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The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology

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Pezawas, Lukas, Verchinski, Beth A., Mattay, Venkata S., Callicott, Joseph H., Kolachana, Bhaskar S., Straub, Richard E., Egan, Michael F., Meyer-Lindenberg, Andreas, Weinberger, Daniel R.·2004·The Journal of Neuroscience

DOI 10.1523/jneurosci.2680-04.2004PMC PMC6730170

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Abstract

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

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Authors: Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R.
Affiliations: National Institutes of Health (US)
ORCID: Pezawas, Lukas
Mattay, Venkata S.
Callicott, Joseph H.
Kolachana, Bhaskar S.
Straub, Richard E.
Egan, Michael F.
Weinberger, Daniel R.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2004-11-10
Volume: 24
Issue: 45
Pages: 10099-10102
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.2680-04.2004
PMC: PMC6730170
OpenAlex: W2013373204
Cited by: 890
References: 27
Citations by year: 2026: 9 · 2025: 19 · 2024: 12 · 2023: 18 · 2022: 23 · 2021: 22 · 2020: 30 · 2019: 29 · 2018: 20 · 2017: 32 · 2016: 42 · 2015: 47 · 2014: 71 · 2013: 58 · 2012: 76
FWCI: 11.51
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords: brain-derived neurotrophic factor, BDNF Val66Met polymorphism, cortical morphology, hippocampus, prefrontal cortex, brain structure, learning and memory
MeSH terms: Adolescent, Adult, Alleles, Female, Hippocampus, Humans, Learning, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuronal Plasticity, Organ Size, Polymorphism, Genetic, Genetic Variation, Prefrontal Cortex, Brain-Derived Neurotrophic Factor, Amino Acid Substitution, Imaging, Three-Dimensional

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The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology

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