The DOI matches its Crossref record; 26 of the 28 references it cites were found in a registry or an index.
Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum
Open accessAbstract
Neuronal nicotinic acetylcholine receptors (nAChRs) expressed on mesostriatal dopaminergic neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and reinforcement. Using immunoprecipitation and ligand-binding techniques, we have shown that both alpha6beta2* and alpha4(nonalpha6)beta2* nAChRs are expressed in the caudate-putamen and that only alpha6* nAChRs can bind alpha-conotoxin MII and methyllycaconitine with affinities of 1.3 and 40 nm, respectively. Further studies performed on 6-hydroxydopamine-lesioned striatum led to the identification of nAChR subtypes selectively expressed on dopaminergic terminals [alpha4alpha5beta2, alpha4alpha6beta2(beta3), and alpha6beta2(beta3)], nondopaminergic neuronal structures (alpha2alpha4beta2), or both structures (alpha4beta2). The identification of the nAChRs expressed on striatal dopaminergic terminals opens up the possibility of developing selective nAChR ligands active on dopaminergic systems and associated diseases, such as Parkinson's disease.
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“DA neurons express heteromeric nAChRs containing the α4, α5, α6, β2, and β3 subunits in various combinations, with the predominant subtypes being α4/β2/α5 and α4/α6/ β2/β3.”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Zoli et al. 2002
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LIGAND: A versatile computerized approach for characterization of ligand-binding systems
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Self-citationNicotinic Receptors at the Amino Acid Level
Corringer, P., Novère, N. G. L., & Changeux, J. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.431 · Cited by 832
Role of dopamine in the behavioural actions of nicotine related to addiction
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Self-citationEndogenous nicotinic cholinergic activity regulates dopamine release in the striatum
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A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors
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Identification of four classes of brain nicotinic receptors using beta2 mutant mice.
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Research works printed but not linked: 1
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Sicre, M. (2021) · theses.fr (ABES) · doi:10.70675/b8ead46dzaf07z4156zb06bzc3755176fcfc
Matera, C., Grilli, M., Pucci, L., Fassi, E. M. A., Fucile, S., Marchi, M., Fiorentini, C., Clementi, F., Zoli, M., Dallanoce, C., et al. (2026) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2026.119867
Self-citationBindingDB (2012) · UC San Diego · doi:10.7270/q2bk19xs
Regulation and Function of Neuronal Nicotinic Acetylcholine Receptors in Lung Cancer: A Dissertation
Improgo, M. R. (2011) · eScholarship@UMassChan · doi:10.13028/2t06-nc13
Buhlman, L. M. (2007) · UA Campus Repository (The University of Arizona)
Regulation of Neuronal Nicotinic Receptor Expression by Novel Ligands and Mechanisms
Hussmann, G. P. (2012) · DigitalGeorgetown (Georgetown University Library)
Metadata
- Authors
- Zoli, M., Moretti, M., Zanardi, A., McIntosh, J. M., Clementi, F., & Gotti, C.
- Affiliations
- University of Milan (IT)
- University of Modena and Reggio Emilia (IT)
- University of Utah (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-10-15
- Volume
- 22
- Issue
- 20
- Pages
- 8785-8789
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757689
- OpenAlex
- W2162000418
- Cited by
- 407
- References
- 28
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 9 · 2016: 16 · 2015: 13 · 2014: 16 · 2013: 10 · 2012: 14
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH53631, R01MH053631, R29MH053631)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, dopaminergic terminals, striatum, caudate-putamen, alpha4beta2 nAChR, alpha-conotoxin MII, methyllycaconitine, nicotine, 6-hydroxydopamine lesion, Parkinson's disease
- MeSH terms
- Animals, Binding, Competitive, Corpus Striatum, Dopamine, Ligands, Male, Precipitin Tests, Receptors, Nicotinic, Specific Pathogen-Free Organisms, Oxidopamine, Rats, Sprague-Dawley, Presynaptic Terminals, Nicotinic Agonists, Nicotinic Antagonists, Dopamine Uptake Inhibitors, Protein Subunits, Rats
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