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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
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Defects in induction, maturation, or lysosomal clearance impair protein degradation.
“Defects in induction, maturation, or lysosomal clearance impair protein degradation (Zhong et al. 2009), (Pickford et al. 2008), (Ravikumar et al. 2005), (Webb et al. 2004), (Iwata et al. 2005), (Kimura et al. 2008), (Wong and Cuervo 2010), (Lee et al. 2010), and is assessable via LC3-II turnover or p62 degradation (Mizushima et al. 2010), (Ju et al. 2010), (Klionsky et al. 2008b), (Tanida et al.”
From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Pickford et al. 2008
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Cell “Self‐Eating” (Autophagy) Mechanism in Alzheimer's Disease
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Autophagy and misfolded proteins in neurodegeneration
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Autophagy Dysfunction in Alzheimer’s Disease: Mechanistic Insights and New Therapeutic Opportunities
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“Alterations in autophagy pathways have been described in AD (Nixon et al., 2005; Pickford et al., 2008), PD (Cuervo et al.”
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Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion
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Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease
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“(171) found reduced levels of Beclin-1 in brains of earlystage AD and demonstrated that Beclin-1-deficient mice have enhanced APP-mediated neurodegeneration and reduced clearance of APP and APP cleavage products; these deficiencies were rescued by the expression of Beclin-1.”
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Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis
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The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics
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Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
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NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models
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Clinical Applications Involving CNS Gene Transfer
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APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain
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Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.
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Recent progress in the role of autophagy in neurological diseases
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Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles
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The Implications of Autophagy in Alzheimer’s Disease
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Self-citationThe role of glial autophagy in Alzheimer’s disease
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Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
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“Nonetheless, AD patients showed a massive decline in the transcriptional levels of the autophagy initiator Beclin1 during early stages of AD and strategies that have aimed to enhance the degree of autophagy, such as the lentivirusmediated expression of Beclin 1 or the autophagy-inducing blockage of mTor by rapamycin,…”
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The role of autophagy in axonal degeneration of the optic nerve
Koch, J. C., & Lingor, P. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.08.016 · Cited by 46
The pleiotropic roles of autophagy in Alzheimer’s disease: From pathophysiology to therapy
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Preserved autophagy in cognitively intact non‐demented individuals with Alzheimer's neuropathology
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A new method to measure autophagy flux in the nervous system
Matus, S., Valenzuela, V., & Hetz, C. (2014) · Autophagy · doi:10.4161/auto.28434 · Cited by 29
Metadata
- Authors
- Pickford, F., Masliah, E., Britschgi, M., Lucin, K., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., & Wyss-Coray, T.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-05-01
- ISSN
- 0021-9738
- Cited by
- 268
- References
- 16
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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