Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling
Open accessAbstract
The occurrence of cognitive disturbances upon CNS inflammation or infection has been correlated with increased levels of the cytokine tumor necrosis factor-α (TNFα). To date, however, no specific mechanism via which this cytokine could alter cognitive circuits has been demonstrated. Here, we show that local increase of TNFα in the hippocampal dentate gyrus activates astrocyte TNF receptor type 1 (TNFR1), which in turn triggers an astrocyte-neuron signaling cascade that results in persistent functional modification of hippocampal excitatory synapses. Astrocytic TNFR1 signaling is necessary for the hippocampal synaptic alteration and contextual learning-memory impairment observed in experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis (MS). This process may contribute to the pathogenesis of cognitive disturbances in MS, as well as in other CNS conditions accompanied by inflammatory states or infections.
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Reactive microglia may shift astrocyte signaling from physiological to pathological by increasing production of TNFα, thus altering synaptic functions and behavior.
“Reactive microglia may shift astrocyte signaling from physiological to pathological by increasing production of tumor necrosis factor α (TNFα), thus altering synaptic functions and behavior57.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [57]
In EAE mice, a local inflammatory focus in dorsal hippocampus caused TNFα increases, long-lasting modification of excitatory neurotransmission and impaired contextual memory.
“In particular, in EAE mice, a local inflammatory focus in dorsal hippocampus caused TNFα increase s, longlasting modification of excitatory neurotransmission and impaired contextual memory.”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [62]
These EAE effects depend on enhanced TNFα signaling via astrocytic TNFR1, which hijacked the regulatory mechanism controlling astrocytic glutamate release and caused long-lasting potentiation of excitatory synapses.
“These effects depend on enhanced TNFα signal ing via its astrocytic type-1 receptor (TNFR1), which hijacked the regulatory mechanism controlling astrocytic glutamate release (see above) and caused long-lasting potentiation of excitatory synapses.”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [62]
The synaptic and behavioral phenotype in EAE mice was abolished in global TNFR1 knockout mice and could be restored by re-expressing the receptor solely in astrocytes, demonstrating that astrocytes mediate the deleterious action of TNFα on memory function in EAE mice.
“This synaptic and behavioral phenotype was abolished in global TNFR1 knockout EAE mice and could be restored by inducing re-expression of the receptor solely in astrocytes (Table 1), demonstrating that astrocytes mediate the deleterious action of TNFα on memory function in EAE mice 62 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [62]
In the EAE model of multiple sclerosis, abnormal TNFα-dependent signaling by astrocytes causes cognitive deficits resembling those seen in patients.
“An example of this was observed in the experimental autoimmune encephalitis (EAE) model of multiple sclerosis, where abnormal TNFα -dependent signaling by astrocytes causes cognitive deficits resembling those seen in patients 62 (Fig. 4d).”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [62]
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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121 · see citing works
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
Paoletti, P., Bellone, C., & Zhou, Q. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3504 · Cited by 2,523 · see citing works
Cognitive impairment in multiple sclerosis
Chiaravalloti, N. D., & DeLuca, J. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70259-x · Cited by 2,088 · see citing works
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711 · see citing works
Optogenetic stimulation of a hippocampal engram activates fear memory recall
Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K. A., & Tonegawa, S. (2012) · Nature · doi:10.1038/nature11028 · Cited by 1,669 · see citing works
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308 · see citing works
Self-citationAstrocytic Purinergic Signaling Coordinates Synaptic Networks
Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280 · see citing works
Rothe, J., Lesslauer, W., Loetscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R. M., Steinmetz, M., & Bluethmann, H. (1993) · Nature · doi:10.1038/364798a0 · Cited by 1,246 · see citing works
Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., & Becher, B. (2011) · Nature Immunology · doi:10.1038/ni.2027 · Cited by 1,191 · cited 3× · see citing works
“Our studies were performed in the EAE mouse model, using an adoptive transfer induction protocol (AT-EAE, Codarri et al. (2011); see Experimental Procedures), which allows the EAE CNS pathology to develop effectively also in TNFR1-deficient mice.”
InfluentialSelf-citationDifferential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α
Stellwagen, D., Beattie, E. C., Seo, J. Y., & Malenka, R. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4486-04.2005 · Cited by 985 · cited 1× · see citing works
“It could be, in contrast, post-synaptic, consistent with the reported capacity of TNFα to promote surface insertion of AMPAR subunits at dendritic spines via stimulation of neuronal TNFR1 (Stellwagen et al., 2005).”
Bezzi, P., Domercq, M., Brambilla, L., Galli, R., Schols, D., De Clercq, E., Vescovi, A., Bagetta, G., Kollias, G., Meldolesi, J., et al. (2001) · Nature Neuroscience · doi:10.1038/89490 · Cited by 964 · see citing works
Self-citationImpaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., Younkin, L., Good, M. A., Bliss, T. V. P., Hyman, B. T., et al. (1999) · Nature Neuroscience · doi:10.1038/6374 · Cited by 946 · see citing works
Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
Halassa, M. M., Florian, C., Fellin, T., Munoz, J. R., Lee, S.-Y., Abel, T. G., Haydon, P. G., & Frank, M. G. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.024 · Cited by 877 · see citing works
Glutamate exocytosis from astrocytes controls synaptic strength
Jourdain, P., Bergersen, L. H., Bhaukaurally, K., Bezzi, P., Santello, M., Domercq, M., Matute, C., Tonello, F., Gundersen, V., & Volterra, A. (2007) · Nature Neuroscience · doi:10.1038/nn1849 · Cited by 806 · see citing works
Self-citationTumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline
Terrando, N., Monaco, C. G., Ma, D., Foxwell, B. M. J., Feldmann, M., & Maze, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014557107 · Cited by 730 · see citing works
Han, X., Chen, M., Wang, F., Windrem, M., Wang, S., Shanz, S., Xu, Q., Oberheim, N. A., Bekar, L., Betstadt, S., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2012.12.015 · Cited by 635 · see citing works
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
Xu, Z., Zhang, L., Liu, T., Park, J. Y., Berta, T., Yang, R., Serhan, C. N., & Ji, R. (2010) · Nature Medicine · doi:10.1038/nm.2123 · Cited by 593 · see citing works
Synapse formation on neurons born in the adult hippocampus
Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience · doi:10.1038/nn1908 · Cited by 579 · see citing works
Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis
Denny, C. A., Kheirbek, M. A., Alba, E. L., Tanaka, K. F., Brachman, R. A., Laughman, K. B., Tomm, N. K., Turi, G. F., Losonczy, A., & Hen, R. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.018 · Cited by 558 · see citing works
Han, J., Kesner, P., Metna-Laurent, M., Duan, T., Xu, L., Georges, F., Koehl, M., Abrous, D. N., Mendizabal-Zubiaga, J., Grandes, P., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.037 · Cited by 514 · see citing works
Cunningham, A. J., Murray, C. A., O'Neill, L. A. J., Lynch, M. A., & O'Connor, J. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12252-4 · Cited by 433 · see citing works
Optical controlling reveals time-dependent roles for adult-born dentate granule cells
Gu, Y., Arruda-Carvalho, M., Wang, J., Janoschka, S., Josselyn, S. A., Frankland, P. W., & Ge, S. (2012) · Nature Neuroscience · doi:10.1038/nn.3260 · Cited by 423 · see citing works
Renno, T., Krakowski, M., Piccirillo, C., Lin, J. Y., & Owens, T. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.2.944 · Cited by 401 · see citing works
He, P., Zhong, Z., Lindholm, K., Berning, L., Lee, W., Lemere, C., Staufenbiel, M., Li, R., & Shen, Y. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705042 · Cited by 390 · see citing works
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
Gregory, A., Dendrou, C. A., Attfield, K. E., Haghikia, A., Xifara, D. K., Butter, F., Poschmann, G., Kaur, G., Lambert, L., Leach, O. A., et al. (2012) · Nature · doi:10.1038/nature11307 · Cited by 384 · see citing works
TNFα Controls Glutamatergic Gliotransmission in the Hippocampal Dentate Gyrus
Santello, M., Bezzi, P., & Volterra, A. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.003 · Cited by 362 · see citing works
Self-citationCentonze, D., Muzio, L., Rossi, S., Cavasinni, F., De Chiara, V., Bergami, A., Musella, A., D'Amelio, M., Cavallucci, V., Martorana, A., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5804-08.2009 · Cited by 352 · see citing works
Kassiotis, G., & Kollias, G. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.427 · Cited by 332 · see citing works
Self-citationBélarbi, K., Jopson, T. D., Tweedie, D., Arellano, C., Luo, W., Greig, N. H., & Rosi, S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-23 · Cited by 285 · see citing works
Astrocytes contribute to gamma oscillations and recognition memory
Lee, H. S., Ghetti, A., Pinto‐Duarte, A., Wang, X., Dziewczapolski, G., Galimi, F., Huitrón‐Reséndiz, S., Piña-Crespo, J., Roberts, A. J., Verma, I. M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410893111 · Cited by 259 · see citing works
Pribiag, H., & Stellwagen, D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0530-13.2013 · Cited by 249 · see citing works
TNFα in synaptic function: switching gears
Santello, M., & Volterra, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.001 · Cited by 245 · see citing works
Self-citationThe roles of TNF in brain dysfunction and disease
Clark, I. A., Alleva, L. M., & Vissel, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.007 · Cited by 232 · see citing works
P2Y1 Receptor-evoked Glutamate Exocytosis from Astrocytes
Domercq, M., Brambilla, L., Pilati, E., Marchaland, J., Volterra, A., & Bezzi, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606429200 · Cited by 215 · see citing works
Self-citationHirrlinger, P. G., Scheller, A., Braun, C., Hirrlinger, J., & Kirchhoff, F. (2006) · Glia · doi:10.1002/glia.20342 · Cited by 200 · see citing works
Yang, J., Murphy, T. L., Ouyang, W., & MURPHY, K. M. M. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199902)29:02 · Cited by 195 · see citing works
Self-citationRetrograde amnesia after hippocampal damage: Recent vs. remote memories in two tasks
Sutherland, R. J., Weisend, M. P., Mumby, D. G., Astur, R. S., Hanlon, F. M., Koerner, A., Thomas, M. J., Wu, Y., Moses, S. N., Cole, C., et al. (2001) · Hippocampus · doi:10.1002/1098-1063(2001)11:1 · Cited by 190 · see citing works
NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity
Larsen, R. S., Corlew, R., Henson, M. A., Roberts, A. C., Mishina, M., Watanabe, M., Lipton, S. A., Nakanishi, N., Pérez‐Otaño, I., Weinberg, R. J., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2750 · Cited by 165 · see citing works
TNF-α-mediated anxiety in a mouse model of multiple sclerosis
Haji, N., Mandolesi, G., Gentile, A., Sacchetti, L., Fresegna, D., Rossi, S., Musella, A., Sepman, H., Motta, C., Studer, V., et al. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.07.010 · Cited by 161 · see citing works
Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1
Hauwermeiren, F. V., Vandenbroucke, R. E., & Libert, C. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.09.004 · Cited by 149 · see citing works
Tombaugh, G. C., Rowe, W. B., Chow, A. R., Michael, T. H., & Rose, G. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09932.2002 · Cited by 144 · see citing works
Acharjee, S., Nayani, N., Tsutsui, M., Hill, M. N., Ousman, S. S., & Pittman, Q. J. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.07.003 · Cited by 128 · see citing works
Gold, S., Kern, K. C., O'Connor, M., Montag, M. J., Kim, A., Yoo, Y.-S., Giesser, B., & Sicotte, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.025 · Cited by 126 · see citing works
Victoratos, P., Lagnel, J., Tzima, S., Alimzhanov, M. B., Rajewsky, K., Pasparakis, M., & Kollias, G. A. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.013 · Cited by 123 · see citing works
Self-citationYang, G., Parkhurst, C. N., Hayes, S., & Gan, W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222895110 · Cited by 102 · see citing works
Gabbita, S. P., Srivastava, M. K., Eslami, P., Johnson, M. F., Kobritz, N., Tweedie, D., Greig, N. H., Zemlan, F. P., Sharma, S. P., & Harris‐White, M. E. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-99 · Cited by 93 · see citing works
Metaplasticity of Mossy Fiber Synaptic Transmission Involves Altered Release Probability
Goussakov, I. V., Fink, K., Elger, C. E., & Beck, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03434.2000 · Cited by 88 · see citing works
Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer’s disease
Tansey, M. G., & McAlpine (2008) · Journal of Inflammation Research · doi:10.2147/jir.s4397 · Cited by 54 · see citing works
Wang, S., Ota, S., Guo, B., Ryu, J. E., Rhodes, C., Xiong, Y., Kalim, S., Zeng, L., Chen, Y., Teitell, M. A., et al. (2011) · Nano Letters · doi:10.1021/nl2018838 · Cited by 49 · see citing works
A link between microbial infection and cognition?
Swardfager, W., & Black, S. E. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.93 · Cited by 14 · see citing works
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Reactive astrocyte nomenclature, definitions, and future directions
Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,533 · see citing works
Self-citationVerkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
Yuan, J., Amin, P., & Ofengeim, D. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0093-1 · Cited by 967 · see citing works
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Santello, M., Toni, N., & Volterra, A. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0325-8 · Cited by 737 · see citing works
Self-citationInflammation: the link between comorbidities, genetics, and Alzheimer’s disease
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Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389 · see citing works
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Bindocci, E., Savtchouk, I., Liaudet, N., Becker, D., Carriero, G., & Volterra, A. (2017) · Science · doi:10.1126/science.aai8185 · Cited by 342 · see citing works
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Self-citationNie, X., Kitaoka, S., Tanaka, K., Segi‐Nishida, E., Imoto, Y., Ogawa, A., Nakano, F., Tomohiro, A., Nakayama, K., Taniguchi, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.035 · Cited by 318 · see citing works
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Schroer, A. B., Ventura, P. B., Sucharov, J., Misra, R., Chui, M. K. K., Bieri, G., Horowitz, A. M., Smith, L. K., Encabo, K., Tenggara, I., et al. (2023) · Nature · doi:10.1038/s41586-023-06436-3 · Cited by 252 · see citing works
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Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222 · see citing works
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Cai, W., Xue, C., Sakaguchi, M., Konishi, M., Shirazian, A., Ferris, H. A., Li, M. E., Yu, R., Kleinridders, A., Pothos, E. N., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99366 · Cited by 222 · see citing works
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Hou, B., Zhang, Y., Liang, P., He, Y., Peng, B., Liu, W., Han, S., Yin, J., & He, X. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2565-2 · Cited by 187 · see citing works
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Sen, M. K., Mahns, D. A., Coorssen, J. R., & Shortland, P. J. (2022) · Glia · doi:10.1002/glia.24148 · Cited by 166 · see citing works
Patel, H., McIntire, J., Ryan, S. T., Dunah, A. W., & Loring, R. H. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0967-6 · Cited by 153 · see citing works
The role of glial cells in multiple sclerosis disease progression
Healy, L. M., Stratton, J. A., Kuhlmann, T., & Antel, J. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00624-x · Cited by 152 · see citing works
Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions
Ongnok, B., Chattipakorn, N., & Chattipakorn, S. C. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113118 · Cited by 145 · see citing works
Yamamoto, M., Kim, M., Imai, H., Itakura, Y., & Ohtsuki, G. (2018) · Cell Reports · doi:10.1016/j.celrep.2019.07.078 · Cited by 138 · see citing works
Steeland, S., Libert, C., & Vandenbroucke, R. E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051442 · Cited by 137 · see citing works
Inflammaging as a target for healthy ageing
Dugan, B., Conway, J., & Duggal, N. A. (2023) · Age and Ageing · doi:10.1093/ageing/afac328 · Cited by 142 · see citing works
CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α
Garré, J. M., Silva, H. M., Lafaille, J. J., & Yang, G. (2017) · Nature Medicine · doi:10.1038/nm.4340 · Cited by 130 · see citing works
TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)
Yang, X., Wang, X., Shao, L., Jiang, G.-T., Min, J., Mei, X.-Y., He, X., Liu, W., Huang, W., & Peng, B. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1487-3 · Cited by 124 · see citing works
Re-Examining the Role of TNF in MS Pathogenesis and Therapy
Fresegna, D., Bullitta, S., Musella, A., Rizzo, F. R., Vito, F. D., Guadalupi, L., Caioli, S., Balletta, S., Sanna, K., Dolcetti, E., et al. (2020) · Cells · doi:10.3390/cells9102290 · Cited by 117 · see citing works
Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis
Hammond, J. W., Bellizzi, M. J., Ware, C., Qiu, W. Q., Saminathan, P., Li, H., Luo, S., Ma, S. A., Li, Y., & Gelbard, H. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.004 · Cited by 118 · see citing works
Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes
Soung, A., & Klein, R. S. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.09.001 · Cited by 116 · see citing works
Synaptic Elimination in Neurological Disorders
Cardozo, P. L., de Lima, I. B. Q., Maciel, E. M. A., Silva, N. C., Dobránsky, T., & Ribeiro, F. M. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190603170511 · Cited by 113 · see citing works
Wang, L., Yang, J., Lin, L.-T., Huang, J., Wang, X., Su, X.-T., Cao, Y., Fisher, M., & Liu, C. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8253904 · Cited by 115 · see citing works
Doxorubicin-Induced Cognitive Impairment: The Mechanistic Insights
Du, J., Zhang, A., Li, J., Liu, X., Wu, S., Wang, B., Wang, Y., & Jia, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.673340 · Cited by 115 · see citing works
Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook
Olson, B. G., & Marks, D. L. (2019) · Cancers · doi:10.3390/cancers11050687 · Cited by 115 · see citing works
Roles and regulation of microglia activity in multiple sclerosis: insights from animal models
Distéfano‐Gagné, F., Bitarafan, S., Lacroix, S., & Gosselin, D. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00709-6 · Cited by 112 · see citing works
Cytokines and cytokine networks target neurons to modulate long-term potentiation
Prieto, G. A., & Cotman, C. W. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.03.005 · Cited by 111 · see citing works
Anti-TNF-α Compounds as a Treatment for Depression
Uzzan, S., & Azab, A. N. (2021) · Molecules · doi:10.3390/molecules26082368 · Cited by 109 · see citing works
Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning
Hösli, L., Binini, N., Ferrari, K. D., Thieren, L., Looser, Z. J., Zuend, M., Zanker, H. S., Berry, S., Holub, M., Möbius, W., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110484 · Cited by 100 · see citing works
Interactions between inflammation, sex steroids, and Alzheimer’s disease risk factors
Uchoa, M. F., Moser, V. A., & Pike, C. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.09.001 · Cited by 102 · see citing works
Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase
Xin, W., Mironova, Y. A., Shen, H., Marino, R. A. M., Waisman, A., Lamers, W. H., Bergles, D. E., & Bonci, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.094 · Cited by 100 · see citing works
Depression in Autoimmune Diseases
Pryce, C. R., & Fontana, A. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_7 · Cited by 100 · see citing works
Self-citationPendyala, G., Chou, S., Jung, Y., Coiro, P., Spartz, E., Padmashri, R., Li, M., & Dunaevsky, A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.7 · Cited by 99 · see citing works
Activation of group 2 innate lymphoid cells alleviates aging-associated cognitive decline
Fung, I. T. H., Sankar, P., Zhang, Y., Robison, L. S., Zhao, X., D’Souza, S. S., Salinero, A. E., Wang, Y., Qian, J., Kuentzel, M. L., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190915 · Cited by 97 · see citing works
Inflammation at the crossroads of COVID-19, cognitive deficits and depression
Silva, N. M. L. E., Barros‐Aragão, F. G. Q., Felice, F. G. D., & Ferreira, S. T. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109023 · Cited by 93 · see citing works
Dong, R., Han, Y., Jiang, L., Liu, S., Zhang, F., Peng, L., Wang, Z., Ma, Z., Xia, T., & Gu, X. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02424-y · Cited by 90 · see citing works
Emerging evidence for astrocyte dysfunction in schizophrenia
Figueiredo, E. C. D. O., Calì, C., Petrelli, F., & Bezzi, P. (2022) · Glia · doi:10.1002/glia.24221 · Cited by 85 · see citing works
Visceral Inflammation and Immune Activation Stress the Brain
Holzer, P., Farzi, A., Hassan, A. M., Zenz, G., Jačan, A., & Reichmann, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01613 · Cited by 84 · see citing works
Nikolic, L. M., Shen, W., Nobili, P., Virenque, A., Ulmann, L., & Audinat, É. (2018) · Glia · doi:10.1002/glia.23519 · Cited by 81 · see citing works
Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain
Varol, D., Mildner, A., Blank, T., Shemer, A., Barashi, N., Yona, S., David, E., Boura‐Halfon, S., Segal-Hayoun, Y., Chappell‐Maor, L., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.003 · Cited by 81 · see citing works
Li, Y., Shen, R., Wen, G., Ding, R., Du, A., Zhou, J., Dong, Z., Ren, X., Yao, H., Zhao, R., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00139 · Cited by 80 · see citing works
HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?
Canet, G., Dias, C., Gabelle, A., Simonin, Y., Gosselet, F., Marchi, N., Makinson, A., Tuaillon, É., de Perre, P. V., Givalois, L., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00307 · Cited by 78 · see citing works
Jiang, J., Tang, B., Wang, L., Huo, Q., Tan, S., Misrani, A., Han, Y., Li, H., Hu, H.-D., Wang, J., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.017 · Cited by 80 · see citing works
Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin
Corrigan, M., O’Rourke, A. M., Moran, B., Fletcher, J. M., & Harkin, A. (2023) · Neuronal Signaling · doi:10.1042/ns20220054 · Cited by 77 · see citing works
Etten, J. L. V., Agarkova, I. V., & Dunigan, D. D. (2019) · Viruses · doi:10.3390/v12010020 · Cited by 79 · see citing works
Functions of Astrocytes under Normal Conditions and after a Brain Disease
Vallés, S. L., Singh, S. K., Campos-Campos, J., Colmena, C., Campo-Palacio, I., Alvarez-Gamez, K., Caballero, Ó., & Jorda, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098434 · Cited by 76 · see citing works
Dysfunction of the Blood-Brain Barrier—A Key Step in Neurodegeneration and Dementia
Noe, C. R., Noe-Letschnig, M., Handschuh, P. A., Noe, C. A., & Lanzenberger, R. R. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00185 · Cited by 74 · see citing works
Chimenti, M. S., Caso, F., Alivernini, S., Martino, E. D., Costa, L., Tolusso, B., Triggianese, P., Conigliaro, P., Gremese, E., Scarpa, R., et al. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.11.007 · Cited by 70 · see citing works
The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis
Marin-Rodero, M., Cintado, E., Walker, A. J., Jayewickreme, T., Pinho-Ribeiro, F. A., Richardson, Q., Jackson, R. P., Chiu, I. M., Benoist, C. O., Stevens, B., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adu2910 · Cited by 70 · see citing works
Innate Immune Functions of Astrocytes are Dependent Upon Tumor Necrosis Factor-Alpha
Rodgers, K. R., Lin, Y., Langan, T. J., Iwakura, Y., & Chou, R. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-63766-2 · Cited by 64 · see citing works
Fu, Q., Li, J., Qiu, L., Ruan, J., Mao, M., Li, S., & Mao, Q.-H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106317 · Cited by 61 · see citing works
Planche, V., Panatier, A., Hiba, B., Ducourneau, E., Raffard, G., Dubourdieu, N., Maître, M., Leste-Lasserre, T., Brochet, B., Dousset, V., et al. (2017) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2016.11.010 · Cited by 52 · see citing works
Stojić-Vukanić, Z., Hadzibegovic, S., Nicole, O., Nacka-Aleksić, M., Lestarevic, S., & Leposavić, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.566225 · Cited by 45 · see citing works
Visceral adiposity, inflammation, and hippocampal function in obesity
Stranahan, A. M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108920 · Cited by 63 · see citing works
Planche, V., Koubiyr, I., Romero, J. E., Manjón, J. V., Pierrick Coupé, A., Deloire, M., Dousset, V., Brochet, B., Ruet, A., & Tourdias, T. (2018) · Human Brain Mapping · doi:10.1002/hbm.23970 · Cited by 57 · see citing works
Domínguez-Rivas, E., Ávila-Muñoz, E., Schwarzacher, S. W., & Zepeda, A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.06.014 · Cited by 57 · see citing works
Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity
Fourrier, C., Bosch‐Bouju, C., Boursereau, R., Sauvant, J., Aubert, A., Capuron, L., Ferreira, G., Layé, S., & Castanon, N. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.316 · Cited by 55 · see citing works
Neurocognitive impacts of arbovirus infections
Clé, M., Eldin, P., Briant, L., Lannuzel, A., Simonin, Y., Van de Perre, P., Cabié, A., & Salinas, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01904-3 · Cited by 67 · see citing works
Namba, M. D., Kupchik, Y. M., Spencer, S. M., García‐Keller, C., Goenaga, J. G., Powell, G. L., Vicino, I., Hogue, I. B., & Gipson, C. D. (2019) · Addiction Biology · doi:10.1111/adb.12797 · Cited by 56 · see citing works
Wang, X., Yang, X., Kong, W., Zeng, M., Shao, L., Jiang, G.-T., Cheng, J., Kong, S., He, X., Liu, W., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1618-x · Cited by 56 · see citing works
Mallah, K., Couch, C., Alshareef, M., Borucki, D. M., Yang, X., Alawieh, A. M., & Tomlinson, S. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01179-6 · Cited by 54 · see citing works
Labarta-Bajo, L., & Allen, N. J. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.010 · Cited by 58 · see citing works
Purinergic signaling in epilepsy
Rassendren, F., & Audinat, É. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23770 · Cited by 54 · see citing works
Bourel, J., Planche, V., Dubourdieu, N., Oliveira, A., Séré, A., Ducourneau, E., Tible, M., Maître, M., Lesté-Lasserre, T., Nadjar, A., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105533 · Cited by 54 · see citing works
Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Opportunities
Zhang, R., Song, Y., & Su, X. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220809 · Cited by 53 · see citing works
Licht-Murava, A., Meadows, S. M., Palaguachi, F., Song, S. C., Bram, Y., Zhou, C. Q., Jackvony, S., Schwartz, R. E., Froemke, R. C., Orr, A. L., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade1282 · Cited by 53 · see citing works
In Vivo Imaging of Microglial Calcium Signaling in Brain Inflammation and Injury
Tvrdík, P., & Kalani, M. Y. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112366 · Cited by 51 · see citing works
Microglial Cytokines Mediate Plasticity Induced by 10 Hz Repetitive Magnetic Stimulation
Eichler, A., Kleidonas, D., Turi, Z., Fliegauf, M., Kirsch, M., Pfeifer, D., Masuda, T., Prinz, M., Lenz, M., & Vlachos, A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2226-22.2023 · Cited by 37 · see citing works
Contributions of monocytes to nervous system disorders
Garré, J. M., & Yang, G. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1672-3 · Cited by 51 · see citing works
Altered astrocytic function in experimental neuroinflammation and multiple sclerosis
das Neves, S. P., Sousa, J. C., Sousa, N., Cerqueira, J., & Marques, F. (2020) · Glia · doi:10.1002/glia.23940 · Cited by 47 · see citing works
Brain–immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders
Zhao, F., Li, B., Yang, W., Ge, T., & Cui, R. (2022) · Cell Proliferation · doi:10.1111/cpr.13295 · Cited by 47 · see citing works
Crombe, A., Planche, V., Raffard, G., Bourel, J., Dubourdieu, N., Panatier, A., Fukutomi, H., Dousset, V., Oliet, S., Hiba, B., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.01.061 · Cited by 49 · see citing works
Neuroinflammation in l-DOPA-induced dyskinesia: beyond the immune function
Pisanu, A., Boi, L., Mulas, G., Spiga, S., Fenu, S., & Carta, A. R. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1874-4 · Cited by 49 · see citing works
Novel insights into RIPK1 as a promising target for future Alzheimer’s disease treatment
Li, S., Qu, L., Wang, X., & Kong, L. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107979 · Cited by 50 · see citing works
Azuma, N., Mawatari, T., Saito, Y., Tsukamoto, M., Sampei, M., & Iwama, Y. (2023) · Nutrients · doi:10.3390/nu15194175 · Cited by 48 · see citing works
Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury
Glotfelty, E. J., Delgado, T., Tovar‐y‐Romo, L. B., Luo, Y., Hoffer, B. J., Olson, L., Karlsson, T. E., Mattson, M. P., Harvey, B. K., Tweedie, D., et al. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00003 · Cited by 48 · see citing works
Role of astrocyte purinergic signaling in epilepsy
Nikolic, L. M., Nobili, P., Shen, W., & Audinat, É. (2019) · Glia · doi:10.1002/glia.23747 · Cited by 49 · see citing works
Brambilla, L., Guidotti, G., Martorana, F., Iyer, A. M., Aronica, E., Valori, C. F., & Rossi, D. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw161 · Cited by 46 · see citing works
Mainardi, M., Spinelli, M., Scala, F., Mattera, A., Fusco, S., D’Ascenzo, M., & Grassi, C. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00225 · Cited by 46 · see citing works
Shim, H. G., Jang, S.-S., Kim, S. H., Hwang, E. M., Min, J. O., Kim, H. Y., Kim, Y. S., Ryu, C., Chung, G., Kim, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29786-9 · Cited by 46 · see citing works
- Authors
- Habbas, S., Santello, M., Becker, D., Stubbe, H., Zappia, G., Liaudet, N., Klaus, F. R., Kollias, G., Fontana, A., Pryce, C. R., Suter, T., & Volterra, A.
- Affiliations
- University of Lausanne (CH)
- University of Zurich (CH)
- Alexander Fleming Biomedical Sciences Research Center (GR)
- University Hospital Zurich (CH)
- Corresponding author
- Volterra, Andrea
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 163
- Issue
- 7
- Pages
- 1730-1741
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2190725993
- Cited by
- 347
- References
- 52
- Citations by year
- 2026: 25 · 2025: 28 · 2024: 28 · 2023: 31 · 2022: 43 · 2021: 42 · 2020: 35 · 2019: 41 · 2018: 30 · 2017: 29 · 2016: 14 · 2015: 1
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- IRIS (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (140999, 141137, 31003A)
- Université de Lausanne
- Universität Zürich
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- TNF-α, TNFR1, astrocytes, astrocyte-neuron communication, hippocampus, dentate gyrus, synaptic plasticity, memory impairment, contextual learning, experimental autoimmune encephalitis, multiple sclerosis, neuroinflammation, cognitive impairment
- MeSH terms
- Animals, Astrocytes, Encephalomyelitis, Autoimmune, Experimental, Humans, Learning, Memory, Multiple Sclerosis, Piperidines, Tumor Necrosis Factor-alpha, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Dentate Gyrus, Receptors, Tumor Necrosis Factor, Type I, Mice
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