The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Visual Transmission Deficits in Mice with Targeted Disruption of the Gap Junction Gene Connexin36
Open accessAbstract
In the mammalian retina, rods feed into the cone pathway through electrotonic coupling, and recent histological data suggest the involvement of connexin36 (Cx36) in this pathway. We therefore generated Cx36 null mice and monitored the functional consequences of this deficiency on early visual transmission. The homozygous mutant mice had a normally developed retina and showed no changes in the cellular organization of the rod pathway. In contrast, the functional coupling between AII amacrine cells and bipolar cells was impaired. Recordings of electroretinograms revealed a significant decrease of the scotopic b-wave in mutant animals and an increased cone threshold that is compatible with a distorted, gap junctional transmission between AII amacrine cells and cone bipolar cells. Recordings of visual evoked potentials showed extended latency in mutant mice but unaffected ON and OFF components. Our results demonstrate that Cx36-containing gap junctions are essential for normal synaptic transmission within the rod pathway.
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Cites
A network of fast-spiking cells in the neocortex connected by electrical synapses
Galarreta, M., & Hestrin, S. (1999) · Nature · doi:10.1038/47029 · Cited by 960
Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons
Tamás, G., Buhl, E. H., Lörincz, A., & Somogyi, P. (2000) · Nature Neuroscience · doi:10.1038/73936 · Cited by 648
Cited by
Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome
Willecke, K., Eiberger, J., Degen, J., Eckardt, D., Romualdi, A., Güldenagel, M., Deutsch, U., & Söhl, G. (2002) · Biological Chemistry · doi:10.1515/bc.2002.076 · Cited by 1,158
Self-citationELECTRICAL SYNAPSES IN THE MAMMALIAN BRAIN
Connors, B. W., & Long, M. A. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131128 · Cited by 784
The diverse functional roles and regulation of neuronal gap junctions in the retina
Bloomfield, S. A., & Völgyi, B. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2636 · Cited by 428
Update on connexins and gap junctions in neurons and glia in the mammalian nervous system
Nagy, J. I., Dudek, F. E., & Rash, J. E. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.05.005 · Cited by 375
Ravier, M. A., Güldenagel, M., Charollais, A., Gjinovci, A., Caille, D., Söhl, G., Wollheim, C. B., Willecke, K., Henquin, J.-C., & Meda, P. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1798 · Cited by 360
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Metadata
- Authors
- Güldenagel, M., Ammermüller, J., Feigenspan, A., Teubner, B., Degen, J., Söhl, G., Willecke, K., & Weiler, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-08-15
- Volume
- 21
- Issue
- 16
- Pages
- 6036-6044
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2148804180
- Cited by
- 267
- References
- 2
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Güldenagel, M., Ammermüller, J., Feigenspan, A., Teubner, B., Degen, J., Söhl, G., Willecke, K., & Weiler, R. (2001). Visual Transmission Deficits in Mice with Targeted Disruption of the Gap Junction Gene Connexin36. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.21-16-06036.2001
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