CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation
Open accessAbstract
The stabilization of learned information into long-term memories requires new gene expression. CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a histone acetyltransferase (HAT) that alters chromatin structure. To dissect the chromatin remodeling versus platform function of CBP or the developmental versus adult role of this gene, we generated transgenic mice that express CBP in which HAT activity is eliminated. Acquisition of new information and short-term memory is spared in these mice, while the stabilization of short-term memory into long-term memory is impaired. The behavioral phenotype is due to an acute requirement for CBP HAT activity in the adult as it is rescued by both suppression of transgene expression or by administration of the histone deacetylase inhibitor Trichostatin A (TSA) in adult animals.
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CBP is required for the consolidation of long-term memory.
“CBP is also required for the consolidation of long-term memory93.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [93]
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- Authors
- Korzus, E., Rosenfeld, M. G., & Mayford, M.
- Affiliations
- Scripps Research Institute (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Korzus, Edward
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 42
- Issue
- 6
- Pages
- 961-972
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC8048715
- OpenAlex
- W2046244011
- Cited by
- 823
- References
- 68
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 27 · 2023: 23 · 2022: 26 · 2021: 29 · 2020: 25 · 2019: 35 · 2018: 18 · 2017: 40 · 2016: 57 · 2015: 39 · 2014: 63 · 2013: 62 · 2012: 51
- FWCI
- 15.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3333 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K01 MH01785)
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- CREB-binding protein, histone acetyltransferase activity, memory consolidation, long-term memory, short-term memory, chromatin remodeling, transcriptional coactivator, histone deacetylase inhibitors, trichostatin A, transgenic mice, neuronal gene expression
- MeSH terms
- Acetyltransferases, Animals, Behavior, Animal, Conditioning, Psychological, Fear, Hippocampus, Hydroxamic Acids, Immunohistochemistry, Memory, Memory Disorders, Mice, Mutant Strains, Mice, Transgenic, Motor Activity, Neurons, Nuclear Proteins, Protein Synthesis Inhibitors, Psychomotor Performance, RNA, Messenger, Trans-Activators, Gene Expression, Genes, fos, In Situ Hybridization, Maze Learning, Reverse Transcriptase Polymerase Chain Reaction, CREB-Binding Protein, Mice, Histone Acetyltransferases
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