The DOI matches its Crossref record; 77 of the 78 references it cites were found in a registry or an index.
Millisecond Precision Spike Timing Shapes Tactile Perception
Open accessAbstract
In primates, the sense of touch has traditionally been considered to be a spatial modality, drawing an analogy to the visual system. In this view, stimuli are encoded in spatial patterns of activity over the sheet of receptors embedded in the skin. We propose that the spatial processing mode is complemented by a temporal one. Indeed, the transduction and processing of complex, high-frequency skin vibrations have been shown to play an important role in tactile texture perception, and the frequency composition of vibrations shapes the evoked percept. Mechanoreceptive afferents innervating the glabrous skin exhibit temporal patterning in their responses, but the importance and behavioral relevance of spike timing, particularly for naturalistic stimuli, remains to be elucidated. Based on neurophysiological recordings from Rhesus macaques, we show that spike timing conveys information about the frequency composition of skin vibrations, both for individual afferents and for afferent populations, and that the temporal fidelity varies across afferent class. Furthermore, the perception of skin vibrations, measured in human subjects, is better predicted when spike timing is taken into account, and the resolution that predicts perception best matches the optimal resolution of the respective afferent classes. In light of these results, the peripheral representation of complex skin vibrations draws a powerful analogy with the auditory and vibrissal systems.
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“Indeed, tactile sensations are shaped in part by the timing of afferent responses, down to near millisecond precision (Mackevicius et al., 2012).”
From Biomimetic approaches to bionic touch through a peripheral nerve interface (2015) · cites this paper as Mackevicius et al., 2012
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First spikes in ensembles of human tactile afferents code complex spatial fingertip events
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Spatial and temporal codes mediate the tactile perception of natural textures
Weber, A. I., Saal, H. P., Lieber, J. D., Cheng, J.-W., Manfredi, L. R., Dammann, J. F., & Bensmaia, S. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305509110 · Cited by 421
Self-citationTouch is a team effort: interplay of submodalities in cutaneous sensibility
Saal, H. P., & Bensmaia, S. J. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.012 · Cited by 280
Self-citationSimulating tactile signals from the whole hand with millisecond precision
Saal, H. P., Delhaye, B. P., Rayhaun, B. C., & Bensmaı̈a, S. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704856114 · Cited by 274
Self-citationNeural Basis of Touch and Proprioception in Primate Cortex
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Metadata
- Authors
- Mackevicius, E. L., Best, M. D., Saal, H. P., & Bensmaia, S. J.
- Affiliations
- University of Chicago (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-10-31
- Volume
- 32
- Issue
- 44
- Pages
- 15309-15317
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3752122
- OpenAlex
- W2073272844
- Cited by
- 171
- References
- 78
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 16 · 2023: 10 · 2022: 18 · 2021: 13 · 2020: 17 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 6 · 2013: 13 · 2012: 2
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1150209)
- National Institutes of Health
- National Institute of General Medical Sciences (T32GM007484)
- National Institute of Neurological Disorders and Stroke (NS-18787, R01NS018787)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- spike timing, tactile perception, skin vibration, tactile texture, mechanoreceptors, frequency composition, temporal resolution, rhesus monkeys, glabrous skin
- MeSH terms
- Adolescent, Algorithms, Animals, Data Interpretation, Statistical, Female, Form Perception, Humans, Macaca mulatta, Male, Neurons, Afferent, Physical Stimulation, Psychophysics, Skin, Vibration, Touch Perception, Electrophysiological Phenomena, Young Adult
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