Neuronal Pentraxins Mediate Synaptic Refinement in the Developing Visual System
Open accessAbstract
Neuronal pentraxins (NPs) define a family of proteins that are homologous to C-reactive and acute-phase proteins in the immune system and have been hypothesized to be involved in activity-dependent synaptic plasticity. To investigate the role of NPs in vivo, we generated mice that lack one, two, or all three NPs. NP1/2 knock-out mice exhibited defects in the segregation of eye-specific retinal ganglion cell (RGC) projections to the dorsal lateral geniculate nucleus, a process that involves activity-dependent synapse formation and elimination. Retinas from mice lacking NP1 and NP2 had cholinergically driven waves of activity that occurred at a frequency similar to that of wild-type mice, but several other parameters of retinal activity were altered. RGCs cultured from these mice exhibited a significant delay in functional maturation of glutamatergic synapses. Other developmental processes, such as pathfinding of RGCs at the optic chiasm and hippocampal long-term potentiation and long-term depression, appeared normal in NP-deficient mice. These data indicate that NPs are necessary for early synaptic refinements in the mammalian retina and dorsal lateral geniculate nucleus. We speculate that NPs exert their effects through mechanisms that parallel the known role of short pentraxins outside the CNS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NPTXs also regulate early synaptic refinements in retinal ganglion cell projections to dorsal lateral geniculate nucleus.
“They are not exclusively present in PV interneuron synapses in the hippocampus, as they also regulate early synaptic refinements in retinal ganglion cell projections to dorsal lateral geniculate nucleus (Bjartmar et al. 2006).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Bjartmar et al. 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048 · see citing works
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688 · see citing works
Self-citationDEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532 · see citing works
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380 · see citing works
Self-citationBanker, G. A., & Goslin, K. (1998) · Cited by 1,290 · see citing works
Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina
Meister, M., Wong, R. O. L., Baylor, D. A., & Shatz, C. J. (1991) · Science · doi:10.1126/science.2035024 · Cited by 1,110 · see citing works
Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115756 · Cited by 885 · see citing works
Functional requirement for class I MHC in CNS development and plasticity
Huh, G. S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M., & Shatz, C. J. (2000) · Science · doi:10.1126/science.290.5499.2155 · Cited by 828 · see citing works
Perin, M. S., Fried, V. A., Mignery, G. A., Jahn, R., & Südhof, T. C. (1990) · Nature · doi:10.1038/345260a0 · Cited by 813 · see citing works
Self-citationTransient period of correlated bursting activity during development of the mammalian retina
Wong, R., Meister, M., & Shatz, C. J. (1993) · Neuron · doi:10.1016/0896-6273(93)90122-8 · Cited by 555 · see citing works
Requirement for Cholinergic Synaptic Transmission in the Propagation of Spontaneous Retinal Waves
Feller, M. B., Wellis, D. P., Stellwagen, D., Werblin, F. S., & Shatz, C. J. (1996) · Science · doi:10.1126/science.272.5265.1182 · Cited by 550 · see citing works
Self-citationBarres, B. A., Silverstein, B. E., Corey, D. P., & Chun, L. L. Y. (1988) · Neuron · doi:10.1016/0896-6273(88)90127-4 · Cited by 520 · see citing works
Self-citationCompetition in Retinogeniculate Patterning Driven by Spontaneous Activity
Penn, A. A., Riquelme, P. A., Feller, M. B., & Shatz, C. J. (1998) · Science · doi:10.1126/science.279.5359.2108 · Cited by 514 · see citing works
Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product narp.
O’Brien, R. J., Xu, D., Petralia, R. S., Steward, O., Huganir, R. L., & Worley, P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80782-5 · Cited by 471 · see citing works
Self-citationThe Developing Synapse: Construction and Modulation of Synaptic Structures and Circuits
Cohen‐Cory, S. (2002) · Science · doi:10.1126/science.1075510 · Cited by 471 · see citing works
Retinal Ganglion Cells Do Not Extend Axons by Default
Goldberg, J. L., Espinosa, J. S., Xu, Y., Davidson, N., Kovacs, G. T. A., & Barres, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00602-5 · Cited by 452 · see citing works
Self-citationBreviario, F., D’Aniello, E., Golay, J., Peri, G., Bottazzi, B., Bairoch, A., Saccone, S., Marzella, R., Predazzi, V., & Rocchi, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41653-5 · Cited by 416 · see citing works
Prenatal and postnatal development of retinogeniculate and retinocollicular projections in the mouse
Godement, P., Salaün, J., & Imbert, M. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902300406 · Cited by 378 · see citing works
An instructive role for retinal waves in the development of retinogeniculate connectivity
Stellwagen, D., & Shatz, C. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00577-9 · Cited by 342 · see citing works
Self-citationTsui, C., Copeland, N., Gilbert, D., Jenkins, N., Barnes, C., & Worley, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02463.1996 · Cited by 315 · see citing works
Self-citationDevelopment of precise maps in visual cortex requires patterned spontaneous activity in the retina
Cang, J., Rentería, R. C., Kaneko, M., Liu, X., Copenhagen, D. R., & Stryker, M. P. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.015 · Cited by 306 · see citing works
Self-citationOrganic Glasses: A New Class of Photorefractive Materials
Lundquist, P. M., Wortmann, R., Geletneky, C., Twieg, R. J., Jurich, M. C., Lee, V. Y., Moylan, C. R., & Burland, D. M. (1996) · Science · doi:10.1126/science.274.5290.1182 · Cited by 284 · see citing works
Xu, D., Hopf, C., Reddy, R., Cho, R. W., Guo, L., Lanahan, A., Petralia, R. S., Wenthold, R. J., O'Brien, R. J., & Worley, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00463-x · Cited by 265 · see citing works
Self-citationRossi, F., Pizzorusso, T., Porciatti, V., Marubio, L. M., Maffei, L., & Changeux, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101120998 · Cited by 246 · see citing works
A study of normal and congenitally abnormal retinogeniculate projections in cats
Guillery, R. W., & Kaas, J. H. (1971) · The Journal of Comparative Neurology · doi:10.1002/cne.901430106 · Cited by 242 · see citing works
Pfeiffenberger, C., Cutforth, T., Woods, G., Yamada, J., Rentería, R. C., Copenhagen, D. R., Flanagan, J. G., & Feldheim, D. A. (2005) · Nature Neuroscience · doi:10.1038/nn1508 · Cited by 189 · see citing works
Self-citationBall, S. L., Powers, P. A., Shin, H., Morgans, C. W., Peachey, N. S., & Gregg, R. G. (2002) · PubMed · Cited by 186 · see citing works
Self-citationRetinogeniculate Axons Undergo Eye-Specific Segregation in the Absence of Eye-Specific Layers
Muir-Robinson, G., Hwang, B. J., & Feller, M. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05259.2002 · Cited by 186 · see citing works
Quina, L. A., Pak, W., Lanier, J., Banwait, P., Gratwick, K., Liu, Y., Velasquez, T., O’Leary, D. D. M., Goulding, M., & Turner, E. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2837-05.2005 · Cited by 170 · see citing works
Dodds, D. C., Omeis, I. A., Cushman, S. J., Helms, J. A., & Perin, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21488 · Cited by 170 · see citing works
Self-citationNeuronal plasticity and cellular immunity: shared molecular mechanisms
Boulanger, L. M., Huh, G. S., & Shatz, C. J. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00251-8 · Cited by 170 · see citing works
Demas, J., Eglen, S. J., & Wong, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02851.2003 · Cited by 167 · see citing works
Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system
Schlimgen, A. K., Helms, J. A., Vogel, H. S., & Perin, M. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90308-9 · Cited by 163 · see citing works
Self-citationPak, W., Hindges, R., Lim, Y.-S., Pfaff, S. L., & O’Leary, D. D. M. (2004) · Cell · doi:10.1016/j.cell.2004.10.026 · Cited by 162 · see citing works
Visual Deprivation Alters Development of Synaptic Function in Inner Retina after Eye Opening
Tian, N., & Copenhagen, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00470-6 · Cited by 158 · see citing works
Self-citationTorborg, C. L., Hansen, K. A., & Feller, M. B. (2004) · Nature Neuroscience · doi:10.1038/nn1376 · Cited by 150 · see citing works
Biochemical Interactions of the Neuronal Pentraxins
Kirkpatrick, L., Matzuk, M. M., Dodds, D. C., & Perin, M. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002254200 · Cited by 149 · see citing works
Self-citationEye-specific retinogeniculate segregation independent of normal neuronal activity
Huberman, A. D., Wang, G.-Y., Liets, L. C., Collins, O. A., Chapman, B., & Chalupa, L. M. (2003) · Science · doi:10.1126/science.1080694 · Cited by 129 · see citing works
Identification of the Gene and the Mutation Responsible for the MousenobPhenotype
Gregg, R. G., Mukhopadhyay, S., Candille, S. I., et al. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0501 · Cited by 116 · see citing works
Human Neuronal Pentraxin II (NPTX2): Conservation, Genomic Structure, and Chromosomal Localization
Hsu, Y., & Perin, M. S. (1995) · Genomics · doi:10.1006/geno.1995.1134 · Cited by 103 · see citing works
Self-citationWhitehead, A. S., Zahedi, K. A., Rits, M., Mortensen, R. F., & Lélias, J.-M. (1990) · Biochemical Journal · doi:10.1042/bj2660283 · Cited by 95 · see citing works
Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleus
Huberman, A. D., Murray, K. D., Warland, D. K., Feldheim, D. A., & Chapman, B. (2005) · Nature Neuroscience · doi:10.1038/nn1505 · Cited by 94 · see citing works
Self-citationThe influence of early experience on the development of sensory systems
Grubb, M. S., & Thompson, I. D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.06.006 · Cited by 94 · see citing works
Decoupling Eye-Specific Segregation from Lamination in the Lateral Geniculate Nucleus
Huberman, A. D., Stellwagen, D., & Chapman, B. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09419.2002 · Cited by 85 · see citing works
Self-citationNoland, T. D., Friday, B. B., Maulit, M. T., & Gerton, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31677-6 · Cited by 84 · see citing works
Genetic Mechanisms Determining the Central Visual Pathways of Mice
Guillery, R. W., Scott, G., Cattanach, B. M., et al. (1973) · Science · doi:10.1126/science.179.4077.1014 · Cited by 83 · see citing works
Apexin, an acrosomal pentaxin.
Reid, M. S., & Blobel, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31678-8 · Cited by 77 · see citing works
The Information Content of Spontaneous Retinal Waves
Butts, D. A., & Rokhsar, D. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00961.2001 · Cited by 61 · see citing works
Novel Reticular Calcium Binding Protein Is Purified on Taipoxin Columns
Dodds, D. C., Schlimgen, A. K., Lu, S., & Perin, M. S. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052339.x · Cited by 52 · see citing works
Self-citationGrubb, M. S., & Thompson, I. D. (2004) · Vision Research · doi:10.1016/j.visres.2004.09.003 · Cited by 44 · see citing works
Paulsen, O., & Heggelund, P. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021725 · Cited by 37 · see citing works
Ren, J.-C., LaVail, M. M., & Peachey, N. S. (2000) · Experimental Eye Research · doi:10.1006/exer.1999.0804 · Cited by 31 · see citing works
Self-citationLearning Something ORIGINal at the Drosophila Neuromuscular Junction
DiAntonio, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80743-6 · Cited by 28 · see citing works
Neuronal plasticity and cellular immunity: shared molecular mechanisms
Boulanger, L. M., Huh, G. S., & Shatz, C. J. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00300-8 · Cited by 22 · see citing works
Rat serum amyloid P component. Analysis of cDNA sequence and gene expression
Dowton, S. B., & Mcgrew, S. D. (1990) · Biochemical Journal · doi:10.1042/bj2700553 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works
Self-citationThe Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works
Self-citationThe Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease
Stephan, A. H., Barres, B. A., & Stevens, B. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113810 · Cited by 1,113 · see citing works
Self-citationMechanisms underlying development of visual maps and receptive fields
Huberman, A. D., Feller, M. B., & Chapman, B. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125533 · Cited by 628 · see citing works
Self-citationThe “quad‐partite” synapse: Microglia‐synapse interactions in the developing and mature CNS
Schafer, D. P., Lehrman, E. K., & Stevens, B. (2013) · Glia · doi:10.1002/glia.22389 · Cited by 570 · see citing works
Immune proteins in brain development and synaptic plasticity
Boulanger, L. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.001 · Cited by 555 · see citing works
Bialas, A. R., & Stevens, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3560 · Cited by 519 · see citing works
RetractedExtracellular Matrix: Functions in the Nervous System
Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506 · see citing works
Yilmaz, M., Yalcin, E., Presumey, J., Aw, E., Ma, M., Whelan, C. W., Stevens, B., McCarroll, S. A., & Carroll, M. C. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00763-8 · Cited by 321 · see citing works
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons
Chang, M. C., Park, J. M., Pelkey, K. A., Grabenstatter, H. L., Xu, D., Linden, D. J., Sutula, T. P., McBain, C. J., & Worley, P. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2621 · Cited by 316 · see citing works
Self-citationSynapse elimination and learning rules co-regulated by MHC class I H2-Db
Lee, H., Brott, B. K., Kirkby, L. A., Adelson, J. D., Cheng, S., Feller, M. B., Datwani, A., & Shatz, C. J. (2014) · Nature · doi:10.1038/nature13154 · Cited by 228 · see citing works
Classical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity
Datwani, A., McConnell, M. J., Kanold, P. O., Micheva, K. D., Busse, B., Shamloo, M., Smith, S. J., & Shatz, C. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.10.015 · Cited by 212 · see citing works
Sia, G.-M., Béïque, J.-C., Rumbaugh, G., Cho, R., Worley, P. F., & Huganir, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.020 · Cited by 201 · see citing works
Self-citationFarhy-Tselnicker, I., van Casteren, A. C. M., Lee, A., Chang, V. T., Aricescu, A. R., & Allen, N. J. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.053 · Cited by 199 · see citing works
Presynaptic neuronal pentraxin receptor organizes excitatory and inhibitory synapses
Lee, S.-J., Wei, M., Zhang, C., Maxeiner, S., Pak, C., Calado Botelho, S., Trotter, J., Sterky, F. H., & Südhof, T. C. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2768-16.2016 · Cited by 146 · see citing works
Stafford, B. K., Sher, A., Litke, A. M., & Feldheim, D. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.021 · Cited by 156 · see citing works
Cho, R. W., Park, J. M., Wolff, S. B. E., Xu, D., Hopf, C., Kim, J.-A., Reddy, R. C., Petralia, R. S., Perin, M. S., Linden, D. J., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.010 · Cited by 125 · see citing works
Self-citationTwo Classes of Secreted Synaptic Organizers in the Central Nervous System
Yuzaki, M. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121322 · Cited by 125 · see citing works
Cell adhesion and matricellular support by astrocytes of the tripartite synapse
Hillen, A. E. J., Burbach, J. P. H., & Hol, E. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.02.002 · Cited by 108 · see citing works
Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112 · see citing works
Neuroimmune regulation of homeostatic synaptic plasticity
Pribiag, H., & Stellwagen, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.008 · Cited by 106 · see citing works
Self-citationAbad, M. A., Enguita, M., DeGregorio-Rocasolano, N., Ferrer, I., & Trullas, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0575-06.2006 · Cited by 102 · see citing works
The role of glial cells in synapse elimination
Chung, W.-S., & Barres, B. A. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.003 · Cited by 89 · see citing works
Self-citationMoran, L. B., Hickey, L., Michael, G. J., Derkacs, M., Christian, L. M., Kalaitzakis, M. E., Pearce, R. K. B., & Graeber, M. B. (2008) · Acta Neuropathologica · doi:10.1007/s00401-007-0309-3 · Cited by 69 · see citing works
Neuroinflammation in Alzheimer’s disease: Pleiotropic roles for cytokines and neuronal pentraxins
Swanson, A., Wolf, T., Sitzmann, A., & Willette, A. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.015 · Cited by 72 · see citing works
Neuronal Pentraxin 1 Negatively Regulates Excitatory Synapse Density and Synaptic Plasticity
Figueiro-Silva, J., Gruart, A., Clayton, K. B., Podlesniy, P., Abad, M. A., Gasull, X., Delgado-García, J. M., & Trullas, R. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2548-14.2015 · Cited by 53 · see citing works
Kovács, R. Á., Vadászi, H., Bulyáki, É., Török, G., Tóth, V., Mátyás, D., Kun, J., Hunyadi-Gulyás, É., Fedor, F. Z., Csincsi, Á., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599771 · Cited by 43 · see citing works
Xie, M., Wang, T., Feng, J., Ma, D., Feng, L., & Hao, Y. (2025) · Current Neuropharmacology · doi:10.2174/1570159x23666250225091729 · Cited by 7 · see citing works
- Authors
- Bjartmar, L., Huberman, A. D., Ullian, E. M., Renteria, R. C., Liu, X., Xu, W., Prezioso, J., Susman, M. W., Stellwagen, D., Stokes, C. C., Cho, R., Worley, P., Malenka, R. C., Ball, S., Peachey, N. S., Copenhagen, D., Chapman, B., Nakamoto, M., Barres, B. A., & Perin, M. S.
- Affiliations
- Cleveland Clinic (US)
- ORCID
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-06-07
- Volume
- 26
- Issue
- 23
- Pages
- 6269-6281
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2579897
- OpenAlex
- W2152913498
- Cited by
- 179
- References
- 55
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 12 · 2017: 4 · 2016: 7 · 2015: 9 · 2014: 11 · 2013: 9 · 2012: 11
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ValpoScholar (Valparaiso University) (submittedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- Funders
- Research to Prevent Blindness
- That Man May See
- National Institutes of Health (5r01ns039283-04, MH63394)
- U.S. Public Health Service (R01 11310)
- National Institute of Mental Health (F32MH065752, MH065752, MH63394)
- National Institute on Drug Abuse (R01DA015043, R01-DA-15043)
- National Eye Institute (R01EY011369, EY11369, R01EY001869)
- National Institute of Diabetes and Digestive and Kidney Diseases (T90DK070103, 1-T90 DK070103)
- National Institute of Neurological Disorders and Stroke (NS039283)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD042191, R01HD039886, HD039886, R01HD042191)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- synaptic refinement, retinal ganglion cells, dorsal lateral geniculate nucleus, knockout mice, visual system development
- MeSH terms
- Pentraxins, Animals, C-Reactive Protein, Cells, Cultured, Geniculate Bodies, Hippocampus, Nerve Tissue Proteins, Synaptic Transmission, Neuronal Plasticity, Neurons, Retina, Retinal Ganglion Cells, Synapses, Visual Pathways, Mice, Knockout, Glutamic Acid, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
