The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity
Open accessAbstract
Experience-dependent plasticity in the cortex is often higher during short critical periods in postnatal development. The mechanisms limiting adult cortical plasticity are still unclear. Maturation of intracortical GABAergic inhibition is suggested to be crucial for the closure of the critical period for ocular dominance (OD) plasticity in the visual cortex. We find that reduction of GABAergic transmission in the adult rat visual cortex partially reactivates OD plasticity in response to monocular deprivation (MD). This is accompanied by an enhancement of activity-dependent potentiation of synaptic efficacy but not of activity-dependent depression. We also found a decrease in the expression of chondroitin sulfate proteoglycans in the visual cortex of MD animals with reduced inhibition, after the reactivation of OD plasticity. Thus, intracortical inhibition is a crucial limiting factor for the induction of experience-dependent plasticity in the adult visual cortex.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Supporting this idea, different studies have found an increased cortical plasticity after the induction of a decrease in inhibitory activity, in some cases involving the depletion of PNNs (Harauzov et al., 2010;Toyoizumi et al., 2013;Lensjø et al., 2017b).”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Harauzov et al., 2010
In the citing paper
“However, this potential remains in mature circuits, as sensitivity to MD can be reestablished in adult mice by suppressing GABA synthesis or reducing PVBC firing rates (465, 614).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [465]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The period of susceptibility to the physiological effects of unilateral eye closure in kittens
Hubel, D. H., & Wiesel, T. N. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009022 · Cited by 3,030
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679
Self-citationHuang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198
Self-citationReshaping the Cortical Motor Map by Unmasking Latent Intracortical Connections
Jacobs, K. M., & Donoghue, J. P. (1991) · Science · doi:10.1126/science.2000496 · Cited by 1,004
Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex
Hensch, T. K., Fagiolini, M., Mataga, N., Stryker, M. P., Baekkeskov, S., & Kash, S. F. (1998) · Science · doi:10.1126/science.282.5393.1504 · Cited by 910
The antidepressant fluoxetine restores plasticity in the adult visual cortex
Vetencourt, J. F. M., Sale, A., Viegi, A., Baroncelli, L., De Pasquale, R., F. O'Leary, O., Castrén, E., & Maffei, L. (2008) · Science · doi:10.1126/science.1150516 · Cited by 890
Self-citationSillito, A. M. (1975) · The Journal of Physiology · doi:10.1113/jphysiol.1975.sp011056 · Cited by 742
Inhibitory threshold for critical-period activation in primary visual cortex
Fagiolini, M., & Hensch, T. K. (2000) · Nature · doi:10.1038/35004582 · Cited by 716
Fagiolini, M., Pizzorusso, T., Berardi, N., Domenici, L., & Maffei, L. (1994) · Vision Research · doi:10.1016/0042-6989(94)90210-0 · Cited by 656
Self-citation
Cited by
Sorted by citations
Items 301–319 of 319
Sa'diyah, C. (2014) · SKRIPSI Jurusan Kependidikan Sekolah Dasar & Prasekolah - Fakultas Ilmu Pendidikan UM
Martinez, J. D., Donnelly, M. J., Popke, D. S., Torres, D., Wilson, L. G., Brancaleone, W. P., Clawson, B. C., Jiang, S., & Aton, S. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.25.477697
Perceptual learning of binocular interactions.
Xu, J. (2011) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/1604
Mechanisms of Experience-dependent Prevention of Plasticity in Visual Circuits
Balmer, T. S. (2022) · Digital Archive @ GSU · doi:10.57709/5814205
Experience-dependent plasticity of cortical inhibition
van Versendaal, D. (2024) · doi:10.5463/thesis.609
Rath, S. S., Gupta, S., & Ganesh, S. (2022) · Delhi Journal of Ophthalmology · doi:10.4103/dljo.dljo_33_23
The role of BDNF/TrkB Signalling in Somatostatin Neurons in Cocaine-Seeking BehaviourPreprint
Ċastrén, E., Didio, G., Klimczak, P., Hovi, H., Porra, E., Karakus, C., Balin, R., Aitta‐aho, T., & Umemori, J. (2025) · Research Square · doi:10.21203/rs.3.rs-6707681/v1
fMRI measures of interocular luminance masking reflect rapid binocular plasticity
Sujanthan, S., Farahani, A., Kingdom, F. A. A., Shmuel, A., & Mendola, J. D. (2025) · Vision Research · doi:10.1016/j.visres.2025.108712
Tschida, K. (2011) · DukeSpace (Duke University)
Functional Organization and Plasticity of Visual Cortex over the Lifespan of the Ferret
Whitney, D. E. (2013) · KiltHub Repository · doi:10.1184/r1/6717416
Learning efficient signal representation in sparse spike-coding networks
Maraš, M. (2019) · theses.fr (ABES) · doi:10.70675/1c258a24z1787z4e9cz9823z848d8095638f
Devienne, G. F. (2019) · theses.fr (ABES) · doi:10.70675/453418efzc908z49e0zba6fz71fefaa50691
Altérations de la connectivité corticale au cours de périodes critiques du développement
Druart, M. (2020) · theses.fr (ABES) · doi:10.70675/b4f48d73za850z42b2z8dadzfad47d4f0a69
Rôle des astrocytes dans la période critique de la plasticité visuelle
Breton, R. (2023) · theses.fr (ABES) · doi:10.70675/9140a00az6c88z4fb6zaabfz9eb16e7593ca
Hebbian and Homeostatic plasticity in the adult visual cortex
Prosper, A. (2025) · theses.fr (ABES) · doi:10.70675/62138cf3zacbdz46b0z8e1azecbeaf4bb955
Bondarenko, Y. D., Kauk, O. I., Hovbakh, I. O., Cherkashyna, L., & Різниченко, О. К. (2026) · Ukrainian Neurosurgical Journal · doi:10.25305/unj.340921
Metadata
- Authors
- Harauzov, A., Spolidoro, M., DiCristo, G., De Pasquale, R., Cancedda, L., Pizzorusso, T., Viegi, A., Berardi, N., & Maffei, L.
- Affiliations
- Scuola Normale Superiore (IT)
- Neuroscience Institute (IT)
- Corresponding author
- Berardi, Nicoletta
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-01-06
- Volume
- 30
- Issue
- 1
- Pages
- 361-371
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632513
- OpenAlex
- W2037289953
- Cited by
- 319
- References
- 57
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 13 · 2023: 16 · 2022: 15 · 2021: 21 · 2020: 21 · 2019: 15 · 2018: 13 · 2017: 25 · 2016: 20 · 2015: 22 · 2014: 31 · 2013: 25 · 2012: 25
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Scuola Normale Superiore di Pisa (submittedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- ocular dominance plasticity, intracortical inhibition, GABAergic inhibition, adult visual cortex, monocular deprivation, critical period, experience-dependent plasticity, synaptic potentiation, synaptic depression, chondroitin sulfate proteoglycans, cortical maturation
- MeSH terms
- Age Factors, Animals, Evoked Potentials, Visual, Neural Inhibition, Neuronal Plasticity, Visual Cortex, Rats, Long-Evans, Dominance, Ocular, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
