The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Impaired Long-Term Memory and NR2A-Type NMDA Receptor-Dependent Synaptic Plasticity in Mice Lacking c-Fos in the CNS
Open accessAbstract
The immediate early gene c-fos is part of the activator protein-1 transcription factor and has been postulated to participate in the molecular mechanisms of learning and memory. To test this hypothesis in vivo, we generated mice with a nervous system-specific c-fos knock-out using the Cre-loxP system. Adult mice lacking c-Fos in the CNS (c-fosΔCNS) showed normal general and emotional behavior but were specifically impaired in hippocampus-dependent spatial and associative learning tasks. These learning deficits correlated with a reduction of long-term potentiation (LTP) in hippocampal CA3-CA1 synapses. The magnitude of LTP was restored by a repeated tetanization procedure, suggesting impaired LTP induction in c-fosΔCNS mice. This rescue was blocked by a selective inhibitor of NR2B-type NMDA receptors. This blockade was compensated in wild-type mice by NR2A-type NMDA receptor-activated signaling pathways, thus indicating that these pathways are compromised in c-fosΔCNS mice. In summary, our data suggest a role for c-Fos in hippocampus-dependent learning and memory as well as in NMDA receptor-dependent LTP formation.
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Cites
Place navigation impaired in rats with hippocampal lesions
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Short-Term Synaptic Plasticity
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Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
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Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
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Self-citationThe essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
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“Because NMDA receptors are necessary for LTP induction at CA1 synapses (Nicoll et al., 1988; Tsien et al., 1996), we examined the expression of NMDA receptor Received April 7, 2003; revised July 18, 2003; accepted July 24, 2003.”
BackgroundExtrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
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Short-Term Synaptic Plasticity
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Cited by
Regulation of histone acetylation during memory formation in the hippocampus
Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131
Flavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832
CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation
Korzus, E., Rosenfeld, M. G., & Mayford, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.002 · Cited by 823
Saura, C. A., Choi, S.-Y., Beglopoulos, V., Malkani, S., Zhang, D., Rao, B. S. S., Chattarji, S., Kelleher, R. J., Kandel, E. R., Duff, K., et al. (2004) · Neuron · doi:10.1016/s0896-6273(04)00182-5 · Cited by 757
Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R. M., Izquierdo, I., & Medina, J. H. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.025 · Cited by 633
Metadata
- Authors
- Fleischmann, A., Hvalby, O., Jensen, V., Strekalova, T., Zacher, C., Layer, L. E., Kvello, A., Reschke, M., Spanagel, R., Sprengel, R., Wagner, E. F., & Gass, P.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-10-08
- Volume
- 23
- Issue
- 27
- Pages
- 9116-9122
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1675950512
- Cited by
- 381
- References
- 41
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Fleischmann, A., Hvalby, O., Jensen, V., Strekalova, T., Zacher, C., Layer, L. E., Kvello, A., Reschke, M., Spanagel, R., Sprengel, R., Wagner, E. F., & Gass, P. (2003). Impaired Long-Term Memory and NR2A-Type NMDA Receptor-Dependent Synaptic Plasticity in Mice Lacking c-Fos in the CNS. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-27-09116.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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