The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Nicotine Regulates Multiple Synaptic Proteins by Inhibiting Proteasomal Activity
Open accessAbstract
Ubiquitination regulates the degradation, membrane trafficking, and transcription of proteins. At mammalian synapses, the ubiquitin-proteasome system (UPS) influences synaptic transmission and plasticity. Nicotine also has the ability to affect synaptic function via mechanisms that remain partially unknown. We found that nicotine, at concentrations achieved by smokers, reduced proteasomal activity, produced accumulation of ubiquitinated synaptic proteins, and increased total protein levels. In particular, a 24 h exposure to nicotine decreased proteasome-dependent degradation of the alpha7 nicotinic acetylcholine receptor (nAChR) subunit, as indicated by the accumulation of ubiquitinated alpha7. The same nicotine treatment increased the levels of the AMPA glutamate receptor subunit GluR1, the NMDA receptor subunit NR2A, the metabotropic receptor mGluR1alpha, the plasticity factor Homer-1A, and the scaffolding postsynaptic density protein PSD-95, whereas the levels of another scaffolding protein, Shank, were reduced. These changes were associated with an inhibition of proteasomal chymotrypsin-like activity by nicotine. The nAChR antagonist mecamylamine was only partially able to block the effects of nicotine on the UPS, indicating that nAChR activation does not completely explain nicotine-induced inhibition of proteasomal catalytic activity. A competition binding assay suggested a direct interaction between nicotine and the 20S proteasome. These results suggest that the UPS might participate in nicotine-dependent synaptic plasticity.
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“Neuronal nAChR upregulation is an important adaptive change and a major contributor to the addictive properties of nicotine [83–86].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [86]
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Cites
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
Glickman, M. H., & Ciechanover, A. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00027.2001 · Cited by 4,304
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,630
Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
Liu, L., Wong, T. P., Pozza, M. F., Lingenhoehl, K., Wang, Y., Sheng, M., Auberson, Y. P., & Wang, Y. T. (2004) · Science · doi:10.1126/science.1096615 · Cited by 1,131
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
Conquet, F., Bashir, Z. I., Davies, C. H., Daniel, H., Ferraguti, F., Bordi, F., Franz-Bacon, K., Reggiani, A., Matarese, V., Condé, F., et al. (1994) · Nature · doi:10.1038/372237a0 · Cited by 743
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720
Research works printed but not linked: 1
- Powers, 2005, Nicotinic receptor modulation of glutamate receptor expression in the mouse brain, Soc Neurosci Abstr, 31, 723
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Items 101–112 of 112
Mendes, C. C. C. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2009.tde-28082009-105421
Tai, H. (2009) · CaltechTHESIS (California Institute of Technology) · doi:10.7907/dgma-1k68 · Cited by 1
THE UBIQUITIN LIGASE UBE4B IS REQUIRED FOR EFFICIENT EPIDERMAL GROWTH FACTOR RECEPTOR DEGRADATION
Sirisaengtaksin, N. (2010) · Digital Commons-TMC (Texas Medical Center)
Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit
Paolini, M. A., Biasi, M. D., & Dani, J. A. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_13
Hosur, V. (2009) · Digital Repository Service (Northeastern University) · doi:10.17760/d20000672
Kara, N. S., Özışık, O., Baudot, A., & Šlachtová, L. (2025) · Neurotoxicity Research · doi:10.1007/s12640-025-00774-y
Wang, N., SLUD, E. V., & Ma, T. (2026) · Computational Statistics & Data Analysis · doi:10.1016/j.csda.2026.108482
Metadata
- Authors
- Rezvani, K., Teng, Y., Shim, D., & De Biasi, M.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-09-26
- Volume
- 27
- Issue
- 39
- Pages
- 10508-10519
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673157
- OpenAlex
- W2027624603
- Cited by
- 113
- References
- 69
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 15
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Philip Morris International
- National Institute on Drug Abuse (DA017173, R01DA017173)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, ubiquitin-proteasome system, proteasome inhibition, synaptic proteins, alpha7 nicotinic acetylcholine receptor, GluR1, NR2A, mGluR1alpha, Homer1a, PSD-95, shank, synaptic plasticity, chymotrypsin-like activity, mecamylamine, 20S proteasome, protein degradation
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Male, Membrane Proteins, Synaptic Transmission, Nicotine, Receptors, Nicotinic, Synapses, Protein Biosynthesis, Prefrontal Cortex, Receptors, Glutamate, Neurotransmitter Agents, Nicotinic Agonists, Models, Animal, Ubiquitin, Proteasome Endopeptidase Complex, Intracellular Signaling Peptides and Proteins, Mice, Guanylate Kinases, Proteasome Inhibitors
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