Cited by 130Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in Mice

Open access

Cain, Chris K., Blouin, Ashley M., Barad, Mark·2002·The Journal of Neuroscience

DOI 10.1523/jneurosci.22-20-09113.2002PMC PMC6757698

Open this paper in CoChat — free account Open PDF

Abstract

It has been shown recently that extinction of conditional fear does not depend acutely on NMDA-type glutamate receptors, although other evidence has led to the hypothesis that L-type voltage-gated calcium channels (LVGCCs) play a role in conditional fear. We therefore tested the role of LVGCCs in the acquisition, expression, and extinction of conditional fear of cue and context in mice. Using systemic injections of two LVGCC inhibitors, nifedipine and nimodipine, which both effectively cross the blood-brain barrier, we show that LVGCCs are essential for the extinction, but not for the acquisition or expression, of conditional fear in mice.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.22-20-09113.2002

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The practice of behavior therapy
Wolpe, J. (1969) · Cited by 2,343
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,878
Effects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear
Rowe, M. K., & Craske, M. G. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10016-x · Cited by 1,782
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
The role of ventromedial prefrontal cortex in the recovery of extinguished fear
Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06225.2000 · Cited by 957 · cited 2×
“First, whereas long-lasting extinction may depend on areas of prefrontal cortex (Morgan et al., 1993), the induction of extinction proceeds normally in animals with frontal lesions (Quirk et al., 2000).”
Background
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · cited 2×
“First, whereas long-lasting extinction may depend on areas of prefrontal cortex (Morgan et al., 1993), the induction of extinction proceeds normally in animals with frontal lesions (Quirk et al., 2000).”
Background
Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala
Miserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824 · cited 1×
“Accumulating evidence indicates that fear acquisition and expression require NMDA-type glutamate receptor (NMDAR) activity in the amygdala (Miserendino et al., 1990; Kim et al., 1991, 1992; Falls et al., 1992; Tang et al., 1999; Rodrigues et al., 2001).”
Background
Contextual control of the extinction of conditioned fear: Tests for the associative value of the context.
Bouton, M. E., & King, D. A. (1983) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.9.3.248 · Cited by 796
Contextual control of the extinction of conditioned fear
Bouton, M. E., & Bolles, R. C. (1979) · Learning and Motivation · doi:10.1016/0023-9690(79)90057-2 · Cited by 796
Latent inhibition.
Lubow, R. E. (1973) · Psychological Bulletin · doi:10.1037/h0034425 · Cited by 793
Reinstatement of fear to an extinguished conditioned stimulus.
Rescorla, R. A., & Heth, C. D. (1975) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.1.1.88 · Cited by 768
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning
Blair, H. T., Schafe, G. E., Bauer, E. P., Rodrigues, S. M., & LeDoux, J. E. (2001) · Learning & Memory · doi:10.1101/lm.30901 · Cited by 610
NMDA Receptors and L-Type Voltage-Gated Calcium Channels Contribute to Long-Term Potentiation and Different Components of Fear Memory Formation in the Lateral Amygdala
Bauer, E. P., Schafe, G. E., & LeDoux, J. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05239.2002 · Cited by 438
N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats.
Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. S. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.6.1365 · Cited by 385
Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory
Santini, E., Muller, R. U., & Quirk, G. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-22-09009.2001 · Cited by 358
Intra-Amygdala Blockade of the NR2B Subunit of the NMDA Receptor Disrupts the Acquisition But Not the Expression of Fear Conditioning
Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06889.2001 · Cited by 350
Amygdalar NMDA Receptors are Critical for New Fear Learning in Previously Fear-Conditioned Rats
Lee, H. J., & Kim, J. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08444.1998 · Cited by 310
Visualization of changes in presynaptic function during long-term synaptic plasticity
Zakharenko, S. S., Zablow, L., & Siegelbaum, S. A. (2001) · Nature Neuroscience · doi:10.1038/89498 · Cited by 305
N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.
Kim, J. J., DeCola, J. P., Landeira-Fernández, J., & Fanselow, M. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.126 · Cited by 301
NMDA-Receptor-Independent Long-Term Potentiation
Johnston, D., Williams, S., Jaffe, D., & Gray, R. (1992) · Annual Review of Physiology · doi:10.1146/annurev.ph.54.030192.002421 · Cited by 300 · cited 2×
“Forms of LVGCC-dependent synaptic modification have been described in a number of synapses in the brain (Johnston et al., 1992; Huang and Malenka, 1993; Christie and Abraham, 1994; Huber et al., 1995; Zhuo and Hawkins, 1995; Kurotani et al., 1996; Izumi and Zorumski, 1998; Kapur et al., 1998;…”
Method
LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit
Rogan, M. T., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90070-5 · Cited by 300
N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats.
Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1365 · Cited by 260
L-Type Voltage-Gated Calcium Channels Mediate NMDA-Independent Associative Long-Term Potentiation at Thalamic Input Synapses to the Amygdala
Weisskopf, M. G., Bauer, E. P., & LeDoux, J. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10512.1999 · Cited by 253
Mitogen-Activated Protein Kinase Cascade in the Basolateral Nucleus of Amygdala Is Involved in Extinction of Fear-Potentiated Startle
Lu, K., Walker, D. L., & Davis, M. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0005.2001 · Cited by 224
State-dependent fear extinction with two benzodiazepine tranquilizers.
Bouton, M. E., Kenney, F. A., & Rosengard, C. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.1.44 · Cited by 212
The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.
Baker, J. D., & Azorlosa, J. L. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.3.618 · Cited by 179
The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.
Baker, J. D., & Azorlosa, J. L. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.3.618 · Cited by 179
Selective impairment of long-term but not short-term conditional fear by the N-methyl-D-aspartate antagonist APV.
Kim, J. J., Fanselow, M. S., DeCola, J. P., & Landeira-Fernández, J. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.4.591 · Cited by 165
Examination of TEA-induced synaptic enhancement in area CA1 of the hippocampus: the role of voltage-dependent Ca2+ channels in the induction of LTP
Huang, Y., & Malenka, R. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00568.1993 · Cited by 163
L-Type Calcium Channels Are Required for One Form of Hippocampal Mossy Fiber LTP
Kapur, A., Yeckel, M. F., Gray, R., & Johnston, D. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.2181 · Cited by 158
The effects of neurotoxic hippocampal lesions on two effects of context after fear extinction.
Frohardt, R. J., Guarraci, F. A., & Bouton, M. E. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.2.227 · Cited by 136
NMDA and non-NMDA receptors contribute to synaptic transmission between the medial geniculate body and the lateral nucleus of the amygdala
Li, X., Phillips, R. G., & LeDoux, J. E. (1995) · Experimental Brain Research · doi:10.1007/bf00242185 · Cited by 118
Electrical Stimuli Patterned After the Theta-Rhythm Induce Multiple Forms of LTP
Morgan, S. L., & Teyler, T. J. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.3.1289 · Cited by 116
Distinct LTP induction mechanisms: contribution of NMDA receptors and voltage-dependent calcium channels
Huber, K. M., Mauk, M. D., & Kelly, P. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.1.270 · Cited by 102
Role of Voltage-Dependent Calcium Channel Long-Term Potentiation (LTP) and NMDA LTP in Spatial Memory
Borroni, A. M., Fichtenholtz, H. M., Woodside, B. L., & Teyler, T. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09272.2000 · Cited by 100
Long-Term Depression: A Learning-Related Type of Synaptic Plasticity in the Mammalian Central Nervous System
Zhuo, M., & Hawkins, R. D. (1995) · Reviews in the Neurosciences · doi:10.1515/revneuro.1995.6.3.259 · Cited by 85
NMDA antagonists make learning and recall state-dependent
Jackson, A., Koek, W., & Colpaert, F. C. (1992) · Behavioural Pharmacology · doi:10.1097/00008877-199208000-00018 · Cited by 78
Functional Aspects of Calcium-Channel Modulation
Disterhoft, J. F., Moyer, J. R., Thompson, L. T., & Kowalska, M. (1993) · Clinical Neuropharmacology · doi:10.1097/00002826-199316001-00003 · Cited by 72
Endoscopic Intraventricular Surgery for Treatment of Hydrocephalus and Loculated CSF Space in Children Less than One Year of Age
Fritsch, M. J., & Mehdorn, H. M. (2002) · Pediatric Neurosurgery · doi:10.1159/000056055 · Cited by 67
L-Type Voltage-Dependent Calcium Channel Blocker Nifedipine Enhances Memory Retention When Infused into the Hippocampus
Quevedo, J., Vianna, M. R. M. R., Daroit, D., de Born, A. G., Kuyven, C. R., Roesler, R., & Quillfeldt, J. A. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3822 · Cited by 64
Spontaneous recovery from the effects of flooding (exposure) in animals
Baum, M. (1988) · Behaviour Research and Therapy · doi:10.1016/0005-7967(88)90118-0 · Cited by 50
Dihydropyridine Calcium Antagonists in Mice: Blood and Brain Pharmacokinetics and Efficacy Against Pentylenetetrazol Seizures
Larkin, J. G., Thompson, G., Scobie, G., Forrest, G., Drennan, J. E., & Brodie, M. J. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb02358.x · Cited by 50
Calcium Channel Antagonists Enhance Retention of Passive Avoidance and Maze Learning in Mice
Quartermain, D., deSoria, V. G., & Kwan, A. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3958 · Cited by 46
Single-Dose Kinetics of Nifedipine in Rat Plasma and Brain
Janicki, P. K., Siembab, D., Paulo, E., & Krząścik, P. (2008) · Pharmacology · doi:10.1159/000138382 · Cited by 41
L-type voltage-sensitive calcium channel antagonists block heterosynaptic long-term depression in the dentate gyrus of anaesthetized rats
Christie, B. R., & Abraham, W. C. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)91023-5 · Cited by 41
State-dependent impairment in object recognition after hippocampal NOS inhibition
Blokland, A., Prickaerts, J., Honig, W. M. M., & de Vente, J. (1998) · Neuroreport · doi:10.1097/00001756-199812210-00037 · Cited by 36
Nifedipine and verapamil block the memory-facilitating effect of corticotropin-releasing factor in rats
Lee, E. H. Y., & Lin, W. R. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90530-o · Cited by 35
Disruption of State-Dependent learning (memory retrieval) by emotionally-important stimuli
Connelly, J. F., Connelly, J. M., & Phifer, R. (1975) · Psychopharmacology · doi:10.1007/bf00421071 · Cited by 17
LTP in CA1 of the adult rat hippocampus and voltage-activated calcium channels
Izumi, Y., & Zorumski, C. F. (1998) · Neuroreport · doi:10.1097/00001756-199811160-00022 · Cited by 16
Nifedipine blocks retention of a visual discrimination task in chicks
Deyo, R. A., Nix, D. A., & Parker, T. W. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90262-3 · Cited by 16
Protein and RNA synthesis-dependent and -independent LTPs in developing rat visual cortex
Kurotani, T., Higashi, S., Inokawa, H., & Toyama, K. (1996) · Neuroreport · doi:10.1097/00001756-199612200-00008 · Cited by 14
Facilitation of shuttle-box avoidance behaviour in mice treated with nifedipine in combination with amphetamine
Vetulani, J., Battaglia, M., Castellano, C., & Sansone, M. (1993) · Psychopharmacology · doi:10.1007/bf02245700 · Cited by 14
NMDA-Receptor-Independent Long-Term Potentiation
Johnston, D. (1992) · Annual Review of Physiology · doi:10.1146/annurev.physiol.54.1.489 · Cited by 13
Erratum: Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Staubli, U. V., & LeDoux, J. E. (1998) · Nature · doi:10.1038/35910 · Cited by 11
Experimental research on the effect of calcium channel blockers nifedipine and verapamil on the anxiety in mice.
Fulga, I. G., & STROESCU, V. (1997) · PubMed · Cited by 7

Sorted by citations

Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.195 · Cited by 1,605
Mechanisms of fear extinction
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277
Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
Suzuki, A., Josselyn, S. A., Frankland, P. W., Masushige, S., Silva, A. J., & Kida, S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5491-03.2004 · Cited by 1,127
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994

See all 130

Authors: Cain, C. K., Blouin, A. M., & Barad, M.
Affiliations: University of California, Los Angeles (US)
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2002-10-15
Volume: 22
Issue: 20
Pages: 9113-9121
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.22-20-09113.2002
PMC: PMC6757698
OpenAlex: W2109508453
Cited by: 130
References: 55
Citations by year: 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 2 · 2015: 1 · 2014: 6 · 2013: 5 · 2012: 6
FWCI: 3.85
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Mental Health (F31MH065809)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: L-type calcium channels, fear extinction, fear acquisition, fear expression, nifedipine, nimodipine, calcium channel blockers, NMDA receptor, contextual fear, mice
MeSH terms: Animals, Behavior, Animal, Calcium Channel Blockers, Conditioning, Classical, Cues, Electroshock, Extinction, Psychological, Fear, Male, Mice, Inbred C57BL, Nifedipine, Nimodipine, Retention, Psychology, Calcium Channels, L-Type, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in Mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks