Cited by 633Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus

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Bekinschtein, Pedro, Cammarota, Martín, Igaz, Lionel Müller, Bevilaqua, Lia R.M., Izquierdo, Iván, Medina, Jorge H.·2007·Neuron

Abstract

Persistence is the most characteristic attribute of long-term memory (LTM). To understand LTM, we must understand how memory traces persist over time despite the short-lived nature and rapid turnover of their molecular substrates. It is widely accepted that LTM formation is dependent upon hippocampal de novo protein synthesis and Brain-Derived Neurotrophic Factor (BDNF) signaling during or early after acquisition. Here we show that 12 hr after acquisition of a one-trial associative learning task, there is a novel protein synthesis and BDNF-dependent phase in the rat hippocampus that is critical for the persistence of LTM storage. Our findings indicate that a delayed stabilization phase is specifically required for maintenance, but not formation, of the memory trace. We propose that memory formation and memory persistence share some of the same molecular mechanisms and that recurrent rounds of consolidation-like events take place in the hippocampus for maintenance of the memory trace.

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Crossref · 10.1016/j.neuron.2006.11.025

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  • Following inhibitory avoidance training in rats, late peaks in BDNF expression and C/EBP expression occur at about 12 hours post-training, and inhibiting BDNF action at this time blocks memory maintenance.

    “Following inhibitory avoidance training in rats, late peaks in brain-derived neurotrophic factor (BDNF) expression and in C/EBP expression occur at ~12 hours post-training, and inhibiting BDNF action at this time blocks memory maintenance59.”
  • In the hippocampus, CREB and C/EBP can remain active for many hours after learning.

    “Recent data also illustrate that, in the hippocampus, CREB and CCAAT enhancer-binding protein (C/EBP), another transcription factor that is important for LTP, can remain active for many hours after learning.”

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Authors
Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R. M., Izquierdo, I., & Medina, J. H.
Affiliations
  • Universidad de Buenos Aires (AR)
  • Pontifícia Universidade Católica do Rio Grande do Sul (BR)
Corresponding author
Medina, Jorge H.
Venue
Neuron
Publisher
Elsevier BV
Published
2007-01
Volume
53
Issue
2
Pages
261-277
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2029712849
Cited by
633
References
126
Citations by year
2026: 12 · 2025: 15 · 2024: 24 · 2023: 29 · 2022: 25 · 2021: 32 · 2020: 25 · 2019: 37 · 2018: 34 · 2017: 33 · 2016: 41 · 2015: 46 · 2014: 47 · 2013: 60 · 2012: 38
FWCI
18.32
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
long-term memory, memory persistence, hippocampus, de novo protein synthesis, BDNF signaling, memory consolidation, associative learning, memory maintenance
MeSH terms
Animals, Avoidance Learning, Conditioning, Psychological, Fear, Learning, Male, Memory, Nerve Tissue Proteins, Swimming, Time Factors, Rats, Wistar, Maze Learning, Brain-Derived Neurotrophic Factor, Rats

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