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Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity
Open accessAbstract
Experience-dependent plasticity in the cortex is often higher during short critical periods in postnatal development. The mechanisms limiting adult cortical plasticity are still unclear. Maturation of intracortical GABAergic inhibition is suggested to be crucial for the closure of the critical period for ocular dominance (OD) plasticity in the visual cortex. We find that reduction of GABAergic transmission in the adult rat visual cortex partially reactivates OD plasticity in response to monocular deprivation (MD). This is accompanied by an enhancement of activity-dependent potentiation of synaptic efficacy but not of activity-dependent depression. We also found a decrease in the expression of chondroitin sulfate proteoglycans in the visual cortex of MD animals with reduced inhibition, after the reactivation of OD plasticity. Thus, intracortical inhibition is a crucial limiting factor for the induction of experience-dependent plasticity in the adult visual cortex.
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“Supporting this idea, different studies have found an increased cortical plasticity after the induction of a decrease in inhibitory activity, in some cases involving the depletion of PNNs (Harauzov et al., 2010;Toyoizumi et al., 2013;Lensjø et al., 2017b).”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Harauzov et al., 2010
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“However, this potential remains in mature circuits, as sensitivity to MD can be reestablished in adult mice by suppressing GABA synthesis or reducing PVBC firing rates (465, 614).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [465]
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Metadata
- Authors
- Harauzov, A., Spolidoro, M., DiCristo, G., De Pasquale, R., Cancedda, L., Pizzorusso, T., Viegi, A., Berardi, N., & Maffei, L.
- Affiliations
- Scuola Normale Superiore (IT)
- Neuroscience Institute (IT)
- Corresponding author
- Berardi, Nicoletta
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-01-06
- Volume
- 30
- Issue
- 1
- Pages
- 361-371
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632513
- OpenAlex
- W2037289953
- Cited by
- 319
- References
- 57
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 13 · 2023: 16 · 2022: 15 · 2021: 21 · 2020: 21 · 2019: 15 · 2018: 13 · 2017: 25 · 2016: 20 · 2015: 22 · 2014: 31 · 2013: 25 · 2012: 25
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Scuola Normale Superiore di Pisa (submittedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- ocular dominance plasticity, intracortical inhibition, GABAergic inhibition, adult visual cortex, monocular deprivation, critical period, experience-dependent plasticity, synaptic potentiation, synaptic depression, chondroitin sulfate proteoglycans, cortical maturation
- MeSH terms
- Age Factors, Animals, Evoked Potentials, Visual, Neural Inhibition, Neuronal Plasticity, Visual Cortex, Rats, Long-Evans, Dominance, Ocular, Rats
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