The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders
Open accessAbstract
Antiretroviral therapy has increased the life span of HIV+ individuals; however, HIV-associated neurocognitive disorder (HAND) occurrence is increasing in aging HIV patients. Previous studies suggest HIV infection alters autophagy function in the aging CNS and HIV-1 proteins affect autophagy in monocyte-derived cells. Despite these findings, the mechanisms leading to dysregulated autophagy in the CNS remain unclear. Here we sought to determine how HIV Tat dysregulates autophagy in neurons. Tat caused a dose-dependent decrease in autophagosome markers, microtubule-associated protein-1 light chain β II (LC3II), and sequestosome 1(SQSTM1), in a membrane-enriched fraction, suggesting Tat increases autophagic degradation. Bafilomycin A1 increased autophagosome number, LC3II, and SQSTM1 accumulation; Tat cotreatment diminished this effect. Tat had no effect when 3-methyladenine or knockdown of beclin 1 blocked early stages of autophagy. Tat increased numbers of LC3 puncta and resulted in the formation of abnormal autophagosomes in vitro. Likewise, in vivo studies in GFAP-Tat tg mice showed increased autophagosome accumulation in neurons, altered LC3II levels, and neurodegeneration. These effects were reversed by rapamycin treatment. Tat colocalized with autophagosome and lysosomal markers and enhanced the colocalization of autophagosome with lysosome markers. Furthermore, co-IP studies showed that Tat interacts with lysosomal-associated membrane protein 2A (LAMP2A) in vitro and in vivo, and LAMP2A overexpression reduces Tat-induced neurotoxicity. Hence, Tat protein may induce autophagosome and lysosome fusion through interaction with LAMP2A leading to abnormal neuronal autophagy function and dysregulated degradation of critical intracellular components. Therapies targeting Tat-mediated autophagy alterations may decrease neurodegeneration in aging patients with HAND.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“HIV-TAT can damage lysosome function in microglia and in neuron [46, 75].”
From HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV (2025) · cites this paper as [75]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Crews, L. A., Spencer, B. J., Desplats, P., Patrick, C., Paulino, A., Rockenstein, E. M., Hansen, L. A., Adame, A., Galasko, D. R., & Masliah, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009313 · Cited by 379 · cited 3×
“43 software (NIH), as previously described (Crews et al., 2010).”
BackgroundInfluentialSelf-citationRetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903
Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578 · cited 1×
“LC3II interaction with SQSTM1 mediates selective recruitment of ubiquitylated proteins to the autophagosome (Pankiv et al., 2007).”
BackgroundHeaton, R. K., Clifford, D. B., Franklin, D. R., Woods, S. P., Ake, C., Vaida, F., Ellis, R. J., Letendre, S. L., Marcotte, T. D., Atkinson, J. H., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e318200d727 · Cited by 2,353 · cited 2×
“Modern treatment regimens result in HIV suppression and immune recovery; however, the prevalence of HIV-associated neurocognitive disorders (HAND) and neurodegeneration (Budka et al., 1987; Wiley and Achim, 1994; Gendelman et al., 1997; Cherner et al., 2007; Heaton et al., 2010) has remained the same or increased (Jos…”
BackgroundImpaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024 · cited 5×
“Therefore, Tat may interfere with CMA and thereby indirectly increase macroautophagy function as a feedback mechanism to maintain recycling of neuronal components.”
BackgroundInfluentialExtensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · cited 2×
“Alterations in autophagy pathways have been described in AD (Nixon et al., 2005; Pickford et al., 2008), PD (Cuervo et al.”
BackgroundInfluentialGroups, F. T. C. A. H., Heaton, R. K., Franklin, D. R., Ellis, R. J., McCutchan, J. A., Letendre, S. L., Leblanc, S. K. D., Corkran, S. H., Duarte, N. A., Clifford, D. B., et al. (2010) · Journal of NeuroVirology · doi:10.1007/s13365-010-0006-1 · Cited by 1,521
Naldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11382 · Cited by 1,499 · cited 1×
“Lentiviruses (LVs) were prepared by transient transfection in 293T cells (Naldini et al., 1996a, b; Tiscornia et al., 2006).”
MethodAutophagy: in sickness and in health
Cuervo, A. M. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.12.002 · Cited by 828 · cited 3×
“DOI:10.1523/JNEUROSCI.3207-14.2015 Copyright © 2015 the authors 0270-6474/15/351921-18$15.00/0 Alterations in autophagy pathways have been described in AD (Nixon et al., 2005; Pickford et al., 2008), PD (Cuervo et al., 2004; Crews et al., 2010), and other CNS disorders (Cuervo, 2004).”
BackgroundInfluentialClonal cell lines from the rat central nervous system
Schubert, D. A., Heinemann, S. F., Carlisle, W., Tarikas, H., Kimes, B. W., Patrick, J. W., Steinbach, J. H., Culp, W., & Brandt, B. L. (1974) · Nature · doi:10.1038/249224a0 · Cited by 713 · cited 2×
“B103 rat neuroblastoma cells were used here for the cholinergic and GABAergic phenotypes (Schubert et al., 1974), both of which are implicated in frontal cortex and basal ganglia function (Stocco et al.”
MethodSpencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., & Masliah, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4390-09.2009 · Cited by 595 · cited 2×
“In addition, double-immunolabeling studies were performed as previously described (Spencer et al., 2009) to determine the cellular localization of Tat, LC3, CTSD, and LAMP2A.”
MethodSelf-citationChaperone-Mediated Autophagy Markers in Parkinson Disease Brains
Alvarez‐Erviti, L., Rodríguez-Oroz, M. C., Cooper, J. A. D., Caballero, C., Ferrer, I., Obeso, J. A., & Schapira, A. H. V. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.198 · Cited by 577 · cited 1×
“Conversely, LAMP2A is important for CMA (Cuervo et al., 2004; Bandyopadhyay and Cuervo, 2007; Zhang and Cuervo, 2008; Alvarez-Erviti et al., 2010).”
Canonical and non-canonical autophagy: variations on a common theme of self-eating?
Codogno, P., Mehrpour, M., & Proikas‐Cezanne, T. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3249 · Cited by 565 · cited 1×
“Initially, autophagy-related proteins form a phagophore, which develops into the autophagosome, a double-membrane sac that delivers cytoplasmic material to the lysosomal compartment for degradation (Codogno et al., 2012).”
BackgroundThe apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
González‐Polo, R. A., Boya, P., Pauleau, A., Jalil, A., Larochette, N., Souquère, S., Eskelinen, E., Pierron, G., Säftig, P., & Kroemer, G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02447 · Cited by 532
Zhang, C., & Cuervo, A. M. (2008) · Nature Medicine · doi:10.1038/nm.1851 · Cited by 520 · cited 6×
“Furthermore, LAMP2A is necessary for efficient macroautophagy and chaperone-mediated autophagy (CMA) progression (GonzálezPolo et al., 2005; Zhang and Cuervo, 2008).”
BackgroundInfluentialAutophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
Kyei, G. B., Dinkins, C., Davis, A. S., Roberts, E., Singh, S. B., Dong, C., Wu, L., Kominami, E., Ueno, T., Yamamoto, A., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903070 · Cited by 509 · cited 2×
“Nef, a viral replication facilitator, prevents the destruction of HIV components by autophagolysosomes by inhibiting autophagic maturation in the host cells (Kyei et al., 2009).”
Backgroundβ-Synuclein Inhibits α-Synuclein Aggregation
Hashimoto, M., Rockenstein, E., Mante, M., Mallory, M., & Masliah, E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00462-7 · Cited by 398 · cited 1×
“Immunoprecipitation assays were performed essentially as previously described (Hashimoto et al., 2001).”
MethodSelf-citationStocco, A., Lebiere, C. J., & Anderson, J. R. (2010) · Psychological Review · doi:10.1037/a0019077 · Cited by 383 · cited 2×
“…neuroblastoma cells were used here for the cholinergic and GABAergic phenotypes (Schubert et al., 1974), both of which are implicated in frontal cortex and basal ganglia function (Stocco et al., 2010; Nguyen and Lin, 2014) and relevant to HAND (Masliah et al., 1994; Hesselgesser and Horuk, 1999).”
BackgroundMethodTransient Exposure to HIV-1 Tat Protein Results in Cytokine Production in Macrophages and Astrocytes
Nath, A., Conant, K. E., Chen, P., Scott, C., & Major, E. O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17098 · Cited by 363 · cited 2×
“HIV-1 Tat-induced acute neurotoxicity is enhanced by BafA1, but reversed with Rapam cotreatment or LAMP2A overexpression HIV-1 Tat causes neurodegeneration and neuroinflammation in vitro (Nath et al., 1999; Nath and Steiner, 2014) and in tg mouse models (Kim et al.”
BackgroundBrain pathology induced by infection with the human immunodeficiency virus (HIV)
Budka, H., Costanzi, G., Cristina, S., Lechi, A., Parravicini, C., Trabattoni, R., & Vago, L. (1987) · Acta Neuropathologica · doi:10.1007/bf00687080 · Cited by 317
Chemokine and chemokine receptor expression in the central nervous system
Hesselgesser, J., & Horuk, R. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909029741 · Cited by 286 · cited 11×
“This mechanism could contribute, in concert with other Tat actions, HIV proteins, or inflammatory factors, to neurodegeneration in HAND and reduced neuronal autophagy in aged HIV patients.”
BackgroundMethodInfluentialPickford, F., Masliah, E., Britschgi, M., Lucin, K., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 268 · cited 2×
“Alterations in autophagy pathways have been described in AD (Nixon et al., 2005; Pickford et al., 2008), PD (Cuervo et al.”
BackgroundInfluentialSelf-citationKim, B. O., Liu, Y., Ruan, Y., Xu, Z. C., Schantz, L. D., & He, J. J. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64304-0 · Cited by 248 · cited 5×
“The model is associated with neurodegeneration and neurotoxicity similar to that seen in brains of HIV patients (Kim et al., 2003).”
BackgroundMethodResultInfluentialSelf-citationLAMP-2: A control step for phagosome and autophagosome maturation
Säftig, P., Beertsen, W., & Eskelinen, E. (2008) · Autophagy · doi:10.4161/auto.5724 · Cited by 245 · cited 1×
“Indeed, LAMP2A levels are reduced with age in some organs, and it has been suggested that restoring levels may reverse some aging effects (Saftig and Eskelinen, 2008; Saftig et al., 2008; Zhang and Cuervo, 2008).”
BackgroundWiley, C. A., & Achim, C. L. (1994) · Annals of Neurology · doi:10.1002/ana.410360422 · Cited by 233
Rockenstein, E. M., Mallory, M. E., Mante, M., Sisk, A., & Masliaha, E. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1247 · Cited by 221 · cited 1×
“Grids were analyzed with a Zeiss OM 10 electron microscope as previously described (Rockenstein et al., 2001).”
MethodSelf-citationHIV‐Tat protein induces oxidative and inflammatory pathways in brain endothelium
Toborek, M. J., Lee, Y. W., Pu, H., Małecki, A., Flora, G., Garrido, R., Hennig, B., Bauer, H., & Nath, A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01543.x · Cited by 208
Orenstein, J. M., Alkan, S., Blauvelt, A., Jeang, K., Weinstein, M. D., Ganem, D., & HERNDIER, B. G. (1997) · AIDS · doi:10.1097/00002030-199705000-00001 · Cited by 208
The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes
Shvets, E., Fass, E., Scherz‐Shouval, R., & Elazar, Z. (2008) · Journal of Cell Science · doi:10.1242/jcs.026005 · Cited by 166
Mechanisms of Neuronal Injury and Death in HIV-1 Associated Dementia
Kaul, M., & Lipton, S. A. (2006) · Current HIV Research · doi:10.2174/157016206777709384 · Cited by 165 · cited 2×
“HIV-Tat colocalizes with autophagosome and lysosome markers in neuronal cells and in primary neurons Previous studies have shown that HIV-1 Tat can permeate the cell membrane of neurons and other cells where it may affect organelle function (Kaul and Lipton, 2006; Alirezaei et al., 2007).”
BackgroundResultDisruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration
Alirezaei, M., Kiosses, W. B., Flynn, C. T., Brady, N. R., & Fox, H. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002906 · Cited by 151 · cited 4×
“…HAND are not completely understood; however, recent studies have shown that HIV proteins interfere with clearance pathways such as macroautophagy (Alirezaei et al., 2008a, b; Zhou et al., 2011), a pathway necessary for recycling proteins or defective and older intracellular organelles (Cuervo,…”
BackgroundInfluentialHIV-1 Inhibits Autophagy in Bystander Macrophage/Monocytic Cells through Src-Akt and STAT3
Grol, J. V., Subauste, M. C., Andrade, R. M., Fujinaga, K., Nelson, J. A. E., & Subauste, C. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011733 · Cited by 135 · cited 2×
“HIV-1 Tat suppresses autophagy function in macrophages (Li et al., 2011) and bystander monocytes (Van Grol et al., 2010).”
BackgroundThe neuropathogenesis of the AIDS dementia complex.
Gendelman, H. E., Persidsky, Y., Ghorpade, A., Limoges, J., Stins, M. F., Fiala, M., & Morrisett, R. A. (1997) · PubMed · Cited by 130
Does highly active antiretroviral therapy improve neurocognitive function? A systematic review
Joska, J. A., Gouse, H., Paul, R. H., Stein, D. J., & Flisher, A. J. (2010) · Journal of NeuroVirology · doi:10.3109/13550281003682513 · Cited by 129 · cited 2×
“, 2010) has remained the same or increased (Joska et al., 2010; Heaton et al., 2011), in particular among people over the age of 50.”
BackgroundHIV-1 Tat Causes Apoptotic Death and Calcium Homeostasis Alterations in Rat Neurons
Bonavia, R., Bajetto, A., Barbero, S., Albini, A., Noonan, D. M., & Schettini, G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5743 · Cited by 125 · cited 1×
“…interaction with caspase machinery or NMDA receptors and thereby induce apoptosis, regulate calcium levels, alter glutamate excitotoxicity, and induce chemotaxis in bystander cells (Bonavia et al., 2001; Singh et al., 2005; Hargus and Thayer, 2013; Dalvi et al., 2014; Darbinian et al., 2014).”
BackgroundChaperone-mediated autophagy in aging and neurodegeneration: Lessons from α-synuclein
Bandyopadhyay, U., & Cuervo, A. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.05.019 · Cited by 103
Autophagy Is Increased in Postmortem Brains of Persons With HIV-1-Associated Encephalitis
Zhou, D., Masliah, E., & Spector, S. A. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir163 · Cited by 95 · cited 6×
“Our laboratory recently reported autophagy machinery levels are altered in postmortem brains of HIV patients (Zhou et al., 2011), and more recently that “young” ( 50) HIV patients express high levels of autophagy machinery while levels are low in brains from “aged” ( 50) patients (Fields et al.,…”
BackgroundInfluentialSelf-citationRole of Endolysosomes in HIV-1 Tat-Induced Neurotoxicity
Hui, L., Chen, X., Haughey, N. J., & Geiger, J. D. (2012) · ASN NEURO · doi:10.1042/an20120017 · Cited by 94 · cited 4×
“Tat treatment caused altered endolysosome morphology and function leading to neurotoxic effects (Hui et al., 2012).”
BackgroundResultInfluentialDesign and cloning of lentiviral vectors expressing small interfering RNAs
Tiscórnia, G., Singer, O., & Verma, I. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.36 · Cited by 92 · cited 1×
“Lentiviruses (LVs) were prepared by transient transfection in 293T cells (Naldini et al., 1996a, b; Tiscornia et al., 2006).”
MethodImpact of HIV and aging on neuropsychological function
Wendelken, L. A., & Valcour, V. (2012) · Journal of NeuroVirology · doi:10.1007/s13365-012-0094-1 · Cited by 90 · cited 1×
“The aged and young distinctions are made in the context of HIV infection, consistent with other reports that suggest HIV patients over 50 are more susceptible to cognitive impairments (Wendelken and Valcour, 2012).”
ResultScott, J. C., Woods, S. P., Carey, C. L., Weber, E., Bondi, M. W., & Grant, I. (2010) · AIDS and Behavior · doi:10.1007/s10461-010-9815-8 · Cited by 89
AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons
Amadoro, G., Corsetti, V., Florenzano, F., Atlante, A., Ciotti, M. T., Mongiardi, M. P., Bussani, R., Nicolin, V., Nori, S. L., Campanella, M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.018 · Cited by 86 · cited 3×
“For example, BafA1 and Chloro disrupt autophagy by blocking acidification of lysosomes, and subsequent fusion of lysosomes with autophagosomes (Amadoro et al., 2014), resulting in accumulation of LC3II and SQSTM1.”
BackgroundResultInfluentialDecreased neuronal autophagy in HIV dementia: A mechanism of indirect neurotoxicity
Alirezaei, M., Kiosses, W. B., & Fox, H. S. (2008) · Autophagy · doi:10.4161/auto.6805 · Cited by 83
Singh, I. N., El‐Hage, N., Campbell, M. E., Lutz, S. E., Knapp, P. E., Nath, A., & Hauser, K. F. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.028 · Cited by 73
Cherner, M., Cysique, L. A., Heaton, R. K., Marcotte, T. D., Ellis, R. J., Masliah, E., & Grant, I. (2007) · Journal of NeuroVirology · doi:10.1080/13550280601089175 · Cited by 72 · cited 2×
“Modern treatment regimens result in HIV suppression and immune recovery; however, the prevalence of HIV-associated neurocognitive disorders (HAND) and neurodegeneration (Budka et al., 1987; Wiley and Achim, 1994; Gendelman et al., 1997; Cherner et al., 2007; Heaton et al., 2010) has remained the same or increased (Jos…”
BackgroundSelf-citationFields, J. A., Dumaop, W., Rockenstein, E. M., Mante, M., Spencer, B. J., Grant, I., Ellis, R. J., Letendre, S. L., Patrick, C., Adame, A., et al. (2013) · Journal of NeuroVirology · doi:10.1007/s13365-012-0145-7 · Cited by 69 · cited 7×
“Interestingly, in vitro experiments using HIV-infected microglial supernatant or gp120-transgenic mice showed a decrease in autophagy through possible decreases in Beclin levels and activity (Alirezaei et al., 2008a; Fields et al., 2013).”
BackgroundMethodInfluentialSelf-citationAlirezaei, M., Watry, D. D., Flynn, C. F., Kiosses, W. B., Masliah, E., Williams, B. R. G., Kaul, M., Lipton, S. A., & Fox, H. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2733-07.2007 · Cited by 67 · cited 2×
“HIV-Tat colocalizes with autophagosome and lysosome markers in neuronal cells and in primary neurons Previous studies have shown that HIV-1 Tat can permeate the cell membrane of neurons and other cells where it may affect organelle function (Kaul and Lipton, 2006; Alirezaei et al., 2007).”
BackgroundResultSelf-citationBenelli, R., Barbero, A., Ferrini, S., Scapini, P., Cassatella, M. A., Bussolino, F., Tacchetti, C., Noonan, D. M., & Albini, A. (2000) · The Journal of Infectious Diseases · doi:10.1086/317597 · Cited by 67 · cited 1×
“The present findings are consistent with previous studies in which HIV proteins are secreted from infected cells and subsequently enter bystander cells (Benelli et al., 2000; Kandanearatchi et al., 2005; Kaul and Lipton, 2006; Alirezaei et al., 2007).”
ResultLi, J., Au, K.-Y., Fang, J., Yim, H. C. H., Chow, K., Ho, P., & Lau, A. S. (2010) · AIDS · doi:10.1097/qad.0b013e328340fd61 · Cited by 55
Aβ1–42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD
Masliah, E., Alford, M. F., Adame, A., Rockenstein, E. M., Galasko, D., Salmon, D. P., Hansen, L. A., & Thal, L. J. (2003) · Neurology · doi:10.1212/01.wnl.0000073987.79060.4b · Cited by 53 · cited 2×
“Briefly, as previously described (Masliah et al., 2003), free-floating 40- m-thick vibratome sections of mouse brains were washed with TBS, pH 7.4, pretreated in 3% H2O2, and blocked with 10% serum (Vector Laboratories), 3% BSA (Sigma), and 0.2% gelatin in TBS-T.”
MethodInfluentialSelf-citationHargus, N. J., & Thayer, S. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1312-13.2013 · Cited by 52 · cited 2×
“HIV proteins affect cell processes through interaction with caspase machinery or NMDA receptors and thereby induce apoptosis, regulate calcium levels, alter glutamate excitotoxicity, and induce chemotaxis in bystander cells (Bonavia et al., 2001; Singh et al., 2005; Hargus and Thayer, 2013; Dalvi et al., 2014; Darbini…”
BackgroundDalvi, P., Wang, K., Mermis, J. D., Zeng, R., Sanderson, M., Johnson, S. H., Dai, Y., Sharma, G., O'Brien-Ladner, A. R., & Dhillon, N. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085246 · Cited by 47 · cited 1×
“…interaction with caspase machinery or NMDA receptors and thereby induce apoptosis, regulate calcium levels, alter glutamate excitotoxicity, and induce chemotaxis in bystander cells (Bonavia et al., 2001; Singh et al., 2005; Hargus and Thayer, 2013; Dalvi et al., 2014; Darbinian et al., 2014).”
BackgroundA frontal cortex event-related potential driven by the basal forebrain
Nguyen, D. P., & Lin, S. (2014) · eLife · doi:10.7554/elife.02148 · Cited by 37 · cited 2×
“…neuroblastoma cells were used here for the cholinergic and GABAergic phenotypes (Schubert et al., 1974), both of which are implicated in frontal cortex and basal ganglia function (Stocco et al., 2010; Nguyen and Lin, 2014) and relevant to HAND (Masliah et al., 1994; Hesselgesser and Horuk, 1999).”
BackgroundMethodCellular neuropathology in HIV encephalitis.
Masliah, E., Achim, C. L., Ge, N., Teresa, R. D., & Wiley, C. A. (1994) · PubMed · Cited by 37
Self-citationAutophagy and CD4+T lymphocyte destruction by HIV-1
Espert, L., Denizot, M., Grimaldi, M., Robert-Hebmann, V., Gay, B., Varbanov, M., Codogno, P., & Biard‐Piechaczyk, M. (2007) · Autophagy · doi:10.4161/auto.3275 · Cited by 31 · cited 2×
“Gp120 was reported to increase autophagy in uninfected T-cells (Espert et al., 2007) as well as in LV-infected SK N SH cells (Zhou et al.”
BackgroundVeinbergs, I., Van Uden, E., Mallory, M., Alford, M., McGiffert, C., DeTeresa, R., Orlando, R., & Masliah, E. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7684 · Cited by 29
Self-citationSynaptodendritic injury with HIV-Tat protein: What is the therapeutic target?
Nath, A., & Steiner, J. P. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.11.004 · Cited by 28
Säftig, P., & Eskelinen, E. (2008) · Nature Medicine · doi:10.1038/nm0908-909 · Cited by 18 · cited 1×
“Indeed, LAMP2A levels are reduced with age in some organs, and it has been suggested that restoring levels may reverse some aging effects (Saftig and Eskelinen, 2008; Saftig et al., 2008; Zhang and Cuervo, 2008).”
BackgroundNeuroprotective Activity of p DING in Response to HIV ‐1 Tat
Darbinian, N., Khalili, K., & Amini, S. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24392 · Cited by 18 · cited 2×
“HIV proteins affect cell processes through interaction with caspase machinery or NMDA receptors and thereby induce apoptosis, regulate calcium levels, alter glutamate excitotoxicity, and induce chemotaxis in bystander cells (Bonavia et al., 2001; Singh et al., 2005; Hargus and Thayer, 2013; Dalvi et al., 2014; Darbini…”
BackgroundRichard, J., Pham, T. N. Q., Ishizaka, Y., & Cohen, É. A. (2013) · Virology · doi:10.1016/j.virol.2013.04.037 · Cited by 17 · cited 1×
“HIV-1 Tat affects basal autophagy function in a neuronal cell line and primary neurons Previous studies have shown that HIV-1 Tat can be secreted from infected macrophage/microglia cells and affect bystander cells, such as neurons (Toborek et al., 2003; Van Grol et al., 2010; Richard et al., 2013).”
BackgroundProtection against HIV-1 gp120 and HIV-1 Tat neurotoxicity
Kandanearatchi, A., Nath, A., Lipton, S. A., Masliah, E., & Everall, I. (2005) · doi:10.1093/oso/9780198526100.003.0019 · Cited by 1
Self-citation
Research works printed but not linked: 2
- Department of Health and Human Services, Public Health Service: Centers for Disease Control and Prevention (2005) HIV/AIDS surveillance report, pages 1–63.
- Department of Health and Human Services, Public Health Service: Centers for Disease Control and Prevention (2007) HIV/AIDS surveillance report, pages 1–54.
Cited by
Sorted by citations
Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders
Cai, Y. C., Arikkath, J., Yang, L., Guo, M., Periyasamy, P., & Buch, S. J. (2016) · Autophagy · doi:10.1080/15548627.2015.1121360 · Cited by 259
“8).(182,183) Autophagy dysfunction in HIV patients has also been linked with aging.”
BackgroundTherapeutic targeting of autophagy in neurodegenerative and infectious diseases
Rubinsztein, D. C., Bento, C. F., & Deretic, V. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150956 · Cited by 202
Sarıbaş, A. S., Cicalese, S. M., Ahooyi, T. M., Khalili, K., Amini, S., & Sariyer, I. K. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.467 · Cited by 136
Tavera-Mendoza, L. E., Westerling, T., Libby, E., Marusyk, A., Cato, L., Cassani, R., Cameron, L., Ficarro, S. B., Marto, J. A., Klawitter, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615015114 · Cited by 124
“Because autophagosome accumulation is toxic to cells (27, 28), we hypothesized that inducing autophagosome formation with 1,25(OH)2D3 and then blocking autophagosome degradation would be detrimental to cell survival.”
BackgroundBasic science and pathogenesis of ageing with HIV
Lagathu, C., Cossarizza, A., Béréziat, V., Nasi, M., Capeau, J., & Pinti, M. (2017) · AIDS · doi:10.1097/qad.0000000000001441 · Cited by 114
Metadata
- Authors
- Fields, J., Dumaop, W., Elueteri, S., Campos, S., Serger, E., Trejo, M., Kosberg, K., Adame, A., Spencer, B., Rockenstein, E., He, J. J., & Masliah, E.
- Affiliations
- University of California San Diego (US)
- University of North Texas Health Science Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-02-04
- Volume
- 35
- Issue
- 5
- Pages
- 1921-1938
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4315828
- OpenAlex
- W2050541584
- Cited by
- 133
- References
- 64
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 6 · 2022: 12 · 2021: 14 · 2020: 21 · 2019: 15 · 2018: 15 · 2017: 13 · 2016: 9 · 2015: 4
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG043384, R01AG043384)
- National Institute of Mental Health (U01MH083506, R01MH062962, U24MH100928, U01MH083500, MH5974, MH83506, MH062962, U24MH100929)
- National Institute of Neurological Disorders and Stroke (F32NS083426)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- HIV-1 Tat protein, neuronal autophagy, autophagosome-lysosome fusion, HIV-associated neurocognitive disorders, neurodegeneration, LAMP2A, LC3-II, p62, bafilomycin A1, rapamycin, neurotoxicity
- MeSH terms
- Animals, Autophagy, Cells, Cultured, Lysosomes, Neurons, Phagosomes, Protein Binding, HIV-1, AIDS Dementia Complex, Cell Line, Tumor, Mice, Rats, Lysosomal-Associated Membrane Protein 2, tat Gene Products, Human Immunodeficiency Virus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
