The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Noise-Induced Hearing Loss (NIHL) as a Target of Oxidative Stress-Mediated Damage: Cochlear and Cortical Responses after an Increase in Antioxidant Defense
Open accessAbstract
This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test the effect of increased antioxidant defenses, a water-soluble coenzyme Q 10 analog (Q ter) was used. We analyzed auditory function, cochlear oxidative stress, morphological alterations in auditory cortices and cochlear structures, and levels of coenzymes Q 9 and Q 10(CoQ 9 and CoQ 10, respectively) as indicators of endogenous antioxidant capability. We report three main results. First, hearing loss and damage in hair cells and spiral ganglion was determined by noise-induced oxidative stress. Second, the acoustic trauma altered dendritic morphology and decreased spine number of II–III and V–VI layer pyramidal neurons of auditory cortices. Third, the systemic administration of the water-soluble CoQ 10 analog reduced oxidative-induced cochlear damage, hearing loss, and cortical dendritic injury. Furthermore, cochlear levels of CoQ 9 and CoQ 10 content increased. These findings indicate that antioxidant treatment restores auditory cortical neuronal morphology and hearing function by reducing the noise-induced redox imbalance in the cochlea and the deafferentation effects upstream the acoustic pathway.
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DeFelipe, J., & Fariñas, I. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90015-7 · Cited by 975
Critical periods for experience-dependent synaptic scaling in visual cortex
Desai, N. S., Cudmore, R. H., Nelson, S. B., & Turrigiano, G. G. (2002) · Nature Neuroscience · doi:10.1038/nn878 · Cited by 582
Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8892 · Cited by 557
Syka, J. (2002) · Physiological Reviews · doi:10.1152/physrev.00002.2002 · Cited by 369 · cited 1×
“There is growing evidence suggesting that NIHL can also induce homeostatic/maladaptive changes in the central auditory system (Syka, 2002; Pienkowski and Eggermont, 2011; Stolzberg et al., 2011; Wang et al., 2011).”
BackgroundDelayed production of free radicals following noise exposure
Yamashita, D., Jiang, H.-Y., Schacht, J., & Miller, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.104 · Cited by 352
Cited by
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Sgarbossa, A., Giacomazza, D., & Di Carlo, M. (2015) · Nutrients · doi:10.3390/nu7075246 · Cited by 282
Metadata
- Authors
- Fetoni, A. R., De Bartolo, P., Eramo, S. L. M., Rolesi, R., Paciello, F., Bergamini, C., Fato, R., Paludetti, G., Petrosini, L., & Troiani, D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-02-27
- Volume
- 33
- Issue
- 9
- Pages
- 4011-4023
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2131847074
- Cited by
- 213
- References
- 5
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fetoni, A. R., De Bartolo, P., Eramo, S. L. M., Rolesi, R., Paciello, F., Bergamini, C., Fato, R., Paludetti, G., Petrosini, L., & Troiani, D. (2013). Noise-Induced Hearing Loss (NIHL) as a Target of Oxidative Stress-Mediated Damage: Cochlear and Cortical Responses after an Increase in Antioxidant Defense. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2282-12.2013
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