New evidence for neurotransmitter influences on brain development

Levitt, Pat; Harvey, John A.; Friedman, Eitan; Simansky, Kenny; Murphy, E.Hazel

doi:10.1016/s0166-2236(96)01028-4

Cited by 362Neurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

New evidence for neurotransmitter influences on brain development

Levitt, Pat, Harvey, John A., Friedman, Eitan, Simansky, Kenny, Murphy, E.Hazel·1997·Trends in Neurosciences

DOI 10.1016/s0166-2236(96)01028-4

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Abstract

The early appearance of monoamine systems in the developing mammalian CNS suggests that they play a role in neural development. We review data from two model systems that provide compelling new evidence of this role. In one model system-in utero exposure to cocaine-specific and robust alterations are seen in dopamine-rich areas of the cerebral cortex, such as the anterior cingulate cortex: D1 receptor-G protein coupling is greatly reduced, the GABAergic system is altered and pyramidal dendrites undergo excessive growth. In a second model system-a transgenic mouse line in which the gene that encodes monoamine oxidase A (MAOA) is disrupted, resulting in excessively high 5-HT levels-barrels fail to form in the developing somatosensory cortex. Both models reveal the effects of very early manipulation of monoamines on forebrain development, and the long-term anomalies that persist into adulthood.

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(2005) · Choice Reviews Online · doi:10.5860/choice.43-0626 · Cited by 4,726 · see citing works
Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020 · see citing works
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works
Psychopharmacology: The Third Generation of Progress.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021 · see citing works
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530 · see citing works
Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems
Moore, R. Y., & Bloom, F. E. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.000553 · Cited by 1,378 · see citing works
Neuronal migration, with special reference to developing human brain: a review
Sidman, R. L., & RAKIC, P. T. (1973) · Brain Research · doi:10.1016/0006-8993(73)90617-3 · Cited by 1,251 · see citing works
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works
Neurons in Rhesus Monkey Visual Cortex: Systematic Relation between Time of Origin and Eventual Disposition
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161 · see citing works
Advances in infancy research
Lipsitt, L. P., & Rovee‐Collier, C. (1981) · Medical Entomology and Zoology · Cited by 1,144 · see citing works
The dopamine hypothesis of the reinforcing properties of cocaine
Kuhar, M. J., Ritz, M. C., & Boja, J. W. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90141-g · Cited by 989 · see citing works
Central Catecholamine Neuron Systems: Anatomy and Physiology of the Dopamine Systems
Moore, R. Y., & Bloom, F. E. (1978) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.01.030178.001021 · Cited by 931 · see citing works
Modulation of visual cortical plasticity by acetylcholine and noradrenaline
Bear, M. F., & Singer, W. (1986) · Nature · doi:10.1038/320172a0 · Cited by 858 · see citing works
Neurotransmitters as growth regulatory signals: role of receptors and second messengers
Lauder, J. M. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90162-f · Cited by 806 · see citing works
Neurobiology of Cingulate Cortex and Limbic Thalamus
Vogt, B. A., & Gabriel, M. (1993) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6704-6 · Cited by 772 · see citing works
Embryonic vertebrate central nervous system: Revised terminology
Angevine, J. B., Bodian, D., Coulombre, A. J., Edds, M. V., Hamburger, V., Jacobson, M., Lyser, K. M., Prestige, M. C., Sidman, R. L., Varon, S. S., et al. (1970) · The Anatomical Record · doi:10.1002/ar.1091660214 · Cited by 727 · see citing works
Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. I. Cell differentiation
Lauder, J. M., & Bloom, F. E. (1974) · The Journal of Comparative Neurology · doi:10.1002/cne.901550407 · Cited by 658 · see citing works
The Biology of the Laboratory Rabbit
(1974) · Elsevier eBooks · doi:10.1016/c2013-0-11681-9 · Cited by 619 · see citing works
From neuropathology to neurodevelopment
Weinberger, D. R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91386-6 · Cited by 568 · see citing works
Development of the dopaminergic innervation in the prefrontal cortex of the rat
Kalsbeek, A., Voorn, P., Buijs, R. M., Pool, C. W., & Uylings, H. B. M. (1988) · Journal of Comparative Neurology · doi:10.1002/cne.902690105 · Cited by 545 · see citing works
Neurotransmitters in the regulation of neuronal cytoarchitecture
Mattson, M. P. (1988) · Brain Research Reviews · doi:10.1016/0165-0173(88)90020-3 · Cited by 514 · see citing works
Lack of Barrels in the Somatosensory Cortex of Monoamine Oxidase A–Deficient Mice: Role of a Serotonin Excess during the Critical Period
Cases, O., Vitalis, T., Seif, I., Maeyer, E. D., Sotelo, C., & Gaspar, P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80048-3 · Cited by 514 · see citing works
Early prenatal ontogeny of central monoamine neurons in the rat: Fluorescence histochemical observations
Olson, L., & Seiger, �. (1972) · Anatomy and Embryology · doi:10.1007/bf00519099 · Cited by 501 · see citing works
The Cognitive Neurosciences
Morris, R. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)60029-0 · Cited by 479 · see citing works
Depletion of Brain Catecholamines: Failure of Ocular Dominance Shift After Monocular Occlusion in Kittens
Kasamatsu, T., & Pettigrew, J. D. (1976) · Science · doi:10.1126/science.959850 · Cited by 432 · see citing works
The serotonin innervation of the cerebral cortex in the rat—an immunohistochemical analysis
Lidov, H. G. W., Grzanna, R., & Molliver, M. E. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90099-8 · Cited by 417 · see citing works
Neurobiology of cingulate cortex and limbic thalamus : a comprehensive handbook
Vogt, B. A., & Gabriel, M. (1993) · Medical Entomology and Zoology · Cited by 378 · see citing works
Immunohistochemical study of the development of serotonergic neurons in the rat CNS
Lidov, H. G. W., & Molliver, M. E. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90164-2 · Cited by 376 · see citing works
Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice.
Xu, M., Hu, X.-T., Cooper, D. C., Moratalla, R., Graybiel, A., White, F. J., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90026-4 · Cited by 347 · see citing works
Growth and targeting of subplate axons and establishment of major cortical pathways [published erratum appears in J Neurosci 1993 Mar;13(3):following table of contents]
Carlos, J. D., & O'Leary, D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-04-01194.1992 · Cited by 339 · see citing works
Areal changes in mouse cortical barrels following vibrissal damage at different postnatal ages
Woolsey, T. A., & Wann, J. R. (1976) · The Journal of Comparative Neurology · doi:10.1002/cne.901700105 · Cited by 328 · see citing works
The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific
Lewis, D., Campbell, M., Foote, S., Goldstein, M., & Morrison, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-01-00279.1987 · Cited by 325 · see citing works
D1-type dopamine receptors inhibit growth cone motility in cultured retina neurons: evidence that neurotransmitters act as morphogenic growth regulators in the developing central nervous system.
Lankford, K. L., DeMello, F. G., & Klein, W. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2839 · Cited by 307 · see citing works
Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys
Goldman‐Rakic, P. S., & Brown, R. M. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90146-8 · Cited by 283 · see citing works
Neurotransmitters as developmental signals
Meier, E., Hertz, L., & Schousboe, A. (1991) · Neurochemistry International · doi:10.1016/0197-0186(91)90113-r · Cited by 278 · see citing works
Noradrenaline neuron innervation of the neocortex in the rat
Levitt, P., & Moore, R. Y. (1978) · Brain Research · doi:10.1016/0006-8993(78)90925-3 · Cited by 270 · see citing works
A role for subplate neurons in the patterning of connections from thalamus to neocortex
Ghosh, A., & Shatz, C. J. (1993) · Development · doi:10.1242/dev.117.3.1031 · Cited by 263 · see citing works
Dopamine D1 receptors facilitate transmitter release
Cameron, D. L., & Williams, J. T. (1993) · Nature · doi:10.1038/366344a0 · Cited by 263 · see citing works
Neurotransmitters as morphogens
Lauder, J. M. (1988) · Progress in Brain Research · doi:10.1016/s0079-6123(08)60516-6 · Cited by 257 · see citing works
Histochemical demonstration and mapping of 5-hydroxytryptamine- and catecholamine-containing neuron systems in the human fetal brain
Olson, L., Bor�us, L. O., & Seiger, �. (1973) · Anatomy and Embryology · doi:10.1007/bf00519968 · Cited by 255 · see citing works
Early ingrowth of thalamocortical afferents to the neocortex of the prenatal rat.
Catalano, S. M., Robertson, R. T., & Killackey, H. P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.2999 · Cited by 231 · see citing works
Development of the noradrenergic innervation of neocortex
Levitt, P., & Moore, R. Y. (1979) · Brain Research · doi:10.1016/0006-8993(79)90287-7 · Cited by 214 · see citing works
Ontogeny of D1a and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding
Schambra, U. B., Duncan, G. E., Breese, G. R., Fornaretto, M. G., Caron, M. G., & Fremeau, R. T. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90315-8 · Cited by 209 · see citing works
Region‐specific distribution of catecholamine afferents in primate cerebral cortex: A fluorescence histochemical analysis
Levitt, P., RAKIC, P. T., & Goldman‐Rakic, P. S. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902270105 · Cited by 191 · see citing works
Neural development is regulated by classical neurotransmitters: dopamine D2 receptor stimulation enhances neurite outgrowth.
Todd, R. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90311-m · Cited by 187 · see citing works
Cocaine Effects on the Developing Central Nervous System: Behavioral, Psychopharmacological, and Neurochemical Studies
SPEAR, L. P., Kirstein, C. L., & Frambes, N. A. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb21027.x · Cited by 184 · see citing works
Development of the catecholamine neurons in human embryos and fetuses, with special emphasis on the innervaton of the cerebral cortex
Zecevic, N., & Verney, C. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903510404 · Cited by 149 · see citing works
Structural and functional effects of prenatal cocaine exposure in adult rat brain
Dow-Edwards, D. L., Freed, L. A., & Fico, T. A. (1990) · Developmental Brain Research · doi:10.1016/0165-3806(90)90052-z · Cited by 149 · see citing works
The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey
Levitt, P. R., & RAKIC, P. T. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90095-5 · Cited by 145 · see citing works
Prenatal cocaine exposure disrupts the development of the serotonergic system
Akbari, H. M., Kramer, H. K., Whitaker‐Azmitia, P. M., SPEAR, L. P., & Azmitia, E. C. (1992) · Brain Research · doi:10.1016/0006-8993(92)90450-n · Cited by 140 · see citing works
Innervation of embryonic rat cerebral cortex by catecholamine‐containing fibers
Schlumpf, M., Shoemaker, W. J., & Bloom, F. E. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901920210 · Cited by 132 · see citing works
Cocaine-induced disturbances of corticogenesis in the developing murine brain
Gressèns, P., Kosofsky, B. E., & Evrard, P. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90694-3 · Cited by 125 · see citing works
Growth and Development of the Rabbit Brain
Harel, S., Watanabe, K. S., Linke, I., & Schain, R. J. (2009) · Biology of the Neonate · doi:10.1159/000240527 · Cited by 121 · see citing works
Long‐Term Neurochemical and Neurobehavioral Consequences of Cocaine Use during Pregnancya
Dow-Edwards, D. L. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb21026.x · Cited by 110 · see citing works
Emergence of Connectivity in the Embryonic Rat Parietal Cortex
Erzurumlu, R. S., & Jhaveri, S. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.4.336 · Cited by 106 · see citing works
Prenatal exposure to cocaine selectively reduces D1 dopamine receptor-mediated activation of striatal Gs proteins.
Wang, H. Y., Runyan, S., Yadin, E., & Friedman, E. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09613-2 · Cited by 105 · see citing works
Early phenotype expression of cortical neurons: evidence that a subclass of migrating neurons have callosal axons.
Schwartz, M. L., RAKIC, P. T., & RAKIC, P. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1354 · Cited by 103 · see citing works
Nonuniform Alteration of Dendritic Development in the Cerebral Cortex Following Prenatal Cocaine Exposure
Jones, L. B., Fischer, I., & Levitt, P. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.431 · Cited by 99 · see citing works
Dopamine induces neurite retraction in retinal horizontal cells via diacylglycerol and protein kinase C.
Rodrigues, P. D. S., & Dowling, J. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9693 · Cited by 99 · see citing works
The effect of neonatal 6‐hydroxydopamine treatment on synaptogenesis in the visual cortex of the rat
Blue, M. E., & Parnavelas, J. G. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050211 · Cited by 93 · see citing works
Principles of neurotoxicology
Short, A. L. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)90249-x · Cited by 93 · see citing works
A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons
Lankford, K. L., Mello, F. G. D., & Klein, W. L. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90292-8 · Cited by 87 · see citing works
Effect of prenatal cocaine on dopamine receptor-G protein coupling in mesocortical regions of the rabbit brain
Friedman, E., Yadin, E., & Wang, H. Y. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)83011-9 · Cited by 84 · see citing works
Characterization of the monoaminergic innervation of immature rat neocortex: A histofluorescence analysis
Lidov, H. G. W., Molliver, M. E., & Zečević, N. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901810311 · Cited by 77 · see citing works
Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: effects on neurotransmitter turnover and receptors.
Seidler, F. J., & Slotkin, T. A. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10365-0 · Cited by 77 · see citing works
Context-specific multi-site cingulate cortical, limbic thalamic, and hippocampal neuronal activity during concurrent discriminative approach and avoidance training in rabbits
Freeman, J. H., Cuppernell, C., Flannery, K., & Gabriel, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01538.1996 · Cited by 75 · see citing works
Fluorescence and electron microscopic studies of the early development of the substantia nigra and area ventralis tegmenti in the fetal rabbit
Tennyson, V. M., Mytilineou, C., & Barrett, R. E. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901490208 · Cited by 69 · see citing works
Increased tyrosine hydroxylase immunoreactivity in the rat cortex following prenatal cocaine exposure
Akbari, H. M., & Azmitia, E. C. (1992) · Developmental Brain Research · doi:10.1016/0165-3806(92)90093-c · Cited by 64 · see citing works
Intrauterine cocaine exposure of rabbits: persistent elevation of GABA-immunoreactive neurons in anterior cingulate cortex but not visual cortex
Wang, X.-H., Levitt, P. R., Grayson, D. R., & Murphy, E. H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00528-x · Cited by 60 · see citing works
Novel effects of serotonin on neurite outgrowth in neurons cultured from embryos of Helisoma trivolvis
Goldberg, J. I., Mills, L. R., & Kater, S. B. (1991) · Journal of Neurobiology · doi:10.1002/neu.480220208 · Cited by 60 · see citing works
Prenatal exposure to cocaine disrupts discrimination learning in adult rabbits
Romano, A. G., & Harvey, J. A. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02061-6 · Cited by 60 · see citing works
The intracortical distribution of norepinephrine, dopamine and serotonin in the cerebral cortex of the cat
Reader, T. A., Masse, P., & de Champlain, J. (1979) · Brain Research · doi:10.1016/0006-8993(79)90467-0 · Cited by 56 · see citing works
Principles of neurotoxicology
Tilson, H. A., & Harry, G. J. (2002) · CRC Press eBooks · doi:10.1201/9780203219096-9 · Cited by 53 · see citing works
Different mechanisms of glutamate-induced neuronal death between dopaminergic and non-dopaminergic neurons in rat mesencephalic culture
Sawada, H., Kawamura, T., Shimohama, S., AKAIKE, A., & Kimura, J. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960215)43:4 · Cited by 52 · see citing works
Unique profiles of the alpha 1-, alpha 2-, and beta-adrenergic receptors in the developing cortical plate and transient embryonic zones of the rhesus monkey
Lidow, M. S., & RAKIC, P. T. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04064.1994 · Cited by 48 · see citing works
Prenatal exposure to cocaine selectively disrupts motor responding to d-Amphetamine in young and mature rabbits
Simansky, K. J., & Kachelries, W. J. (1996) · Neuropharmacology · doi:10.1016/0028-3908(95)00151-4 · Cited by 47 · see citing works
Potential mechanisms of cocaine-induced developmental neurotoxicity: a minireview.
Olsen, G. D. (1995) · PubMed · Cited by 46 · see citing works
Prenatal cocaine administration stimulates fetal brain tyrosine hydroxylase activity
Meyer, J. S., & Dupont, S. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90783-j · Cited by 46 · see citing works
Altered neuronal distribution of parvalbumin in anterior cingulate cortex of rabbits exposed in utero to cocaine
Wang, X., Jenkins, A., Choi, L., & Murphy, E. H. (1996) · Experimental Brain Research · doi:10.1007/bf00227942 · Cited by 43 · see citing works
The rabbit as a model for studies of cocaine exposure in utero.
Eh, M., Jg, H., Schumann, M. D., My, G., Xh, W., Jones, L., Ag, R., & Harvey, J. A. (1995) · PubMed · Cited by 35 · see citing works
Activation of D1 receptors stimulates accumulation of γ-aminobutyric acid in slices of the pars reticulata of 6-hydroxydopamine-lesioned rats
Aceves, J., Florán, B., Martínez‐Fong, D., Benitez, J., Sierra, A., & Flores, G. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90198-g · Cited by 33 · see citing works
Normal development of tyrosine hydroxylase and serotonin immunoreactive fibers innervating anterior cingulate cortex and visual cortex in rabbits exposed prenatally to cocaine
Wang, X., Levitt, P. R., Jenkins, A., & Murphy, E. H. (1996) · Brain Research · doi:10.1016/0006-8993(96)00012-1 · Cited by 27 · see citing works
Prenatal cocaine exposure
Fantel, A. G., & Shepard, T. H. (1990) · Reproductive Toxicology · doi:10.1016/0890-6238(90)90001-c · Cited by 17 · see citing works
Prenatal cocaine treatment reduces haloperidol-induced catalepsy on postnatal day 10
Meyer, J. S., Robinson, P., & Todtenkopf, M. S. (1994) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(94)90117-1 · Cited by 16 · see citing works
Prenatal cocaine exposure revealed minimal postnatal changes in rat striatal dopamine D2 receptor sites and mRNA levels in the offspring
Stadlin, A., Choi, H. L., Tsim, K. W. K., & Tsang, D. (1995) · Molecular Neurobiology · doi:10.1007/bf02740685 · Cited by 15 · see citing works
Effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring
Goodwin, G. A., Rajachandran, L., Moody, C. A., Francis, R., Kuhn, C. M., & SPEAR, L. P. (1995) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(95)00010-o · Cited by 9 · see citing works

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Andersen, S. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00005-8 · Cited by 1,503 · see citing works
The developmental role of serotonin: news from mouse molecular genetics
Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297 · see citing works
Is there more to gaba than synaptic inhibition?
Owens, D. F., & Kriegstein, A. R. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn919 · Cited by 1,158 · see citing works
Fetal Nicotine or Cocaine Exposure: Which One is Worse?
Slotkin, T. A. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37495-6 · Cited by 676 · see citing works
Prenatal Substance Abuse: Short- and Long-term Effects on the Exposed Fetus
Behnke, M., Smith, V. C., Behnke, M., Smith, V. C., Levy, S., Ammerman, S. D., Gonzalez, P. K., Ryan, S. A., Smith, V. C., Wunsch, M. J., et al. (2013) · PEDIATRICS · doi:10.1542/peds.2012-3931 · Cited by 603 · see citing works
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Rubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S. C. R., Simmons, A., Andrew, C., & Bullmore, E. T. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00055-x · Cited by 545 · see citing works
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Thompson, B. L., Levitt, P. R., & Stanwood, G. D. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2598 · Cited by 367 · see citing works
Developmental Neuropathology of Environmental Agents
Costa, L. G., Aschner, M., Vitalone, A., Syversen, T. L. M., & Soldin, O. P. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121424 · Cited by 363 · see citing works
Dietary essential fatty acids and brain function: a developmental perspective on mechanisms
Wainwright, P. E. (2002) · Proceedings of the Nutrition Society · doi:10.1079/pns2001130 · Cited by 346 · see citing works
The endogenous cannabinoid system and brain development
Fernández‐Ruíz, J., Berrendero, F., Hernández, M., & Ramos, J. A. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01491-5 · Cited by 345 · see citing works
Roles of NMDA receptor activity and nitric oxide production in brain development
Contestabile, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00018-7 · Cited by 338 · see citing works
DOPA Decarboxylase Activity in Attention Deficit Hyperactivity Disorder Adults. A [Fluorine-18]Fluorodopa Positron Emission Tomographic Study
Ernst, M., Zametkin, A. J., Matochik, J. A., Jons, P. H., & Cohen, R. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05901.1998 · Cited by 320 · see citing works
Mice Lacking the Serotonin Transporter Exhibit 5-HT1A Receptor-Mediated Abnormalities in Tests for Anxiety-like Behavior
Holmes, A., Yang, R. J., Lesch, K., Crawley, J. N., & Murphy, D. L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300266 · Cited by 312 · see citing works
Hereditary progressive dystonia with marked diurnal fluctuation
Segawa, M. (2000) · Brain and Development · doi:10.1016/s0387-7604(00)00148-0 · Cited by 267 · see citing works
Nicotine and brain development
Dwyer, J. B., Broide, R. S., & Leslie, F. M. (2008) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.20118 · Cited by 256 · see citing works
High Midbrain [ <sup>18</sup> F]DOPA Accumulation in Children With Attention Deficit Hyperactivity Disorder
Ernst, M., Zametkin, A. J., Matochik, J. A., Pascualvaca, D., Jons, P. H., & Cohen, R. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1209 · Cited by 256 · see citing works
Dendritic spines: Revisiting the physiological role
Chidambaram, S. B., Rathipriya, A. G., Bolla, S. R., Bhat, A., Ray, B., Mahalakshmi, A. M., Manivasagam, T., Thenmozhi, A. J., Essa, M. M., Guillemin, G. J., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.005 · Cited by 255 · see citing works
5-HT7Receptor Is Coupled to Gα Subunits of Heterotrimeric G12-Protein to Regulate Gene Transcription and Neuronal Morphology
Kvachnina, E., Liu, G., Dityatev, A. E., Renner, U., Dumuis, A., Richter, D. W., Dityatev, A. E., Schachner, M., Voyno-Yasenetskaya, T., & Ponimaskin, E. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1790-05.2005 · Cited by 227 · see citing works
Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release
Persico, A. M., Mengual, E., Moessner, R., Hall, F. S., Revay, R. S., Sora, I., Arellano, J. I., DeFelipe, J., Giménez‐Amaya, J. M., Conciatori, M., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06862.2001 · Cited by 213 · see citing works
The α7 nicotinic acetylcholine receptor in neuronal plasticity
Broide, R. S., & Leslie, F. M. (1999) · Molecular Neurobiology · doi:10.1007/bf02741361 · Cited by 210 · see citing works
Neural correlates associated with suicide and nonsuicidal self-injury in youth
Auerbach, R. P., Pagliaccio, D., Allison, G. O., Alqueza, K. L., & Alonso, M. F. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.002 · Cited by 204 · see citing works
Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood
Moll, G. H., Mehnert, C., Wicker, M., Bock, N., Rothenberger, A., Rüther, E., & Huether, G. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00182-0 · Cited by 204 · see citing works
Lmx1bIs Required for Maintenance of Central Serotonergic Neurons and Mice Lacking Central Serotonergic System Exhibit Normal Locomotor Activity
Zhao, Z.-Q., Scott, M. M., Chiechio, S., Wang, J.-S., Renner, K. J., Gereau, R. W., Johnson, R. L., Deneris, E. S., & Chen, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4143-06.2006 · Cited by 204 · see citing works
Differential Postnatal Development of Catecholamine and Serotonin Inputs to Identified Neurons in Prefrontal Cortex of Rhesus Monkey
Lambe, E. K., Krimer, L. S., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08780.2000 · Cited by 204 · see citing works
Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans
Tan, H. Y., Nicodemus, K. K., Chen, Q., Li, Z., Brooke, J. K., Honea, R. A., Kolachana, B. S., Straub, R. E., Meyer‐Lindenberg, A., Sei, Y., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34725 · Cited by 195 · see citing works
Dopamine Modulates Cell Cycle in the Lateral Ganglionic Eminence
Ohtani, N., Goto, T., Waeber, C., & Bhide, P. G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02840.2003 · Cited by 193 · see citing works
Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation
Resende, R. R., & Adhikari, A. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-20 · Cited by 190 · see citing works
Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC)
Airhart, M. J., Lee, D. H., Wilson, T. D., Miller, B. E., Miller, M. N., & Skalko, R. G. (2007) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.07.005 · Cited by 185 · see citing works
Monoamine Oxidase Expression During Development and Aging
Nicotra, A. (2003) · NeuroToxicology · doi:10.1016/s0161-813x(03)00095-0 · Cited by 181 · see citing works
Phylogenomic analyses provide insights into primate evolution
Shao, Y., Zhou, L., Li, F., Zhao, L., Zhang, B.-L., Shao, F., Chen, J., Chen, C., Bi, X., Zhuang, X.-L., et al. (2023) · Science · doi:10.1126/science.abn6919 · Cited by 170 · see citing works
Hereditary progressive dystonia with marked diurnal fluctuation
Segawa, M. (2010) · Brain and Development · doi:10.1016/j.braindev.2010.10.015 · Cited by 175 · see citing works
The Role of Serotonin in Early Cortical Development
Vitalis, T., & Parnavelas, J. G. (2003) · Developmental Neuroscience · doi:10.1159/000072272 · Cited by 171 · see citing works
Prenatal Exposure to Maternal Cigarette Smoking and the Adolescent Cerebral Cortex
Toro, R., Leonard, G. T., Lerner, J. V., Lerner, R. M., Perron, M., Pike, G. B., Richer, L., Veillette, S., Pausová, Z., & Paus, T. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301484 · Cited by 166 · see citing works
Aromatic l -amino acid decarboxylase deficiency
Pons, R. M., Ford, B., Chiriboga, C. A., Clayton, P. T., Hinton, V. J., Hyland, Κ., Sharma, R., & Vivo, D. C. D. (2004) · Neurology · doi:10.1212/wnl.62.7.1058 · Cited by 163 · see citing works
Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.
Aldridge, J. E., Seidler, F. J., & Slotkin, T. A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6713 · Cited by 162 · see citing works
Fetal programming of neuropsychiatric disorders
Faa, G., Manchia, M., Pintus, R., Gerosa, C., Marcialis, M. A., & Fanos, V. (2016) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21139 · Cited by 160 · see citing works
Plasma Membrane Transporters of Serotonin, Dopamine, and Norepinephrine Mediate Serotonin Accumulation in Atypical Locations in the Developing Brain of Monoamine Oxidase A Knock-Outs
Cases, O., Lebrand, C., Giros, B., Vitalis, T., de Maeyer, E., Caron, M., Price, D., Gaspar, P., & Seif, I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06914.1998 · Cited by 168 · see citing works
Embryonic depletion of serotonin affects cortical development
Vitalis, T., Cases, O., Passemard, S., Callebert, J., & Parnavelas, J. G. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05661.x · Cited by 155 · see citing works
Antiepileptic drugs and brain development
Ikonomidou, C., & Turski, L. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.09.019 · Cited by 148 · see citing works
The physiology of developmental changes in BOLD functional imaging signals
Harris, J. J., Reynell, C., & Attwell, D. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.04.001 · Cited by 142 · see citing works
Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism
Kane, M. J., Angoa‐Pérez, M., Briggs, D. I., Sykes, C. E., Francescutti, D. M., Rosenberg, D. R., & Kuhn, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048975 · Cited by 140 · see citing works
Altering the course of neurodevelopment: a framework for understanding the enduring effects of psychotropic drugs
Andersen, S. L., & Navalta, C. P. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.06.002 · Cited by 139 · see citing works
Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods.
Aldridge, J. E., Seidler, F. J., Meyer, A., Thillai, I., & Slotkin, T. A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6489 · Cited by 142 · see citing works
Discussion point stem cells and neurogenesis in the adult brain
Cameron, H. A., & McKay, R. D. G. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80099-8 · Cited by 140 · see citing works
Malformations of Hypothalamic Nuclei in Hyperinsulinemic Offspring of Rats with Gestational Diabetes
Plagemann, A., Harder, T., Janert, U., Rake, A., Rittel, F., Rohde, W., & Dörner, G. (1999) · Developmental Neuroscience · doi:10.1159/000017367 · Cited by 136 · see citing works
Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders
Cristo, G. D. (2007) · Clinical Genetics · doi:10.1111/j.1399-0004.2007.00822.x · Cited by 131 · see citing works
Cocaine effects on the developing brain: current status
Harvey, J. A. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.006 · Cited by 128 · see citing works
Abnormal Phrenic Motoneuron Activity and Morphology in Neonatal Monoamine Oxidase A-Deficient Transgenic Mice: Possible Role of a Serotonin Excess
Bou, C., Lajard, A.-M., Monteau, R., Maeyer, E. D., Seif, I., Lanoir, J., & Hilaire, G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04646.2000 · Cited by 127 · see citing works
GABA promotes survival but not proliferation of parvalbumin-immunoreactive interneurons in rodent neostriatum: an in vivo study with stereology
Luk, K. C., & Sadikot, A. F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00038-0 · Cited by 126 · see citing works
Glutamate Promotes Proliferation of Striatal Neuronal Progenitors by an NMDA Receptor-Mediated Mechanism
Luk, K. C., Kennedy, T. E., & Sadikot, A. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02239.2003 · Cited by 124 · see citing works
Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder
Du, L., Bakish, D., Lapierre, Y. D., Ravindran, A. V., & Hrdina, P. D. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000207)96:1 · Cited by 229 · see citing works
Sleep abnormalities in mentally retarded autistic subjects: Down's syndrome with mental retardation and normal subjects
Diomedi, M., Curatolo, P., Scalise, A., Placidi, F., Caretto, F., & Gigli, G. L. (1999) · Brain and Development · doi:10.1016/s0387-7604(99)00077-7 · Cited by 121 · see citing works
Neuroimaging of children following prenatal drug exposure
Derauf, C., Kekatpure, M., Neyzi, N., Lester, B., & Kosofsky, B. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.03.001 · Cited by 122 · see citing works
Antiepileptic drugs and the developing brain
Kaindl, A. M., Asimiadou, S., Manthey, D., Hagen, M. V. D., Turski, L., & Ikonomidou, C. (2006) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s00018-005-5348-0 · Cited by 121 · see citing works
Phox2a Gene, A6 Neurons, and Noradrenaline Are Essential for Development of Normal Respiratory Rhythm in Mice
Viemari, J., Bévengut, M., Burnet, H., Coulon, P., Péquignot, J.-M., Tiveron, M.-C., & Hilaire, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3065-03.2004 · Cited by 116 · see citing works
Methylphenidate Administration to Juvenile Rats Alters Brain Areas Involved in Cognition, Motivated Behaviors, Appetite, and Stress
Gray, J. D., Punsoni, M., Tabori, N. E., Melton, J. T., Fanslow, V., Ward, M. J., Zupan, B., Menzer, D., Rice, J., Drake, C. T., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0109-07.2007 · Cited by 112 · see citing works
The role of mesocorticolimbic dopamine in regulating interactions between drugs of abuse and social behavior
Young, K. A., Gobrogge, K. L., & Wang, Z. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.004 · Cited by 111 · see citing works
Influence of Dopamine on Precursor Cell Proliferation and Differentiation in the Embryonic Mouse Telencephalon
Popolo, M., McCarthy, D. M., & Bhide, P. G. (2004) · Developmental Neuroscience · doi:10.1159/000082140 · Cited by 113 · see citing works
Role of endocannabinoids in brain development
Fernández‐Ruíz, J., Berrendero, F., Hernández, M., Romero, J., & Ramos, J. A. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00295-7 · Cited by 111 · see citing works
Cannabinoids and gene expression during brain development
Fernández‐Ruíz, J., Gómez‐Ruíz, M., Hernández, M., de Miguel, R., & Ramos, J. A. (2004) · Neurotoxicity Research · doi:10.1007/bf03033314 · Cited by 110 · see citing works
Primates exposed to cocaine in utero display reduced density and number of cerebral cortical neurons
Lidow, M. S., & Song, Z. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1028 · Cited by 106 · see citing works
Regulation of neuroblast mitosis is determined by PACAP receptor isoform expression
Nicot, A. B., & DiCicco-Bloom, E. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071465398 · Cited by 106 · see citing works
In UteroCocaine-Induced Dysfunction of Dopamine D1Receptor Signaling And Abnormal Differentiation of Cerebral Cortical Neurons
Jones, L. B., Stanwood, G. D., Reinoso, B. S., Washington, R. A., Wang, H.-Y., Friedman, E., & Levitt, P. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04606.2000 · Cited by 106 · see citing works
Drug exposure early in life: functional repercussions of changing neuropharmacology during sensitive periods of brain development
Stanwood, G. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.09.003 · Cited by 105 · see citing works
Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin c: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys
Slotkin, T. A., Seidler, F. J., Qiao, D., Aldridge, J. E., Tate, C. A., Cousins, M. M., Proskocil, B. J., Sekhon, H. S., Clark, J. A., Lupo, S. L., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300544 · Cited by 101 · see citing works
Unique expression patterns of 5‐HT2A and 5‐HT2C receptors in the rat brain during postnatal development: Western blot and immunohistochemical analyses
Li, Q., Nakadate, K., Tanaka‐Nakadate, S., Nakatsuka, D., Cui, Y., & Watanabe, Y. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.11004 · Cited by 99 · see citing works
Fetal Effects of Psychoactive Drugs
Salisbury, A. L., Ponder, K. L., Padbury, J. F., & Lester, B. M. (2009) · Clinics in Perinatology · doi:10.1016/j.clp.2009.06.002 · Cited by 98 · see citing works
Evidence for a susceptibility locus on chromosome 6q influencing phonological coding dyslexia
Petryshen, T. L., Kaplan, B. J., Liu, M. F., de French, N. S., Tobias, R., Hughes, M. L., & Field, L. L. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1475 · Cited by 99 · see citing works
Functional Effect of Adeno-associated Virus Mediated Gene Transfer of Aromatic L-Amino Acid Decarboxylase into the Striatum of 6-OHDA-Lesioned Rats
Sánchez‐Pernaute, R., Harvey-White, J. D., Cunningham, J., & Bankiewicz, K. S. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0466 · Cited by 97 · see citing works
Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: a systematic review
El Marroun, H., White, T., Verhulst, F. C., & Tiemeier, H. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0558-3 · Cited by 92 · see citing works
Prenatal cocaine exposure produces consistent developmental alterations in dopamine-rich regions of the cerebral cortex
Stanwood, G. D., Washington, R. A., Shumsky, J. S., & Levitt, P. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00256-1 · Cited by 94 · see citing works
Serotonergic gene expression and depression: implications for developing novel antidepressants
Lesch, K. P. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00351-7 · Cited by 93 · see citing works
The cholinergic innervation develops early and rapidly in the rat cerebral cortex: a quantitative immunocytochemical study
Mechawar, N., & Descarries, L. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00389-x · Cited by 91 · see citing works
Blockade of the NMDA receptor increases developmental apoptotic elimination of granule neurons and activates caspases in the rat cerebellum
Monti, B., & Contestabile, A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00189.x · Cited by 92 · see citing works
Mechanisms of Action of Drugs of Abuse on the Developing Fetal Brain
Malanga, C. J., & Kosofsky, B. E. (1999) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30070-8 · Cited by 92 · see citing works
Neuromodulation of associative and organizational plasticity across the life span: Empirical evidence and neurocomputational modeling
Li, S., Brehmer, Y., Shing, Y. L., Werkle‐Bergner, M., & Lindenberger, U. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.004 · Cited by 90 · see citing works
Role of the CNS microvascular pericyte in the blood-brain barrier
Balabanov, R. D., & Dore‐Duffy, P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980915)53:6 · Cited by 304 · see citing works
Transplanted Neuroblasts Differentiate Appropriately into Projection Neurons with Correct Neurotransmitter and Receptor Phenotype in Neocortex Undergoing Targeted Projection Neuron Degeneration
Shin, J. J., Fricker‐Gates, R. A., Perez, F. A., Leavitt, B. R., Zurakowski, D., & Macklis, J. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07404.2000 · Cited by 88 · see citing works
Nutrition and the development of cognitive functions: interpretation of behavioral studies in animals and human infants
Wainwright, P. E., & Colombo, J. A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.961 · Cited by 89 · see citing works
Prenatal cocaine exposure impairs selective attention: Evidence from serial reversal and extradimensional shift tasks.
Garavan, H., Morgan, R. E., Mactutus, C. F., Levitsky, D. A., Booze, R. M., & Strupp, B. J. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.4.725 · Cited by 89 · see citing works
Cannabis and neurodevelopment: implications for psychiatric disorders
Sundram, S. (2006) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.762 · Cited by 86 · see citing works
Genetically determined low maternal serum dopamine ?-hydroxylase levels and the etiology of autism spectrum disorders
Robinson, P. D., Schutz, C. K., Macciardi, F. M., White, B. N., & Holden, J. J. A. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1187 · Cited by 88 · see citing works
Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells
Joo, J., Kim, B., Lee, J.-S., Park, J.-Y., Kim, S., Yun, Y.-J., Lee, S.-H., Lee, S., Rhim, H., & Son, H. (2007) · Journal of Cell Science · doi:10.1242/jcs.002154 · Cited by 87 · see citing works
Effects of methamphetamine-induced neurotoxicity on the development of neural circuitry: a hypothesis
Frost, D. O. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00042-4 · Cited by 86 · see citing works
Clinical Spectrum of Dopa-Responsive Dystonia and Related Disorders
Lee, W., & Jeon, B. S. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0461-9 · Cited by 84 · see citing works
Altered Resting Cerebral Blood Flow in Adolescents With in Utero Cocaine Exposure Revealed by Perfusion Functional MRI
Rao, H., Wang, J., Giannetta, J. M., Korczykowski, M., Shera, D. M., Avants, B., Gee, J. C., Detre, J. A., & Hurt, H. (2007) · PEDIATRICS · doi:10.1542/peds.2006-2596 · Cited by 84 · see citing works
Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypes
Vitalis, T., Ansorge, M. S., & Dayer, A. G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00093 · Cited by 83 · see citing works
Prenatal fluoxetine exposure induces life-long serotonin 5-HT3 receptor-dependent cortical abnormalities and anxiety-like behaviour
Smit‐Rigter, L. A., Noorlander, C. W., von Oerthel, L., Chameau, P. J. P., Smidt, M. P., & van Hooft, J. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.015 · Cited by 81 · see citing works
Serotonin Receptor Expression in Human Prefrontal Cortex: Balancing Excitation and Inhibition across Postnatal Development
Lambe, E. K., Fillman, S. G., Webster, M. J., & Weickert, C. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022799 · Cited by 81 · see citing works
Activity Profiles of Single Neurons in Caudal Anterior Cingulate Cortex During Trace Eyeblink Conditioning in the Rabbit
Weible, A. P., Weiss, C., & Disterhoft, J. F. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01097.2002 · Cited by 80 · see citing works
Cocaine Exposure Decreases GABA Neuron Migration from the Ganglionic Eminence to the Cerebral Cortex in Embryonic Mice
Crandall, J. E. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh027 · Cited by 80 · see citing works
Serotonin Promotes the Differentiation of Glutamate Neurons in Organotypic Slice Cultures of the Developing Cerebral Cortex
Lavdas, A. Α., Blue, M. E., Lincoln, J., & Parnavelas, J. G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-20-07872.1997 · Cited by 80 · see citing works
Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease
Levine, M. S., Klapstein, G. J., Koppel, A. B., Gruen, E., Cepeda, C., Vargas, M. E., Jokel, E. S., Carpenter, E. M., Zanjani, H., Hurst, R. S., et al. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991115)58:4 · Cited by 351 · see citing works
Adolescents with and without gestational cocaine exposure: Longitudinal analysis of inhibitory control, memory and receptive language
Betancourt, L. M., Yang, W. P., Brodsky, N. L., Gallagher, P. R., Malmud, E. K., Giannetta, J. M., Farah, M. J., & Hurt, H. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.08.004 · Cited by 75 · see citing works
The Role of Neurotransmitters in Neurite Outgrowth and Synapse Formation
van Kesteren, R. E., & Spencer, G. E. (2003) · Reviews in the Neurosciences · doi:10.1515/revneuro.2003.14.3.217 · Cited by 77 · see citing works
Identification of a Sensitive Period of Prenatal Cocaine Exposure that Alters the Development of the Anterior Cingulate Cortex
Stanwood, G. D. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.5.430 · Cited by 75 · see citing works
Early behavior characteristics and sleep disturbance in Rett syndrome
Nomura, Y. (2005) · Brain and Development · doi:10.1016/j.braindev.2005.03.017 · Cited by 74 · see citing works
Prenatal effects of drugs of abuse on brain development
Levitt, P. R. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00070-2 · Cited by 73 · see citing works
A Fetal Risk Factor for Parkinson’s Disease
Barlow, B. K., Richfield, E. K., Cory‐Slechta, D. A., & Thiruchelvam, M. J. (2004) · Developmental Neuroscience · doi:10.1159/000080707 · Cited by 73 · see citing works
Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects
Costa, L. G., Steardo, L., & Cuomo, V. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.1.5 · Cited by 73 · see citing works

In UteroCocaine-Induced Dysfunction of Dopamine D1Receptor Signaling And Abnormal Differentiation of Cerebral Cortical Neurons
Jones, L. B., Stanwood, G. D., Reinoso, B. S., Washington, R. A., Wang, H.-Y., Friedman, E., & Levitt, P. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04606.2000 · Cited by 106 · see citing works
Pleiotropic Effects of Neurotransmission during Development: Modulators of Modularity
Thompson, B. L., & Stanwood, G. D. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0624-0 · Cited by 22 · see citing works
Ontogeny of Monoamine Neurotransmitters
Sarkar, S., Imam, S. Z., & Walters, J. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00015-8 · Cited by 2 · see citing works
The effects of prenatal exposure to cocaine on dendritic development evidence of targeting of specific cortical areas dependent upon neurotransmitter innervation
Jones, L. B., & Levitt, P. R. (1996) · doi:10.17918/00009588
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Authors: Levitt, P., Harvey, J. A., Friedman, E., Simansky, K., & Murphy, E. H.
Affiliations: University of Pittsburgh (US)
ORCID: Levitt, Pat
Friedman, Eitan
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1997-06
Volume: 20
Issue: 6
Pages: 269-274
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/s0166-2236(96)01028-4
OpenAlex: W2167345246
Cited by: 362
References: 86
Citations by year: 2026: 4 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 11 · 2012: 11
FWCI: 2.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01da006871-04)
National Institute on Drug Abuse (P01DA06871)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: monoaminergic systems, brain development, dopamine, dopamine D1 receptor, G protein coupling, GABAergic system, anterior cingulate cortex, monoamine oxidase A, serotonin, somatosensory cortex, transgenic mice, forebrain development, developmental neurotoxicity
MeSH terms: Animals, Brain, Cocaine, Female, Mice, Transgenic, Pregnancy, Prenatal Exposure Delayed Effects, Neurotransmitter Agents, Mice

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New evidence for neurotransmitter influences on brain development

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