Astrocytes Control Synapse Formation, Function, and Elimination
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Astrocytes, through their close associations with synapses, can monitor and alter synaptic function, thus actively controlling synaptic transmission in the adult brain. Besides their important role at adult synapses, in the last three decades a number of critical findings have highlighted the importance of astrocytes in the establishment of synaptic connectivity in the developing brain. In this article, we will review the key findings on astrocytic control of synapse formation, function, and elimination. First, we will summarize our current structural and functional understanding of astrocytes at the synapse. Then, we will discuss the cellular and molecular mechanisms through which developing and mature astrocytes instruct the formation, maturation, and refinement of synapses. Our aim is to provide an overview of astrocytes as important players in the establishment of a functional nervous system.
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Astrocytes regulate neural communication.
“Astrocytes, the primary non-neuronal cell of the brain, regulate neural communication (Chung et al., 2015)”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Chung et al., 2015
Astrocyte interactions with synaptic circuits are multimodal and multiscale, occur under physiological conditions, and contribute to behavior.
“astrocyte interactions with synaptic circuits are multimodal and multiscale, occur under physiological conditions 2-5 and contribute to behavior 6-8 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [3]
In the developing brain, peak synaptogenesis coincides with the differentiation and maturation of astrocytes.
“In the developing brain, peak synaptogenesis coincides with the differentiation and maturation of astrocytes (reviewed in Chung et al., 2015).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Chung et al., 2015
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- Authors
- Chung, W.-S., Allen, N. J., & Eroglu, C.
- Affiliations
- Stanford Medicine (US)
- Salk Institute for Biological Studies (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-02-06
- Volume
- 7
- Issue
- 9
- Pages
- a020370
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4527946
- OpenAlex
- W2165302236
- Cited by
- 839
- References
- 121
- Citations by year
- 2026: 66 · 2025: 101 · 2024: 92 · 2023: 100 · 2022: 102 · 2021: 97 · 2020: 90 · 2019: 73 · 2018: 53 · 2017: 35 · 2016: 22 · 2015: 8
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA031833)
- National Eye Institute (K99EY024690)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- astrocytes, synaptogenesis, synaptic pruning, synapse maturation, synaptic refinement, synaptic transmission, developing brain, astrocyte-synapse interaction
- MeSH terms
- Animals, Astrocytes, Humans, Synapses
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