Cited by 430Neuropeptides and Animal PhysiologyHeart Rate Variability and Autonomic ControlRegulation of Appetite and Obesity

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

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Yamamoto, Hiroshi, Lee, Charlotte E., Marcus, Jacob N., Williams, Todd D., Overton, J. Michael, Lopez, Marisol E., Hollenberg, Anthony N., Baggio, Laurie +3 more·2002·Journal of Clinical Investigation

Abstract

Glucagon-like peptide-1 (GLP-1) released from the gut functions as an incretin that stimulates insulin secretion.GLP-1 is also a brain neuropeptide that controls feeding and drinking behavior and gastric emptying and elicits neuroendocrine responses including development of conditioned taste aversion.Although GLP-1 receptor (GLP-1R) agonists are under development for the treatment of diabetes, GLP-1 administration may increase blood pressure and heart rate in vivo.We report here that centrally and peripherally administered GLP-1R agonists dose-dependently increased blood pressure and heart rate.GLP-1R activation induced c-fos expression in the adrenal medulla and neurons in autonomic control sites in the rat brain, including medullary catecholamine neurons providing input to sympathetic preganglionic neurons.Furthermore, GLP-1R agonists rapidly activated tyrosine hydroxylase transcription in brainstem catecholamine neurons.These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo.

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Research works printed but not linked: 2

  1. Saper, C.B. 1995. Central autonomic system. Academic Press Inc. San Diego, California, USA. 107-135.
  2. Paxinos, G., and Watson, C. 1997. The rat brain, in stereotaxic coordinates. Compact 3rd edition. Academic Press Inc. San Diego, California, USA. 78 pp.

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Authors
Yamamoto, H., Lee, C. E., Marcus, J. N., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L., Saper, C. B., Drucker, D. J., & Elmquist, J. K.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • Florida State University (US)
  • University of Toronto (CA)
Corresponding author
Elmquist, Joel K.
Venue
Journal of Clinical Investigation
Published
2002-07-01
Volume
110
Issue
1
Pages
43-52
ISSN
0021-9738 (ISSN-L)
OpenAlex
W4252795044
Cited by
429
References
44
Citations by year
2026: 11 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 14 · 2021: 19 · 2020: 16 · 2019: 15 · 2018: 13 · 2017: 18 · 2016: 21 · 2015: 25 · 2014: 30 · 2013: 32 · 2012: 30
FWCI
4.30
Type
journal article
Language
en
Open access
Locations
Journal of Clinical Investigation (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
glucagon-like peptide-1, GLP-1 receptor agonists, blood pressure, heart rate, autonomic regulation, sympathetic nervous system, catecholaminergic neurons, adrenal medulla, Fos expression, tyrosine hydroxylase, brainstem, cardiovascular response, incretins

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