The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Retrograde Regulation of GABA Transmission by the Tonic Release of Oxytocin and Endocannabinoids Governs Postsynaptic Firing
Open accessAbstract
The probability of neurotransmitter release at the nerve terminal is an important determinant of synaptic efficacy. At some central synapses, the postsynaptic, or target, neuron determines neurotransmitter release probability (Pr) at the presynaptic terminal. The mechanisms responsible for this target-cell dependent control of Pr have not been elucidated. Using whole-cell patch-clamp recordings from magnocellular neurosecretory cells in the paraventricular and supraoptic nuclei of the hypothalamus, we demonstrate that inhibitory, GABA synapses specifically onto oxytocin (OT)-producing neurosecretory cells exhibit a low Pr that is relatively uniform at multiple synapses onto the same cell. This low Pr results from a two-step process that requires the tonic release of OT from the postsynaptic cell. The ambient extracellular levels of neuropeptide are sufficient to activate postsynaptic OT receptors and trigger the Ca 2+-dependent production of endocannabinoids, which act in a retrograde manner at presynaptic cannabinoid CB 1 receptors to decrease GABA release. The functional consequence of this tonic inhibition of GABA release is that all inhibitory inputs facilitate uniformly when activated at high rates of activity. This causes inhibition in the postsynaptic cell that is sufficiently powerful to disrupt firing. Blockade of CB 1 receptors increases Pr at these synapses, resulting in a rapid depression of IPSCs at high rates of activity, thereby eliminating the ability of afferent inputs to inhibit postsynaptic firing. By playing a deterministic role in GABA release at the afferent nerve terminal, the postsynaptic OT neuron effectively filters synaptic signals and thereby modulates its own activity patterns.
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“oxytocin signalling controls the probability of presynaptic GABA release through the postsynaptic release of endocannabinoids and the activation of presynaptic CB1 receptors50.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [50]
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Cites
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Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
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Target-cell-specific facilitation and depression in neocortical circuits
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“Although targetcell-dependent modulation of GABA release probability has been reported previously (Reyes et al., 1998; Gupta et al., 2000; Rozov et al., 2001; Koester and Johnston, 2005), there have been few descriptions of the mechanisms used by individual postsynaptic neurons to regulate Pr.”
BackgroundHeterosynaptic LTD of Hippocampal GABAergic Synapses
Chevaleyre, V., & Castillo, P. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00235-6 · Cited by 647
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Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,595
Endocannabinoid Signaling and Synaptic Function
Castillo, P. E., Younts, T. J., Chávez, A. E., & Hashimotodani, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.020 · Cited by 1,191
“Tonic signaling can be observed as an increase in basal synaptic transmission after pharmacological blockade of CB 1 Rs (Auclair et al., 2000; Hentges et al., 2005; Losonczy et al., 2004; Neu et al., 2007; Oliet et al., 2007; Slanina and Schweitzer, 2005; Zhu and Lovinger, 2010).”
BackgroundMultiple Functions of Endocannabinoid Signaling in the Brain
Katona, I., & Freund, T. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150420 · Cited by 630
“…receptors OX1 and OX2 (Haj-Dahmane and Shen, 2005), endothelin-1 and its ETA receptor (Zampronio et al., 2010), oxytocin and its OT receptor (Oliet et al., 2007) or ghrelin and its receptor (Kola et al., 2008), and then regulate feed-back hormonal responses via the modification of synaptic…”
BackgroundCB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity
Busquets-García, A., Bains, J. S., & Marsicano, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.206 · Cited by 365
“This has been demonstrated in hypothalamus where blockade of CB1 receptors increases Pr at GABA synapses, but weakens inhibition to the postsynaptic neuron when GABA inputs are recruited at a high frequency (Oliet et al, 2007).”
BackgroundSelf-citationFerguson, A. V., Latchford, K. J., & Samson, W. K. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.6.717 · Cited by 316
“Although they will not be discussed in-depth here it should also be emphasized that recent studies have also highlighted important roles for both dendritic release of peptides produced in the PVN neurons [11,12] , and glial cell release of amino acid signaling molecules [13] in shaping the integrated outputs of the PV…”
Background
Metadata
- Authors
- Oliet, S. H. R., Baimoukhametova, D. V., Piet, R., & Bains, J. S.
- Affiliations
- Inserm (FR)
- University of Calgary (CA)
- Université Bordeaux Segalen (FR)
- Corresponding author
- Bains, Jaideep S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-02-07
- Volume
- 27
- Issue
- 6
- Pages
- 1325-1333
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673587
- OpenAlex
- W2091992063
- Cited by
- 107
- References
- 64
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 8
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondation pour la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- retrograde regulation, oxytocin, endocannabinoids, CB1 receptor, postsynaptic inhibition, presynaptic inhibition, magnocellular neurosecretory cells, paraventricular nucleus, supraoptic nucleus, hypothalamus, inhibitory synapses
- MeSH terms
- Animals, Calcium, Egtazic Acid, Female, gamma-Aminobutyric Acid, Hypothalamus, Anterior, Male, Morpholines, Naphthalenes, Oxytocin, Paraventricular Hypothalamic Nucleus, Piperidines, Pyrazoles, Rats, Sprague-Dawley, Rats, Wistar, Presynaptic Terminals, Patch-Clamp Techniques, 6-Cyano-7-nitroquinoxaline-2,3-dione, Receptor, Cannabinoid, CB1, Extracellular Fluid, Benzoxazines, Rats, Cannabinoid Receptor Modulators, Endocannabinoids
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