The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Direct and Indirect Excitation of Laterodorsal Tegmental Neurons by Hypocretin/Orexin Peptides: Implications for Wakefulness and Narcolepsy
Open accessAbstract
Compelling evidence links the recently discovered hypothalamic peptides Hypocretin/Orexin (Hcrt/Orx) to rapid eye movement sleep (REM) control and the sleep disorder narcolepsy, yet how they influence sleep-related systems is not well understood. We investigated the action of Hcrt/Orx on mesopontine cholinergic (MPCh) neurons of the laterodorsal tegmental nucleus (LDT), a target group whose function is altered in canine narcolepsy and appears pivotal for normal REM and wakefulness. Extracellular recordings from mouse brainstem slices revealed that Hcrt/Orx evoked prolonged firing of LDT neurons. Whole-cell recordings revealed that Hcrt/Orx had actions on both presynaptic neurons and at postsynaptic sites. Hcrt/Orx produced an increase in frequency and amplitude of spontaneous EPSCs without equivalent effect on IPSCs, by triggering action potentials and enhancing spike-evoked synaptic transmission in glutamatergic afferents. Postsynaptically, Hcrt/Orx produced an inward current and an increase in membrane current noise, which were accompanied by a conductance increase. These persisted in TTX, ionotropic glutamate receptor antagonists, and low extracellular calcium. Both presynaptic and postsynaptic actions were specific because they were not mimicked by an Hcrt/Orx fragment, and both actions were observed for cholinergic and noncholinergic LDT neurons. Finally, extracellular recordings during postsynaptic potential blockade demonstrated that postsynaptic actions of Hcrt/Orx alone could evoke prolonged firing. In the context of other recent work, our findings suggest that Hcrt/Orx neurons may coordinate the activity of the entire reticular activating system during waking. Moreover, these findings address specific hypotheses regarding the cellular mechanisms underlying REM disregulation in narcolepsy.
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Cites
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Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
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Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · cited 3×
“…slice The Hypocretin/Orexin (Hcrt /Orx) peptide system consists of two peptides (Hcrt /Orx-A and Hcrt/Orx-B) derived from a single prepro-peptide (de Lecea et al., 1998; Sakurai et al., 1998) and two high-affinity G-protein-coupled receptors (Hcrt /OrxR1 and Hcrt/OrxR2) (Sakurai et al., 1998)…”
BackgroundNeurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
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Reduced Number of Hypocretin Neurons in Human Narcolepsy
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Cited by
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
Lee, M. G., Hassani, O. K., & Jones, B. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1887-05.2005 · Cited by 871
Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
Mileykovskiy, B. Y., Kiyashchenko, L. I., & Siegel, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.035 · Cited by 848
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., & de Lecea, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507480102 · Cited by 520
Release of Hypocretin (Orexin) during Waking and Sleep States
Kiyashchenko, L. I., Mileykovskiy, B. Y., Maidment, N., Lam, H. A., Wu, M.-F., John, J., Peever, J., & Siegel, J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05282.2002 · Cited by 340
Metadata
- Authors
- Burlet, S., Tyler, C. J., & Leonard, C. S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-04-01
- Volume
- 22
- Issue
- 7
- Pages
- 2862-2872
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2143557510
- Cited by
- 285
- References
- 60
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Burlet, S., Tyler, C. J., & Leonard, C. S. (2002). Direct and Indirect Excitation of Laterodorsal Tegmental Neurons by Hypocretin/Orexin Peptides: Implications for Wakefulness and Narcolepsy. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-07-02862.2002
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