The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Theta-Frequency Synaptic Potentiation in CA1 In Vitro Distinguishes Cognitively Impaired from Unimpaired Aged Fischer 344 Rats
Open accessAbstract
Hippocampal-dependent learning and memory deficits have been well documented in aging rodents. The results of several recent studies have suggested that these deficits arise from weakened synaptic plasticity within the hippocampus. In the present study, we examined the relationship between hippocampal long-term potentiation (LTP) in vitro and spatial learning in aged (24-26 months) Fischer 344 rats. We found that LTP induced in the CA1 region using theta-frequency stimulation (5 Hz) is selectively impaired in slices from a subpopulation of aged rats that had shown poor spatial learning in the Morris water maze. LTP at 5 Hz in aged rats that did not show learning deficits was similar to that seen in young (4-6 months) controls. We also found that 5 Hz LTP amplitude strongly correlated with individual learning performance among aged rats. The difference in 5 Hz LTP magnitude among aged rats was not attributable to an altered response to 5 Hz stimulation or to differences in the NMDA receptor-mediated field EPSP. In addition, no performance-related differences in LTP were seen when LTP was induced with 30 or 70 Hz stimulation protocols. Finally, both 5 Hz LTP and spatial learning in learning-impaired rats were enhanced with the selective muscarinic M2 antagonist BIBN-99 (5,11-dihydro-8-chloro-11-[[4-[3-[(2,2-dimethyl-1-oxopentyl)ethylamino]propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one). These findings reinforce the idea that distinct types of hippocampal LTP offer mechanistic insight into age-associated cognitive decline.
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“Given the importance of the hippocampus in learning and memory and AD neuropathogenesis (Tombaugh et al., 2002)”
From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Tombaugh et al., 2002
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“Notably, abnormalities in hippocampal pathology have been linked to AD and other neurodegenerative disorders (Tombaugh et al., 2002).”
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Habbas, S., Santello, M., Becker, D., Stubbe, H., Zappia, G., Liaudet, N., Klaus, F. R., Kollias, G., Fontana, A., Pryce, C. R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.023 · Cited by 347
Patterson, S. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.020 · Cited by 291
McCutcheon, J. E., & Marinelli, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06648.x · Cited by 299
Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome
Lauterborn, J. C., Rex, C. S., Kramár, E. A., Chen, L. Y., Pandyarajan, V., LYNCH, G. S., & Gall, C. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2624-07.2007 · Cited by 244
Metadata
- Authors
- Tombaugh, G. C., Rowe, W. B., Chow, A. R., Michael, T. H., & Rose, G. M.
- ORCID
- Rose, Gregory M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-11-15
- Volume
- 22
- Issue
- 22
- Pages
- 9932-9940
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757825
- OpenAlex
- W1597519089
- Cited by
- 144
- References
- 86
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 13 · 2012: 9
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, hippocampal CA1, aging, age-related cognitive decline, spatial learning, Morris water maze, M2 muscarinic receptor, NMDA receptor, synaptic plasticity, hippocampal slices
- MeSH terms
- Age Factors, Animals, Behavior, Animal, Cognition Disorders, Dibenzazepines, Electric Stimulation, Hippocampus, Male, Synaptic Transmission, Pyridines, Rats, Inbred F344, Reaction Time, Receptors, Muscarinic, Theta Rhythm, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Muscarinic Antagonists, Maze Learning, Excitatory Postsynaptic Potentials, Receptor, Muscarinic M2, Rats, In Vitro Techniques
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