A network of fast-spiking cells in the neocortex connected by electrical synapses
Open accessAbstract
Encoding of information in the cortex is thought to depend on synchronous firing of cortical neurons. Inhibitory neurons are known to be critical in the coordination of cortical activity, but how interaction among inhibitory cells promotes synchrony is not well understood. To address this issue directly, we have recorded simultaneously from pairs of fast-spiking (FS) cells, a type of gamma-aminobutyric acid (GABA)-containing neocortical interneuron. Here we report a high occurrence of electrical coupling among FS cells. Electrical synapses were not found among pyramidal neurons or between FS cells and other cortical cells. Some FS cells were interconnected by both electrical and GABAergic synapses. We show that communication through electrical synapses allows excitatory signalling among inhibitory cells and promotes their synchronous spiking. These results indicate that electrical synapses establish a network of fast-spiking cells in the neocortex which may play a key role in coordinating cortical activity.
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Within hippocampus and neocortex, dendrodendritic or dendrosomatic electrical synapses are a common feature of many interneurons.
“Within hippocampus and neocortex, dendrodendritic or dendrosomatic electrical synapses are a common feature of many interneurons (80, 370, 371, 376, 398, 1084).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [376]
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- Authors
- Galarreta, M., & Hestrin, S.
- Affiliations
- Central South University (CN)
- Corresponding author
- Hestrin, Shaul
- Venue
- Nature
- Published
- 1999-11
- Volume
- 402
- Issue
- 6757
- Pages
- 72-75
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W10573418
- Cited by
- 960
- References
- 44
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 12 · 2023: 18 · 2022: 11 · 2021: 22 · 2020: 24 · 2019: 26 · 2018: 21 · 2017: 31 · 2016: 39 · 2015: 31 · 2014: 51 · 2013: 44 · 2012: 54
- FWCI
- 27.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.scipedia.com
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by-nc-sa)
- RePEc: Research Papers in Economics (submittedVersion)
- Scientia Iranica
- Funders
- National Science Foundation
- National Natural Science Foundation of China
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fast-spiking interneurons, electrical synapses, neocortex, GABAergic synapses, neuronal synchronization, inhibitory interneurons, cortical oscillations, interneuron networks
- MeSH terms
- Action Potentials, Animals, Electrophysiology, gamma-Aminobutyric Acid, Interneurons, Nerve Net, Neural Inhibition, Synaptic Transmission, Synapses, Rats, Wistar, Neocortex, Rats, In Vitro Techniques
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