Cited by 410Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

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Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

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Zoli, Michele, Moretti, Milena, Zanardi, Alessio, McIntosh, J. Michael, Clementi, Francesco, Gotti, Cecilia·2002·The Journal of Neuroscience

DOI 10.1523/jneurosci.22-20-08785.2002PMC PMC6757689

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Abstract

Neuronal nicotinic acetylcholine receptors (nAChRs) expressed on mesostriatal dopaminergic neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and reinforcement. Using immunoprecipitation and ligand-binding techniques, we have shown that both alpha6beta2* and alpha4(nonalpha6)beta2* nAChRs are expressed in the caudate-putamen and that only alpha6* nAChRs can bind alpha-conotoxin MII and methyllycaconitine with affinities of 1.3 and 40 nm, respectively. Further studies performed on 6-hydroxydopamine-lesioned striatum led to the identification of nAChR subtypes selectively expressed on dopaminergic terminals [alpha4alpha5beta2, alpha4alpha6beta2(beta3), and alpha6beta2(beta3)], nondopaminergic neuronal structures (alpha2alpha4beta2), or both structures (alpha4beta2). The identification of the nAChRs expressed on striatal dopaminergic terminals opens up the possibility of developing selective nAChR ligands active on dopaminergic systems and associated diseases, such as Parkinson's disease.

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Authors: Zoli, M., Moretti, M., Zanardi, A., McIntosh, J. M., Clementi, F., & Gotti, C.
Affiliations: University of Milan (IT)
University of Modena and Reggio Emilia (IT)
University of Utah (US)
ORCID: McIntosh, J. Michael
Gotti, Cecilia
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2002-10-15
Volume: 22
Issue: 20
Pages: 8785-8789
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.22-20-08785.2002
PMC: PMC6757689
OpenAlex: W2162000418
Cited by: 407
References: 28
Citations by year: 2026: 3 · 2025: 12 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 9 · 2016: 16 · 2015: 13 · 2014: 16 · 2013: 10 · 2012: 14
FWCI: 8.95
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Funders: National Institutes of Health
National Institute of Mental Health (MH53631, R01MH053631, R29MH053631)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: nicotinic acetylcholine receptors, dopaminergic terminals, striatum, caudate-putamen, alpha4beta2 nAChR, alpha-conotoxin MII, methyllycaconitine, nicotine, 6-hydroxydopamine lesion, Parkinson's disease
MeSH terms: Animals, Binding, Competitive, Corpus Striatum, Dopamine, Ligands, Male, Precipitin Tests, Receptors, Nicotinic, Specific Pathogen-Free Organisms, Oxidopamine, Rats, Sprague-Dawley, Presynaptic Terminals, Nicotinic Agonists, Nicotinic Antagonists, Dopamine Uptake Inhibitors, Protein Subunits, Rats

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Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

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