GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus

Freund, Tamás F.; Antal, Miklós

doi:10.1038/336170a0

Cited by 1,283Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus

Freund, Tamás F., Antal, Miklós·1988·Nature

DOI 10.1038/336170a0

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Abstract

The hippocampus, in particular the neocortex-hippocampus-neocortex circuit, is widely believed to be crucial in memory. Information flow in this circuit is strongly influenced by relatively sparse afferents derived from subcortical centres, such as the septum, involved in arousal, emotions and autonomic control. A powerful mechanism, by which numerically small inputs can produce profound effects, is feed-forward inhibition, that is, the activation of local inhibitory interneurons, which, in turn, control the activity of large populations of principal cells in the hippocampus. An example is the cholinergic input to the hippocampus from the septum, which is likely to be involved in feed-forward operations. Here, we demonstrate the existence of a circuit underlying another powerful mechanism of subcortical control of hippocampal information processing. We show that GABA-containing afferents originating in the septum innervate most of the GABA-containing interneurons in the hippocampus, making many synaptic contacts with each of them. Activation of the GABA-containing neurons in the septum is likely to lead to disinhibition of the principal neurons in the hippocampal formation and so this pathway is probably crucial in the induction of hippocampal electrical activity patterns, and may be involved in NMDA (N-methyl-D-aspartate) receptor-mediated functions, such as memory, in a permissive manner.

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A population of GABAergic medial septal neurons specifically innervate hippocampal interneurons via long-range projections providing regulation of theta frequency synchronization.
“In addition to entorhinal cortical long-range inhibitory projections described earlier, a population of GABAergic medial septal neurons specifically innervate hippocampal interneurons via long-range projections providing regulation of theta frequency synchronization (351, 438, 1118).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [351]

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Authors: Freund, T. F., & Antal, M.
Affiliations: University of Oxford (GB)
Semmelweis University (HU)
ORCID: Freund, Tamás F.
Antal, Miklós
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1988-11
Volume: 336
Issue: 6195
Pages: 170-173
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/336170a0
OpenAlex: W2045683730
Cited by: 1,283
References: 30
Citations by year: 2026: 20 · 2025: 34 · 2024: 28 · 2023: 27 · 2022: 27 · 2021: 31 · 2020: 29 · 2019: 31 · 2018: 29 · 2017: 35 · 2016: 24 · 2015: 32 · 2014: 32 · 2013: 36 · 2012: 24
FWCI: 24.74
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: septum, hippocampus, GABAergic neurons, inhibitory interneurons, feedforward inhibition, disinhibition, cholinergic input, hippocampal electrical activity, memory, NMDA receptor
MeSH terms: Afferent Pathways, Animals, gamma-Aminobutyric Acid, Hippocampus, Interneurons, Neural Inhibition, Neurons, Afferent, Septum Pellucidum, Rats

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GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus

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