Cited by 294Neuropeptides and Animal PhysiologyRegulation of Appetite and ObesityHeart Rate Variability and Autonomic Control

The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.

Glucagon-Like Peptide-1-Responsive Catecholamine Neurons in the Area Postrema Link Peripheral Glucagon-Like Peptide-1 with Central Autonomic Control Sites

Open access

Yamamoto, Hiroshi, Kishi, Toshiro, Lee, Charlotte E., Choi, Brian J., Fang, Hui, Hollenberg, Anthony N., Drucker, Daniel J., Elmquist, Joel K.·2003·The Journal of Neuroscience

DOI 10.1523/jneurosci.23-07-02939.2003PMC PMC6742071

Open this paper in CoChat — free account Open PDF

Abstract

Glucagon-like peptide-1 (GLP-1) released from the gut is an incretin that stimulates insulin secretion. GLP-1 is also a brain neuropeptide that has diverse central actions, including inhibition of food and water intake, gastric emptying, and stimulation of neuroendocrine responses characteristic of visceral illness. Both intravenous and intracerebroventricular administration of GLP-1 receptor (GLP-1R) agonists increase blood pressure and heart rate and induce Fos-like immunoreactivity (Fos-IR) in autonomic regulatory sites in the rat brain. The area postrema (AP) is a circumventricular organ and has been implicated in processing visceral sensory information. GLP-1Rs are densely expressed in the AP, and peripheral GLP-1R agonists induce Fos-IR in AP neurons to a greater degree than intracerebroventricular administration. Because the AP lacks a blood–brain barrier, we hypothesized that the AP is a key site for peripheral GLP-1 to activate central autonomic regulatory sites. In this study, we found that many tyrosine hydroxylase (TH)-containing neurons in the AP expressed GLP-1Rs and Fos-IR after intravenous GLP-1R agonists. Furthermore, intravenous but not intracerebroventricular GLP-1R agonists induced TH transcription in the AP in vivo. In addition, GLP-1R agonists directly activated TH transcription in an in vitro cell system. Finally, we found that GLP-1-responsive TH neurons in the AP innervate autonomic control sites, including the parabrachial nucleus, nucleus of solitary tract, and ventrolateral medulla. These findings suggest that catecholamine neurons in the AP link peripheral GLP-1 and central autonomic control sites that mediate the diverse neuroendocrine and autonomic actions of peripheral GLP-1.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.23-07-02939.2003

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
A role for glucagon-like peptide-1 in the central regulation of feeding
Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950
Glucagon-like peptide-1 7–36: a physiological incretin in man
Kreymann, B., Ghatei, M. A., Williams, G., & Bloom, S. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91194-9 · Cited by 1,928
Establishment of 2-mercaptoethanol-dependent differentiated insulin- secreting cell lines
Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A., & Wollheim, C. B. (1992) · Endocrinology · doi:10.1210/endo.130.1.1370150 · Cited by 1,165
Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat
Herbert, H., Moga, M. M., & Saper, C. B. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902930404 · Cited by 964
Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.
Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., & Habener, J. F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3434 · Cited by 903
Self-citation
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.
Göke, R., Fehmann, H. C., Linn, T., Schmidt, H., Krause, M., Eng, J., & Göke, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36565-2 · Cited by 837
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene
Scrocchi, L. A., Brown, T. J., Maclusky, N., Brubaker, P. L., Auerbach, A. B., Joyner, A. L., & Drucker, D. J. (1996) · Nature Medicine · doi:10.1038/nm1196-1254 · Cited by 793
Self-citation
Glucagon-Like Peptides
Drucker, D. J. (1998) · Diabetes · doi:10.2337/diab.47.2.159 · Cited by 598
Self-citation

Show all 60 references

Research works printed but not linked: 3

10.1210/en.130.1.167 · DOI
10.1210/en.137.11.5119 · DOI
10.1210/en.133.1.57 · DOI · Paper page

Sorted by citations

Items 201–292 of 292

Cardiovascular and hemodynamic effects of glucagon-like peptide-1
Goodwill, A. G., Mather, K. J., Conteh, A. M., Sassoon, D., Noblet, J. N., & Tune, J. D. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9290-z · Cited by 17
Effect of potatoes and other carbohydrate-containing foods on cognitive performance, glycemic response, and satiety in children
Lee, J. J., Brett, N. R., Wong, V. C. H., de Zepetnek, J. O. T., Fiocco, A. J., & Bellissimo, N. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0792 · Cited by 15
A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew)
Chan, S. W., Lin, G., Yew, D. T. W., & Rudd, J. A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.06.036 · Cited by 15
Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity
Boccardi, V., Ambrosino, I., Papa, M., Fiore, D., Rizzo, M. R., Paolisso, G., & Barbieri, M. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.117 · Cited by 15
Glucagon-Like Peptide-1 Agonist Exendin-4 Leads to Reduction of Weight and Caloric Intake in a Rat Model of Hypothalamic Obesity
Elfers, C., Simmons, J. H., & Roth, C. L. (2012) · Hormone Research in Paediatrics · doi:10.1159/000338464 · Cited by 15
Repurposing glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative disorders
Sabbagh, M. N., Cummings, J. L., Ballard, C. G., van der Flier, W. M., Heneka, M. T., Holst, J. J., Knudsen, L. B., Salloway, S., Tansey, M. G., & Drucker, D. J. (2025) · Nature Aging · doi:10.1038/s43587-025-01029-3 · Cited by 15
Self-citation
Effect of Docosahexaenoic Acid (DHA) at the Enteric Level in a Synucleinopathy Mouse Model
Lamontagne‐Proulx, J., Coulombe, K., Dahhani, F., Côté, M., Guyaz, C., Tremblay, C., Marzo, V. D., Flamand, N., Calon, F., & Soulet, D. (2021) · Nutrients · doi:10.3390/nu13124218 · Cited by 14
A look on food intake and satiety: from humans to rodent models
Costa, D. G., Almeida, C., Cavadas, C., & Carmo‐Silva, S. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac010 · Cited by 17
Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice
Dahir, N. S., Gui, Y., Wu, Y., Sweeney, P., Rouault, A. A. J., Williams, S. Y., Gimenez, L. E., Sawyer, T. K., Joy, S. T., Mapp, A. K., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci178250 · Cited by 17
Hyperglycemia after protein ingestion concurrent with injection of a GLP-1 receptor agonist in rats: a possible role for dietary peptides
Aziz, A. A., Anderson, G. H., Giacca, A., & Cho, F. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00850.2004 · Cited by 12
Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
Gjermeni, E., Kirstein, A., Kolbig, F., Kirchhof, M., Bundalian, L., Katzmann, J. L., Laufs, U., Blüher, M., Garten, A., & Duc, D. L. (2021) · Biomolecules · doi:10.3390/biom11101426 · Cited by 127
Weight-dependent and weight-independent effects of dulaglutide on blood pressure in patients with type 2 diabetes
Ferdinand, K. C., Dunn, J. P., Nicolay, C., Sam, F., Blue, E. K., & Wang, H. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01775-x · Cited by 13
From Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior
Mahishi, D., Agrawal, N., Jiang, W., & Yapici, N. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102202 · Cited by 13
The Enteroendocrine System in Obesity
Miedzybrodzka, E. L., Reimann, F. M., & Gribble, F. M. (2022) · Handbook of experimental pharmacology · doi:10.1007/164_2022_582 · Cited by 12
Glucagon‐Like Peptide‐1 Links Ingestion, Homeostasis, and the Heart
Krieger, J., Daniels, D., Lee, S. J., Mastitskaya, S., & Langhans, W. (2024) · Comprehensive physiology · doi:10.1002/cph4.7 · Cited by 14
Immunohistochemical determination of the site of hypotensive effects of glucagon-like peptide-2 in the rat brain
Sasaki‐Hamada, S., Okada, S., Ito, K. L., Iwai, T., & Oka, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.032 · Cited by 11
Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells
Zhang, T., Ruan, H.-Z., Wang, Y., Shao, Y., Zhou, W., Weng, S.-J., & Zhong, Y. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00826-9 · Cited by 11
Reguladores neuroendocrinos y gastrointestinales del apetito y la saciedad
Calzada‐León, R., Altamirano-Bustamante, N. F., & Ruiz-Reyes, M. D. L. L. (2008) · Boletín Médico del Hospital Infantil de México · Cited by 11
Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
Greco, M., Munir, A., Musarò, D., Coppola, C., & Maffia, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1244022 · Cited by 10
What Is the Role of Glucagon-Like Peptide 1 Signaling in the Nervous System and Its Potential Neuroprotective Effects?
Turcano, P., Savica, R., & Benarroch, E. E. (2024) · Neurology · doi:10.1212/wnl.0000000000209781 · Cited by 11
From pathophysiology to novel approaches for obesity-associated hypertension
Kanbay, M., Yayci, E., Genc, C., Çöpür, S., Aktaş, Ö. Y., Sarafidis, P. A., Covic, A. C., Ortíz, A., & Laffin, L. J. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf218 · Cited by 10
Fetal programming by the parental microbiome of offspring behavior, and DNA methylation and gene expression within the hippocampus
Gustafson, K. L., Busi, S. B., McAdams, Z. L., McCorkle, R. E., Khodakivskyi, P., Bivens, N. J., Davis, D. J., Raju, M., Coghill, L. M., Goun, E. A., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02226-3 · Cited by 12
Factors associated with hypertension remission after gastrectomy for gastric cancer patients
Kang, B., Liu, X., Cheng, Y.-X., Tao, W. Y., & Peng, D. (2022) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v14.i8.743 · Cited by 10
Cardioprotective Actions of a Glucagon‐like Peptide‐1 Receptor Agonist on Hearts Donated After Circulatory Death
Kadowaki, S., Siraj, M. A., Chen, W., Wang, J., Parker, M., Nagy, A., Fan, C. S., Runeckles, K., Li, J., Kobayashi, J., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.027163 · Cited by 10
Action of Administered Ciliary Neurotrophic Factor on the Mouse Dorsal Vagal Complex
Senzacqua, M., Severi, I., Perugini, J., Acciarini, S., Cinti, S., & Giordano, A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00289 · Cited by 10
Conceptualization of a Parasympathetic Endocrine System
Gorky, J. M., & Schwaber, J. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01008 · Cited by 8
Bariatric surgery to treat hypertension
Moriconi, D., Nannipieri, M., & Rebelos, E. (2023) · Hypertension Research · doi:10.1038/s41440-023-01227-9 · Cited by 10
Preoperative Glucagon-Like Peptide-1 Receptor Agonists and Bariatric Surgery Outcomes: A Systematic Review
Esparham, A., Sheikhbahaei, E., Moghadam, H. A., & Khorgami, Z. (2025) · Obesity Surgery · doi:10.1007/s11695-025-08137-4 · Cited by 11
Potential of Glucagon-Like Peptide 1 as a Regulator of Impaired Cholesterol Metabolism in the Brain
Kim, Y., & Song, J. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa080 · Cited by 8
The Effect of Exenatide and Erythromycin on Postprandial Symptoms and Their Relation to Gastric Functions
Yoon, S. B., Choi, M., Lim, C., Kim, J. S., Cho, Y. K., Park, J. M., Lee, I. S., Kim, S. W., Choi, K. Y., & Chung, I. (2012) · Digestion · doi:10.1159/000335933 · Cited by 8
GLP-1 receptor agonists and the risk of postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a single-center, retrospective cohort study
Shan, X., Wang, Y., Xiao, X., Gao, Y., & Sun, X. (2025) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2024.09.013 · Cited by 8
Insights into the neurobiology of weight loss after bariatric surgery and GLP-1R agonists
Cook, T. M., Fuller, K. N. Z., & Sandoval, D. A. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110269 · Cited by 7
The interplay between hypothalamic and brainstem nuclei in homeostatic control of energy balance
Arčon, M. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115398 · Cited by 9
Paying the Price for Eating Ice Cream: Is Excessive GLP-1 Signaling in the Brain the Culprit?
Berthoud, H. (2008) · Endocrinology · doi:10.1210/en.2008-0932 · Cited by 7
Improved leptin sensitivity and increased soluble leptin receptor concentrations may underlie the additive effects of combining PYY(3–36) and exendin-4 on body weight lowering in diet-induced obese mice
Wulff, B. S., Kuhre, R. E., Selvaraj, M., Rehfeld, J. F., Niss, K., Fels, J. J., Secher, A., Raun, K., & Gerstenberg, M. K. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32009 · Cited by 6
Incretins: the novel therapy of type 2 diabetes.
Thongtang, N., & Sriwijitkamol, A. (2008) · PubMed · Cited by 5
Neuroendocrine Control of Energy Stores
Cone, R. D., & Elmquist, J. K. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00035-3 · Cited by 5
Self-citation
Liraglutide increases 24-h heart rate by reducing the cardiac parasympathetic activity of patients with type 2 diabetes: power spectral analysis of heart rate variability on 24-h Holter ECG recordings
Hara, K., Aso, Y., Komatsu, T., Nakamachi, T., Sakai, Y., Takayanagi, K., Kasai, K., & Inukai, T. (2014) · Diabetology International · doi:10.1007/s13340-014-0170-2 · Cited by 4
Intact neural system of the portal vein is important for maintaining normal glucose metabolism by regulating glucagon-like peptide-1 and insulin sensitivity
Trung, V. N., Yamamoto, H., Yamaguchi, T., Murata, S., Aimi, Y., Kuwahara, A., & Tani, T. (2013) · Peptides · doi:10.1016/j.peptides.2013.12.003 · Cited by 4
Self-citation
Vascular Protection with Dipeptidyl Peptidase‐ IV inhibitors in Diabetes: Experimental and Clinical Therapeutics
Ahmed, H. A., May, D. W., Fagan, S. C., & Segar, L. (2015) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1547 · Cited by 4
Gastrointestinal Peptide Hormones Regulating Energy and Glucose Homeostasis
Drucker, D. J. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50009-x · Cited by 4
Self-citation
Overweight and obesity in metabolic syndrome
Nedogoda, S. V., & Васильевна, Ц. О. (2025) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6535 · Cited by 4
The impact of GLP-1 signalling on the energy metabolism of pancreatic islet β-cells and extrapancreatic tissues
Peart, L. A., Draper, M., & Tarasov, A. I. (2024) · Peptides · doi:10.1016/j.peptides.2024.171243 · Cited by 3
A high-fat diet influences neural stem and progenitor cell environment in the medulla of adult mice
Furube, E., Ohgidani, M., Tanaka, Y., Miyata, S., & Yoshida, S. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.08.034 · Cited by 3
Physiological Characteristics of Hypocretin/Orexin Neurons
van den Pol, A. N. (2005) · Springer eBooks · doi:10.1007/0-387-25446-3_8 · Cited by 3
The Role of Adipose Tissue Vasculature in Energy Balance
Kim, H.-J., Choi, S.-H., Chun, B., & Kim, D.-H. (2011) · Journal of Korean Society of Pediatric Endocrinology · doi:10.6065/jkspe.2011.16.3.139 · Cited by 3
Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: Immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain
Weaver, C. V., Turner, N., & Hall, J. L. (2012) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.06.002 · Cited by 2
Effect of Bariatric Surgery on Hypertension
Alhomound, H., & Park, S. S. (2015) · Journal of Metabolic and Bariatric Surgery · doi:10.17476/jmbs.2015.4.2.35 · Cited by 2
Neuroendocrine Control of Energy Stores
Cone, R. D., & Elmquist, J. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00035-6 · Cited by 2
Self-citation
Does endogenous GLP-1 affect resting energy expenditure and fuel selection in overweight and obese adults?
Poggiogalle, E., Donini, L. M., Chiesa, C., Pacifico, L., Lenzi, A., Perna, S., Faliva, M. A., Naso, M., & Rondanelli, M. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0764-1 · Cited by 2
Metabolic cues impact non‐oscillatory intergeniculate leaflet and ventral lateral geniculate nucleus: standard versus high‐fat diet comparative study
Jeczmien‐Lazur, J. S., Sanetra, A. M., Pradel, K., Izowit, G., Chrobok, Ł., Palus‐Chramiec, K., Piggins, H. D., & Lewandowski, M. H. (2023) · The Journal of Physiology · doi:10.1113/jp283757 · Cited by 3
The early impact of bariatric surgery on blood pressure: A hemodynamic analysis using echocardiography in a prospective observational cohort study
Styczyński, G., Kalinowski, P., Cienszkowska, K., Ludwiczak, M., Strzelczyk, J., & Szmigielski, C. A. (2026) · Hypertension Research · doi:10.1038/s41440-026-02602-y · Cited by 1
Mecanismos hormonais do controle de peso corporal e suas possíveis implicações para o tratamento da obesidade Hormonal mechanisms in body weight regulation and therapeutic implications
Neto, B. G., & Pareja, J. C. (2006) · Cited by 1
Dumping syndrome
Loganathan, P., Diaz, J. R., & McCallum, R. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-13911-6.00018-9 · Cited by 1
Bariatric Surgery: Can It Perform Benefits or Risks?
Mostafa, T. A.-H., Abdel-Hameed, A. M., & Ahmed, S. A.-K. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1006090 · Cited by 1
Blood–brain barrier and evolution of peptide regulation of physiological functions
Maryanovich, A. T. (2016) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093016040074 · Cited by 1
Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus
Quan, H. (2019) · Clinical Medicine Research · doi:10.11648/j.cmr.20190802.11 · Cited by 1
Using the body’s natural signals — gut hormones
Chaudhri, O. B., Smith, K. L., & Bloom, S. R. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7425-9_7 · Cited by 1
Autonomic Nervous System: Central Control of the Gastrointestinal Tract
Jänig, W. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00651-3 · Cited by 1
Effets cardiovasculaires du GLP-1 : des données expérimentales aux conséquences thérapeutiques des incrétinomimétiques
Halter, C., Böhme, P., Ziegler, O., & Guerci, B. (2010) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(10)70085-7 · Cited by 1
Las hormonas gastrointestinales en el control de la ingesta
Gil‐Lozano, M., Paz, S. F., Pérez, R. B., Federico, V. G. Y., & Férrer, M. T. (2013)
Einfluss einer Behandlung mit Glukagon-like-peptide-1 (GLP-1) bei Patienten mit Typ 2 Diabetes nach kardiochirurgischem Eingriff auf Intensivstation hinsichtlich kardiopulmonaler Parameter und Sepsisparameter
Öncü, A. (2008)
Gastrointestinal Tract Role in Neural Control of Metabolism, Food Intake and Body Weight: A Summary
Jänig, W. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.02049-0
Effects of palatable diets on appetite regulation, appetite peptides and neurogenesis.
Lindqvist, A. (2006) · Lund University Publications (Lund University)
Metabolic Tuning of Neural, Neuroendocrine, and Behavioral Responses to Stress
Maniscalco, J. W. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
Role of Sensory Circumventricular Organs in the Function of Hormones Affecting Feeding and Energy Balance
Ahmed, A. F. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/27684
Reguladores neuroendocrinos y gastrointestinales del apetito y la saciedad Neuroendocrine and gastrointestinal modulators of appetite and satiety
Calzada‐León, R., & Altamirano-Bustamante, N. F. (2008)
Exenatide as a novel treatment for Parkinson's Disease
Avilés-Olmos, I. (2013) · UCL Discovery (University College London)
Neuroendocrine Control of Hepatic Gluconeogenesis
Mao, Z., & Zhang, W. (2017) · InTech eBooks · doi:10.5772/67535
Enteroendocrine Changes Facilitating Weight Loss Following Gastric Bypass
Cruz-Munoz, N. F. D. L. (2017) · Gastroenterology & Hepatology Open Access · doi:10.15406/ghoa.2017.07.00247
Acute Regulation of Postprandial Lipemia and Chylomicron Production by Glucagon-Like Peptide-1 and Bile Acid Signaling
Farr, S. (2017) · TSpace (University of Toronto)
The role of physiological elevations of glucagon-like peptide-one in glucose regulation in the dog in vivo
Johnson, K. M. S. (2008)
Novel Roles of GLP-1 and GLP-2 in the Regulation of Hepatic Lipid/Lipoprotein Homeostasis and the Involvement of BAT Activation
Taher, J. (2017) · TSpace (University of Toronto)
Metabolic and Electrophysiological Effects of Fibroblast Growth Factor 19 in the Dorsal Vagal Complex
Wean, J. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.383
Dumping Syndrome
Bustamante-Bernal, M. A., Berg, P., & McCallum, R. (2020) · Encyclopedia of Gastroenterology · doi:10.1016/b978-0-12-801238-3.66030-0
The GLP-1RAs: From Evolution to Revolution
Mishra, N. (2022) · The Singapore Family Physician · doi:10.33591/sfp.48.3.u2
The function of the autonomic nervous system in type 1 diabetes and in response to physiological and pharmacological modulations
Nielsen, T. A. (2023) · doi:10.54337/aau588597746
Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview
Rastogi, V., & Soni, S. (2024) · Recent Advances in Food Nutrition & Agriculture · doi:10.2174/012772574x310316240610111659
Activation of the Sympathoadrenal System under the Influence of Glucagon-Like Peptide-1 Mimetic in Rats
Balbotkina, E. V., Marina, A. S., & Кутина, А. В. (2024) · Нейрохимия · doi:10.31857/s1027813324040066
Activation of the Sympathoadrenal System under the Influence of Glucagon-Like Peptide-1 Mimetic in Rats
Balbotkina, E. V., Marina, A. S., & Кутина, А. В. (2024) · Neurochemical Journal · doi:10.1134/s1819712424700338
Long-term impact of bariatric surgery on hypertension control and remission: A meta-analysis of randomized controlled trials
Sebastian, S. A., Shah, Y., & Krishnamoorthy, G. (2025) · Next research. · doi:10.1016/j.nexres.2025.100318
Etude des interfaces sang/cerveau dans la région tubérale de l'hypothalamus médiobasal (rôle des tanycytes de l'éminence médiane)
Mullier, A., & Bouret, S. G. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Acute effects of exercise on appetite, food intake and circulating concentrations of gastrointestinal hormones
Deighton, K. (2013) · Loughborough University Institutional Repository (Loughborough University)
Regulation of Feeding Behavior by Glucagonlike Peptide 1 (GLP-1)
Vuguin, P. M., & Charron, M. J. (2006) · Elsevier eBooks · doi:10.1016/b978-012369442-3/50136-7
Glucagon-like Peptides and Insulin Sensitivity
Holst, J. J., & Knop, F. K. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-116-5_13
Additional file 1 of Weight-dependent and weight-independent effects of dulaglutide on blood pressure in patients with type 2 diabetes
Ferdinand, K. C., Dunn, J., Nicolay, C., Sam, F., Blue, E. K., & Wang, H. (2023) · Figshare · doi:10.6084/m9.figshare.22624691
Type 1 Diabetes: Pathophysiology and Treatment Considerations for Cardiovascular Risk and Disease
Tommerdahl, K. L., & Bjornstad, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-87862-3.00005-7
Détection des nutriments et contrôle central de la prise alimentaire
Delaere, F. (2009) · theses.fr (ABES) · doi:10.70675/2e9fa6a2z6f59z4d47zaabbz04010b09ce15
Glucagon-Like Peptide-1 Receptor Agonists in Inflammatory Bowel Disease: A Narrative Review
Desai, A., Habib, H., Wahbeh, L., & Farraye, F. A. (2026) · Gastro Hep Advances · doi:10.1016/j.gastha.2026.101023
Incretins: From Gene Expression to Secretion and Action of GLP-1 and GIP
Lobato, C. B., & Holst, J. J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-11985-9.00004-4
Pancreatic hormones and the gut-brain axis
Khoshnam, A., Bashir, F., Abediankenari, F., Kherad, M. E., Rahmanian, M., & Deravi, N. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30263-3.00036-1
Pharmacological Mechanisms of Once-Weekly GLP-1 Receptor Agonists for Type 2 Diabetes Management
Ali, M. A., Das, S., Kumar, R. R., & Rabindra, K. (2026) · International Journal of Innovative Science and Research Technology (IJISRT) · doi:10.38124/ijisrt/26oct881

Authors: Yamamoto, H., Kishi, T., Lee, C. E., Choi, B. J., Fang, H., Hollenberg, A. N., Drucker, D. J., & Elmquist, J. K.
Affiliations: Beth Israel Deaconess Medical Center (US)
University of Toronto (CA)
ORCID: Yamamoto, Hiroshi
Lee, Charlotte E.
Hollenberg, Anthony N.
Drucker, Daniel J.
Elmquist, Joel K.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2003-04-01
Volume: 23
Issue: 7
Pages: 2939-2946
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.23-07-02939.2003
PMC: PMC6742071
OpenAlex: W2152880048
Cited by: 294
References: 60
Citations by year: 2026: 6 · 2025: 8 · 2024: 18 · 2023: 12 · 2022: 8 · 2021: 18 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 14 · 2012: 15
FWCI: 5.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk059751-02)
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK056116, DK56116, DK 59751)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: glucagon-like peptide-1, GLP-1 receptor, area postrema, catecholaminergic neurons, tyrosine hydroxylase, Fos expression, autonomic regulation, parabrachial nucleus, solitary tract nucleus, ventrolateral medulla, neuroendocrine response, incretins, blood pressure
MeSH terms: Glucagon-Like Peptide-1 Receptor, Exenatide, Animals, Catecholamines, Cell Line, Central Nervous System, Glucagon, Immunohistochemistry, Male, Neurons, Peptide Fragments, Peptides, Protein Precursors, RNA, Messenger, Tyrosine 3-Monooxygenase, Venoms, Transcriptional Activation, Rats, Sprague-Dawley, In Situ Hybridization, Solitary Nucleus, Autonomic Pathways, Receptors, Glucagon, Area Postrema, Rats, Glucagon-Like Peptide 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glucagon-Like Peptide-1-Responsive Catecholamine Neurons in the Area Postrema Link Peripheral Glucagon-Like Peptide-1 with Central Autonomic Control Sites

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks