The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
P2X Receptor Trafficking in Neurons Is Subunit Specific
Open accessAbstract
P2X receptors within the CNS mediate excitatory synaptic transmission and also act presynaptically to modulate neurotransmitter release. We have studied the targeting and trafficking of P2X4 and P2X2 receptors heterologously expressed in cultured olfactory bulb neurons. Homomeric P2X4 receptors had a punctate distribution, and many of the puncta colocalized with early endosomes. In contrast, P2X2 receptors were primarily localized at the plasma membrane. By antibody-labeling of surface receptors in living neurons, we showed that P2X4 receptors undergo rapid constitutive internalization and subsequent reinsertion into the plasma membrane, whereas P2X2 receptors were not regulated in such a way. The internalization of P2X4 receptors was dynamin-dependent, and the binding of ATP enhanced the basal rate of retrieval in a Ca2+-independent manner. The presence of the P2X4 subunit in a P2X4/6 heteromer governed the trafficking properties of the receptor. P2X receptors acted presynaptically to enhance the release of glutamate, suggesting that the regulated cycling of P2X4-containing receptors might provide a mechanism for modulation of synaptic transmission.
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Cites
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745
Molecular determinants of NMDA receptor internalization
Roche, K. W., Standley, S., McCallum, J., Dune Ly, C., Ehlers, M. D., & Wenthold, R. J. (2001) · Nature Neuroscience · doi:10.1038/90498 · Cited by 550
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448
Cited by
Physiology and Pathophysiology of Purinergic Neurotransmission
Burnstock, G. (2007) · Physiological Reviews · doi:10.1152/physrev.00043.2006 · Cited by 1,585
Activation and Regulation of Purinergic P2X Receptor Channels
Coddou, C., Yan, Z., Obsil, T., Huidobro-Toro, J. P., & Stojilkovic, S. S. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003129 · Cited by 493
Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
Illes, P., Müller, C. E., Jacobson, K. A., Grutter, T., Nicke, A., Fountain, S. J., Kennedy, C., Schmalzing, G., Jarvis, M. F., Stojilkovic, S. S., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15299 · Cited by 313
P2X7 Interactions and Signaling – Making Head or Tail of It
Kopp, R., Krautloher, A., Ramírez-Fernández, A., & Nicke, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00183 · Cited by 217
Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain
Trang, T., Beggs, S., & Salter, M. W. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x12000087 · Cited by 197
Metadata
- Authors
- Bobanovic, L. K., Royle, S. J., & Murrell-Lagnado, R. D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-06-15
- Volume
- 22
- Issue
- 12
- Pages
- 4814-4824
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2112671639
- Cited by
- 164
- References
- 3
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bobanovic, L. K., Royle, S. J., & Murrell-Lagnado, R. D. (2002). P2X Receptor Trafficking in Neurons Is Subunit Specific. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-12-04814.2002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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