Activating Transcription Factor 3 and the Nervous System
Open accessAbstract
Activating transcription factor 3 (ATF3) belongs to the ATF/cyclic AMP responsive element binding family of transcription factors and is often described as an adaptive response gene whose activity is usually regulated by stressful stimuli. Although expressed in a number of splice variants and generally recognized as a transcriptional repressor, ATF3 has the ability to interact with a number of other transcription factors including c-Jun to form complexes which not only repress, but can also activate various genes. ATF3 expression is modulated mainly at the transcriptional level and has markedly different effects in different types of cell. The levels of ATF3 mRNA and protein are normally very low in neurons and glia but their expression is rapidly upregulated in response to injury. ATF3 expression in neurons is closely linked to their survival and the regeneration of their axons following axotomy, and that in peripheral nerves correlates with the generation of a Schwann cell phenotype that is conducive to axonal regeneration. ATF3 is also induced by Toll-like receptor (TLR) ligands but acts as a negative regulator of TLR signaling, suppressing the innate immune response which is involved in immuno-surveillance and can enhance or reduce the survival of injured neurons and promote the regeneration of their axons.
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MEK1/2 inhibition is one of a number of intracellular messengers that can activate Atf3 expression.
“one of a number of intracellular messengers that can activate Atf3 expression [12].”
From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [12]
The ATF3 Induction and Regulation section says several intracellular signaling pathways affect or induce ATF3 expression, supporting the general point. It does not say that MEK1/2 inhibition activates ATF3; its examples instead describe induction through p38 or JNK activation. No page number is available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredUnder normal circumstances, Atf3 is expressed in very few regions of the adult nervous system.
“Under normal circumstances, Atf3 is expressed in very few regions of the adult nervous system [12].”
From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [12]
Atf3 is one of a number of transcription factors upregulated by cellular stress, including the unfolded protein response, tyrosine kinase receptor activation, glutamate receptor hyperactivation, and cellular injury.
“We generated a knock-in mouse expressing CreERT2 driven by the native promoter for activating transcription factor 3 (Atf3), one of a number of transcription factors upregulated by cellular stress, such as the unfolded protein response, tyrosine kinase receptor activation, glutamate receptor hyperactivation, and cellular injury [12].”
From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [12]
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Cites
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“In some of these studies ATF3 has been reported to be absent from Western blots of the mutant cells, even with the Santa Cruz antibody (Hartman et al., 2004; Jiang et al., 2004).”
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Raivich, G., Bohatschek, M., Costa, C. D., Iwata, O., Galiano, M., Hristova, M., Nateri, A. S., Makwana, M., Riera-Sans, L., Wolfer, D. P., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.005 · Cited by 489 · see citing works
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BackgroundInfluentialPTEN: a new guardian of the genome
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Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney
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“ATF3 has been implicated in the cellular response to many varied insults, including ischemia/reperfusion of the kidney or heart (Chen et al., 1996; Yin et al., 1997), liver damage (Chen et al., 1996), ventilation–induced lung damage, and many types of insult to cultured cells including hypoxia…”
BackgroundATF3 transcription factor and its emerging roles in immunity and cancer
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“None the less, some ATF/CREB members can form heterodimers with members of other families (e.g., C/EBP and Maf families), as well as with various other ATF/CREB proteins (Thompson et al., 2009).”
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“ATF3 has been implicated in the PERK-mediated arm (Figure 3), which is initially protective but also has a role in inducing apoptosis via the ATF4–ATF3–CHOP cascade (Mungrue et al., 2009).”
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“An ATF3“knockout”mouse has been used in many experiments to help determine the function of ATF3 in biological processes,particularly stress responses and cancer (Hartman et al., 2004; Khuu et al., 2007; Akram et al., 2010; Zmuda et al., 2010).”
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“, 1997), liver damage (Chen et al., 1996), ventilation–induced lung damage, and many types of insult to cultured cells including hypoxia (Ameri et al.”
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“ATF3 IS UPREGULATED BY SOME TYPES OF CNS NEURONS FOLLOWING INJURY Unlike neurons which project into peripheral nerves, most injured CNS neurons do not regenerate their axons although many produce local sprouts from their injured axons (Fishman and Mattu, 1993; Zeng et al., 1994; Hill et al., 2001).”
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“, 2007) in neurons Promotes neurite outgrowth (Bonilla et al., 2002)”
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Inflammation near the nerve cell body enhances axonal regeneration
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“Inflammatory responses around neurons are positively correlated with axonal regeneration (Shokouhi et al., 2010) and the generation of inflammation around neuronal cell bodies has been shown to enhance regeneration of axons (Lu and Richardson,1991;Yin et al., 2003).”
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“There was a suggestion that satellite cells in DRG upregulate ATF3 following injury to the sciatic nerve (Isacsson et al., 2005; Hu et al., 2007) but this has not been generally reported, perhaps because the expression is weaker than in the sensory neurons.”
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“…of ATF3 expression, c-Jun binds to ATF3. c-Jun co-immunoprecipitates with ATF3 in extracts of reticulocytes (Hai and Curran, 1991), PC12 cells (Nakagomi et al., 2003; Pearson et al., 2003), Neuro-2a cells (Pearson et al., 2003), suggesting that these two transcription factors can form…”
BackgroundThrombospondins 1 and 2 are Necessary for Synaptic Plasticity and Functional Recovery after Stroke
Liauw, J. A., Hoang, S., Choi, M. Y., Eroğlu, Ç., Choi, M., Sun, G.-H., Percy, M., Wildman‐Tobriner, B., Bliss, T. M., Guzman, R. G., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.65 · Cited by 263 · see citing works
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“Although ATF3 has been detected in the nuclei of a very small percentage of primary sensory neurons in DRG of uninjured rats in some studies (Averill et al., 2002), others have failed to find such cells (Tsuzuki et al., 2001; Takahashi et al., 2003; Carlton et al., 2009).”
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“The first described variant results in a protein termed ATF3Δzip owing to its loss of the carboxy-terminal leucine zipper dimerization domain (Chen et al., 1994).”
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“Sciatic nerve CCI elevates ATF3 expression in L4 and L5 dorsal root ganglion neurons (Obata et al., 2003; which could be due to neuropathic pain and/or axotomy) but also in the dorsal horn (Latremoliere et al., 2008).”
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“…known to induce cell cycle arrest and apoptosis in response to cellular stress factors and is also known to promote apoptosis of cancer cell lines (Maytin et al., 2001) CHOP/GADD153 (Wolfgang et al., 1997) in HeLa cells See above CHOP/GADD153 levels in 6-OHDA – treated dopaminergic neurons are…”
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“…claimed to induce axonal regeneration by CNS neurons include antibodies to myelin proteins (Raineteau et al., 1999), administration of neurotrophins (Bradbury et al., 1999), administration of chondroitinase (Bradbury et al., 2002), and the implantation of olfactory glia (Li et al., 1997).”
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“ATF3 was also upregulated in DRG neurons in rat models of arthritis where the extent of axonal injury is unknown (Ivanavicius et al., 2007; Christianson et al., 2010).”
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“…and STAT3 (Kiryu-Seo et al., 2008), each of which has been shown to be important in axonal regeneration (Raivich et al., 2004; Nadeau et al., 2005; Bareyre et al., 2011) and plays an important role for the induction of expression of damageinduced neuronal endopeptidase (DINE) in a neuroblastoma…”
BackgroundThe transcription factor ATF-3 promotes neurite outgrowth
Seijffers, R., Allchorne, A. J., & Woolf, C. J. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.03.005 · Cited by 232 · cited 6× · see citing works
“…disease patients to resist oxidative stress (Cook et al., 2011) and its absent enhances the damage caused by MTPT (Innamorato et al., 2010) c-Jun (Seijffers et al., 2007) in neurons Important regulator of neuronal survival fol- lowing axotomy (Raivich et al., 2004) ATF3ΔZip2 indirectly…”
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“…many examples of ERSR activation in neurodegenerative diseases and following traumatic injury to the nervous system, including Parkinson’s disease (Bellucci et al., 2011) and in vitro models of that condition (Holtz et al., 2006), amyotrophic lateral sclerosis (Kanekura et al., 2009),…”
BackgroundActivating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination
Yan, C., Lü, D., Hai, T., & Boyd, D. D. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600712 · Cited by 214 · cited 3× · see citing works
“(Yan et al., 2005) P53 can activate DNA repair or initiate apop-”
BackgroundInfluentialNegative Regulation of TLR-Signaling Pathways by Activating Transcription Factor-3
Whitmore, M., Iparraguirre, A., Kubelka, L., Weninger, W., Hai, T., & Williams, B. R. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3622 · Cited by 214 · cited 1× · see citing works
“The mutation has effects in non-neural cells (Hartman et al., 2004; Jiang et al., 2004; Whitmore et al., 2007; Akram et al., 2010).”
BackgroundA potential dichotomous role of ATF3, an adaptive-response gene, in cancer development
Yin, X. H., DeWille, J. W., & Hai, T. (2007) · Oncogene · doi:10.1038/sj.onc.1210861 · Cited by 209 · cited 2× · see citing works
“Fibronectin (Yin et al., 2008) in”
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“ATF3 can be induced in macrophages and microglia by the cytokine, IL6 (Dominguez et al., 2010).”
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“Similarly, ATF3 has been reported to suppress or promote cell cycle progression (Fan et al., 2002; Lv et al., 2011).”
BackgroundDavies, J. E., Tang, X., Denning, J. W., Archibald, S. J., & Davies, S. J. A. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03184.x · Cited by 188 · cited 1× · see citing works
“In untransformed chick fibroblasts ATF3 also repressed the expression of decorin (Perez et al., 2001; Yin et al., 2010), a TGFbbinding glycoprotein which may reduce scarring and thus promote regeneration (Davies et al., 2004).”
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α7 Nicotinic Acetylcholine Receptors Mediate β-Amyloid Peptide-induced Tau Protein Phosphorylation
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“Retinal ganglion cells also show a greater capability for axonal regeneration and a greater susceptibility to cell death following axotomy than most other CNS neurons (Allcutt et al., 1984; Campbell et al., 1999, 2003), and these findings are compatible with ATF3 having a role in regulating axonal regeneration and/or…”
ResultAkt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis
Jiang, K., Sun, J., Cheng, J. Q., Djeu, J. Y., Wei, S., & Sebti, S. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5565-5576.2004 · Cited by 182 · see citing works
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“…et al., 2000; Figure 1A), facial motor neurons (Parsadanian et al., 2006; Shokouhi et al., 2010), primary sensory neurons (Tsujino et al., 2000; Tsuzuki et al., 2002), postganglionic sympathetic neurons (Hyatt-Sachs et al., 2007), and preganglionic parasympathetic neurons (Peddie and Keast,…”
BackgroundPeters, C. M., Jiménez‐Andrade, J. M., Kuskowski, M. A., Ghilardi, J. R., & Mantyh, P. W. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.066 · Cited by 175 · cited 2× · see citing works
“Satellite cells and Schwann cells upregulated ATF3 following paclitaxel treatment (Peters et al., 2007a,b) which induced a peripheral neuropathy.”
BackgroundThe regulation of ATF3 gene expression by mitogen-activated protein kinases
Lü, D., Chen, J., & Hai, T. (2006) · Biochemical Journal · doi:10.1042/bj20061081 · Cited by 173 · cited 1× · see citing works
“The p38 pathway, but not the ERK nor the JNK pathways, was also required for ATF3 expression in several cell lines exposed to anisomycin (Lu et al., 2007).”
BackgroundKiryu‐Seo, S., Ohno, N., Kidd, G. J., Komuro, H., & Trapp, B. D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5265-09.2010 · Cited by 172 · cited 2× · see citing works
“Demyelination of DRG/glial cultures also leads to ATF3 upregulation by the neurons (Kiryu-Seo et al., 2010).”
BackgroundA Role for HSP27 in Sensory Neuron Survival
Lewis, S. E., Mannion, R., White, F. A., Coggeshall, R. E., Beggs, S., Costigan, M., Martin, J. W., DILLMANN, W. H., & Woolf, C. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08945.1999 · Cited by 164 · cited 1× · see citing works
“…cell death in cancer cells (Wong et al., 2008) Hsp27 (Seijffers et al., 2007) in neurons Protects neurons from cell death following various insults (Lewis et al., 1999) CHOP/GADD153 in mouse fibroblasts subject to leucine starvation (Jiang et al., 2004) CHOP/GADD153 expression is known to induce…”
BackgroundBeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum
Kim, H. S., Murphy, T. D., Xia, J., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp807 · Cited by 164 · see citing works
Bráz, J. M., & Basbaum, A. I. (2010) · Pain · doi:10.1016/j.pain.2010.05.005 · Cited by 162 · cited 2× · see citing works
“…of capsaicin, formalin, mustard oil, or menthol into the hind paw of mice induced expression of ATF3 in distinct subpopulations of sensory neurons, an observation which was interpreted as showing that the different agents injured different populations of sensory axons (Braz and Basbaum, 2010).”
BackgroundYin, X. H., Wolford, C. C., Chang, Y.-S., McConoughey, S. J., Ramsey, S. A., Aderem, A. A., & Hai, T. (2010) · Journal of Cell Science · doi:10.1242/jcs.064915 · Cited by 160 · cited 2× · see citing works
“In untransformed chick fibroblasts ATF3 also repressed the expression of decorin (Perez et al., 2001; Yin et al., 2010), a TGFbbinding glycoprotein which may reduce scarring and thus promote regeneration (Davies et al., 2004).”
BackgroundER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis
Kanekura, K., Suzuki, H., Aiso, S., & Matsuoka, M. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8054-3 · Cited by 160 · cited 2× · see citing works
“, 2006), amyotrophic lateral sclerosis (Kanekura et al., 2009), Alzheimer’s disease (Salminen et al.”
BackgroundDegeneration and Regeneration in the Nervous System
Dzięgielewska, K. M., Physiology, A., & Physiology (1991) · Taylor & Francis eBooks · doi:10.4324/9780203304488 · Cited by 158 · see citing works
Rasschaert, J., Ladrière, L., Urbain, M., Doğusan, Z., Katabua, B., Sato, S., Akira, S., Gysemans, C. A., Mathieu, C., & Eizirik, D. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502213200 · Cited by 157 · cited 1× · see citing works
“…pancreatic beta cells is induced and stabilized by ATF3 (Kim et al., 2010a) STAT1 is involved in beta cell apoptosis in response to streptozotocin (Rasschaert et al., 2005) Inhibition of differentiation-1 (Id-1; Kashiwakura et al., 2008) ID-1 downregulation is associated with cell death in cancer…”
BackgroundRegeneration of axons in the visual system
Berry, M., Ahmed, Z., Lorber, B., Douglas, M., & Logan, A. (2008) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2008-00446 · Cited by 155 · cited 2× · see citing works
“, 2000), retinal ganglion cells show a stronger and more prolonged upregulation of ATF3 (and other growth-associated molecules; Berry et al., 2008) than most other CNS neurons.”
Backgroundgadd153/Chop10 , a Potential Target Gene of the Transcriptional Repressor ATF3
Wolfgang, C. D., Chen, B. P. C., Martindale, J. L., Holbrook, N. J., & Hai, T. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6700 · Cited by 153 · cited 2× · see citing works
“cancer cells (Tanaka et al., 2011) TNFRSF10B/DR5 and BBC3/PUMA in prostate cancer cells (Tanaka et al., 2011) DR5 and BBC3/PUMA are pro-apoptotic genes (Tanaka et al., 2011) STAT1 in pancreatic beta cells is induced and stabilized by ATF3 (Kim et al., 2010a) STAT1 is involved in beta cell apoptosis in response to stre…”
BackgroundDrexhage, R. C., van der Heul-Nieuwenhuijsen, L., Padmos, R. C., van Beveren, N. J. M., Cohen, D., Versnel, M. A., Nolen, W. A., & Drexhage, H. A. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000799 · Cited by 152 · cited 1× · see citing works
“ATF3 expression by monocytes was increased in schizophrenia and bipolar disorder (Drexhage et al., 2010; Weigelt et al., 2011).”
BackgroundA comprehensive macrophage-T-lymphocyte theory of schizophrenia
Smith, R. S. (1992) · Medical Hypotheses · doi:10.1016/0306-9877(92)90117-u · Cited by 151 · cited 1× · see citing works
“The same applies to dopaminergic neurons in the substantia nigra pars compacta (Song et al., 2008), and olivocerebellar neurons following axotomy within the cerebellum (our unpublished observations).”
BackgroundSox11 transcription factor modulates peripheral nerve regeneration in adult mice
Jankowski, M. P., McIlwrath, S. L., Jing, X., Cornuet, P. K., Salerno, K. M., Koerber, H. R., & Albers, K. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.12.032 · Cited by 147 · cited 2× · see citing works
“…reticulocytes (Weidenfeld-Baranboim et al., 2009), human vascular endothelial cells (Weidenfeld-Baranboim et al., 2009), and neuronal cell lines (Jankowski et al., 2009) but elevation of c-Jun does not appear to be a prerequisite for ATF3 upregulation in human skin fibroblasts (Abe et al.,…”
BackgroundLindwall, C., Dahlin, L. B., Lundborg, G., & Kanje, M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.07.001 · Cited by 147 · cited 2× · see citing works
“As those authors pointed out, it is tempting to construct a pathway involving JNK activation leading to c-Jun phosphorylation and the ATF3 upregulation but some neurons showed elevated ATF3 without pc-Jun or pJNK (Lindwall et al., 2004).”
BackgroundLindwall, C., & Kanje, M. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.002 · Cited by 144 · see citing works
Cook, A. L., Vitale, A. M., Ravishankar, S., Matigian, N., Sutherland, G. T., Shan, J., Sutharsan, R., Perry, C., Silburn, P. A., Mellick, G. D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021907 · Cited by 143 · cited 1× · see citing works
“…in beta cells (Li et al., 2008) NRF2 in mouse mammary epithelial cells NRF2 helps cells from Parkinson’s disease patients to resist oxidative stress (Cook et al., 2011) and its absent enhances the damage caused by MTPT (Innamorato et al., 2010) c-Jun (Seijffers et al., 2007) in neurons Important…”
BackgroundInnamorato, N. G., Jaźwa, A., Rojo, A. I., García, C., Fernández‐Ruíz, J., Grochot‐Przeczek, A., Stachurska, A., Józkowicz, A., Dulak, J., & Cuadrado, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011838 · Cited by 138 · cited 2× · see citing works
“Mitochondrial misfunction is important for axonal pathology in multiple sclerosis (Smith et al., 1999) IRS2 in pancreatic beta cells (Li et al., 2008) IRS2 is anti-apoptotic in beta cells (Li et al., 2008) NRF2 in mouse mammary epithelial cells NRF2 helps cells from Parkinson’s disease patients to resist oxidative str…”
BackgroundZhang, S., Buchthal, B., Lau, D., Hayer, S. N., Dick, O., Schwaninger, M., Veltkamp, R. C., Zou, M., Weiss, U. K., & Bading, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2672-10.2011 · Cited by 137 · cited 2× · see citing works
“Transfection of the neurons with inhibitors of CREB and CaMKIV showed that this expression of ATF3 was regulated by a nuclear calcium signaling pathway involving these molecules (Zhang et al., 2011).”
BackgroundMason, M. R. J., Lieberman, A. R., & Anderson, P. N. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02809.x · Cited by 137 · see citing works
Self-citationHsu, J., Laz, T. M., Mohn, K. L., & Taub, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3511 · Cited by 134 · cited 1× · see citing works
“In most healthy tissues ATF3 is expressed at a very low level, if at all (Hsu et al., 1991; Chen et al., 1994; Allen-Jennings et al., 2001).”
BackgroundCharacterization of the acute and persistent pain state present in K/BxN serum transfer arthritis
Christianson, C. A., Corr, M., Firestein, G. S., Mobargha, A., Yaksh, T. L., & Svensson, C. I. (2010) · Pain · doi:10.1016/j.pain.2010.07.030 · Cited by 132 · cited 1× · see citing works
“ATF3 was also upregulated in DRG neurons in rat models of arthritis where the extent of axonal injury is unknown (Ivanavicius et al., 2007; Christianson et al., 2010).”
BackgroundKawauchi, J., Zhang, C., Nobori, K., Hashimoto, Y., Adachi, M. T., Noda, A., Sunamori, M., & Kitajima, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202974200 · Cited by 131 · see citing works
Holtz, W. A., Turetzky, J. M., Jong, Y.-J. I., & O’Malley, K. L. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04025.x · Cited by 126 · cited 1× · see citing works
“…and following traumatic injury to the nervous system, including Parkinson’s disease (Bellucci et al., 2011) and in vitro models of that condition (Holtz et al., 2006), amyotrophic lateral sclerosis (Kanekura et al., 2009), Alzheimer’s disease (Salminen et al., 2009), and following peripheral…”
BackgroundSuganami, T., Yuan, X., Shimoda, Y., Uchio‐Yamada, K., Nakagawa, N., Shirakawa, I., Usami, T., Tsukahara, T., Nakayama, K., Miyamoto, Y., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.196261 · Cited by 122 · cited 1× · see citing works
“Although ATF3 has been detected in the nuclei of a very small percentage of primary sensory neurons in DRG of uninjured rats in some studies (Averill et al., 2002), others have failed to find such cells (Tsuzuki et al., 2001; Takahashi et al., 2003; Carlton et al., 2009).”
Backgroundvon Banchet, G. S., Boettger, M. K., Fischer, N., Gajda, M. R., Bräuer, R., & Schaible, H. (2009) · Pain · doi:10.1016/j.pain.2009.06.002 · Cited by 119 · cited 1× · see citing works
“However, Freund’s complete adjuvant, when injected into the footpad, did not produce ATF3 upregulation despite the profound inflammation produced at the injection site (Tsujino et al., 2000; Segond von Banchet et al., 2009; Braz and Basbaum, 2010).”
BackgroundLatrémolière, A., Mauborgne, A., Masson, J., Bourgoin, S., Kayser, V., Hamon, M., & Pohl, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2552-08.2008 · Cited by 118 · cited 1× · see citing works
“Sciatic nerve CCI elevates ATF3 expression in L4 and L5 dorsal root ganglion neurons (Obata et al., 2003; which could be due to neuropathic pain and/or axotomy) but also in the dorsal horn (Latremoliere et al., 2008).”
BackgroundThe Roles of ATF3 in Glucose Homeostasis
Allen-Jennings, A. E., Hartman, M. G., Kociba, G. J., & Hai, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100986200 · Cited by 116 · cited 1× · see citing works
“In most healthy tissues ATF3 is expressed at a very low level, if at all (Hsu et al., 1991; Chen et al., 1994; Allen-Jennings et al., 2001).”
BackgroundStress response gene ATF3 is a target of c‐myc in serum‐induced cell proliferation
Tamura, K., Hua, B., Adachi, S., Guney, I., Kawauchi, J., Morioka, M. S., Tamamori‐Adachi, M., Tanaka, Y., Nakabeppu, Y., Sunamori, M., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600742 · Cited by 114 · see citing works
Pan, Y., Chen, H., Siu, F., & Kilberg, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304574200 · Cited by 112 · cited 5× · see citing works
“Modified from Pan et al. (2003). aa, Amino acids. amino acid sequence.”
BackgroundMethodInfluentialNovel changes in gene expression following axotomy of a sympathetic ganglion: A microarray analysis
Boeshore, K. L., Schreiber, R. C., Vaccariello, S. A., Sachs, H. H., Salazar, R., Lee, J.-H., Ratan, R. R., Leahy, P. S., & Zigmond, R. E. (2004) · Journal of Neurobiology · doi:10.1002/neu.10308 · Cited by 111 · cited 3× · see citing works
“MOLECULAR NEUROSCIENCE REVIEW ARTICLE published: 14 February 2012 doi: 10.3389/fnmol.2012.00007 Activating transcription factor 3 and the nervous system”
BackgroundInfluentialMashima, T., Udagawa, S., & Tsuruo, T. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1130 · Cited by 108 · cited 2× · see citing works
“Both gene delivery (Mashima et al., 2001) and gene inactivation experiments (Nawa et al.”
BackgroundATF3 enhances c-Jun-mediated neurite sprouting
Pearson, A. G., Gray, C. W., Pearson, J. F., Greenwood, J. M., During, M. J., & Dragunow, M. (2003) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.09.014 · Cited by 107 · cited 5× · see citing works
“…with ATF3 in extracts of reticulocytes (Hai and Curran, 1991), PC12 cells (Nakagomi et al., 2003; Pearson et al., 2003), Neuro-2a cells (Pearson et al., 2003), suggesting that these two transcription factors can form heterodimers, at least in non-neuronal cells and “neuronal” cell…”
BackgroundInfluentialActivating transcription factor 3 is a negative regulator of allergic pulmonary inflammation
Gilchrist, M., Henderson, W. R., Clark, A., Simmons, R. M., Ye, X., Smith, K. D., & Aderem, A. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072254 · Cited by 106 · cited 1× · see citing works
“Toll-like receptor (TLR)3, TLR4, and TLR9 agonists are potent inducers of ATF3 expression in macrophages and epithelial cells (Gilchrist et al., 2006; Suganami et al., 2009; Roussel et al., 2011) as is TCR ligation in CD4 lymphocytes (Gilchrist et al., 2008).”
BackgroundChaisuksunt, V., Zhang, Y., Anderson, P. N., Campbell, G., Vaudano, E., Schachner, M., & Lieberman, A. R. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00254-2 · Cited by 105 · cited 1× · see citing works
“Cerebellar Purkinje cells which are particularly poor at regenerating axons (Anderson et al., 1998; Chaisuksunt et al., 2000) do not upregulate ATF3 after axotomy (Figure 1C).”
BackgroundSelf-citationTranscriptional Autorepression of the Stress-inducible GeneATF3
Wolfgang, C. D., Liang, G., Okamoto, Y., Allen, A. E., & Hai, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909637199 · Cited by 105 · cited 1× · see citing works
“In addition, ATF3 represses its own expression (Wolfgang et al., 2000), limiting the period of its expression in response to stressful stimuli.”
BackgroundNodal promotes growth and invasion in human gliomas
Lee, C.-C., Jan, H.-J., Jh, L., et al. (2010) · Oncogene · doi:10.1038/onc.2010.55 · Cited by 103 · see citing works
Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages
Khuu, C. H., Barrozo, R. M., Hai, T., & Weinstein, S. L. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.08.006 · Cited by 102 · cited 1× · see citing works
“An ATF3“knockout”mouse has been used in many experiments to help determine the function of ATF3 in biological processes,particularly stress responses and cancer (Hartman et al., 2004; Khuu et al., 2007; Akram et al., 2010; Zmuda et al., 2010).”
Methodp53-mediated neuronal cell death in ischemic brain injury
Hong, L.-Z., Zhao, X.-Y., & Zhang, H.-L. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-1111-0 · Cited by 98 · see citing works
Expression of ATF3 and axonal outgrowth are impaired after delayed nerve repair
Saito, H., & Dahlin, L. B. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-88 · Cited by 96 · cited 1× · see citing works
“Schwann cells in the distal stump of injured sciatic nerves in rats and mice upregulate ATF3 (Hunt et al., 2004; Isacsson et al., 2005; Kataoka et al., 2007; Dahlin et al., 2008; Saito and Dahlin, 2008) in addition to c-Jun.”
Barrette, B., Calvo, E. L., Vallières, N., & Lacroix, S. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.07.249 · Cited by 95 · cited 2× · see citing works
“MOLECULAR NEUROSCIENCE REVIEW ARTICLE published: 14 February 2012 doi: 10.3389/fnmol.2012.00007 Activating transcription factor 3 and the nervous system”
InfluentialTakeda, M., Kato, H., Takamiya, A., Yoshida, A., & Kiyama, H. (2000) · PubMed · Cited by 94 · see citing works
A transcriptional role for C/EBP β in the neuronal response to axonal injury
Nadeau, S., Hein, P., Fernandes, K. J. L., Peterson, A. C., & Miller, F. D. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.04.004 · Cited by 94 · see citing works
6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
Bernstein, A. I., Garrison, S. P., Zambetti, G. P., & O’Malley, K. L. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-2 · Cited by 94 · cited 3× · see citing works
“There is one report (Bernstein et al., 2011) of effects of the mutation on cultured neurons (CHOP levels were reduced in 6-OHDA – treated dopaminergic neurons) but the preliminary data make it unlikely that any effects of this mutation on axonal regeneration will be profound.”
BackgroundInfluentialHashimoto, Y. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2398 · Cited by 94 · cited 4× · see citing works
“The same ATF3Δzip2 protein modulates the activity of the full-length ATF3 protein during stress responses and cellular proliferation (Hashimoto et al., 2002).”
BackgroundMethodInfluentialAnderson, P. N., Campbell, G., Zhang, Y., & Lieberman, A. R. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)64018-2 · Cited by 93 · cited 2× · see citing works
“Cerebellar Purkinje cells which are particularly poor at regenerating axons (Anderson et al., 1998; Chaisuksunt et al., 2000) do not upregulate ATF3 after axotomy (Figure 1C).”
BackgroundSelf-citationKim, S., Choi, J. H., Lim, H. I., et al. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.034 · Cited by 93 · see citing works
Kashiwakura, Y., Ochiai, K., Watanabe, M., Abarzúa, F., Sakaguchi, M., Takaoka, M., Tanimoto, R., Nasu, Y., Huh, N.-H., & Kumon, H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0080 · Cited by 91 · see citing works
Green, T. A., Alibhai, I. N., Unterberg, S., Neve, R. L., Ghose, S., Tamminga, C. A., & Nestler, E. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5273-07.2008 · Cited by 89 · cited 1× · see citing works
“A non-toxic dose of amphetamine, which increases dopamine levels in the striatum, also upregulated ATF3 mRNA in the striatum but to a lesser extent (Green et al., 2008).”
BackgroundKiryu‐Seo, S., Kato, R., Ogawa, T., Nakagomi, S., Nagata, K., & Kiyama, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707514200 · Cited by 88 · cited 10× · see citing works
“Using Sp1 as a scaffold, ATF3 interacts with at least three other transcription factors, C/EBP, c-Jun, and STAT3 (Kiryu-Seo et al., 2008), each of which has been shown to be important in axonal regeneration (Raivich et al., 2004; Nadeau et al., 2005; Bareyre et al., 2011) and plays an important…”
BackgroundMethodInfluentialLiu, G., Su, L., Hao, X., Zhong, N., Zhong, D., Singhal, S. K., & Liu, X. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01401.x · Cited by 87 · see citing works
Allcutt, D. A., Berry, M., & Sievers, J. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90028-2 · Cited by 87 · cited 2× · see citing works
“Retinal ganglion cells also show a greater capability for axonal regeneration and a greater susceptibility to cell death following axotomy than most other CNS neurons (Allcutt et al., 1984; Campbell et al., 1999, 2003), and these findings are compatible with ATF3 having a role in regulating axonal regeneration and/or…”
ResultJayanthi, S., McCoy, M. T., Beauvais, G., Ladenheim, B., Gilmore, K., Wood, W. H., Becker, K. G., & Cadet, J. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006092 · Cited by 84 · cited 1× · see citing works
“Methamphetamine also raised ATF3 levels in the striatum of rats (Jayanthi et al., 2009).”
BackgroundMitchell, K., Bates, B. D., Keller, J. M., Lopez, M., Scholl, L., Navarro, J., Madian, N., Haspel, G., Nemenov, M. I., & Iadarola, M. J. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-94 · Cited by 83 · see citing works
Lee, S.-H., Bahn, J. H., Whitlock, N. C., & Baek, S. J. (2010) · Oncogene · doi:10.1038/onc.2010.251 · Cited by 79 · cited 1× · see citing works
“For example, the induction of ATF3 expression in colonic cancer cells treated with tolfenamic acid, a pro-apoptotic drug, is mediated by p38 activation leading to phosphorylation of ATF2 and involves the ATF/C/EBP-binding site in the ATF3 promoter (Lee et al., 2010).”
BackgroundKey role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells
Taketani, K., Kawauchi, J., Tanaka, M., Ishizaki, H., Tanaka, Y., Sakai, T., Miyoshi, J., Maehara, Y., & Kitajima, S. (2011) · Oncogene · doi:10.1038/onc.2011.397 · Cited by 79 · see citing works
Jiménez‐Andrade, J. M., Peters, C. M., Mejia, N. A., Ghilardi, J. R., Kuskowski, M. A., & Mantyh, P. W. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.043 · Cited by 78 · see citing works
Nawa, T., Nawa, M., Adachi, M. T., UCHIMURA, I., Shimokawa, R., Fujisawa, K., Tanaka, A., Numano, F., & Kitajima, S. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00639-6 · Cited by 78 · cited 1× · see citing works
“Both gene delivery (Mashima et al., 2001) and gene inactivation experiments (Nawa et al., 2002) have attributed pro-apoptotic effects to ATF3, yet anti-apoptotic effects have also been described (Kawauchi et al., 2002).”
BackgroundAmeri, K., Hammond, E. M., Culmsee, C., Raida, M., Katschinski, D. M., Wenger, R. H., Wagner, E., Davis, R. J., Hai, T., Denko, N. C., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209781 · Cited by 77 · cited 1× · see citing works
“…insults, including ischemia/reperfusion of the kidney or heart (Chen et al., 1996; Yin et al., 1997), liver damage (Chen et al., 1996), ventilation–induced lung damage, and many types of insult to cultured cells including hypoxia (Ameri et al., 2007) and other treatments (Lerner et al., 1996).”
BackgroundExpression of stress-response ATF3 is mediated by Nrf2 in astrocytes
Kim, K., Jeong, J., Surh, Y., & Kim, K. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp865 · Cited by 77 · cited 5× · see citing works
“Treatment with Nrf2 activators and oxidants provokes ATF3 induction in astrocytes, and ATF3 expression is reduced in Nrf2-depleted cells (Kim et al., 2010b).”
BackgroundInfluentialWeigelt, K., de Carvalho, L. A., Drexhage, R. C., Wijkhuijs, A. J. M., de Wit, H., van Beveren, N. J. M., Birkenhäger, T. K., Bergink, V., & Drexhage, H. A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.006 · Cited by 75 · cited 1× · see citing works
“The mutation has effects in non-neural cells (Hartman et al., 2004; Jiang et al., 2004; Whitmore et al., 2007; Akram et al., 2010).”
BackgroundSpermidine Alleviates Severity of Murine Experimental Autoimmune Encephalomyelitis
Guo, X., Harada, C., Namekata, K., Kimura, A. K., Mitamura, Y., Yoshida, H., Matsumoto, Y., & Harada, T. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6015 · Cited by 72 · see citing works
Early Gene Expression Changes in the Retinal Ganglion Cell Layer of a Rat Glaucoma Model
Guo, Y., Johnson, E. C., Cepurna, W. O., Dyck, J. A., Doser, T. A., & Morrison, J. C. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5930 · Cited by 71 · cited 1× · see citing works
“Raised intraocular pressure in a rat model of glaucoma also elevates ATF3 expression in retinal ganglion cells to an extent that correlates linearly with the degree of injury to their axons (Guo et al., 2009, 2011).”
BackgroundBiochemical specificity of von economo neurons in hominoids
Stimpson, C. D., Tetreault, N. A., Allman, J. M., Jacobs, B., Butti, C., Hof, P. R., & Sherwood, C. C. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21135 · Cited by 69 · cited 1× · see citing works
“Toll-like receptor (TLR)3, TLR4, and TLR9 agonists are potent inducers of ATF3 expression in macrophages and epithelial cells (Gilchrist et al., 2006; Suganami et al., 2009; Roussel et al., 2011) as is TCR ligation in CD4 lymphocytes (Gilchrist et al., 2008).”
BackgroundTanaka, Y., Nakamura, A., Morioka, M. S., Inoue, S., Tamamori‐Adachi, M., Yamada, K., Taketani, K., Kawauchi, J., Tanaka, M., Miyoshi, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026848 · Cited by 68 · cited 2× · see citing works
“cancer cells (Tanaka et al., 2011) TNFRSF10B/DR5 and BBC3/PUMA in prostate cancer cells (Tanaka et al., 2011) DR5 and BBC3/PUMA are pro-apoptotic genes (Tanaka et al., 2011) STAT1 in pancreatic beta cells is induced and stabilized by ATF3 (Kim et al., 2010a) STAT1 is involved in beta cell apoptosis…”
BackgroundLi, D., Yin, X. H., Zmuda, E. J., Wolford, C. C., Dong, X. C., White, M. F., & Hai, T. (2007) · Diabetes · doi:10.2337/db07-0717 · Cited by 68 · cited 2× · see citing works
“Mitochondrial misfunction is important for axonal pathology in multiple sclerosis (Smith et al., 1999) IRS2 in pancreatic beta cells (Li et al., 2008) IRS2 is anti-apoptotic in beta cells (Li et al., 2008) NRF2 in mouse mammary epithelial cells NRF2 helps cells from Parkinson’s disease patients to…”
BackgroundHunt, D. P. J., Hossain-Ibrahim, K., Mason, M. R. J., Coffin, R. S., Lieberman, A. R., Winterbottom, J. K., & Anderson, P. N. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-9 · Cited by 66 · cited 2× · see citing works
“…by glia around the degenerating axons within the CNS was less than that by glial cells around the same degenerating axons within the dorsal root (Hunt et al., 2004), i.e., ATF3 was upregulated by glia where axonal regeneration normally occurs but upregulated to a much lesser extent where axonal…”
BackgroundSelf-citationDecorin promotes robust axon growth on inhibitory CSPGs and myelin via a direct effect on neurons
Minor, K. H., Tang, X., Kahrilas, G. A., Archibald, S. J., Davies, J. E., & Davies, S. J. A. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.06.009 · Cited by 64 · see citing works
Perez, S., Vial, E., van Dam, H., & Castellazzi, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204200 · Cited by 63 · cited 2× · see citing works
“In untransformed chick fibroblasts ATF3 also repressed the expression of decorin (Perez et al., 2001; Yin et al., 2010), a TGFbbinding glycoprotein which may reduce scarring and thus promote regeneration (Davies et al.”
BackgroundTakahashi, N., Kikuchi, S., Dai, Y., Kobayashi, K., Fukuoka, T., & Noguchi, K. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00432-9 · Cited by 62 · cited 1× · see citing works
“After optic nerve injury (Takeda et al., 2000), retinal ganglion cells show a stronger and more prolonged upregulation of ATF3 (and other growth-associated molecules; Berry et al., 2008) than most other CNS neurons.”
BackgroundActivating Transcription Factor 3, a Useful Marker for Regenerative Response after Nerve Root Injury
Lindå, H., Sköld, M. K., & Ochsmann, T. (2011) · Frontiers in Neurology · doi:10.3389/fneur.2011.00030 · Cited by 62 · cited 2× · see citing works
“Indeed, ATF3 has become a standard marker for neurons axotomized by peripheral nerve injury (Tsuzuki et al., 2001; Yamanaka et al., 2005;Yano et al., 2008; Linda et al., 2011) and its expression by injured neurons is closely correlated with a regenerative response.”
BackgroundDynamic Pattern of Reg-2 Expression in Rat Sensory Neurons after Peripheral Nerve Injury
Averill, S., Davis, D. R., Shortland, P. J., Priestley, J. V., & Hunt, S. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07493.2002 · Cited by 60 · cited 2× · see citing works
“Although ATF3 has been detected in the nuclei of a very small percentage of primary sensory neurons in DRG of uninjured rats in some studies (Averill et al., 2002), others have failed to find such cells (Tsuzuki et al.”
BackgroundAutophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons
Penas, C., Font-Nieves, M., Forés, J., Petegnief, V, Planas, A., Navarro, X., & Casas, C. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.24 · Cited by 58 · cited 2× · see citing works
“, 2009), and following peripheral nerve injury (Penas et al., 2011).”
BackgroundA critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: Controlled by ATF3
Kim, W., Lee, S. H., Song, E. H., Park, Y. M., Lim, J.-Y., Kim, D. J., Choi, K., Park, S. I., Gao, B., & Kim, W. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.07.011 · Cited by 57 · cited 1× · see citing works
“It has been reported that STAT1 is necessary for nuclear expression of ATF3 in hepatocytes and pancreatic beta cells (Kim et al., 2009, 2010a).”
BackgroundZmuda, E. J., Viapiano, M. S., Grey, S. T., Hadley, G. A., Garcı́a-Ocaña, A., & Hai, T. (2010) · Diabetologia · doi:10.1007/s00125-010-1696-x · Cited by 57 · cited 2× · see citing works
“An ATF3“knockout”mouse has been used in many experiments to help determine the function of ATF3 in biological processes,particularly stress responses and cancer (Hartman et al., 2004; Khuu et al., 2007; Akram et al., 2010; Zmuda et al., 2010).”
BackgroundMethodMiyazaki, K., Inoue, S., Yamada, K., Watanabe, M., Liu, Q., Watanabe, T., Adachi, M. T., Tanaka, Y., & Kitajima, S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn1082 · Cited by 57 · cited 4× · see citing works
“The variant 5′UTR sequences may be important in the regulation of translation; Miyazaki et al. (2009) reported that the structure of the 5′UTRs of the P1 transcripts, as well as the differential use of transcription start sites appears to affect the level of translation in response to stress.”
BackgroundInfluentialAKAP79/150 Signal Complexes in G-Protein Modulation of Neuronal Ion Channels
Zhang, J., Bal, M., Bierbower, S. M., Zaika, O., & Shapiro, M. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4446-10.2011 · Cited by 57 · see citing works
MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3
Mo, P., Wang, H., Lu, H., Boyd, D. D., & Yan, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132597 · Cited by 56 · cited 1× · see citing works
“Double minute 2 (MDM2) is an E3 ubiquitin ligase for ATF3 and regulates ATF3 expression by promoting its degradation, at least in HCT116 (colorectal carcinoma) cells and mouse embryonic fibroblasts (Mo et al., 2010).”
BackgroundThe ATF Transcription Factors in Cellular Adaptive Responses
Hai, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-40049-5_20 · Cited by 56 · cited 6× · see citing works
“Its expression in many tissues is associated with tissue dysfunction and disease progression (Hai, 2006) but in neurons its expression is usually correlated with the responses to injury that lead to axonal regeneration and neuroprotection.”
BackgroundInfluentialIdentification of Peptide Substrates for Human MMP-11 (Stromelysin-3) Using Phage Display
Pan, W., Arnone, M. R., Kendall, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304436200 · Cited by 55 · see citing works
Peripheral Sensory Axon Growth: From Receptor Binding to Cellular Signaling
Tucker, B. A., & Mearow, K. M. (2008) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100009331 · Cited by 54 · see citing works
Activating Transcription Factor 3 Confers Protection against Ventilator-induced Lung Injury
Akram, A., Han, B., Masoom, H., Peng, C., Lam, E., Litvack, M. L., Bai, X., Shan, Y., Hai, T., Batt, J., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200906-0925oc · Cited by 53 · see citing works
Hua, B., Tamamori‐Adachi, M., Luo, Y., Tamura, K., Morioka, M. S., Fukuda, M., Tanaka, Y., & Kitajima, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508471200 · Cited by 52 · cited 2× · see citing works
“Hua et al. (2006) also reported that ATF3Δzip2 displaces the positive cofactor CBP/300 from a protein complex involved in the transcriptional control at nuclear factor-κB (NFκB) sites in the anti-apoptotic gene cIAP2.”
BackgroundLerner, A., Clayton, L. K., Mizoguchi, E., Ghendler, Y., van Ewijk, W., Koyasu, S., Bhan, A. K., & Reinherz, E. L. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00974.x · Cited by 51 · see citing works
Morrow, D., Campbell, G., Lieberman, A. R., & Anderson, P. N. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1040 · Cited by 50 · cited 2× · see citing works
“…implantation of nerve grafts into the thalamus more than 90% of the neurons that regenerate axons into the graft come from the thalamic reticular nucleus (TRN; Morrow et al., 1993), whereas just few thalamic projection neurons and no corticothalamic neurons regenerate their axons into the grafts.”
BackgroundSelf-citationWilliams, K. L., Rahimtula, M., & Mearow, K. M. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20983 · Cited by 50 · cited 2× · see citing works
“cancer cells (Tanaka et al., 2011) TNFRSF10B/DR5 and BBC3/PUMA in prostate cancer cells (Tanaka et al., 2011) DR5 and BBC3/PUMA are pro-apoptotic genes (Tanaka et al., 2011) STAT1 in pancreatic beta cells is induced and stabilized by ATF3 (Kim et al., 2010a) STAT1 is involved in beta cell apoptosis in response to stre…”
BackgroundRaineteau, O., Z'Graggen, W. J., Thallmair, M., & Schwab, M. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00560.x · Cited by 50 · cited 2× · see citing works
“The many treatments claimed to induce axonal regeneration by CNS neurons include antibodies to myelin proteins (Raineteau et al., 1999), administration of neurotrophins (Bradbury et al.”
BackgroundWang, J., Cao, Y., & Steiner, D. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305456200 · Cited by 49 · cited 2× · see citing works
“6 cells, which results from splicing of 106 bases within exon B (Wang et al., 2003).”
BackgroundOver expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid
Francis, J. S., Dragunow, M., & During, M. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.10.027 · Cited by 48 · cited 3× · see citing works
“Hippocampus Strong ATF3 expression was identified in the nuclei of dentate gyrus neurons following injection of kainate, an excitotoxin (Francis et al., 2004).”
BackgroundInfluentialSaul, K. E., Koke, J. R., & Garcia, D. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.10.042 · Cited by 47 · cited 1× · see citing works
“In marked contrast, Purkinje cells, which never regenerate into such grafts, do not upregulate ATF3 (Figure 1C) ATF3 upregulation has been reported in retinal ganglion cells of Zebrafish during axonal regeneration following optic nerve crush (Saul et al., 2010).”
BackgroundSpontaneous axonal regeneration after optic nerve injury in adult rat
Campbell, G., Holt, J. K. L., Shotton, H. R., et al. (1999) · Neuroreport · doi:10.1097/00001756-199912160-00042 · Cited by 45 · see citing works
Huo, J. S., McEachin, R. C., Cui, T. X., Duggal, N. K., Hai, T., States, D. J., & Schwartz, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508492200 · Cited by 44 · cited 1× · see citing works
“As would be expected, c-Jun/AP-1, ATF2, ATF4, ATF6, CREB, Myc, C/EBPB, Erg-1, and other transcription factors have all been shown to induce ATF3 expression (Tamura et al., 2005; Huo et al., 2006).”
BackgroundWeidenfeld-Baranboim, K., Hasin, T., Darlyuk‐Saadon, I., Heinrich, R., Elhanani, O., Pan, J.-B., Yokoyama, K. K., & Aronheim, A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp083 · Cited by 43 · cited 2× · see citing works
“ATF3 expression by monocytes was increased in schizophrenia and bipolar disorder (Drexhage et al., 2010; Weigelt et al., 2011).”
BackgroundGuo, Y., Johnson, E. C., Cepurna, W. O., Jia, L., Dyck, J. A., & Morrison, J. C. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.08.003 · Cited by 42 · cited 1× · see citing works
“Raised intraocular pressure in a rat model of glaucoma also elevates ATF3 expression in retinal ganglion cells to an extent that correlates linearly with the degree of injury to their axons (Guo et al., 2009, 2011).”
BackgroundZeng, B., Anderson, P. N., Campbell, G., & Lieberman, A. R. (1994) · Europe PMC (PubMed Central) · Cited by 41 · see citing works
Self-citationInduction of activating transcription factor 3 after different sciatic nerve injuries in adult rats
Kataoka, K., Kanje, M., & Dahlin, L. B. (2007) · Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery · doi:10.1080/02844310701318288 · Cited by 41 · cited 1× · see citing works
“Schwann cells in the distal stump of injured sciatic nerves in rats and mice upregulate ATF3 (Hunt et al., 2004; Isacsson et al., 2005; Kataoka et al., 2007; Dahlin et al., 2008; Saito and Dahlin, 2008) in addition to c-Jun.”
BackgroundNagata, K., Kiryu‐Seo, S., Maeda, M., Yoshida, K., Morita, T., & Kiyama, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4521-09.2010 · Cited by 40 · cited 1× · see citing works
“DINE is necessary for the branching of motor neuron axons within muscle during development and the formation of adequate neuromuscular junctions (Nagata et al., 2010).”
BackgroundYano, K., Kawasaki, K., Hattori, T., Tawara, S., Toshima, Y., Ikegaki, I., Sasaki, Y., Satoh, S.-I., Asano, T., & Seto, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.07.045 · Cited by 40 · see citing works
Campbell, G., Hutchins, K. D., Winterbottom, J. K., Grenningloh, G., Lieberman, A. R., & Anderson, P. N. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.11.026 · Cited by 40 · cited 2× · see citing works
“The nervous system appears to be a special context in that while ATF3 tends to produce tissue dysfunction and disease progression in many types of non-neuronal cells (Hai, 2006), in the nervous system ATF3 appears to contribute to the regenerative response (Campbell et al., 2005).”
BackgroundSelf-citationAxonal guidance molecules and the failure of axonal regeneration in the adult mammalian spinal cord
Bolsover, S. R., Fabes, J., & Anderson, P. N. (2008) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2008-00448 · Cited by 39 · see citing works
Self-citationBiphasic expression of activating transcription factor-3 in neurons after cerebral infarction
Ohba, N., Maeda, M., Nakagomi, S., Muraoka, M., & Kiyama, H. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00181-5 · Cited by 36 · cited 1× · see citing works
“Activating transcription factor 3 is upregulated in neurons around cortical ischemic infarcts and in cortical neurons thought to project through the damaged region (Ohba et al., 2003, 2004).”
BackgroundMicroglial responses around intrinsic CNS neurons are correlated with axonal regeneration
Nedjat-Shokouhi, B., Wong, B. Z. Y., Siddiqui, S., Lieberman, A. R., Campbell, G., Tohyama, K., & Anderson, P. N. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-13 · Cited by 35 · cited 1× · see citing works
“Mitochondrial misfunction is important for axonal pathology in multiple sclerosis (Smith et al., 1999) IRS2 in pancreatic beta cells (Li et al., 2008) IRS2 is anti-apoptotic in beta cells (Li et al., 2008) NRF2 in mouse mammary epithelial cells NRF2 helps cells from Parkinson’s disease patients to…”
BackgroundSelf-citationHabecker, B. A., Sachs, H. H., Rohrer, H., & Zigmond, R. E. (2009) · Developmental Neurobiology · doi:10.1002/dneu.20706 · Cited by 35 · cited 1× · see citing works
“Moreover, deletion of gp130, a component of the common neurokine receptor, upstream of STAT3 phosphorylation (Habecker et al., 2009), abolishes the conditioning lesion response in explanted, sympathetic neurons, even though ATF3 is still upregulated (Hyatt-Sachs et al., 2010).”
BackgroundYamanaka, H., Obata, K., Fukuoka, T., Dai, Y., Kobayashi, K., Tokunaga, A., & Noguchi, K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.003 · Cited by 33 · cited 1× · see citing works
“Indeed, ATF3 has become a standard marker for neurons axotomized by peripheral nerve injury (Tsuzuki et al., 2001; Yamanaka et al., 2005;Yano et al., 2008; Linda et al., 2011) and its expression by injured neurons is closely correlated with a regenerative response.”
BackgroundLv, D., Meng, D., Zou, F., Li, F., Zhang, P., Yu, Y., & Fang, J. (2011) · IUBMB Life · doi:10.1002/iub.416 · Cited by 33 · cited 1× · see citing works
“Similarly, ATF3 has been reported to suppress or promote cell cycle progression (Fan et al., 2002; Lv et al., 2011).”
BackgroundThe conditioning lesion effect on sympathetic neurite outgrowth is dependent on gp130 cytokines
Sachs, H. H., Rohrer, H., & Zigmond, R. E. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.01.019 · Cited by 32 · cited 2× · see citing works
“, 2009), abolishes the conditioning lesion response in explanted, sympathetic neurons, even though ATF3 is still upregulated (Hyatt-Sachs et al., 2010).”
BackgroundSachs, H. H., Schreiber, R. C., Shoemaker, S. E., Sabe, A. A., Reed-Geaghan, E. G., & Zigmond, R. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.008 · Cited by 32 · cited 3× · see citing works
“A similar low number of sympathetic neurons with ATF3-positive nuclei have been found in the superior cervical ganglia of intact rats (Hyatt-Sachs et al., 2007).”
BackgroundLiang, L., Wang, Z., Lü, N., Yang, J., Zhang, Y., & Zhao, Z. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22439 · Cited by 31 · cited 1× · see citing works
“…and crush injuries to peripheral nerve have been most often used to upregulate ATF3 in peripheral neurons but tetanic stimulation of rat sciatic nerve, which produces Wallerian degeneration in the nerve, also induces ATF3 expression in DRG neurons (none was found in naïve rats; Liang et al., 2010).”
BackgroundKenney, A. M., & Kocsis, J. D. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00211-8 · Cited by 29 · cited 2× · see citing works
“A transient upregulation of JunB has been reported in axotomized neurons (Kenney and Kocsis, 1997),”
BackgroundParsadanian, A. S., Pan, Y., Li, W., Myckatyn, T. M., & Brakefield, D. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.014 · Cited by 29 · cited 4× · see citing works
“…with axons projecting into injured peripheral nerves, including spinal motor neurons (Tsujino et al., 2000; Figure 1A), facial motor neurons (Parsadanian et al., 2006; Shokouhi et al., 2010), primary sensory neurons (Tsujino et al., 2000; Tsuzuki et al., 2002), postganglionic sympathetic…”
BackgroundInfluentialOhba, N., Kiryu‐Seo, S., Maeda, M., Muraoka, M., Ishii, M., & Kiyama, H. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02784.x · Cited by 28 · see citing works
Induction of activating transcription factor 3 (ATF3) by peripheral nerve compression
Isacsson, A., Kanje, M., & Dahlin, L. B. (2005) · Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery · doi:10.1080/02844310410004892 · Cited by 27 · cited 2× · see citing works
“There was a suggestion that satellite cells in DRG upregulate ATF3 following injury to the sciatic nerve (Isacsson et al., 2005; Hu et al., 2007) but this has not been generally reported, perhaps because the expression is weaker than in the sensory neurons.”
BackgroundHyperoxia-induced activation of the integrated stress response in the newborn rat lung
Raup‐Konsavage, W. M., Zhang, L., Wu, Y., & Shenberger, J. S. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00174.2011 · Cited by 25 · cited 2× · see citing works
“Phosphorylation of the α -subunit of the eukaryotic translation initiation factor 2 (eIF2) in lung cells in response to hypoxia leads to nuclear translocation of ATF4 and a subsequent increase in ATF3 expression (Konsavage et al., 2012).”
BackgroundHossain-Ibrahim, M., Rezajooi, K., MacNally, J., Mason, M., Lieberman, A. R., & Anderson, P. N. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-8 · Cited by 24 · cited 1× · see citing works
“Lipopolysaccharide, a highly inflammatory bacterial product, applied to the motor cortex induced ATF3 expression in the nuclei of many glial cells in the subcortical white matter (Hossain-Ibrahim et al., 2006).”
Self-citationSong, D., Yang, Y. C., Shin, D. H., Sugama, S., Kim, Y. S., Lee, B. H., JOH, T. H., & Cho, B. P. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.09.033 · Cited by 24 · cited 1× · see citing works
“Cytoplasmic ATF3 has been reported in von Economo neurons in the anterior cingulate gyrus of primates including man (Stimpson et al., 2011); this is quite different from the normal pattern of ATF3 expression in which the gene is only expressed at times of Frontiers in Molecular Neuroscience…”
BackgroundDahlin, L. B., Stenberg, L., Luthman, H., & Thomsen, N. (2008) · Neuroreport · doi:10.1097/wnr.0b013e328302f4ec · Cited by 23 · cited 1× · see citing works
“Schwann cells in the distal stump of injured sciatic nerves in rats and mice upregulate ATF3 (Hunt et al., 2004; Isacsson et al., 2005; Kataoka et al., 2007; Dahlin et al., 2008; Saito and Dahlin, 2008) in addition to c-Jun.”
BackgroundRapid and preferential induction of ATF3 transcription in response to low doses of UVA light
Takaya, A., Oue, N., Yasui, W., & Ryoji, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.143 · Cited by 23 · cited 2× · see citing works
“, 2009) but elevation of c-Jun does not appear to be a prerequisite for ATF3 upregulation in human skin fibroblasts (Abe et al., 2003) and primary sensory neurons (Tsujino et al.”
BackgroundKim, W., Song, E. H., Lee, S., Lim, J. H., Choi, J. S., Koh, I.-U., Song, J., & Kim, W. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.06.007 · Cited by 22 · cited 5× · see citing works
“Treatment with Nrf2 activators and oxidants provokes ATF3 induction in astrocytes, and ATF3 expression is reduced in Nrf2-depleted cells (Kim et al., 2010b).”
BackgroundInfluentialDiehlmann, A., Ida, N., Weggen, S., Grünberg, J., Haass, C., Masters, C. L., Bayer, T. A., & Beyreuther, K. T. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990515)56:4 · Cited by 21 · see citing works
Malaspina, A., Ngoh, S. F. A., Ward, R. E., Hall, J. C. E., Tai, F. W. D., Yip, P. K., Jones, C., Jokic, N., Averill, S., Michael-Titus, A. T., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.053 · Cited by 20 · cited 1× · see citing works
“Similarly, ATF3 is upregulated in motor neurons in models of amyotrophic lateral sclerosis (Malaspina et al., 2010) which also involve dying-back of axons.”
BackgroundFate of Severed Cortical Projection Axons
Fishman, P. S., & MATTU, A. (1993) · Journal of Neurotrauma · doi:10.1089/neu.1993.10.457 · Cited by 18 · cited 1× · see citing works
“ATF3 IS UPREGULATED BY SOME TYPES OF CNS NEURONS FOLLOWING INJURY Unlike neurons which project into peripheral nerves, most injured CNS neurons do not regenerate their axons although many produce local sprouts from their injured axons (Fishman and Mattu, 1993; Zeng et al., 1994; Hill et al., 2001).”
BackgroundNeutral sphingomyelinase 2 induces dopamine uptake through regulation of intracellular calcium
Kim, S. K., Ahn, K. H., Ji, J. E., Choi, J. M., Jeon, H. J., Jung, S. Y., Jung, K., & Kim, D. K. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.012 · Cited by 18 · see citing works
Peddie, C. J., & Keast, J. R. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00006 · Cited by 15 · cited 1× · see citing works
“…Figure 1A), facial motor neurons (Parsadanian et al., 2006; Shokouhi et al., 2010), primary sensory neurons (Tsujino et al., 2000; Tsuzuki et al., 2002), postganglionic sympathetic neurons (Hyatt-Sachs et al., 2007), and preganglionic parasympathetic neurons (Peddie and Keast, 2011; Figure1B).”
BackgroundIntrinsic determinants of differential axonal regeneration by adult mammalian CNS neurons
Anderson, P., & Lieberman, A. R. (1999) · UCL Discovery (University College London) · Cited by 14 · see citing works
Self-citationZigmond, R. E., & Vaccariello, S. A. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.019 · Cited by 13 · cited 1× · see citing works
“…in the superior cervical ganglion expressed ATF3 after decentralization (section of the cervical sympathetic trunk); this procedure induces the anterograde degeneration of preganglionic fibers and some of the ATF3 expression was probably around degenerating fibers (Zigmond and Vaccariello, 2007).”
BackgroundLiang, Y., Jiang, H., Ratovitski, T., Jie, C., Nakamura, M., Hirschhorn, R. R., Wang, X., Smith, W. W., Hai, T., Poirier, M. A., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.049 · Cited by 13 · cited 1× · see citing works
“Overexpression of ATF3 had neuroprotective effects on PC12 cells expressing mutant Huntingtin, whereas knock down of ATF3 increased toxicity (Liang et al., 2009).”
BackgroundScanning gene expression during neuronal cell death evoked by nerve growth factor depletion
Mayumi-Matsuda, K., Kojima, S., Nakayama, T., Suzuki, H., & Sakata, T. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00204-3 · Cited by 13 · cited 1× · see citing works
“A similar effect had been demonstrated previously in differentiated PC12 cells (Mayumi-Matsuda et al., 1999).”
BackgroundRoussel, L., Robins, S., Schachter, A., Bérubé, J., Hamid, Q. A., & Rousseau, S. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.03.034 · Cited by 13 · cited 1× · see citing works
“Toll-like receptor (TLR)3, TLR4, and TLR9 agonists are potent inducers of ATF3 expression in macrophages and epithelial cells (Gilchrist et al., 2006; Suganami et al., 2009; Roussel et al., 2011) as is TCR ligation in CD4 lymphocytes (Gilchrist et al., 2008).”
BackgroundInactivation of ID-1 Gene Induces Sensitivity of Prostate Cancer Cells to Chemotherapeutic Drugs
Wong, Y. C., Zhang, X., Ling, M.-T., & Wang, X. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-69080-3_58 · Cited by 9 · cited 2× · see citing works
“…et al., 2005) Inhibition of differentiation-1 (Id-1; Kashiwakura et al., 2008) ID-1 downregulation is associated with cell death in cancer cells (Wong et al., 2008) Hsp27 (Seijffers et al., 2007) in neurons Protects neurons from cell death following various insults (Lewis et al.,…”
BackgroundTsuzuki, K., Noguchi, K., Mohri, D., Yasuno, H., Umemoto, M., Shimobayashi, C., Fukazawa, K., & Sakagami, M. (2002) · Acta Oto-Laryngologica · doi:10.1080/00016480252814162 · Cited by 9 · see citing works
Different effects of astrocytes and Schwann cells on regenerating retinal axons
Campbell, G., Kitching, J., Anderson, P. N., & Lieberman, A. R. (2003) · Neuroreport · doi:10.1097/00001756-200311140-00015 · Cited by 7 · cited 1× · see citing works
“…capability for axonal regeneration and a greater susceptibility to cell death following axotomy than most other CNS neurons (Allcutt et al., 1984; Campbell et al., 1999, 2003), and these findings are compatible with ATF3 having a role in regulating axonal regeneration and/or in cell death in…”
ResultSelf-citationHuang, H., Liao, C., Chen, P., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04660.x · Cited by 7 · see citing works
Lovas, G., Nielsen, J. J., Johnson, K., & Hudson, L. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458509357063 · Cited by 6 · cited 3× · see citing works
“Brainstem Pontocerebellar neurons show a prolonged (weeks) upregulation of ATF3 after axotomy (Lovas et al., 2010).”
BackgroundInfluentialAnderson, P. A. V., Campbell, G., Zhang, Y., & Lieberman, A. R. (1998) · UCL Discovery (University College London) · Cited by 5 · see citing works
Self-citationStress response gene ATF3 is a target of c‐myc in serum‐induced cell proliferation
Kitajima, S., Tamura, K., Hua, B., Adachi, S., Guney, I., Adachi, M. T., Tanaka, Y., & Sedivy, J. M. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.4.a37-c · Cited by 2 · see citing works
The conditioning lesion effect on sympathetic neurite outgrowth is dependent on gp130 cytokines
Hyatt-Sachs, H., Rohrer, H., & Ziegmond, R. (2010) · MPG.PuRe (Max Planck Society) · Cited by 1 · see citing works
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Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury
Renthal, W. R., Tochitsky, I., Yang, L., Cheng, Y., Li, E., Kawaguchi, R., Geschwind, D. H., & Woolf, C. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.07.026 · Cited by 544 · see citing works
Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer
Ku, H.-C., & Cheng, C.-F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00556 · Cited by 345 · see citing works
“Taketani et al. reported that the DR5 gene is a direct target of ATF3 upon DNA damage, and ATF3 plays a key role in apoptosis induced by camptothecin (CPT) /TRAIL co-treatment of human colorectal cancer cells (90).”
BackgroundInfluentialXu, L., Cao, Y., Xie, Z., Huang, Q., Baï, Q., Yang, X., He, R., Hao, Y., Wang, H., Zhao, T., et al. (2015) · Nature Immunology · doi:10.1038/ni.3229 · Cited by 223 · see citing works
“Indeed, the transcriptional repressor ATF3 uses a similar mechanism to activate its own gene expression by reversing the auto-repressive effect through the formation of ATF3 heterodimers with the transcription factor c-Jun or members of the ATF-CREB family of transcription factors 40 .”
A role for human brain pericytes in neuroinflammation
Jansson, D., Rustenhoven, J., Feng, S. X., Hurley, D., Oldfield, R. L., Bergin, P., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-104 · Cited by 168 · see citing works
“We also see an increase in activating transcription factor 3 (ATF3) gene expression which is activated in response to stress and may be acting as a negative feedback mechanism to inhibit IL-6 expression [93,94].”
BackgroundStott, S., & Barker, R. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12459 · Cited by 143 · see citing works
“ATF-3 is a member of the ATF-3/Creb family of basic-leucine zipper-type transcription factors, acting as a stress-inducible regulator of various anti- and pro-apoptotic pathways (Bernstein et al., 2011; Tanaka et al., 2011; Hunt et al., 2012).”
Li, J., Yang, Y., Tam, R. C. Y., Chan, V. W., Lan, H. Y., Hori, S., Zhou, B., & Lui, K. O. (2019) · Theranostics · doi:10.7150/thno.32734 · Cited by 135 · see citing works
“We also highlighted several significantly upregulated genes in C2 compared to C1 that have been reported to regulate macrophage activity such as apolipoprotein E (Apoe) [26] and CXCL4 (Pf4) [27]; and to facilitate tissue regeneration such as granulin (Grn) [28-30] and activating transcription factor 3 (Atf3) [31, 32]…”
BackgroundATF3 Is a Key Regulator of Macrophage IFN Responses
Labzin, L. I., Schmidt, S. V., Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lütjohann, D., Schultze, J. L., Latz, E., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500204 · Cited by 124 · see citing works
“Humans, however, express six different isoforms of ATF3 (43), some of which are thought to act as transcriptional activators rather than repressors due to truncations in the C-terminal DNAbinding leucine zipper domain.”
BackgroundIncorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons
Reid, D. A., Reed, P. J., Schlachetzki, J. C. M., Nitulescu, I. I., Chou, G., Tsui, E. C., Jones, J. R., Chandran, S., Lu, A. T., McClain, C. A., et al. (2021) · Science · doi:10.1126/science.abb9032 · Cited by 121 · see citing works
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
Baruch, E. N., Gleber‐Netto, F. O., Nagarajan, P., Rao, X., Akhter, S., Eichwald, T., Xie, T., Balood, M., Adewale, A., Na’ara, S., et al. (2025) · Nature · doi:10.1038/s41586-025-09370-8 · Cited by 134 · see citing works
“This analysis demonstrated that an increase in the abundance of NFH + ATF3 + injured nerves was coupled with an increase in Article the intratumoural infiltration of immunosuppressive macrophages and exhausted CD8 + T cells in the entire TME.”
InfluentialRohini, M., Menon, A. H., & Selvamurugan, N. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.08.107 · Cited by 117 · see citing works
Gerbino, V., Kaunga, E., Ye, J., Canzio, D., O’Keeffe, S., Rudnick, N. D., Guarnieri, P., Lutz, C. M., & Maniatis, T. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.005 · Cited by 102 · see citing works
A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma
Milon, B. C., Shulman, E. D., So, K. S., Cederroth, C. R., Lipford, E. L., Sperber, M., Sellon, J. B., Sarlus, H., Pregernig, G., Shuster, B., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109758 · Cited by 113 · see citing works
“Of note, Atf3 and Atf4 are known to be induced in neurons following multiple stresses and are associated with neuronal survival and axonal regeneration (Hunt et al., 2012; Sun et al., 2013).”
Carozzi, V., Renn, C. L., Bardini, M., Fazio, G., Chiorazzi, A., Meregalli, C., Oggioni, N., Shanks, K., Quartu, M., Serra, M. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072995 · Cited by 111 · see citing works
Gey, M., Wanner, R., Schilling, C., Pedro, M. T., Sinske, D., & Knöll, B. (2016) · Open Biology · doi:10.1098/rsob.160091 · Cited by 110 · see citing works
“ATF3 exerts both transcriptional repression and activation of target genes including Hsp27, Sprr1a and c-Jun [18,19].”
InfluentialChen, M., Liu, Y., Yang, Y., Qiu, Y., Wang, Z., Li, X., & Zhang, W. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.04.008 · Cited by 111 · see citing works
“To date, five alternative isomers, ATF3Dzip, ATF3Dzip2 (ATF3Dzip2a and ATF3Dzip2b), ATF3Dzip2c, ATF3Dzip3, and ATF3b, of ATF3 have been reported in different cell systems, all of which are formed by a canonical ATF3 truncation of the C- or N-terminal region.(71) Functionally, other subtypes (leucine zipper domain defe…”
BackgroundInfluentialJager, S. E., Pallesen, L. T., Richner, M., Harley, P., Hore, Z. L., McMahon, S. B., Denk, F., & Vægter, C. B. (2020) · Glia · doi:10.1002/glia.23785 · Cited by 107 · see citing works
“Remarkable in the context of our observations in SGC, the top gene pathway regulated in spinal astrocytes in a rodent model of chronic autoimmune encephalomyelitis (EAE) is, in fact, the cholesterol synthesis pathway, with downregulation of several genes (Itoh et al., 2017).”
BackgroundAbraham, E., Hendler, T., Zagoory‐Sharon, O., & Feldman, R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw090 · Cited by 90 · see citing works
Rod microglia and their role in neurological diseases
Holloway, O. G., Canty, A. J., King, A. E., & Ziebell, J. M. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.02.005 · Cited by 71 · see citing works
Kole, C., Brommer, B., Nakaya, N., Sengupta, M. B., Bonet‐Ponce, L., Zhao, T., Wang, C., Li, W. S., He, Z., & Tomarev, S. I. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.2.31 · Cited by 74 · see citing works
“10 One of these factors is the transcription factor ATF3, known to be inducible by stress and axonal injury in both the peripheral nervous system and CNS. 27,30 In the adult intact retina, expression of ATF3 is not detected in RGCs; however, a fraction of RGCs were shown to upregulate ATF3 after ONC.”
Boyd, J. T., Lococo, P. M., Furr, A. R., Bendele, M., Tram, M., Li, Q., Chang, F.-M., Colley, M. E., Samenuk, G. M., Arris, D., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00410-x · Cited by 71 · see citing works
Förstner, P., Rehman, R., Anastasiadou, S., Haffner‐Luntzer, M., Sinske, D., Ignatius, A. A., Roselli, F., & Knöll, B. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5593 · Cited by 68 · see citing works
Seijffers, R., Zhang, J., Matthews, J. C., Chen, A., Tamrazian, E., Babaniyi, O., Selig, M. K., Hynynen, M., Woolf, C. J., & Brown, R. H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314826111 · Cited by 65 · see citing works
“In neurons (17), induction of ATF3 expression prevents cell death and promotes neurite formation and elongation, leading to enhanced nerve regeneration through transcriptional induction of survival and growth-associated genes (18–26).”
BackgroundAnastasiadou, S., & Knöll, B. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.012 · Cited by 63 · see citing works
“ATF3 is a regeneration associated gene (RAG) encoding for a neuroprotective transcription factor (Hunt et al., 2012; Seijffers et al., 2007).”
Ricca, A., Rufo, N., Ungari, S., Morena, F., Martino, S., Kulik, W., Alberizzi, V., Bolino, A., Bianchi, F., Carro, U. D., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv086 · Cited by 62 · see citing works
“Even if the role of ATF3 upregulation in damaged neurons is not completely understood (37,68), the rapid and stable downregulation to physiological levels observed in combined-treated Twimice suggests an additional benefit provided by this treatment.”
BackgroundKristensen, U., Epanchintsev, A., Rauschendorf, M., Laugel, V., Stevnsner, T., Bohr, V. A., Coin, F., & Egly, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220071110 · Cited by 61 · see citing works
“Focusing on the neurodegenerative aspects of CS, we selected a set of genes that become down-regulated in CS1AN cells 24 h after UV treatment (51).”
MethodLoss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay
Kurosaki, T., Imamachi, N., Pröschel, C., Mitsutomi, S., Nagao, R., Akimitsu, N., & Maquat, L. E. (2021) · Nature Cell Biology · doi:10.1038/s41556-020-00618-1 · Cited by 59 · see citing works
Wan, L., Cai, H., Ren, L., Yang, Y., Yang, H., Liu, J., Li, S., Zhang, Y., Zheng, X., Tan, W., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.09.012 · Cited by 59 · see citing works
da Silva‐Junior, A. J., Mesentier-Louro, L. A., Nascimento‐dos‐Santos, G., Teixeira‐Pinheiro, L. C., Vasques, J. F., Chimeli-Ormonde, L., Bodart‐Santos, V., de Carvalho, L. R. P., Santiago, M. F., & Méndez‐Otero, R. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02130-7 · Cited by 54 · see citing works
Lens ER-stress response during cataract development in Mip-mutant mice
Zhou, Y., Bennett, T. M., & Shiels, A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.05.003 · Cited by 52 · see citing works
“Atf3 encodes a bZip transcription factor that acts as an integration hub for various stress responses including ER-stress downstream of the Eif2ak3/PerkAtf4 branch of the UPR [63].”
BackgroundNyunt, T., Britton, M., Wanichthanarak, K., Budamagunta, M. S., Voss, J. C., Wilson, D. W., Rutledge, J. C., & Aung, H. H. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.07.024 · Cited by 51 · see citing works
“ATF3 is expressed under stress condition in the brain with seizures [23,24] and in injured neurons of peripheral nerve [25,26], in central nervous system (CNS) glia [27], and in hippocampus [28,29], which have associations with various neurological and cognitive functions.”
BackgroundThe Role of Timing in Nerve Reconstruction
Dahlin, L. B. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-420045-6.00007-9 · Cited by 50 · see citing works
Nascimento, D. S. M., Castro‐Lopes, J. M., & Neto, F. L. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108152 · Cited by 50 · see citing works
Amodeo, G., Niada, S., Moschetti, G., Franchi, S., Savadori, P., Brini, A. T., & Sacerdote, P. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.011 · Cited by 48 · see citing works
Yousuf, M. S., Noh, M., Friedman, T. N., Zubkow, K., Johnson, J. C., Tenorio, G., Kurata, H. T., Smith, P. A., & Kerr, B. J. (2019) · eNeuro · doi:10.1523/eneuro.0024-19.2019 · Cited by 47 · see citing works
“ATF3 expression in our MOG-EAE model was found to be dramatically increased as compared to CFA-controls although to a much lesser degree than models of peripheral nerve injury (Tsujino et al., 2000; Hunt et al., 2012).”
ResultNie, D. A., Chen, Z., Ebrahimi‐Fakhari, D., Nardo, A. D., Jülich, K., Robson, V. K., Cheng, Y.-C., Woolf, C. J., Heiman, M., & Şahin, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4796-14.2015 · Cited by 45 · see citing works
“Atf3 is a transcription factor in the CREB protein family that is induced by action potential bursting and nuclear calcium signaling (Zhang et al., 2009; Zhang et al., 2011; Hunt et al., 2012).”
BackgroundTamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis
Denk, F., Ramer, L. M., Erskine, E. L. K. S., Nassar, M. A., Bogdanov, Y., Signore, M., Wood, J. N., McMahon, S. B., & Ramer, M. S. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0255-6 · Cited by 44 · see citing works
“We generated a knock-in mouse expressing CreERT2 driven by the native promoter for activating transcription factor 3 (Atf3), one of a number of transcription factors upregulated by cellular stress, such as the unfolded protein response, tyrosine kinase receptor activation, glutamate receptor hyperactivation, and cellu…”
InfluentialMoschetti, G., Amodeo, G., Paladini, M. S., Molteni, R., Balboni, G., Panerai, A. E., Sacerdote, P., & Franchi, S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.012 · Cited by 45 · see citing works
Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury
zu Reckendorf, C. M., Brand, C., Pedro, M. T., Hegler, J., Schilling, C., Lerner, R., Bîndilă, L., Antoniadis, G., & Knöll, B. (2020) · Nature Communications · doi:10.1038/s41467-020-15915-4 · Cited by 42 · see citing works
Liu, Q., Long, Q., Zhao, J., Wu, W., Lin, Z., Sun, W., Gu, P., Deng, T., Loomes, K. M., Wu, D., et al. (2023) · Research · doi:10.34133/research.0182 · Cited by 42 · see citing works
“The top 2 up-regulated genes Amphiregulin (Areg) and Atf3 are implicated in Schwann cell growth and axonal outgrowth [35,36], demonstrating that cold exposure vividly induces peripheral nerve growth.”
BackgroundArc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease
Leung, H.-W., Foo, G., & VanDongen, A. M. J. (2022) · Biomedicines · doi:10.3390/biomedicines10081946 · Cited by 39 · see citing works
ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program
Radyk, M. D., Spatz, L. B., Peña, B. L., Brown, J. W., Burclaff, J., Cho, C. J., Kefalov, Y., Shih, C., Fitzpatrick, J. A. J., & Mills, J. C. (2021) · EMBO Reports · doi:10.15252/embr.202051806 · Cited by 37 · see citing works
Zhu, X., Xie, W., Zhang, J., Strong, J. A., & Zhang, J. (2021) · Pain · doi:10.1097/j.pain.0000000000002321 · Cited by 40 · see citing works
Venkatesh, I., Simpson, M. T., Coley, D. M., & Blackmore, M. G. (2016) · Neuroepigenetics · doi:10.1016/j.nepig.2016.10.002 · Cited by 37 · see citing works
“…programs (Chandran et al., 2016; Fagoe et al., 2015; Raivich et al., 2004; Ruff et al., 2012; Makwana et al., 2010; Saijilafu et al., 2011; Fontana et al., 2012; Lerch et al., 2014; Seijffers et al., 2007; Campbell et al., 2005; Shokouhi et al., 2010; Saul et al., 2010; Hunt et al., 2012).”
Marek, V., Potey, A., Goazigo, A. R.-L., Reboussin, É., Charbonnier, A., Villette, T., Baudouin, C., Rostène, W. H., Denoyer, A., & Parsadaniantz, S. M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.029 · Cited by 37 · see citing works
“Normally low, they are rapidly up-regulated in response to neural stimulation [50,51].”
BackgroundLockwood, S., Lopes, D. M., McMahon, S. B., & Dickenson, A. H. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.12.017 · Cited by 37 · see citing works
Xu, L., Zu, T., Li, T., Li, M., Mi, J., Bai, F., Liu, G., Wen, J., Li, H., Brakebusch, C., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009283 · Cited by 37 · see citing works
“Both the nuclear and cytoplasmic localization of ATF3 has been reported in different situations related to the cell type [38], and the nuclear localization of ATF3 has been linked to its activation [39–41].”
BackgroundThe basic science of optic nerve regeneration
Fague, L., Liu, Y., & Marsh‐Armstrong, N. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5351 · Cited by 36 · see citing works
“Also downstream of DLK and the Jnk cascade are the endoplasmic reticulum (ER) stress response genes CHOP (official name: DDIT3) and Atf3 (activating transcription factor 3), and the intrinsic apoptotic pathway already described (BH3s > Bax > caspases) (43,75-77).”
BackgroundATF3 is a novel nuclear marker for migrating ependymal stem cells in the rat spinal cord
Mladinić, M., Bianchetti, E., Dekanic, A., Mazzone, G. L., & Nistri, A. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.03.006 · Cited by 36 · see citing works
“Previous studies have demonstrated that the signal transduction pathways mediating ATF3 expression include c-Jun co-expressed with ATF3 in the nervous system after injury and stress (Hunt et al., 2012).”
BackgroundInfluentialImplication of Melanopsin and Trigeminal Neural Pathways in Blue Light Photosensitivity in vivo
Marek, V., Reboussin, É., Dégardin, J., Charbonnier, A., Domínguez-López, A., Villette, T., Denoyer, A., Baudouin, C., Goazigo, A. R.-L., & Parsadaniantz, S. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00497 · Cited by 35 · see citing works
Microglia-independent peripheral neuropathic pain in male and female mice
Tu, Y., Muley, M. M., Beggs, S., & Salter, M. W. (2022) · Pain · doi:10.1097/j.pain.0000000000002643 · Cited by 34 · see citing works
“ATF3 is reported to be induced by peripheral nerve compression 49 and also by stress loading, 83 both of which also drive microgliosis in the dorsal horn.”
InfluentialShu, M., Du, T., Zhou, G. G., & Roizman, B. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515369112 · Cited by 32 · see citing works
“ATF3 is a member of the ATF/CREB family of transcriptional factors (13, 14).”
BackgroundImpact of Heat Shock Proteins in Neurodegeneration: Possible Therapeutical Targets
Beretta, G., & Shala, A. L. (2022) · Annals of Neurosciences · doi:10.1177/09727531211070528 · Cited by 32 · see citing works
The potential roles of ATF family in the treatment of Alzheimer's disease
Yang, T., Zhang, Y., Chen, L., Thomas, E. R., Yu, W., Cheng, B., & Li, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114544 · Cited by 30 · see citing works
Pizzano, M., Vereertbrugghen, A., Cernutto, A., Sabbione, F., Keitelman, I. A., Shiromizu, C. M., Aguilar, D. V., Fuentes, F., Giordano, M., Trevani, A. S., et al. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.01.015 · Cited by 30 · see citing works
Novel Link of Anti-apoptotic ATF3 with Pro-apoptotic CTMP in the Ischemic Brain
Huang, C. Y., Chen, J. J., Wu, J., Tsai, H. D., Lin, H., Yan, Y.-T., Hsu, C. Y., Ho, Y. S., & Lin, T. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8710-0 · Cited by 30 · see citing works
Nho, B., Lee, J.-H., Lee, J., Ko, K. R., Lee, S. J., & Kim, S. (2018) · The FASEB Journal · doi:10.1096/fj.201800476r · Cited by 29 · see citing works
An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle
Holland, S. D., Ramer, L. M., McMahon, S. B., Denk, F., & Ramer, M. S. (2019) · eNeuro · doi:10.1523/eneuro.0025-19.2019 · Cited by 29 · see citing works
“ATF3 is not only upregulated after PNI but also after CNS trauma including spinal cord injury (Huang et al., 2007), albeit usually meagerly and/or transiently, rendering expression patterns difficult to reveal (for review, see Hunt et al., 2012).”
BackgroundNoh, M., Mikler, B., Joy, T., & Smith, P. A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.040 · Cited by 28 · see citing works
Selvaraj, P., Wen, J., Tanaka, M., & Zhang, Y. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.6226 · Cited by 27 · see citing works
“29,55 The mRNA expression of ATF3, COX-1, and pTau proteins was increased in the TBI mouse brain and reduced by PF04457845 treatment, suggesting that PF04457845 treatment can mitigate inflammatory and neurodegenerative response after brain injury.”
Early Gene Expression Profile in Retinal Ganglion Cell Layer After Optic Nerve Crush in Mice
Ueno, S., Yoneshige, A., Koriyama, Y., Hagiyama, M., Shimomura, Y., & Ito, A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22438 · Cited by 27 · see citing works
ATF3 in atherosclerosis: a controversial transcription factor
Wang, B., Yang, X., Sun, X., Liu, J., Fu, Y., Liu, B., Qiu, J., Lian, J., & Zhou, J. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02263-7 · Cited by 25 · see citing works
“Except for ATF3b, other isoforms may not bind to DNA to counteract the transcriptional repression effect of ATF3 [7, 8].”
BackgroundExploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis
Dharshini, S. A. P., Taguchi, Y., & Gromiha, M. M. (2018) · Genomics · doi:10.1016/j.ygeno.2018.05.024 · Cited by 25 · see citing works
ATF3 is a neuron‐specific biomarker for spinal cord injury and ischaemic stroke
Pan, J. Z., Wang, Z., Sun, W., Pan, P., Li, W., Sun, Y., Chen, S., Lin, A., Tan, W., He, L., et al. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1650 · Cited by 23 · see citing works
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“Like other cells in the organism, neurons express high levels of ATF3 mRNA and protein after toxic stress, and a proper ATF3-mediated response is a key mechanism for neurons to improve their survival and function under threatening conditions (Hunt et al., 2012).”
BackgroundEbbinghaus, M., Müller, S., von Banchet, G. S., Eitner, A., Wank, I., Heß, A., Hilger, I., Kamradt, T., & Schaible, H. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41051 · Cited by 24 · see citing works
Transcription factor ATF-3 regulates allele variation phenotypes of the human SLC11A1 gene
Τaka, S., Gazouli, M., Politis, P. K., Pappa, K. I., & Anagnou, N. P. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2289-1 · Cited by 23 · see citing works
“Finally, an unconventional mechanism of action for ATF3 and c-Jun has been proposed, in which the constitutively expressed transcription factor Sp1 (a member of the Sp/KLF family) acts as scaffold protein to bring about the association of ATF-3, c-Jun, and STAT3 at the Sp1 binding sites, [56].”
BackgroundZhang, T., Guo, X., & Chen, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065058 · Cited by 22 · see citing works
“It is an adaptive response gene and can act both as a transcriptional activator or repressor depending on the cell type and stimulus [38,39,40].”
BackgroundBadu, P., Baniulyte, G., Sammons, M. A., & Pager, C. T. (2024) · Journal of Virology · doi:10.1128/jvi.01055-24 · Cited by 23 · see citing works
“ATF3 affects a host of cellular systems, including cell cycle (93), apoptosis (94), neuron regeneration (95, 96), serine and nucleotide biosynthesis (97, 98), and the immune response (30).”
BackgroundPai, C.-S., Sharma, P. K., Huang, H.-T., Loganathan, S., Lin, H., Hsu, Y.-L., Phasuk, S., & Liu, I. Y. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00037 · Cited by 23 · see citing works
“Under stressed condition, ATF3 is expressed in the hippocampus (Hunt et al., 2012), which is a vital structure in learning and memory.”
BackgroundZhang, L., Yue, Y., Ouyang, M., Liu, H., & Li, Z. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2192-1 · Cited by 22 · see citing works
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Chuang, D.-J., Pethaperumal, S., Siwakoti, B., Chien, H., Cheng, C., Hung, S., Lien, T.-S., Sun, D., & Chang, H. (2021) · Cells · doi:10.3390/cells10123530 · Cited by 19 · see citing works
“In the neuronal system, ATF3 plays a pro-survival role in ganglion cells and neurons [94].”
BackgroundPoupon-Bejuit, L., Hughes, M. P., Liu, W., Geard, A. F., Faour-Slika, N., Whaler, S. M., Massaro, G., & Rahim, A. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-17338-1 · Cited by 19 · see citing works
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“cell homeostasis through the transcriptional control of stress-response and death/survival-response genes.(5,6) ATF2 is constitutively expressed in many tissues, including those of the nervous system.”
BackgroundHalawani, D., Wang, Y., Ramakrishnan, A., Estill, M. S., He, X., Shen, L., Friedel, R. H., & Zou, H. (2023) · Nature Communications · doi:10.1038/s41467-023-40816-7 · Cited by 18 · see citing works
“…we initially anticipated induction of a wide range of RAGs, but sur-veying RAGs in uninjured DRGs from Bmal1 cKO vs. control mice revealed no signi fi cant upregulation of well-known RAGs such as Atf3 (a marker of conditioning lesion 60 ), neurotrophins ( Bdnf, Ngf, Ntf3 ), Gal , or Gap43 (Fig.”
BackgroundRaimondo, S., Soury, M. E., García‐García, Ó. D., Tarulli, I., Chato‐Astrain, J., Perroteau, I., Geuna, S., Gambarotta, G., & Carriel, V. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.358605 · Cited by 17 · see citing works
“Finally, significantly up-regulated c-Jun / ATF3 expression was observed in the ADMSC group, important transcription factors for SC dedifferentiation into a “repair” phenotype (Hunt et al., 2012; Jessen and Mirsky, 2016).”
Pianka, M.-L., Hesse, L., Deisinger, F., Sipos, B., Röcken, C., Arlt, A., Sebens, S., Helm, O., & Schäfer, H. (2018) · Oncogene · doi:10.1038/s41388-018-0518-3 · Cited by 17 · see citing works
“Since the expression of ATF3 variants depends on the splicing of different mRNAs deriving from transcription through two different ATF3 promoter regions [44, 45], the identity of the transcripts was verified by qPCR.”
BackgroundInfluentialKunst, S., Wolloscheck, T., Hoelter, P., Wengert, A., Grether, M., Sticht, C., Weyer, V., Uwe Wolfrum, B., & Spessert, R. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12089 · Cited by 17 · see citing works
“…is Atf3 that encodes a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors that – interacting with a number of other transcription factors – bind to cyclic AMP response elements (CREs) in the promoters of various genes (for review, see Hunt et al. 2012).”
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Bonneau, N., Potey, A., Vitoux, M.-A., Magny, R., Guerin, C., Baudouin, C., Peyrin, J., Brignole‐Baudouin, F., & Goazigo, A. R.-L. (2023) · The Ocular Surface · doi:10.1016/j.jtos.2023.11.004 · Cited by 16 · see citing works
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“ATF has the ability to interact with a number of other transcription factors including c-Jun to form complexes that can activate various genes (Seijffers et al., 2007; Hunt et al., 2012).”
BackgroundMechanism of Action of Radiofrequency Ablation
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Polyester Nanoparticle Encapsulation Mitigates Paclitaxel-Induced Peripheral Neuropathy
Ganugula, R., Deng, M., Arora, M., Pan, H., & Kumar, M. N. V. R. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00703 · Cited by 14 · see citing works
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The Time Sequence of Gene Expression Changes after Spinal Cord Injury
Mun, S., Han, K., & Hyun, J. K. (2022) · Cells · doi:10.3390/cells11142236 · Cited by 13 · see citing works
“expression and is a major mechanism for controlling inflammatory reactions by controlling anti-inflammatory cytokines [27].”
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Meta-Analysis Reveals Transcription Factor Upregulation in Cells of Injured Mouse Sciatic Nerve
Li, M., Banton, M. C., Min, Q., Parkinson, D. B., & Dun, X. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.688243 · Cited by 13 · see citing works
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“These liposomes are digested by lysosomal phospholipases, while the clodronate remains in the macrophage.”
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“108,206 The molecular responses to injury differ slightly between the DRG and TG 163 and so are likely to diverge for other sensory ganglia as well.”
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“[39] [40] [41] [42] VIP is a neurotransmitter in the mucosa, lamina propria, and myenteric plexus of the small and large intestine, which can respond to secretomotor refl exes and activate adenylate cyclase.”
BackgroundIGF-1 via PI3K/Akt/S6K signaling pathway protects DRG neurons with high glucose-induced toxicity
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Biomechanical Forces Regulate Gene Transcription During Stretch-Mediated Growth of Mammalian Neurons
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Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients
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Pavlou, M. A. S., Singh, K., Ravichandran, S., Halder, R., Nicot, N., Birck, C., Grandbarbe, L., del Sol, A., & Michelucci, A. (2023) · Cells · doi:10.3390/cells12060948 · Cited by 11 · see citing works
“Atf3 expression in astrocytes is induced by NRF2, a key regulator of stress-induced antioxidant response [84].”
Background
- Authors
- Hunt, D., Raivich, G., & Anderson, P. N.
- Affiliations
- Newham University Hospital (GB)
- University College London (GB)
- Corresponding author
- Anderson, Patrick Norval
- ORCID
- Hunt, David
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 5
- Pages
- 7-7
- ISSN
- 1662-5099 (ISSN-L)
- PMC
- PMC3278981
- OpenAlex
- W2124172625
- Cited by
- 162
- References
- 185
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 8 · 2023: 16 · 2022: 13 · 2021: 19 · 2020: 12 · 2019: 17 · 2018: 19 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 2
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Frontiers in Molecular Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- ATF3, ATF/CREB family, transcriptional repressor, c-Jun, neuronal injury response, axon regeneration, axotomy, Schwann cell phenotype, peripheral nerve injury, Toll-like receptor signaling, innate immune response, neuronal survival, glia
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