The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Dopamine Modulates Cell Cycle in the Lateral Ganglionic Eminence
Open accessAbstract
Dopamine is a neuromodulator the functions of which in the regulation of complex behaviors such as mood, motivation, and attention are well known. Dopamine appears in the brain early in the embryonic period when none of those behaviors is robust, raising the possibility that dopamine may influence brain development. The effects of dopamine on specific developmental processes such as neurogenesis are not fully characterized. The neostriatum is a dopamine-rich region of the developing and mature brain. If dopamine influenced neurogenesis, the effects would likely be pronounced in the neostriatum. Therefore, we examined whether dopamine influenced neostriatal neurogenesis by influencing the cell cycle of progenitor cells in the lateral ganglionic eminence (LGE), the neuroepithelial precursor of the neostriatum. We show that dopamine arrives in the LGE via the nigrostriatal pathway early in the embryonic period and that neostriatal neurogenesis progresses in a dopamine-rich milieu. Dopamine D1-like receptor activation reduces entry of progenitor cells from the G 1 - to S-phase of the cell cycle, whereas D2-like receptor activation produces the opposite effects by promoting G 1 - to S-phase entry. D1-like effects are prominent in the ventricular zone, and D2-like effects are prominent in the subventricular zone. The overall effects of dopamine on the cell cycle are D1-like effects, most likely because of the preponderance of D1-like binding sites in the embryonic neostriatum. These data reveal a novel developmental role for dopamine and underscore the relevance of dopaminergic signaling in brain development.
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“It has furthermore been shown that dopamine and GABA interactions can influence these processes [187, 188].”
From Development of prefrontal cortex (2022) · cites this paper as [187]
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Cites
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Sorted by citations
Dopamine depletion impairs precursor cell proliferation in Parkinson disease
Höglinger, G. U., Rizk, P., Mp, M., Duyckaerts, C. J., Oertel, W. H., Caillé, I., & Hirsch, É. C. (2004) · Nature Neuroscience · doi:10.1038/nn1265 · Cited by 974
“, and affects cell proliferation in the embryonic germinal zone”
BackgroundGenomic Analysis of Mouse Retinal Development
Blackshaw, S., Harpavat, S., Trimarchi, J. M., Cai, L., Huang, H., Kuo, W. P., Weber, G. M., Lee, K., Fraioli, R. E., Cho, S., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020247 · Cited by 586
“…circuits have formed fits with data from other parts of the developing CNS showing early expression of neurotransmitter receptors and suggesting that neurotransmitters may act on mitotic progenitor cells to regulate cell cycle or cell fate specification (Rueda et al. 2002; Ohtani et al. 2003).”
BackgroundKellendonk, C., Simpson, E. H., Polan, H. J., Malleret, G., Vronskaya, S., Winiger, V., Moore, H., & Kandel, E. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.023 · Cited by 520
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378
“It has furthermore been shown that dopamine and GABA interactions can influence these processes [187, 188].”
BackgroundChang, G., Gaysinskaya, V. A., Karatayev, O., & LEIBOWITZ, S. F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2642-08.2008 · Cited by 374
“A possible mechanism underlying the HFD-induced increase in neurogenesis may involve changes in the cell-cycle kinetics, as suggested for the dopamine system in the brain (Ohtani et al., 2003).”
Background
Metadata
- Authors
- Ohtani, N., Goto, T., Waeber, C., & Bhide, P. G.
- Affiliations
- Pediatrics and Genetics (US)
- Harvard University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-04-01
- Volume
- 23
- Issue
- 7
- Pages
- 2840-2850
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC1201391
- OpenAlex
- W2150700826
- Semantic Scholar
- 5c05744728753731ef7333746826dd9b22331c10
- Cited by
- 193
- References
- 68
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- U.S. Public Health Service (HD 05515)
- National Institute of Neurological Disorders and Stroke (NS 43426, NS 62005, R01NS043426)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD005515, HD05515)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- dopamine, lateral ganglionic eminence, neostriatum, cell cycle, neurogenesis, D1-like receptors, D2-like receptors, progenitor cells, G1/S transition, nigrostriatal pathway, subventricular zone, ventricular zone, brain development, embryonic development
- MeSH terms
- Animals, Bromodeoxyuridine, Cell Cycle, Cell Division, Dopamine, Ganglia, Neurons, Stem Cells, Neostriatum, Receptors, Dopamine D1, Receptors, Dopamine D2, Culture Techniques, Mice
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