The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
CXCR4 Regulates Interneuron Migration in the Developing Neocortex
Open accessAbstract
The chemotactic factors directing interneuron migration during cerebrocortical development are essentially unknown. Here we identify the CXC chemokine receptor 4 (CXCR4) in interneuron precursors migrating from the basal forebrain to the neocortex and demonstrate that stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for isolated striatal precursors. In addition, we show that CXCR4 is present in early generated Cajal-Retzius cells of the cortical marginal zone. In mice with a null mutation in CXCR4 or SDF-1, interneurons were severely underrepresented in the superficial layers and ectopically placed in the deep layers of the neocortex. In contrast, the submeningeal positioning of Cajal-Retzius cells was unaffected. Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development.
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Cites
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
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Self-citationThe chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
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Self-citationA highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
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Guidance of Primordial Germ Cell Migration by the Chemokine SDF-1
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Deverman, B. E., & Patterson, P. H. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.002 · Cited by 865
Fused cerebral organoids model interactions between brain regions
Bagley, J. A., Reumann, D., Bian, S., Lévi-Strauss, J., & Knoblich, J. A. (2017) · Nature Methods · doi:10.1038/nmeth.4304 · Cited by 790
The immune system and developmental programming of brain and behavior
Bilbo, S. D., & Schwarz, J. M. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.08.006 · Cited by 580
Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia
Meyer, U., Feldon, J., Schedlowski, M., & Yee, B. K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.012 · Cited by 494
Metadata
- Authors
- Stumm, R. K., Zhou, C., Ara, T., Lazarini, F., Dubois-Dalcq, M., Nagasawa, T., Höllt, V., & Schulz, S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-06-15
- Volume
- 23
- Issue
- 12
- Pages
- 5123-5130
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1857372604
- Cited by
- 450
- References
- 39
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stumm, R. K., Zhou, C., Ara, T., Lazarini, F., Dubois-Dalcq, M., Nagasawa, T., Höllt, V., & Schulz, S. (2003). CXCR4 Regulates Interneuron Migration in the Developing Neocortex. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-12-05123.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
