The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release
Open accessAbstract
Thalamocortical neurons innervating the barrel cortex in neonatal rodents transiently store serotonin (5-HT) in synaptic vesicles by expressing the plasma membrane serotonin transporter (5-HTT) and the vesicular monoamine transporter (VMAT2). 5-HTT knock-out (ko) mice reveal a nearly complete absence of 5-HT in the cerebral cortex by immunohistochemistry, and of barrels, both at P7 and adulthood. Quantitative electron microscopy reveals that 5-HTT ko affects neither the density of synapses nor the length of synaptic contacts in layer IV. VMAT2 ko mice, completely lacking activity-dependent vesicular release of monoamines including 5-HT, also show a complete lack of 5-HT in the cortex but display largely normal barrel fields, despite sometimes markedly reduced postnatal growth. Transient 5-HTT expression is thus required for barrel pattern formation, whereas activity-dependent vesicular 5-HT release is not.
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New evidence for neurotransmitter influences on brain development
Levitt, P., Harvey, J. A., Friedman, E., Simansky, K., & Murphy, E. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01028-4 · Cited by 362
Estimation of the number of synapses in the cerebral cortex: methodological considerations
DeFelipe, J. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.7.722 · Cited by 193
Self-citationLoss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex
Abdel-Majid, R. M., Leong, W. L., Schalkwyk, L. C., Smallman, D. S., Wong, S. T., Storm, D. R., Fine, A., Dobson, M. J., Guernsey, D. L., & Neumann, P. E. (1998) · Nature Genetics · doi:10.1038/980 · Cited by 163
Cited by
The developmental role of serotonin: news from mouse molecular genetics
Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297
Balancing Plasticity/Stability Across Brain Development
Takesian, A. E., & Hensch, T. K. (2013) · Progress in Brain Research · doi:10.1016/b978-0-444-63327-9.00001-1 · Cited by 667
The serotonin system in autism spectrum disorder: From biomarker to animal models
Muller, C. L., Anacker, A. M. J., & Veenstra-VanderWeele, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.010 · Cited by 531
Targeting the murine serotonin transporter: insights into human neurobiology
Murphy, D. L., & Lesch, K.-P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2284 · Cited by 478
Self-citationLesch, K.-P., & Waider, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.013 · Cited by 435
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Metadata
- Authors
- Persico, A. M., Mengual, E., Moessner, R., Hall, S. F., Revay, R. S., Sora, I., Arellano, J., DeFelipe, J., Giménez-Amaya, J. M., Conciatori, M., Marino, R., Baldi, A., Cabib, S., Pascucci, T., Uhl, G. R., Murphy, D. L., Lesch, K. P., & Keller, F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-09-01
- Volume
- 21
- Issue
- 17
- Pages
- 6862-6873
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1713895945
- Cited by
- 213
- References
- 4
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Persico, A. M., Mengual, E., Moessner, R., Hall, S. F., Revay, R. S., Sora, I., Arellano, J., DeFelipe, J., Giménez-Amaya, J. M., Conciatori, M., Marino, R., Baldi, A., Cabib, S., Pascucci, T., Uhl, G. R., Murphy, D. L., Lesch, K. P., & Keller, F. (2001). Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.21-17-06862.2001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
