The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance
Open accessAbstract
The ability to develop counter-regulatory mechanisms to maintain energy balance in response to environmental and physiologic insults is essential for survival, but the mechanisms underlying these compensatory regulations are poorly understood. Agouti-related peptide (AGRP) and Neuropeptide Y are potent orexigens and are coexpressed in neurons in the arcuate nucleus of the hypothalamus. Acute ablation of these neurons leads to severe anorexia and weight loss, whereas progressive degeneration of these neurons has minimal impact on food intake and body weight, suggesting that compensatory mechanisms are developed to maintain orexigenic drive. In this study, we show that cell proliferation is increased in the hypothalamus of adult mutant animals in which AgRP neurons undergo progressive neurodegeneration due to deletion of mitochondrial transcription factor A, and that a subset of these newly generated cells differentiate into AgRP neurons along with other resident neuronal subtypes. Furthermore, some of the newly generated cells are capable of responding to leptin, and a central blockade of cell proliferation in adult animals results in decreases in food intake and body adiposity in mutant but not in control animals. Our study indicates that neurons important for energy homeostasis can be regenerated in adult feeding centers under neurodegenerative conditions. It further suggests that de novo neurogenesis might serve as a compensatory mechanism contributing to the plastic control of energy balance in response to environmental and physiologic insults.
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Cites
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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
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Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
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“The redundant wiring and differential regulation of Pomc and MC4R neurons provide another safeguarding mechanism to ensure sufficient inhibition of anorexigenic drive.”
BackgroundInfluentialPI3K integrates the action of insulin and leptin on hypothalamic neurons
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Cited by
Hill, A. S., Sahay, A., & Hen, R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.85 · Cited by 557
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3079 · Cited by 502
The cellular and molecular bases of leptin and ghrelin resistance in obesity
Cui, H., López, M., & Rahmouni, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.222 · Cited by 477
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
Huang, H.-S., Allen, J. A., Mabb, A. M., King, I. F., Miriyala, J., Taylor-Blake, B., Sciaky, N., Dutton, J. W., Lee, H.-M., Chen, X., et al. (2012) · Nature · doi:10.1038/nature10726 · Cited by 387
Neurotransmitter Switching in the Adult Brain Regulates Behavior
Dulcis, D., Jamshidi, P., Leutgeb, S., & Spitzer, N. C. (2013) · Science · doi:10.1126/science.1234152 · Cited by 317
Metadata
- Authors
- Pierce, A. A., & Xu, A. W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-01-13
- Volume
- 30
- Issue
- 2
- Pages
- 723-730
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2106189359
- Cited by
- 223
- References
- 9
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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