The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Integrin Requirement for Hippocampal Synaptic Plasticity and Spatial Memory
Open accessAbstract
The establishment of memory requires coordinated signaling between presynaptic and postsynaptic terminals in the CNS. The integrins make up a large family of cell adhesion receptors that are known to mediate bidirectional signaling between cells or between cells and their external environment. We show here that many different integrins, including alpha3 and alpha5, are expressed broadly in the adult mouse brain and are associated with synapses. Mice with genetically reduced expression of alpha3 integrin fail to maintain long-term potentiation (LTP) generated in hippocampal CA1 neurons. Mice with reduced expression of the alpha3 and alpha5 integrins exhibit a defect in paired-pulse facilitation. Mice with reduced expression of alpha3, alpha5, and alpha8 are defective in hippocampal LTP and spatial memory in the water maze but have normal fear conditioning. These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Differential signaling via the same axon of neocortical pyramidal neurons
Markram, H., Wang, Y., & Tsodyks, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5323 · Cited by 1,102
Target-cell-specific facilitation and depression in neocortical circuits
Reyes, A., Lujan, R., Rozov, A., Burnashev, N., Somogyi, P., & Sakmann, B. (1998) · Nature Neuroscience · doi:10.1038/1092 · Cited by 716 · cited 1×
“DG, Dentate gyrus; CC corpus callosum; Slu, stratum lucidum. significant role in modulating transmitter release at the presynaptic terminals (Davis and Murphey, 1993; Markram et al., 1998; Reyes et al., 1998; Scanziani et al., 1998).”
BackgroundLearning deficit in BDNF mutant mice.
Linnarsson, S., Björklund, A., & Ernfors, P. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01687.x · Cited by 471
Time-Dependent Reversal of Long-Term Potentiation by an Integrin Antagonist
Stäubli, U., Chun, D., & Lynch, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03460.1998 · Cited by 205
Target cell-specific modulation of transmitter release at terminals from a single axon
Scanziani, M., Gähwiler, B. H., & Charpak, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.12004 · Cited by 167
Cited by
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708
Unraveling mechanisms of homeostatic synaptic plasticity
Pozo, K., & Goda, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.028 · Cited by 565
OLFACTORY MEMORY FORMATION IN DROSOPHILA: From Molecular to Systems Neuroscience
Davis, R. L. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135651 · Cited by 543
Self-citationMatrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R. M., Silva, A. J., Kaczmarek, L., & Huntley, G. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4359-05.2006 · Cited by 499
Metadata
- Authors
- Chan, C.-S., Weeber, E. J., Kurup, S., Sweatt, J. D., & Davis, R. L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-08-06
- Volume
- 23
- Issue
- 18
- Pages
- 7107-7116
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1622692223
- Cited by
- 204
- References
- 8
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Integrin Requirement for Hippocampal Synaptic Plasticity and Spatial Memory. https://app.cochat.ai/papers/10.1523/jneurosci.23-18-07107.2003
- The paper
- Chan, C.-S., Weeber, E. J., Kurup, S., Sweatt, J. D., & Davis, R. L. (2003). Integrin Requirement for Hippocampal Synaptic Plasticity and Spatial Memory. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-18-07107.2003
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
