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L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in Mice

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Cain, Chris K., Blouin, Ashley M., Barad, Mark·2002·The Journal of Neuroscience

DOI 10.1523/jneurosci.22-20-09113.2002PMC PMC6757698

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Abstract

It has been shown recently that extinction of conditional fear does not depend acutely on NMDA-type glutamate receptors, although other evidence has led to the hypothesis that L-type voltage-gated calcium channels (LVGCCs) play a role in conditional fear. We therefore tested the role of LVGCCs in the acquisition, expression, and extinction of conditional fear of cue and context in mice. Using systemic injections of two LVGCC inhibitors, nifedipine and nimodipine, which both effectively cross the blood-brain barrier, we show that LVGCCs are essential for the extinction, but not for the acquisition or expression, of conditional fear in mice.

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Authors: Cain, C. K., Blouin, A. M., & Barad, M.
Affiliations: University of California, Los Angeles (US)
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2002-10-15
Volume: 22
Issue: 20
Pages: 9113-9121
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.22-20-09113.2002
PMC: PMC6757698
OpenAlex: W2109508453
Cited by: 130
References: 55
Citations by year: 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 2 · 2015: 1 · 2014: 6 · 2013: 5 · 2012: 6
FWCI: 3.85
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Mental Health (F31MH065809)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: L-type calcium channels, fear extinction, fear acquisition, fear expression, nifedipine, nimodipine, calcium channel blockers, NMDA receptor, contextual fear, mice
MeSH terms: Animals, Behavior, Animal, Calcium Channel Blockers, Conditioning, Classical, Cues, Electroshock, Extinction, Psychological, Fear, Male, Mice, Inbred C57BL, Nifedipine, Nimodipine, Retention, Psychology, Calcium Channels, L-Type, Mice

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L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in Mice

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