Dynamic Pattern of Reg-2 Expression in Rat Sensory Neurons after Peripheral Nerve Injury
Open accessAbstract
The 16 kDa pancreatitis-associated protein Reg-2 has recently been shown to facilitate the regeneration of motor and sensory neurons after peripheral nerve injury in the adult rat. Reg-2 has also been shown to be a neurotrophic factor that is an essential intermediate in the pathways through which CNTF supports the survival of motor neurons during development. Here we report the dynamic expression of Reg-2 in rat sensory neurons after peripheral nerve injury. Reg-2 is normally not expressed by dorsal root ganglion (DRG) cells, but we show, using immunocytochemistry, that Reg-2 is rapidly upregulated in DRG cells after sciatic nerve transection and after 24 hr recovery is expressed almost exclusively in small-diameter neurons that bind the lectin Griffonia simplicifolia IB4 and express the purinoceptor P2X3. However, by 7 d after axotomy, Reg-2 is expressed in medium to large neurons and coexists partly with the neuropeptides galanin and neuropeptide Y, which are also upregulated after peripheral nerve transection. At this time point, Reg-2 is no longer expressed in small neurons, and there is no colocalization with IB4 binding neurons, demonstrating a shift in Reg-2 expression from one subset of DRG neurons to another. We also show by double labeling for activating transcription factor 3, a transcription factor that is upregulated after nerve injury, that Reg-2 expression occurs predominantly in axotomized DRG cells but that a small percentage of uninjured DRG cells also upregulate Reg-2. The selective expression within IB4/P2X3 cells, and the dynamic shift from small to large cells, is unique among DRG peptides and suggests that Reg-2 has a distinctive role in the injury response.
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A small number of uninjured sensory neurons express Atf3.
“We and others have found that a small number of uninjured sensory neurons express Atf3 [23]”
From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [23]
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Functional Organization of Dorsal Horn Interneurons
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Major cellular events in peripheral nerve regeneration: A brief overview
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- Authors
- Averill, S., Davis, D. R., Shortland, P. J., Priestley, J. V., & Hunt, S. P.
- Affiliations
- Queen Mary University of London (GB)
- University College London (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-09-01
- Volume
- 22
- Issue
- 17
- Pages
- 7493-7501
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757959
- OpenAlex
- W2118352181
- Cited by
- 60
- References
- 43
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 6
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- European Commission
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- pancreatitis-associated protein, sensory neurons, dorsal root ganglia, peripheral nerve injury, sciatic nerve transection, axotomy, neurotrophic factors, P2X3 receptor, galanin, neuropeptide Y, ATF3, neuropeptide expression, small-diameter neurons
- MeSH terms
- Pancreatitis-Associated Proteins, Animals, Axonal Transport, Calcium-Binding Proteins, Disease Models, Animal, Ganglia, Spinal, Immunohistochemistry, Lumbosacral Region, Male, Nerve Crush, Nerve Tissue Proteins, Neurons, Afferent, Peripheral Nerves, Sciatic Nerve, Time Factors, Transcription Factors, Rats, Sprague-Dawley, Rats, Wistar, Axotomy, Sciatic Neuropathy, Cell Size, Rats, Activating Transcription Factor 3, Lithostathine, Peripheral Nerve Injuries
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