Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
Open accessAbstract
Coenzyme Q 10 is an essential cofactor of the electron transport chain as well as a potent free radical scavenger in lipid and mitochondrial membranes. Feeding with coenzyme Q 10 increased cerebral cortex concentrations in 12- and 24-month-old rats. In 12-month-old rats administration of coenzyme Q 10 resulted in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q 10 . Oral administration of coenzyme Q 10 markedly attenuated striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increased life span in a transgenic mouse model of familial amyotrophic lateral sclerosis. These results show that oral administration of coenzyme Q 10 increases both brain and brain mitochondrial concentrations. They provide further evidence that coenzyme Q 10 can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases.
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CoQ10 produces neuroprotective effects in transgenic mouse models of ALS and HD.
“We also demonstrated that CoQ10 produces neuroprotective effects in transgenic mouse models of ALS and HD150, 151.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [150]
Oral administration of CoQ10 exerts significant neuroprotective effects against striatal lesions in rats produced by aminoxyacetic acid, malonate and 3-NP.
“Oral administration of CoQ10 exerts significant neuroprotective effects against striatal lesions in rats produced by aminoxyacetic acid, and the mitochondrial toxins malonate and 3-NP148-150.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [150]
Oral administration of CoQ10 for 1 week prior to 3-NP resulted in a significant 90% neuroprotection against 3-NP induced striatal lesions.
“Similarly, oral administration of CoQ10 for 1 week, prior to administration of 3-NP resulted in a significant 90% neuroprotection against 3-NP induced striatal lesions150.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [150]
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- Authors
- Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F.
- Affiliations
- Harvard University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1998-07-21
- Volume
- 95
- Issue
- 15
- Pages
- 8892-8897
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC21173
- OpenAlex
- W2100454943
- Cited by
- 557
- References
- 49
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 24 · 2020: 26 · 2019: 18 · 2018: 15 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 19 · 2013: 22 · 2012: 20
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns031579-05)
- National Institute on Aging (P01 AG 12992, P01AG012992)
- National Institute of Neurological Disorders and Stroke (NS 16367, NS31579, P50NS016367)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- coenzyme Q10, cerebral cortex, neuroprotection, 3-nitropropionic acid, striatal lesions, amyotrophic lateral sclerosis, transgenic mouse model, lifespan, neurodegenerative diseases, electron transport chain, free radical scavenging, oral administration
- MeSH terms
- Administration, Oral, Animals, Brain, Coenzymes, Humans, Male, Mice, Transgenic, Mitochondria, Rats, Inbred F344, Superoxide Dismutase, Ubiquinone, Rats, Sprague-Dawley, Neuroprotective Agents, Mice, Rats
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