Decoupling Eye-Specific Segregation from Lamination in the Lateral Geniculate Nucleus
Open accessAbstract
To determine whether there is a critical period for development of eye-specific layers in the lateral geniculate nucleus (LGN), we prevented the normal segregation of retinogeniculate afferents and then allowed an extended period of time for recovery. After recovery, both anatomy and physiology revealed strictly nonoverlapping territories of input from the two eyes. However, the normal stereotyped pattern of eye-specific afferent and cellular layers never developed. Instead, the eye-specific territories of afferent input emerged as variable and disorganized patches with no corresponding interlaminar spaces in the LGN. These findings reveal a critical period for coordinating the development of three processes in the LGN: the segregation of afferents from the two eyes, the spatial organization of those afferents into layers, and the alignment of postsynaptic cytoarchitecture with the afferent inputs. We also assessed the physiological consequences of preventing normal lamination and found normal single-cell responses and topographic representation of visual space in the LGN. Clusters of ON-center and OFF-center LGN cells were segregated from one another as in normal animals. However, the organization of ON and OFF sublaminas in the treated animals was disrupted.
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Monocular epibatidine injection preserves eye-specific segregation and induces the affected weaker projections to lose their territory preferentially.
“Previous work has shown that injecting epibatidine binocularly blocks eye-specific segregation in dLGN, whereas injecting epibatidine monocularly preserves eye-specific segregation, inducing the affected weaker projections to lose their territory preferentially.”
From Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways (2013) · cites this paper as [26]
The Results section reports that binocular epibatidine treatment prevented eye-specific segregation in ferrets at P10. The copy describes territory gained by an active eye at the expense of an inactive eye only in a passage indexed as the Abstract; the non-abstract passages do not establish that monocular epibatidine preserves segregation or preferentially reduces the treated projection. (LLM, conf=0.82)
Experimental — accuracy not yet measuredBinocular epibatidine injection blocks eye-specific segregation in dLGN.
“Previous work has shown that injecting epibatidine binocularly blocks eye-specific segregation in dLGN, whereas injecting epibatidine monocularly preserves eye-specific segregation, inducing the affected weaker projections to lose their territory preferentially.”
From Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways (2013) · cites this paper as [26]
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Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
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“To find out, we intraocularly injected epibatidine, a potent agonist for neuronal nicotinic acetylcholine receptors in order to specifically block the spontaneous retinal waves 17,25,26 .”
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Astrocytes Control Synapse Formation, Function, and Elimination
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Mechanisms underlying development of visual maps and receptive fields
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Self-citationRetinal waves coordinate patterned activity throughout the developing visual system
Ackman, J. B., Burbridge, T. J., & Crair, M. C. (2012) · Nature · doi:10.1038/nature11529 · Cited by 525 · see citing works
McLaughlin, T., Torborg, C. L., Feller, M. B., & O'Leary, D. D. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00790-6 · Cited by 422 · see citing works
Development of precise maps in visual cortex requires patterned spontaneous activity in the retina
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Pfeiffenberger, C., Cutforth, T., Woods, G., Yamada, J., Rentería, R. C., Copenhagen, D. R., Flanagan, J. G., & Feldheim, D. A. (2005) · Nature Neuroscience · doi:10.1038/nn1508 · Cited by 189 · see citing works
Chandrasekaran, A. R., Plas, D. T., Gonzalez, E., & Crair, M. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1470-05.2005 · Cited by 192 · see citing works
Neuronal Pentraxins Mediate Synaptic Refinement in the Developing Visual System
Bjartmar, L., Huberman, A. D., Ullian, E. M., Renteria, R. C., Liu, X., Xu, W., Prezioso, J., Susman, M. W., Stellwagen, D., Stokes, C. C., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4212-05.2006 · Cited by 179 · see citing works
Self-citationEye-specific retinogeniculate segregation independent of normal neuronal activity
Huberman, A. D., Wang, G.-Y., Liets, L. C., Collins, O. A., Chapman, B., & Chalupa, L. M. (2003) · Science · doi:10.1126/science.1080694 · Cited by 129 · see citing works
A precritical period for plasticity in visual cortex
Feller, M. B., & Scanziani, M. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.012 · Cited by 92 · see citing works
ERK signaling is required for eye-specific retino-geniculate segregation
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- Authors
- Huberman, A. D., Stellwagen, D., & Chapman, B.
- Affiliations
- University of California, Davis (US)
- Stanford Medicine (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-11-01
- Volume
- 22
- Issue
- 21
- Pages
- 9419-9429
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2662346
- OpenAlex
- W1664668314
- Cited by
- 85
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 2
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (EY12576)
- National Eye Institute (R01EY011369, EY12576, EY11369, P30EY012576)
- National Cancer Institute (P01CA095616)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- lateral geniculate nucleus, eye-specific segregation, critical period, interlaminar space, topographic representation, visual development
- MeSH terms
- Aging, Animals, Cholera Toxin, Critical Period, Psychological, Drug Administration Routes, Electrodes, Implanted, Eye, Ferrets, Geniculate Bodies, Pyridines, Retina, Retinal Ganglion Cells, Rhodamines, Visual Fields, Visual Pathways, Bridged Bicyclo Compounds, Heterocyclic, Fluorescein, Recovery of Function
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