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Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction

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Anglada-Figueroa, David, Quirk, Gregory J.·2005·The Journal of Neuroscience

DOI 10.1523/jneurosci.2600-05.2005PMC PMC6725741

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Abstract

Although the role of the amygdala in acquisition of conditioned fear is well established, there is debate concerning the intra-amygdala circuits involved. The lateral nucleus of the amygdala (LA) is thought to be an essential site of plasticity in fear conditioning. The LA has both direct and indirect [via the basal nuclei; basal amygdala (BA)] projections to the central nucleus (Ce) of the amygdala, an essential output for fear behaviors. Lesions of the LA or Ce prevent acquisition of conditioned freezing to a conditioned stimulus, but BA lesions do not, suggesting that the BA is not normally involved in fear conditioning. If true, posttraining BA lesions should also have no effect. Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also showed normal long-term retention and extinction of conditioned fear. Unexpectedly, BA lesions made after training completely blocked expression of conditioned fear. Despite this deficit, lesioned rats were able to learn a new tone-shock association. Thus, although the LA-Ce system is sufficient for fear acquisition in the absence of the BA, it is not sufficient when the BA is present, suggesting that the BA is an important site of plasticity in fear conditioning. The pattern of lesion deficits we observed (after but not before training) might be explained by homeostatic mechanisms that balance plasticity over multiple inputs, regulating the influence of the BA and LA onto Ce output neurons.

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Authors: Anglada-Figueroa, D., & Quirk, G. J.
Affiliations: Ponce Health Sciences University (PR)
Corresponding author: Quirk, Gregory J.
ORCID: Quirk, Gregory J.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2005-10-19
Volume: 25
Issue: 42
Pages: 9680-9685
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.2600-05.2005
PMC: PMC6725741
OpenAlex: W2079935199
Cited by: 238
References: 58
Citations by year: 2026: 2 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 15 · 2019: 15 · 2018: 9 · 2017: 7 · 2016: 14 · 2015: 16 · 2014: 15 · 2013: 18 · 2012: 12
FWCI: 7.94
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5s06gm008239-23)
National Institute of Mental Health (R01-MH-58883, R01MH058883)
National Institute of General Medical Sciences (S06 GM-08239, S06-GM 008239)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: basal amygdala, fear conditioning, fear extinction, lateral amygdala, central amygdala, amygdala lesions, fear expression, homeostatic plasticity
MeSH terms: Amygdala, Animals, Conditioning, Psychological, Extinction, Psychological, Fear, Male, Rats, Sprague-Dawley, Rats

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Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction

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