The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
AMPA Receptor Channels with Long-Lasting Desensitization in Bipolar Interneurons Contribute to Synaptic Depression in a Novel Feedback Circuit in Layer 2/3 of Rat Neocortex
Open accessAbstract
A novel, local inhibitory circuit in layer 2/3 of rat somatosensory cortex is described that connects pyramidal cells reciprocally with GABAergic vasoactive intestinal polypeptide-immunoreactive bipolar interneurons. In paired whole-cell recordings, the glutamatergic unitary responses (EPSPs or EPSCs) in bipolar cells evoked by repetitive (10 Hz) stimulation of a pyramidal cell show strong frequency-dependent depression. Unitary IPSPs evoked in pyramidal cells by repetitive stimulation of bipolar cells, on average, maintained their amplitude. This suggests that the excitatory synapses on bipolar cells act as a low-pass filter in the reciprocal pyramid-to-bipolar circuit. The EPSCs in bipolar cells are mediated predominantly by AMPA receptor (AMPAR) channels. AMPARs desensitize rapidly and recover slowly from desensitization evoked by a brief pulse of glutamate. In slices, reduction of AMPAR desensitization by cyclothiazide (50-100 microm) or conditioning steady-state desensitization induced by application of extracellular AMPA (50 nm) or glutamate (50 microm) strongly reduced synaptic depression. It is concluded that in the local circuits between pyramidal and bipolar cells the desensitization of AMPARs in bipolar cells contributes to low-pass feedback inhibition of layer 2/3 pyramidal neurons by bipolar cells.
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“Excitatory inputs to VIP cells are depressing, as is the case for the inputs from most INs (Porter et al., 1998; Rozov et al., 2001).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Rozov et al., 2001
Experimental — accuracy not yet measuredIn the citing paper
“In situ hybridization and RT-PCR coupled with electrophysiological approaches subsequently revealed the presence of both inwardly rectifying, GluA2-lacking Ca2+-permeable (CP) AMPARs and GluA2-containing CI-AMPARs on inhibitory interneurons throughout the cortex and hippocampal formation (11, 51, 107, 388, 539, 769, 960).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [960]
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Citations
Cites
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
Sommer, B., KEINÄNEN, K. P., Verdoorn, T. A., Wisden, W., Burnashev, N., Herb, A., Köhler, M. G., Takagi, T., Sakmann, B. J., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.1699275 · Cited by 1,272
Self-citationGeiger, J. R. P., Melcher, T., Koh, D.-S., Sakmann, B., Seeburg, P. H., Jonas, P., & Monyer, H. (1995) · Neuron · doi:10.1016/0896-6273(95)90076-4 · Cited by 1,260
Self-citationDifferential signaling via the same axon of neocortical pyramidal neurons
Markram, H., Wang, Y., & Tsodyks, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5323 · Cited by 1,102
Markram, H., Lübke, J., Frotscher, M., Roth, A., & Sakmann, B. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022031 · Cited by 960
Self-citationStuart, G. J., Dodt, H., & Sakmann, B. J. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374949 · Cited by 800
Self-citationControl of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing
Lomeli, H., Mosbacher, J., Melcher, T., Höger, T., Geiger, J. R. P., Kuner, T., Monyer, H., Higuchi, M., Bach, A., & Seeburg, P. H. (1994) · Science · doi:10.1126/science.7992055 · Cited by 746
Molecular and Physiological Diversity of Cortical Nonpyramidal Cells
Cauli, B., Audinat, E., Lambolez, B., Angulo, M. C., Ropert, N., Tsuzuki, K., Hestrin, S., & Rossier, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03894.1997 · Cited by 738
Target-cell-specific facilitation and depression in neocortical circuits
Reyes, A., Lujan, R., Rozov, A., Burnashev, N., Somogyi, P., & Sakmann, B. (1998) · Nature Neuroscience · doi:10.1038/1092 · Cited by 716 · cited 8×
“Thus, in layer 2/3 of the rat somatosensory cortex along with the previously described GABAergic bitufted and multipolar interneurons (Reyes et al., 1998), bipolar cells form an additional local circuit (Fig.”
BackgroundInfluentialSelf-citationA Molecular Determinant for Submillisecond Desensitization in Glutamate Receptors
Mosbacher, J., Schoepfer, R., Monyer, H., Burnashev, N., SEEBURG, P. H., & Ruppersberg, J. P. (1994) · Science · doi:10.1126/science.7973663 · Cited by 610
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A Cognitive Model Based Framework and Multi-layer Storage Architecture for Associative Memory
Li, J., Huang, R., & Wang, K. I. (2020) · IEEE International Conference on Cognitive Informatics & Cognitive Computing (ICCI*CC) · doi:10.1109/iccicc50026.2020.9450213
Metadata
- Authors
- Rozov, A., Jerecic, J., Sakmann, B., & Burnashev, N.
- Affiliations
- Max Planck Society (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-10-15
- Volume
- 21
- Issue
- 20
- Pages
- 8062-8071
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6763867
- OpenAlex
- W2135917845
- Cited by
- 103
- References
- 33
- Citations by year
- 2024: 2 · 2023: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- AMPA receptor desensitization, synaptic depression, vasoactive intestinal peptide, pyramidal neurons, reciprocal inhibition, product inhibition, low-pass filtering, somatosensory cortex, layer 2/3, cyclothiazide, glutamate, inhibitory interneurons
- MeSH terms
- Animals, Axons, Benzothiadiazines, Dendrites, Electric Stimulation, Feedback, gamma-Aminobutyric Acid, Interneurons, Ion Channels, Lysine, Membrane Potentials, Synaptic Transmission, Somatosensory Cortex, Synapses, Rats, Wistar, Receptors, Glutamate, Pyramidal Cells, Receptors, AMPA, Patch-Clamp Techniques, Neocortex, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques
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