The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Glial Cell Inhibition of Neurons by Release of ATP
Open accessAbstract
ATP is released by neurons and functions as a neurotransmitter and modulator in the CNS. Here I show that ATP released from glial cells can also serve as a potent neuromodulator, inhibiting neurons in the retina of the rat. Activation of glial cells by focal ejection of ATP, ATPγS, dopamine, thrombin, or lysophosphatidic acid or by mechanical stimulation evoked hyperpolarizing responses and outward currents in a subset of retinal ganglion cells by increasing a Ba 2+-sensitive K+conductance in the neurons. This glia-evoked inhibition reduced the firing rate of those neurons that displayed spontaneous spike activity. The inhibition was abolished by the A 1 adenosine receptor antagonist DPCPX (8-cyclopentyl-1,3-dipropylxanthine) (10 n m) and was reduced by the ecto-ATPase inhibitor ARL-67156 (6-N,N-diethyl-d-β,γ-dibromomethyleneATP) (50 μ m) and by the ectonucleotidase inhibitor AOPCP [adenosine-5′-O-(α,β-methylene)-diphosphonate] (250 μ m). Selective activation of retinal glial cells demonstrated that Müller cells, but not astrocytes, mediate the inhibition. ATP release from Müller cells into the inner plexiform layer of the retina was shown using the luciferin–luciferase chemiluminescence assay. These findings demonstrate that activated glial cells can inhibit neurons in the retina by the release of ATP, which is converted to adenosine by ectoenzymes and subsequently activates neuronal adenosine receptors. The results lend support to the hypothesis that glial cells play an active role in information processing in the CNS.
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Cites
Glia: listening and talking to the synapse
Haydon, P. G. (2001) · Nature Reviews Neuroscience · doi:10.1038/35058528 · Cited by 1,408
Astrocyte-mediated potentiation of inhibitory synaptic transmission
Kang, J., Jiang, L., Goldman, S. A., & Nedergaard, M. (1998) · Nature Neuroscience · doi:10.1038/3684 · Cited by 842
Pasti, L., Volterra, A., Pozzan, T., & Carmignoto, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-20-07817.1997 · Cited by 793
Connexins regulate calcium signaling by controlling ATP release
Cotrina, M. L., Lin, J. H.-C., Alves-Rodrigues, A., Liu, S., Li, J., Azmi-Ghadimi, H., Kang, J., Naus, C. C. G., & Nedergaard, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15735 · Cited by 772
Microdomains for neuron–glia interaction: parallel fiber signaling to Bergmann glial cells
Grosche, J., Matyash, V., Möller, T., Verkhratsky, A., Reichenbach, A., & Kettenmann, H. (1999) · Nature Neuroscience · doi:10.1038/5692 · Cited by 662
Hippocampal AstrocytesIn SituRespond to Glutamate Released from Synaptic Terminals
Porter, J. T., & McCarthy, K. D. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05073.1996 · Cited by 638
Cunha, R. A. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00034-6 · Cited by 631
Dynamic Signaling Between Astrocytes and Neurons
Araque, A., Carmignoto, G., & Haydon, P. G. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.795 · Cited by 611
Hippocampal Astrocytes In Situ Respond to Glutamate Released from Synaptic Terminals
Porter, J. T., & McCarthy, K. D. (2021) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/s4kv-rg05 · Cited by 553
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00221.x · Cited by 541
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Tripartite synapses: astrocytes process and control synaptic information
Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1722 · Cited by 1,770
Diffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory
Panatier, A., Theodosis, D. T., Mothet, J.-P., Touquet, B., Pollegioni, L., Poulain, D. A., & Oliet, S. H. R. (2006) · Cell · doi:10.1016/j.cell.2006.02.051 · Cited by 934
Metadata
- Authors
- Newman, E. A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-03-01
- Volume
- 23
- Issue
- 5
- Pages
- 1659-1666
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2166911878
- Cited by
- 426
- References
- 40
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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