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The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
Open accessAbstract
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
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“Yet another example is the consequence of having the Val66Met allele of the BDNF gene on hippocampal volume, memory and mood disorders (Hariri et al., 2003; Pezawas et al., 2004; Jiang et al., 2005; Szeszko et al., 2005).”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Pezawas et al., 2004
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“Yet another example is the consequence of having the Val66Met allele of the brain-derived neurotrophic factor (BDNF) gene on hippocampal volume, memory, and mood disorders.54-57”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [56]
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Metadata
- Authors
- Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-11-10
- Volume
- 24
- Issue
- 45
- Pages
- 10099-10102
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6730170
- OpenAlex
- W2013373204
- Cited by
- 890
- References
- 27
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 12 · 2023: 18 · 2022: 23 · 2021: 22 · 2020: 30 · 2019: 29 · 2018: 20 · 2017: 32 · 2016: 42 · 2015: 47 · 2014: 71 · 2013: 58 · 2012: 76
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, cortical morphology, hippocampus, prefrontal cortex, brain structure, learning and memory
- MeSH terms
- Adolescent, Adult, Alleles, Female, Hippocampus, Humans, Learning, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuronal Plasticity, Organ Size, Polymorphism, Genetic, Genetic Variation, Prefrontal Cortex, Brain-Derived Neurotrophic Factor, Amino Acid Substitution, Imaging, Three-Dimensional
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