Cited by 823Memory and Neural MechanismsGenomics and Chromatin DynamicsNeuroscience and Neuropharmacology Research

CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation

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Korzus, Edward, Rosenfeld, Michael G, Mayford, Mark·2004·Neuron

Abstract

The stabilization of learned information into long-term memories requires new gene expression. CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a histone acetyltransferase (HAT) that alters chromatin structure. To dissect the chromatin remodeling versus platform function of CBP or the developmental versus adult role of this gene, we generated transgenic mice that express CBP in which HAT activity is eliminated. Acquisition of new information and short-term memory is spared in these mice, while the stabilization of short-term memory into long-term memory is impaired. The behavioral phenotype is due to an acute requirement for CBP HAT activity in the adult as it is rescued by both suppression of transgene expression or by administration of the histone deacetylase inhibitor Trichostatin A (TSA) in adult animals.

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Crossref · 10.1016/j.neuron.2004.06.002

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Authors
Korzus, E., Rosenfeld, M. G., & Mayford, M.
Affiliations
  • Scripps Research Institute (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Korzus, Edward
Venue
Neuron
Publisher
Elsevier BV
Published
2004-06
Volume
42
Issue
6
Pages
961-972
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2046244011
Cited by
823
References
68
Citations by year
2026: 17 · 2025: 12 · 2024: 27 · 2023: 23 · 2022: 26 · 2021: 29 · 2020: 25 · 2019: 35 · 2018: 18 · 2017: 40 · 2016: 57 · 2015: 39 · 2014: 63 · 2013: 62 · 2012: 51
FWCI
15.30
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (K01 MH01785)
  • National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
CREB-binding protein, histone acetyltransferase activity, memory consolidation, long-term memory, short-term memory, chromatin remodeling, transcriptional coactivator, histone deacetylase inhibitors, trichostatin A, transgenic mice, neuronal gene expression
MeSH terms
Acetyltransferases, Animals, Behavior, Animal, Conditioning, Psychological, Fear, Hippocampus, Hydroxamic Acids, Immunohistochemistry, Memory, Memory Disorders, Mice, Mutant Strains, Mice, Transgenic, Motor Activity, Neurons, Nuclear Proteins, Protein Synthesis Inhibitors, Psychomotor Performance, RNA, Messenger, Trans-Activators, Gene Expression, Genes, fos, In Situ Hybridization, Maze Learning, Reverse Transcriptase Polymerase Chain Reaction, CREB-Binding Protein, Mice, Histone Acetyltransferases

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