Unraveling mechanisms of homeostatic synaptic plasticity
Open accessAbstract
Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of synaptic strength regulation, and in contrast to the popular view of homeostatic plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity.
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Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.
“Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.11, 12, 13, 14, 15”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [14]
The Introduction describes activity-dependent changes in synaptic strength and their role in maintaining network stability. The Excitatory-inhibitory balance section also notes synapse remodeling in developing networks. Our copy does not establish the claimed importance of dendritic morphogenesis or synaptogenesis for developing and maintaining functional networks. (LLM, conf=0.84)
Experimental — accuracy not yet measuredKv7 channels furnish a non-inactivating M-current that stabilizes the axon initial segment; redistribution or pharmacologic enhancement reduces spurious spiking and limits burst afterdepolarizations.
“Kv7 channels furnish a non-inactivating M-current that stabilizes the axon initial segment; redistribution or pharmacologic enhancement reduces spurious spiking and limits burst afterdepolarizations [360,362].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [360]
The Excitatory-inhibitory balance section mentions developmental changes in the spatial distribution of ion channels and intrinsic excitability, but does not identify Kv7 channels. Searches for Kv7, M-current, the axon initial segment, and burst afterdepolarizations found no passage addressing the claimed mechanism or effects; page numbers were unavailable in our copy. (LLM, conf=0.76)
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Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery
Tanaka, M. (2026) · Biomedicines · doi:10.3390/biomedicines14061265
- Authors
- Pozo, K., & Goda, Y.
- Affiliations
- MRC Laboratory for Molecular Cell Biology (GB)
- Corresponding author
- Goda, Yukiko
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 66
- Issue
- 3
- Pages
- 337-351
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3021747
- OpenAlex
- W2010356589
- Cited by
- 565
- References
- 176
- Citations by year
- 2026: 20 · 2025: 41 · 2024: 19 · 2023: 29 · 2022: 29 · 2021: 33 · 2020: 37 · 2019: 31 · 2018: 36 · 2017: 31 · 2016: 31 · 2015: 40 · 2014: 34 · 2013: 47 · 2012: 54
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- homeostatic plasticity, synaptic homeostasis, negative feedback, neuronal excitation, neuronal inhibition, synaptic efficacy, molecular mechanisms, cellular mechanisms
- MeSH terms
- Animals, Homeostasis, Models, Neurological, Nerve Net, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses
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