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Cited by 199

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus

Open access
Mizoguchi, Hiroyuki, Nakade, Junya, Tachibana, Masaki, Ibi, Daisuke, Someya, Eiichi, Koike, Hiroyuki, Kamei, Hiroyuki, Nabeshima, Toshitaka, Itohara, Shigeyoshi, Takuma, Kazuhiro, Sawada, Makoto, Sato, Jun, Yamada, Kiyofumi·2011·The Journal of Neuroscience
DOI 10.1523/jneurosci.3118-11.2011
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Abstract

Recurrent seizure activity has been shown to induce a variety of permanent structural changes in the brain. Matrix metalloproteinases (MMPs) function to promote neuronal plasticity, primarily through cleavage of extracellular matrix proteins. Here, we investigated the role of MMP-9 in the development of pentylenetetrazole (PTZ)-induced kindled seizure in mice. Repeated treatment with PTZ (40 mg/kg) produced kindled seizure, which was accompanied by enhanced MMP-9 activity and expression in the hippocampus. No change in MMP-9 activity was observed in the hippocampi of mice with generalized tonic seizure following single administration of PTZ (60 mg/kg). MMP-9 colocalized with the neuronal marker NeuN and the glial marker GFAP in the dentate gyrus of the kindled mouse hippocampus. Coadministration of diazepam or MK-801 with PTZ inhibited the development of kindling and the increased MMP-9 levels in the hippocampus. Marked suppression of kindled seizure progression in response to repeated PTZ treatment was observed in MMP-9(−/−)mice compared with wild-type mice, an observation that was accompanied by decreased hippocampal levels of mature brain-derived neurotrophic factor. Microinjecting the BDNF scavenger TrkB-Fc into the right ventricle before each PTZ treatment significantly suppressed the development of kindling in wild-type mice, whereas no effect was observed in MMP-9(−/−)mice. On the other hand, bilateral injections of pro-BDNF into the hippocampal dentate gyrus significantly enhanced kindling in wild-type mice but not MMP-9(−/−)mice. These findings suggest that MMP-9 is involved in the progression of behavioral phenotypes in kindled mice because of conversion of pro-BDNF to mature BDNF in the hippocampus.

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Metadata

Authors
Mizoguchi, H., Nakade, J., Tachibana, M., Ibi, D., Someya, E., Koike, H., Kamei, H., Nabeshima, T., Itohara, S., Takuma, K., Sawada, M., Sato, J., & Yamada, K.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2011-09-07
Volume
31
Issue
36
Pages
12963-12971
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.3118-11.2011
OpenAlex
W2070308471
Cited by
199
References
10
FWCI
6.89
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus. https://app.cochat.ai/papers/10.1523/jneurosci.3118-11.2011
The paper
Mizoguchi, H., Nakade, J., Tachibana, M., Ibi, D., Someya, E., Koike, H., Kamei, H., Nabeshima, T., Itohara, S., Takuma, K., Sawada, M., Sato, J., & Yamada, K. (2011). Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.3118-11.2011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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