Role of ampa receptor endocytosis in synaptic plasticity
Abstract
Activity-mediated changes in the strength of synaptic communication are important for the establishment of proper neuronal connections during development and for the experience-dependent modification of neural circuitry that is believed to underlie all forms of behavioural plasticity. Owing to the wide-ranging significance of synaptic plasticity, considerable efforts have been made to identify the mechanisms by which synaptic changes are triggered and expressed. New evidence indicates that one important expression mechanism of several long-lasting forms of synaptic plasticity might involve the physical transport of AMPA-type glutamate receptors in and out of the synaptic membrane. Here, we focus on the rapidly accumulating evidence that AMPA receptors undergo regulated endocytosis, which is important for long-term depression.
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The insertion and removal of AMPARs during LTP and LTD, respectively, is believed to involve classical mechanisms of SNARE protein-mediated exocytosis and dynamin-dependent endocytosis via clathrin-coated vesicles.
“The insertion and removal of AMPARs during LTP and LTD, respectively, is believed to involve classical mechanisms of SNARE protein -mediated exocytosis and dynamin-dependent endocytosis via clathrin-coated vesicles (Lu ¨scher et al. 1999;Carroll et al. 2001;Kennedy and Ehlers 2011).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Carroll et al. 2001
There is now strong evidence that calcineurin and PP1 do indeed play a role in LTD, perhaps in part by influencing the phosphorylation state of AMPARs.
“There is now strong evidence that these two phosphatases do indeed play a role in LTD (Mulkey et al. 1993, 1994: Carroll et al. 2001), perhaps in part by influencing the phosphorylation state of AMPARs.”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Carroll et al. 2001
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- Authors
- Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C.
- Affiliations
- Albert Einstein College of Medicine (US)
- University of California, San Francisco (US)
- Stanford Medicine (US)
- ORCID
- Malenka, Robert C.
- Venue
- Nature Reviews Neuroscience
- Published
- 2001-05
- Volume
- 2
- Issue
- 5
- Pages
- 315-324
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2003729768
- Cited by
- 448
- References
- 5
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 7 · 2021: 15 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 10 · 2014: 22 · 2013: 11 · 2012: 14
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- AMPA receptor endocytosis, synaptic plasticity, long-term depression, AMPA receptors, receptor trafficking, synaptic membranes
- MeSH terms
- Animals, Central Nervous System, Endocytosis, Humans, Neuronal Plasticity, Synapses, Signal Transduction, Receptors, AMPA, Protein Transport
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