscious awareness.

    “the experience of pain eventually enters conscious awareness (Borsook et al., 2018)”

    From Physiological feelings (2019) · cites this paper as Borsook et al., 2018

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  1. Fitzgerald M McKelvey R 2016b Nerve injury and neuropathic pain — a question of age Exp Neurol 275 296 302 26220898 PMC4691235

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Authors
Borsook, D., Youssef, A. M., Barakat, N., Sieberg, C. B., & Elman, I.
Affiliations
  • Center for Pain and the Brain (US)
  • Dayton VA Medical Center (US)
Corresponding author
Borsook, David
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2018-05
Volume
88
Pages
1-15
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2793055948
Cited by
21
References
273
Citations by year
2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 1
FWCI
0.33
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD083133)
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords
chronic pain, pain awareness, brain network reorganization, epigenetic modulation, socioeconomic factors, early therapeutic intervention, nociception
MeSH terms
Animals, Awareness, Brain, Consciousness, Humans, Pain, Unconscious, Psychology, Unconsciousness

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