The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in Mice
Open accessAbstract
It has been shown recently that extinction of conditional fear does not depend acutely on NMDA-type glutamate receptors, although other evidence has led to the hypothesis that L-type voltage-gated calcium channels (LVGCCs) play a role in conditional fear. We therefore tested the role of LVGCCs in the acquisition, expression, and extinction of conditional fear of cue and context in mice. Using systemic injections of two LVGCC inhibitors, nifedipine and nimodipine, which both effectively cross the blood-brain barrier, we show that LVGCCs are essential for the extinction, but not for the acquisition or expression, of conditional fear in mice.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“extinction appears to depend upon activation of LVGCCs and protein degradation.”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Cain et al., 2002
In the citing paper
“Administration of the LVGCC antagonists nifedipine or nimodipine blocked extinction (Cain et al., 2002) with prolonged re-exposure”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Cain et al., 2002
Citations
Cites
The practice of behavior therapy
Wolpe, J. (1969) · Cited by 2,343
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,878
Effects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear
Rowe, M. K., & Craske, M. G. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10016-x · Cited by 1,782
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
The role of ventromedial prefrontal cortex in the recovery of extinguished fear
Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06225.2000 · Cited by 957 · cited 2×
“First, whereas long-lasting extinction may depend on areas of prefrontal cortex (Morgan et al., 1993), the induction of extinction proceeds normally in animals with frontal lesions (Quirk et al., 2000).”
BackgroundExtinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · cited 2×
“First, whereas long-lasting extinction may depend on areas of prefrontal cortex (Morgan et al., 1993), the induction of extinction proceeds normally in animals with frontal lesions (Quirk et al., 2000).”
BackgroundMiserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824 · cited 1×
“Accumulating evidence indicates that fear acquisition and expression require NMDA-type glutamate receptor (NMDAR) activity in the amygdala (Miserendino et al., 1990; Kim et al., 1991, 1992; Falls et al., 1992; Tang et al., 1999; Rodrigues et al., 2001).”
BackgroundBouton, M. E., & King, D. A. (1983) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.9.3.248 · Cited by 796
Contextual control of the extinction of conditioned fear
Bouton, M. E., & Bolles, R. C. (1979) · Learning and Motivation · doi:10.1016/0023-9690(79)90057-2 · Cited by 796
Lubow, R. E. (1973) · Psychological Bulletin · doi:10.1037/h0034425 · Cited by 793
Cited by
Sorted by citations
Items 101–130 of 130
Rosenkranz, J. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0690-11.2011 · Cited by 10
Proteins linked to extinction in contextual fear conditioning in the C57BL/6J mouse
Li, L., Boddul, S. V., Patil, S. S., Zheng, J., An, G., Höger, H., & Lübec, G. (2011) · PROTEOMICS · doi:10.1002/pmic.201000444 · Cited by 9
The Role of L-type Calcium Channels in Olfactory Learning and Its Modulation by Norepinephrine
Ghosh, A., Carew, S. J., Chen, X., & Yuan, Q. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00394 · Cited by 7
An, X., Yang, P., Chen, S., Zhang, F., & Yu, D. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00259 · Cited by 7
Second Messengers: Calcium and cAMP Signaling
Eckel‐Mahan, K. L., & Storm, D. R. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00021-8 · Cited by 7
Sepahvand, T., Nazari, N., Qin, T., Rajani, V., & Yuan, Q. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309986120 · Cited by 7
Mitogen-Activated Protein Kinases in Synaptic Plasticity and Memory
Kelleher, R. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00024-3 · Cited by 4
Nitric Oxide-Dependent LTD at Infralimbic Cortex
Noriega‐Prieto, J. A., Maglio, L. E., Gallero-Salas, Y., & de Sevilla, D. F. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.08.029 · Cited by 5
Mechanisms of Fear Extinction: Toward Improved Treatment for Anxiety
Barad, M., & Cain, C. K. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511500008.008 · Cited by 5
Self-citationHemati, T., Abbasnejad, M., Mollashahi, M., Esmaeili‐Mahani, S., & Shahraki, A. S. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000611 · Cited by 3
Characterisation of the neural basis underlying appetitive extinction & renewal in Cacna1c rats
Gasalla, P., Manahan‐Vaughan, D., Dwyer, D. M., Hall, J., & Méndez‐Couz, M. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109444 · Cited by 3
Fear Conditioning and Extinction as a Model of PTSD in Mice
Gafford, G. M., & Ressler, K. J. (2011) · Neuromethods · doi:10.1007/978-1-61779-313-4_11 · Cited by 3
Divide and conquer: An L-type voltage-gated calcium channel subtype finds a role in conditioned fearPreprint
Barad, M. (2006) · Learning & Memory · doi:10.1101/lm.402806 · Cited by 3
Self-citationMemory Reconsolidation Versus Extinction
Kida, S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-386892-3.00006-8 · Cited by 3
Abdel-Raheem, I. T. (2010) · Cited by 2
Correa-Netto, N. F., Masukawa, M. Y., Silva-Gomes, A. M., Linardi, A., & Santos-Junior, J. G. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114212 · Cited by 1
Postnatal development of the relaxin-3 innervation of the rat medial septum
Ros‐Bernal, F., Gil‐Miravet, I., Morales, J. L., Navarro-Sánchez, M., Castillo-Gómez, E., Gundlach, A. L., & Olucha-Bordonau, F. E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1176587 · Cited by 1
Malan‐Müller, S. (2014) · SUNScholar (Stellenbosch University) · Cited by 1
Domingos, L. B. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2020.tde-19082020-223048 · Cited by 1
NEUROBIOLOGICAL PERSPECTIVES ON TRAUMA
Kirmayer, L. J., Lemelson, R., & Barad, M. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511500008.004 · Cited by 1
Self-citationUntersuchungen zur Rolle des endogenen Cannabinoidsystems bei der Anpassung an aversive Situationen
Kamprath, K. (2006) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.6000
McKinney, B. C. (2010) · Deep Blue (University of Michigan)
Finding anti-anxiety targets in fear mechanisms
Sutherland, S. P. (2002) · TARGETS · doi:10.1016/s1477-3627(02)02226-2
Memory improvement with the metabolic enhancer methylene blue
Wrubel, K. M. (2006) · Texas ScholarWorks (Texas Digital Library)
DIABETES MELLITUS: A PLOTTER OF COGNITIVE DECLINE
Mishra, S., Jamuna Rani, R., & Dabburu, K. (2013) · Journal of Pharmaceutical and Scientific Innovation · doi:10.7897/2277-4572.02338
Sampaio, A. M. (2008) · Americanae (AECID Library)
Sykes, L. (2016) · ORCA Online Research @Cardiff (Cardiff University)
Sexually dimorphic interplay between anxiety-related phenotype and fear memory extinctionPreprint
Bonilla, M. I., Lee, H.-L., Kim, I.-J., & Rudenko, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.17.460842
L-type calcium channels regulate decision-making process during fear learning in the zebrafishPreprint
Ogawa, S., Lim, G. W., & Roy, N. (2024) · Research Square · doi:10.21203/rs.3.rs-5614626/v1
Pérez-Cuesta, L. M. (2010) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Metadata
- Authors
- Cain, C. K., Blouin, A. M., & Barad, M.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-10-15
- Volume
- 22
- Issue
- 20
- Pages
- 9113-9121
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757698
- OpenAlex
- W2109508453
- Cited by
- 130
- References
- 55
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 2 · 2015: 1 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Mental Health (F31MH065809)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- L-type calcium channels, fear extinction, fear acquisition, fear expression, nifedipine, nimodipine, calcium channel blockers, NMDA receptor, contextual fear, mice
- MeSH terms
- Animals, Behavior, Animal, Calcium Channel Blockers, Conditioning, Classical, Cues, Electroshock, Extinction, Psychological, Fear, Male, Mice, Inbred C57BL, Nifedipine, Nimodipine, Retention, Psychology, Calcium Channels, L-Type, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
